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Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemia: Topline Efficacy and Safety Results from the Pivotal Augment-101 Phase 2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel N. Mannis, Alexander Perl, David S. Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J. Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G. Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 2): LBA-5.
https://doi.org/10.1182/blood-2023-192042
Published: 2023
Journal Articles

Socioeconomic Status Is a Mediator of Overall Survival in Acute Myeloid Leukemia (AML)

Cassandra Duarte, Diana Abbott, Grace N Bosma, Christine M. McMahon, Jonathan A Gutman, Marc Schwartz, Daniel Pollyea, Maria L Amaya
Journal: Blood
Blood (2023) 142 (Supplement 1): 5176.
https://doi.org/10.1182/blood-2023-174996
Published: 2023
Journal Articles

The Genomic and Transcriptomic Landscape of Myeloid Sarcoma and Associated Acute Myeloid Leukemia

Bettina Nadorp, Audrey Lasry, Sanam Loghavi, Ravi Patel, Ben Kelly, Christopher J. Walker, Stephanie LaHaye, Jill Buss, Isaiah Boateng, Karen Nahmod, Adrienne Heyrosa, Helee Desai, Andrea Langanson, Hasan Abaza, Linda Procell, Tejas Patel, Benjamin Kaffenberger, Saranga Wijeratne, Maria Guillamot Ruano, Anna Yeaton, Geraldine Cayanan, Maria Velegraki, Zihai Li, Kieran D Sahasrabudhe, Lynne V. Abruzzo, Daniel Pollyea, Christine M. McMahon, Arwa Shana'Ah, John C. Byrd, Aristotelis Tsirigos, Elaine R Mardis, Alice Mims, Iannis Aifantis, Ann-Kathrin Eisfeld
Journal: Blood
Blood (2023) 142 (Supplement 1): 292.
https://doi.org/10.1182/blood-2023-182967
Published: 2023
Journal Articles

Consolidation with Ponatinib Plus Sequential Blinatumomab and Chemotherapy after Low Intensity Dasatinib-Based Induction in Adults with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Outcomes from a Single Institution

Marc Schwartz, Christine M. McMahon, Maria L Amaya, Matthew Witkowski, Daniel A. Pollyea, Jonathan A Gutman, Mohd Minhajuddin, Clayton Smith, Craig T. Jordan
Journal: Blood
Blood (2023) 142 (Supplement 1): 4247.
https://doi.org/10.1182/blood-2023-188118
Published: 2023
Journal Articles

Impact of Type of Hypomethylating Agent (HMA) Used on Outcomes of Patients (Pts) with Higher-Risk Myelodysplastic Syndromes/Neoplasms (HR-MDS) - a Large, Multicenter, Retrospective Analysis

Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Maximilian Stahl, Najla H Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L Uy, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine M. McMahon, Joshua F. Zeidner, Michael R. Savona, Jessica M. Stempel, Namrata Sonia Chandhok, Rahul Ramaswamy, Gail J. Roboz, Benjamin Rolles, Eunice S. Wang, Amyah C. Harris, Maria L Amaya, Hayley Hawkins, Justin Grenet, Carmelo Gurnari, Rory M. Shallis, Zhuoer Xie, Jaroslaw P. Maciejewski, David A Sallman, Matteo Giovanni Della Porta, Rami S. Komrokji, Amer M. Zeidan
Journal: Blood
Blood (2023) 142 (Supplement 1): 4613.
https://doi.org/10.1182/blood-2023-178728
Published: 2023
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemias: Efficacy and Safety Results from the Augment-101 Phase 1/2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael J Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel Mannis, Alexander Perl, David Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2907.
https://doi.org/10.1182/blood-2023-189762
Published: 2023
Journal Articles

Results from a Phase (Ph) 1 Clinical Study of the All-Oral Regimen of CC-486 and Venetoclax for Relapsed and Refractory Acute Myeloid Leukemia

