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Jane F Apperley
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Journal Articles

Long-Term Results from the Optic Trial: A Dose-Optimization Study of 3 Starting Doses of Ponatinib

Jorge Cortes, Michael Deininger, Elza Lomaia, Beatriz Moiraghi, Soledad Undurraga, Carolina Pavlovsky, Charles Chuah, Tomasz Sacha, Jeffrey H. Lipton, James McCloskey, Andreas Hochhaus, Philippe Rousselot, Gianantonio Rosti, Hugues de Lavallade, Anna Turkina, Lori Maness, Moshe Talpaz, Michael Mauro, Vickie Lu, Alexander Vorog, Jane F Apperley
Journal: Blood
Blood (2023) 142 (Supplement 1): 3164.
https://doi.org/10.1182/blood-2023-178790
Published: 2023
Journal Articles

Sustained Efficacy and Safety with Asciminib (ASC) after Almost 4 Years of Median Follow-up from Ascembl, a Phase 3 Study of ASC Vs Bosutinib (BOS) in Patients (Pts) with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) after ≥2 Prior Tyrosine Kinase Inhibitors (TKIs): An End of Study Treatment (EOS Tx) Update, Including Results from Switch Population

Michael Mauro, Yosuke Minami, Andreas Hochhaus, Elza Lomaia, Sergei Voloshin, Anna Turkina, Dong-Wook Kim, Jane F Apperley, Jorge Cortes, Andre N.R. Abdo, Laura Maria Fogliatto, Dennis Dong Hwan Kim, Philipp le Coutre, Susanne Saussele, Mario Annunziata, Timothy P Hughes, Naeem A. Chaudhri, Lynette C.Y. Chee, Valentín García Gutiérrez, Koji Sasaki, Carla Maria Boquimpani De Moura Freitas, Shruti Kapoor, Noemi Espurz, Vishal Dhamal, Delphine Rea
Journal: Blood
Blood (2023) 142 (Supplement 1): 4536.
https://doi.org/10.1182/blood-2023-186854
Published: 2023
Journal Articles

Incidence, Interpretation and Management of Liver Function Abnormalities in Patients with Chronic Myeloid Leukemia (CML) Treated with Tyrosine Kinase Inhibitors (TKI)

Harry F Robertson, Victoria Orovboni, Jeeyune Bahk, Richard Szydlo, Fiona R Fernando, Afzal Khan, Sarmad Toma, Chloe Hayden, Simone Claudiani, Andrew J Innes, Dragana Milojkovic, Jane F Apperley
Journal: Blood
Blood (2023) 142 (Supplement 1): 6370.
https://doi.org/10.1182/blood-2023-188740
Published: 2023
Journal Articles

Does Detection of <20% Lymphoblasts in Patients with CML Herald Imminent Blast Crisis? a Study from BCR::ABL1 Pathology Group

Zimu Gong, Lianqun Qiu, Joseph DiGiuseppe, Mengxing Xue, Lorinda Soma, Wei Wang, Yi Zhou, Qi Shen, Mingqing Zhu, Anisha Naik, Weina Chen, Wei J Wang, Sa A. Wang, L. Jeffrey Medeiros, Elias Jabbour, Hagop M. Kantarjian, Jorge Cortes, Jerald P. Radich, Joseph D. Khoury, Andreas Hochhaus, Jane F Apperley, Suning Chen, Kikkeri N Naresh, Shimin Hu
Journal: Blood
Blood (2023) 142 (Supplement 1): 6364.
https://doi.org/10.1182/blood-2023-187020
Published: 2023
Journal Articles

Digital Droplet (dd) Polymerase Chain Reaction (PCR) Assays Offer Limited Advantages over Conventional Reverse-Transcriptase Quantitative PCR (RT-qPCR) for the Prediction of Molecular Recurrence after Treatment Discontinuation in Chronic Myeloid Leukemia (CML): Results from the Destiny Study

Kathy Dominy, Matthew Salmon, Richard Szydlo, Chloe Hayden, Helen E White, Mary Alikian, Dragana Milojkovic, Mhairi Copland, Letizia Foroni, Nicholas C.P. Cross, Richard E Clark, Jane F. Apperley
Journal: Blood
Blood (2022) 140 (Supplement 1): 9631–9632.
https://doi.org/10.1182/blood-2022-170375
Published: 2022
Journal Articles

Molecular Response of ≤10% BCR::ABL1 IS Is Predictive of Positive Outcomes in Treatment-Resistant Patients with Chronic Phase Chronic Myeloid Leukemia (CP-CML) Treated with Ponatinib from the Phase 2 Optic Trial

