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Liam Hackett
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Journal Articles

CD47-blockade induces programmed necroptosis and complements the effects of BCL-2 inhibition in lymphoid malignancies

Free
Stephen Chong, Rebecca Valentin, Jing Wang, Fen Zhu, Praful Gokhale, Benjamin Eschle, Filip Garbicz, Tomasz Sewastianik, Johany Penailillo, Jeremy Zhang, Liam Hackett, Mary Collins, Timothy Lehmberg, Marisa Peluso, Ammar Adam, Li Zhang, Caroline Armet, Matthew Rausch, Benjamin Lee, Pamela Holland, Vito Palombella, Alison Paterson, Li Ren Kong, Elisa Ten Hacken, Jennifer Guerriero, Charles Herbaux, Catherine Wu, Shazib Pervaiz, Carsten Niemann, Ruben Carrasco, Matthew S Davids
Journal: Blood
Blood (2025) 146 (Supplement 1): 1525.
https://doi.org/10.1182/blood-2025-1525
Published: 2025
Journal Articles

Inhibition of PRMT5 with JNJ-64619178 sensitizes B-cell non-Hodgkin lymphoma cells to both intrinsic and extrinsic apoptosis

Free
Fen Zhu, Jing Wang, Christine Ryan, Liam Hackett, Jeremy Zhang, Stephen Chong, Matthew S Davids
Journal: Blood
Blood (2025) 146 (Supplement 1): 5076.
https://doi.org/10.1182/blood-2025-5076
Published: 2025
Journal Articles

Large-scale dependency and drug screens to characterize the therapeutic vulnerabilities of multiple myeloma with 1q+

Available to Purchase
Romanos Sklavenitis-Pistofidis, Elizabeth D. Lightbody, Mairead Reidy, Junko Tsuji, Jean-Baptiste Alberge, Michelle P. Aranha, Daniel Heilpern-Mallory, Harvey G. Roweth, Daisy Huynh, Stephen J. F. Chong, Anna Y. Chung, Jeremy Zhang, Liam Hackett, Nicholas J. Haradhvala, Ting Wu, Nang K. Su, Brianna Berrios, Saveliy Belkin, Ankit K. Dutta, Ryan A. Knudson, Carolyn Brandt, Patricia T. Greipp, Matthew S. Davids, Maria Papaioannou, Gad Getz, Irene M. Ghobrial, Salomon Manier
Journal: Blood
Blood (2025) 146 (1): 89–103.
https://doi.org/10.1182/blood.2024025102
Published: 2025
Includes: Supplemental data
Journal Articles

Mechanistic Insights and Therapeutic Potential of a PRMT5 Inhibitor Combined with Venetoclax in B Cell Malignancies

Free
Fen Zhu, Jing Wang, Christine E. Ryan, Liam Hackett, Jeremy Zhang, Stephen Jun Fei Chong, Matthew S. Davids
Journal: Blood
Blood (2024) 144 (Supplement 1): 1615.
https://doi.org/10.1182/blood-2024-205802
Published: 2024
Journal Articles

Primary Endpoint Evaluation of a Multicenter, Phase 2 Study of Acalabrutinib, Venetoclax, Obinutuzumab (AVO) in a Population of Previously Untreated Patients with CLL Enriched for High-Risk Disease

Free
Matthew S. Davids, Christine E. Ryan, Yue Ren, Liam Hackett, Jeremy Zhang, Svitlana Tyekucheva, Stacey M. Fernandes, Jennifer L. Crombie, Austin I. Kim, Matthew Weinstock, Josie Montegaard, Heather A. Walker, Claire Greenman, Victoria Patterson, Caron A. Jacobson, Ann S. LaCasce, Philippe Armand, David C. Fisher, Steve Lo, Adam J. Olszewski, Jon E. Arnason, Inhye E. Ahn, Jennifer R. Brown
Journal: Blood
Blood (2024) 144 (Supplement 1): 1865.
https://doi.org/10.1182/blood-2024-206556
Published: 2024
Journal Articles

Lysosomal Membrane Permeabilization Sensitizes Ctss-Hyperactive Tumors to BCL2-Targeting Therapies

Free
Johannes Adrian Hildebrand, Sarah Haebe, Verena Passerini, Michael Heide, William Keay, Louisa Adolph, Lukas Ulrich, Natyra Tahiri, Raphael Koch, Jessica Duffy, Haley Martin, Liam Hackett, Jeremy Zhang, Christina Ludwig, Stefanie Wilhelm, Björn Häupl, Carmen Doebele, Michael von Bergwelt-Baildon, Axel Lechner, Tobias Herold, Christian Kellner, Martina Rudelius, Thomas Oellerich, Marc Schmidt-Supprian, Abner Louissaint, Matthew S Davids, Oliver Weigert
Journal: Blood
Blood (2023) 142 (Supplement 1): 4358.
https://doi.org/10.1182/blood-2023-174384
Published: 2023
Journal Articles

BH3 profiling identifies ruxolitinib as a promising partner for venetoclax to treat T-cell prolymphocytic leukemia

Free
Charles Herbaux, Christoph Kornauth, Stéphanie Poulain, Stephen J. F. Chong, Mary C. Collins, Rebecca Valentin, Liam Hackett, Olivier Tournilhac, François Lemonnier, Jehan Dupuis, Adrien Daniel, Cecile Tomowiak, Kamel Laribi, Loïc Renaud, Damien Roos-Weil, Cedric Rossi, Eric Van Den Neste, Cecile Leyronnas, Fatiha Merabet, Jean Valère Malfuson, Mourad Tiab, Loïc Ysebaert, Samuel Ng, Franck Morschhauser, Philipp B. Staber, Matthew S. Davids
Journal: Blood
Blood (2021) 137 (25): 3495–3506.
https://doi.org/10.1182/blood.2020007303
Published: 2021
Includes: Supplemental data
Journal Articles

Characterizing Specificities of Chronic Lymphoid Leukemia Harboring a BCL2 rearrangement

Free
Charles Herbaux, MD MSc, Imelda Raczkiewicz, Kamel Laribi, MD, Loic Ysebaert, MD PhD, Agnes Daudignon, Sabine Tricot, Aurelie Caillault-Venet, Alain Jacques Delmer, MD PhD, Pascale Cornillet-Lefebvre, Cymbalista Florence, Virginie Eclache, Pierre Morel, MD, Gauthier Decool, Morgane Nudel, Romain Guieze, MD, Liam Hackett, BS, Stephen Jun Fei Chong, Mary C Collins, BS, Florence Nguyen-Khac, MD PhD, Fatiha Merabet, MD, Jasmine Chauzeix, Stéphanie Struski, MD, Jennifer R. Brown, MD PhD, Matthew S. Davids, MD, Stéphanie Poulain, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-139210
Published: 2020
Journal Articles

Re-Wiring BCL-2 Family Anti-Apoptotic Protein Dependencies through Modulating Phosphorylation to Re-Sensitize Venetoclax-Resistant Lymphoid Malignancies to BCL-2 Inhibition

Free
Stephen Jun Fei Chong, Mary C Collins, BS, Liam Hackett, BS, Matthew S. Davids, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–36.
https://doi.org/10.1182/blood-2020-140455
Published: 2020