Maria L Amaya, Christine M. McMahon, Marc Schwartz, Jonathan A Gutman, Connor Sohalski, Jennifer Tobin, Austin E Gillen, Anagha Inguva Sheth, Brett M Stevens, Clayton Smith, Craig T. Jordan, Daniel A. Pollyea
Journal: Blood
Blood (2023) 142 (Supplement 1): 2914.
https://doi.org/10.1182/blood-2023-182966
Published: 2023
Journal Articles

Age-Adapted Chemotherapy for Adults >40 Years Old with Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia: Single Center Outcomes

Marc Schwartz, Jonathan A Gutman, Christine M. McMahon, Maria L Amaya, Daniel A. Pollyea, Matthew Witkowski, Mohd Minhajuddin, Clayton Smith, Craig T. Jordan
Journal: Blood
Blood (2023) 142 (Supplement 1): 5898.
https://doi.org/10.1182/blood-2023-188298
Published: 2023
Journal Articles

Validation of the Composite Complete Response (cCR) Definitions in the International Working Group (IWG) 2023 Criteria in Patients (Pts) with Higher-Risk Myelodysplastic Syndromes/Neoplasms (HR-MDS) Treated with Hypomethylating Agents (HMA) - a Large, Multicenter, Retrospective Analysis from the Validate Database

Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Maximilian Stahl, Najla H Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L Uy, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine M. McMahon, Joshua F. Zeidner, Michael R. Savona, Jessica M. Stempel, Namrata Sonia Chandhok, Constantine Logothetis, Gail J. Roboz, Benjamin Rolles, Eunice S. Wang, Amyah C. Harris, Maria L Amaya, Hayley Hawkins, Justin Grenet, Rory M. Shallis, Zhuoer Xie, Jaroslaw P. Maciejewski, David A Sallman, Matteo Giovanni Della Porta, Rami S. Komrokji, Amer M. Zeidan
Journal: Blood
Blood (2023) 142 (Supplement 1): 324.
https://doi.org/10.1182/blood-2023-180299
Published: 2023
Journal Articles

Outcomes of Haplo-Cord and Dual-Cord Transplants: A Single-Center Retrospective Analysis

Michael K Jones, Andrew Kent, Kellen Gil, Enkhtsetseg Purev, Bradley M. Haverkos, Marc Schwartz, Christine M. McMahon, Maria L Amaya, Grace N Bosma, Rachel Rabinovitch, Daniel A. Pollyea, Jonathan A Gutman
Journal: Blood
Blood (2023) 142 (Supplement 1): 7084.
https://doi.org/10.1182/blood-2023-190558
Published: 2023
Journal Articles

Clinical and Molecular Features of Highly Durable Response to Azacitidine+Venetoclax in Acute Myeloid Leukemia

Alexander Hayden, Grace Bosma, Jonathan A. Gutman, Maria L. Amaya, Diana Abbott, Clayton Smith, Brett M. Stevens, Craig T. Jordan, Daniel A. Pollyea, Christine M. McMahon
Journal: Blood
Blood (2022) 140 (Supplement 1): 9163–9164.
https://doi.org/10.1182/blood-2022-171064
Published: 2022
Journal Articles

Initial Results from SELECT-AML-1, a Phase 2 Study of Tamibarotene in Combination with Venetoclax and Azacitidine in RARA-Positive Newly Diagnosed AML Patients Ineligible for Standard Induction Chemotherapy

Suman Kambhampati, Christine M. McMahon, Alireza Eghtedar, Daniel A. Pollyea, Stephane de Botton, Arnaud Pigneux, Mohamad Cherry, Brian J Ball, Gautam Borthakur, Thomas Cluzeau, Gary J. Schiller, Beibei Hu, Angela Volkert, Joanie Aasen Gausman, Graeme Hodgson, David A. Roth, Erica D. Warlick, Michael J. Kelly, Eytan Stein
Journal: Blood
Blood (2022) 140 (Supplement 1): 3333–3335.
https://doi.org/10.1182/blood-2022-156564
Published: 2022
Journal Articles