Jane F. Apperley, Jorge E. Cortes, Elias Jabbour, Andreas Hochhaus, Timothy Hughes, Charles Chuah, Hugues de Lavallade, Michael W. Deininger, Jeffrey H. Lipton, Elza Lomaia, Lori Maness, Michael Mauro, James McCloskey, Beatriz Moiraghi, Carolina Pavlovsky, Christine Rojas, Philippe Rousselot, Tomasz Sacha, Moshe Talpaz, Anna Turkina, Maria Undurraga Sutton, Xiaowei Ren, Alexander Vorog, Gianantonio Rosti
Journal: Blood
Blood (2022) 140 (Supplement 1): 6760–6762.
https://doi.org/10.1182/blood-2022-157956
Published: 2022
Journal Articles

Dynamics of Response and Response Factors in Patients (Pts) with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) after ≥2 Prior Tyrosine Kinase Inhibitors (TKIs) in the Phase 3 Ascembl Study

Timothy Hughes, Delphine Rea, Carla Boquimpani, Yosuke Minami, Michael Mauro, Jorge E. Cortes, Jane F. Apperley, Valentín García Gutiérrez, Shruti Kapoor, Alex Allepuz, Sarah Quenet, Yifan Zhang, Andreas Hochhaus
Journal: Blood
Blood (2022) 140 (Supplement 1): 6757–6759.
https://doi.org/10.1182/blood-2022-169110
Published: 2022
Journal Articles

Real-World Experience of Asciminib: Factors Associated with Response

Andrew J. Innes, Chloe Hayden, Victoria Orovboni, David Rees, Simone Claudiani, Fiona Fernando, Afzal Khan, Jennifer Byrne, Paolo Gallipoli, Sebastian Francis, Mhairi Copland, Gillian Horne, Manoj Raghavan, Claire Arnold, Angela Collins, Tanya Cranfield, Nicholas Cunningham, Akila Danga, Peter Forsyth, Rebecca Frewin, Paula Garland, Guy Hannah, Sandra Hassan, Brian James Patrick Huntly, Jissan Husain, Sudhakaran Makkuni, Kate Rothwell, Letizia Foroni, Jane F. Apperley, Dragana Milojkovic
Journal: Blood
Blood (2022) 140 (Supplement 1): 6796–6797.
https://doi.org/10.1182/blood-2022-165501
Published: 2022
Journal Articles

Chronic Myeloid Leukemia Diagnosed during Pregnancy: How to Manage? Description of 86 Cases from ELN International Registry

Ekaterina Yu. Chelysheva, Anna Turkina, Jane F. Apperley, Mohamed A Yassin, Delphine Rea, Franck E. Nicolini, Daniela Barraco, Konstantin Kotlyarchuk, Khamida Kazakbaeva, Sukhrob Saliev, Adi Shacham, Dong-Wook Kim, Salam Al-Kindi, Penka Ganeva, Roman Shmakov, Jennifer Byrne, Harry Robertson, Cerrano Marco, Evgenia Polushkina, Malgorzata Monika Trawinska, Elisabetta Abruzzese
Journal: Blood
Blood (2022) 140 (Supplement 1): 1498–1500.
https://doi.org/10.1182/blood-2022-159993
Published: 2022
Journal Articles

Three-Year Update from the Optic Trial: A Dose-Optimization Study of 3 Starting Doses of Ponatinib

Jorge E. Cortes, Michael W. Deininger, Elza Lomaia, Beatriz Moiraghi, Maria Undurraga Sutton, Carolina Pavlovsky, Charles Chuah, Tomasz Sacha, Jeffrey H. Lipton, James McCloskey, Andreas Hochhaus, Philippe Rousselot, Gianantonio Rosti, Hugues de Lavallade, Christine Rojas, Anna Turkina, Lori Maness, Moshe Talpaz, Michael Mauro, Vickie Lu, Alexander Vorog, Jane F. Apperley
Journal: Blood
Blood (2022) 140 (Supplement 1): 1495–1497.
https://doi.org/10.1182/blood-2022-157822
Published: 2022
Journal Articles

Efficacy and Safety of Vodobatinib in Patients (pts) with Chronic Phase Philadelphia Positive Chronic Myeloid Leukemia (Ph+ CML): A Sub Group Analysis By Lines of Tyrosine Kinase Inhibitor (TKI) Therapy

Jorge E. Cortes, Tapan Saikia, Dong-Wook Kim, Yesid Alvarado, Franck E. Nicolini, Krishnakumar Rathnam, Navin Khattry, Sachin Punatar, Jane F. Apperley, Aude Charbonnier, Michael Deininger, Hugues de Lavallade, Nikki Granacher, Carlo Gambacorti-Passerini, Alessandro Lucchesi, Michael Mauro, Peter Vandenberghe, Gregor Verhoef, Andrew R. Whiteley, Arijit Nag, Shashikant Apte, Siu-Long Yao, Sandeep Inamdar, Ruchika Irene Dillu, Jayasree Sreenivasan, Geetanjali Chimote
Journal: Blood
Blood (2022) 140 (Supplement 1): 205–207.
https://doi.org/10.1182/blood-2022-166452
Published: 2022
Journal Articles

A phase 3, open-label, randomized study of asciminib, a STAMP inhibitor, vs bosutinib in CML after 2 or more prior TKIs

Clinical Trials & Observations
Delphine Réa, Michael J. Mauro, Carla Boquimpani, Yosuke Minami, Elza Lomaia, Sergey Voloshin, Anna Turkina, Dong-Wook Kim, Jane F. Apperley, Andre Abdo, Laura Maria Fogliatto, Dennis Dong Hwan Kim, Philipp le Coutre, Susanne Saussele, Mario Annunziata, Timothy P. Hughes, Naeem Chaudhri, Koji Sasaki, Lynette Chee, Valentin García-Gutiérrez, Jorge E. Cortes, Paola Aimone, Alex Allepuz, Sara Quenet, Véronique Bédoucha, Andreas Hochhaus
Journal: Blood
Blood (2021) 138 (21): 2031–2041.
https://doi.org/10.1182/blood.2020009984
Published: 2021
Includes: Supplemental data
Journal Articles

Post Hoc Analysis of Responses to Ponatinib in Patients with Chronic-Phase Chronic Myeloid Leukemia (CP-CML) By Baseline BCR-ABL1 Level and Baseline Mutation Status in the Optic Trial

Michael W. Deininger, Jane F Apperley, Christopher Kevin Arthur, Charles Chuah, Andreas Hochhaus, Hugues De Lavallade, Jeffrey H. Lipton, Elza Lomaia, James K McCloskey, Lori J. Maness, Michael J. Mauro, Beatriz Moiraghi, Carolina Pavlovsky, Gianantonio Rosti, Philippe Rousselot, Soledad S. Undurraga, Vickie Lu, Alexander Vorog, Jorge E. Cortes
Journal: Blood
Blood (2021) 138 (Supplement 1): 307.
https://doi.org/10.1182/blood-2021-145995
Published: 2021
Journal Articles

Comparative Study of Unrelated and Haploidentical Donor Hematopoietic Cell Transplant for Chronic Myeloid Leukemia with Post Transplant Cyclophosphamide As Graft-Versus-Host Disease Prophylaxis: A Study from the Chronic Malignancies Working Party of EBMT

Guillermo Ortí, Luuk Gras, Sr., Nienke Zinger, Aleksandr D. Kulagin, Jennifer Byrne, Jane F Apperley, Kazimierz Halaburda, Igor Wolfgang Blau, Andrew Clark, Nicolaus Kröger, Laimonas Griskevicius, Kristina Carlson, Matthew P. Collin, Adrian Bloor, Emanuele Angelucci, Didier Blaise, Mahmoud Aljurf, Lucia Lopez Corral, Achilles Anagnostopoulos, Yves Beguin, Tomasz Wrobel, Luigi Rigacci, Patrick John Hayden, Yves Chalandon, Ibrahim Yakoub-Agha
Journal: Blood
Blood (2021) 138 (Supplement 1): 3954.
https://doi.org/10.1182/blood-2021-147684
Published: 2021
Journal Articles

Transplant Outcomes in Patients with Ph+ Chronic Myeloid Leukemia: Haploidentical Donors Compared to Matched Sibling Donors and Matched/Mismatched Unrelated Donors: A Retrospective Analysis from the EBMT Chronic Malignancies Working Party (EBMT-CMWP)

Francesco Onida, Ge Junran, Linda Koster, Rose-Marie Hamladji, Jennifer Byrne, Victoria Potter, Mahmoud Aljurf, Marie Robin, Kazimierz Halaburda, Jakob R. Passweg, Urpu Salmenniemi, Henrik Sengeloev, Jane F Apperley, Andrew Clark, Péter Reményi, Elena V. Morozova, Charles Craddock, Stig Lenhoff, Arnold Ganser, Ka Lung Wu, Antonio Perez Martinez, Patrick John Hayden, Luuk Gras, Sr., Yves Chalandon, Ibrahim Yakoub-Agha
Journal: Blood
Blood (2021) 138 (Supplement 1): 3959.
https://doi.org/10.1182/blood-2021-146366
Published: 2021
Journal Articles

Dose Modification Dynamics of Ponatinib in Patients with Chronic-Phase Chronic Myeloid Leukemia (CP-CML) from the PACE and Optic Trials

Elias J. Jabbour, Michael W. Deininger, Elisabetta Abruzzese, Jane F Apperley, Jorge E. Cortes, Charles Chuah, Daniel J. DeAngelo, John F. DiPersio, Andreas Hochhaus, Jeffrey H. Lipton, Franck E. Nicolini, Javier Pinilla Ibarz, Delphine Rea, Gianantonio Rosti, Philippe Rousselot, Michael J. Mauro, Neil P Shah, Moshe Talpaz, Alexander Vorog, Vickie Lu, Hagop Kantarjian
Journal: Blood
Blood (2021) 138 (Supplement 1): 2550.
https://doi.org/10.1182/blood-2021-146175
Published: 2021
Journal Articles

An Update of Safety and Efficacy Results from Phase 1 Dose-Escalation and Expansion Study of Vodobatinib, a Novel Oral BCR-ABL1 Tyrosine Kinase Inhibitor (TKI), in Patients with Chronic Myeloid Leukemia (CML) and Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Failing Prior TKI Therapies

Jorge E. Cortes, Tapan Saikia, Dong-Wook Kim, Yesid Alvarado, Franck E. Nicolini, Krishnakumar Rathnam, Navin Khattry, Jane F Apperley, Michael W. Deininger, Hugues de Lavallade, Aude Charbonnier, Nikki Granacher, Carlo Gambacorti-Passerini, Alessandro Lucchesi, Michael J. Mauro, Peter Vandenberghe, Gregor Verhoef, Andrew R. Whiteley, Arijit Nag, Vivek S Radhakrishnan, Shashikant Apte, Siu-Long Yao, Sandeep Inamdar, Jayasree Sreenivasan, Ruchika Irene Dillu, Geetanjali Chimote
Journal: Blood
Blood (2021) 138 (Supplement 1): 309.
https://doi.org/10.1182/blood-2021-152548
Published: 2021
Journal Articles

Efficacy and Safety Results from Ascembl, a Multicenter, Open-Label, Phase 3 Study of Asciminib, a First-in-Class STAMP Inhibitor, Vs Bosutinib in Patients with Chronic Myeloid Leukemia in Chronic Phase after ≥2 Prior Tyrosine Kinase Inhibitors: Update after 48 Weeks

Michael J. Mauro, Yosuke Minami, Delphine Rea, Andreas Hochhaus, Elza Lomaia, Sergey Voloshin, Anna G. Turkina, Dong-Wook Kim, Jane F Apperley, Jorge E. Cortes, Andre N.R. Abdo, Laura Fogliatto, Dennis Dong Hwan Kim, Philipp D le Coutre, Susanne Saussele, Mario Annunziata, Timothy P. Hughes, Naeem A. Chaudhri, Lynette C.Y. Chee, Valentín Garcia Gutierrez, Koji Sasaki, Shruti Kapoor, Alex Allepuz, Sarah Quenet, Véronique Bédoucha, Carla Boquimpani
Journal: Blood
Blood (2021) 138 (Supplement 1): 310.
https://doi.org/10.1182/blood-2021-152561
Published: 2021
Journal Articles

Introducing a Predictive Score for Successful Treatment Free Remission in Chronic Myeloid Leukemia (CML)

Simone Claudiani, MD, Silvia Metelli, PhD, Rafiee Kamvar, BSc, Richard Szydlo, PhD, Afzal Khan, Jenny Byrne, MD PhD, Paolo Gallipoli, PhD, Simon J Bulley, Gillian A. Horne, MBChB BSc, MRCP, MRes, PhD, Kate Rothwell, BA MB BChir, PhD, Mhairi Copland, PhD MBBChir, FRCP, FRCPath, Richard E. Clark, MA, MD MRCP, FRCPath, Jamshid S Khorashad, MD PhD, Letizia Foroni, MD PhD, Dragana Milojkovic, MBBS, MD, Jane F. Apperley, MD FRCP, FRCPath, MB
Journal: Blood
Blood (2019) 134 (Supplement_1): 26.
https://doi.org/10.1182/blood-2019-131500
Published: 2019
Journal Articles

Pregnancy Management in CML Patients: To Treat or Not to Treat? Report of 224 Outcomes of the European Leukemia Net (ELN) Database

Elisabetta Abruzzese, MD, Anna G. Turkina, Prof., MD, Jane F. Apperley, MD FRCP, FRCPath, MB, Francesco Bondanini, MD, Paolo de Fabritiis, MD, Dong-Wook Kim, Iryna Dyagil, MD PhD, Penka Ganeva, Valentín Garcia-Gutiérrez, MD PhD, Khamida Kazakbaeva, MD, Hana Klamová, MD PhD, Konstantin Kotlyarchuk, Michael J. Mauro, MD, Dragana Milojkovic, MBBS, MD, Beatriz Moriaghi, MD, Karen Meliktesyan, MD, Franck E Nicolini, MD PhD, Evgenia Polushkina, Delphine Rea, MD, Philippe Rousselot, MD PhD, Adi Shacham, MD, Roman Shmakov, MD PhD, Malgorzata Monika Trawinska, MD, Ekaterina Yu. Chelysheva, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 498.
https://doi.org/10.1182/blood-2019-124430
Published: 2019