Overall Survival and Its Interplay with Allogeneic Stem Cell Transplant and Age in Newly Diagnosed AML Patients Treated with Ven/Aza

Diana Abbott, Grace Bosma, Christine M. McMahon, Marc Schwartz, Jonathan A. Gutman, Daniel A. Pollyea
Journal: Blood
Blood (2022) 140 (Supplement 1): 6181–6182.
https://doi.org/10.1182/blood-2022-169026
Published: 2022
Journal Articles

Response to Intensive Induction Chemotherapy after Failure of Frontline Azacitidine+Venetoclax in Acute Myeloid Leukemia

Christine M. McMahon, Kellen Gil, Maria L. Amaya, Jonathan A. Gutman, Alexander Hayden, Marc Schwartz, Grace Bosma, Diana Abbott, Brett M. Stevens, Clayton Smith, Craig T Jordan, Daniel A. Pollyea
Journal: Blood
Blood (2022) 140 (Supplement 1): 6185–6186.
https://doi.org/10.1182/blood-2022-170168
Published: 2022
Journal Articles

Higher-Dose Venetoclax with Measurable Residual Disease-Guided Azacitidine Discontinuation in Newly Diagnosed Patients with Acute Myeloid Leukemia: Phase 2 Hiddav Study

Jonathan A. Gutman, Amanda C. Winters, Andrew Kent, Maria L. Amaya, Christine M. McMahon, Clayton Smith, Craig T Jordan, Brett M. Stevens, Mohammad Minhajuddin, Shanshan Pei, Jeffrey Schowinsky, Jennifer Tobin, Kelly O'Brien, Angela Falco, Elizabeth Taylor, Constance Brecl, Phuong Ho, Connor Sohalski, Jessica Dell-Martin, Olivia Ondracek, Diana Abbott, Daniel A. Pollyea
Journal: Blood
Blood (2022) 140 (Supplement 1): 3275–3276.
https://doi.org/10.1182/blood-2022-157802
Published: 2022
Journal Articles

Targeting MDS Stem Cells with Omacetaxine and Azacitidine for Newly Diagnosed High Grade Patients: Phase 1 Trial Results and Preliminary Mechanistic Studies

Brett M. Stevens, Amanda C. Winters, Mohammad Minhajuddin, Maria L. Amaya, Christine M. McMahon, Jonathan A. Gutman, Clayton Smith, Deng Wang, Connor Adkins, Olivia Ondracek, Craig T. Jordan, Daniel A. Pollyea
Journal: Blood
Blood (2021) 138 (Supplement 1): 2612.
https://doi.org/10.1182/blood-2021-150824
Published: 2021
Journal Articles

Venetoclax and Azacitidine for Newly Diagnosed Non-Elderly Adult Patients with Acute Myeloid Leukemia and Adverse Risk Features

Jonathan A. Gutman, MD, Amanda Winters, MDPhD, Maria L Amaya, MD PhD, Christine M. McMahon, MD, Jeffrey Schowinsky, MD, Diana Abbott, PhD, Andrew Hammes, MS, Shanshan Pei, PhD, Brett M. Stevens, PhD, Craig T. Jordan, PhD, Clayton Smith, MD, Daniel A. Pollyea
Journal: Blood
Blood (2020) 136 (Supplement 1): 9.
https://doi.org/10.1182/blood-2020-136120
Published: 2020
Journal Articles

Longitudinal Monitoring of AML Tumors with High-Throughput Single-Cell DNA Sequencing Reveals Rare Clones Prognostic for Disease Progression and Therapy Response

Dennis J. Eastburn, PhD, Christine M. McMahon, MD, Robert Durruthy-Durruthy, PhD, Martin Carroll, MD, Catherine C. Smith, MD, Alexander E. Perl, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1476.
https://doi.org/10.1182/blood-2018-99-119869
Published: 2018
Journal Articles

Characteristics, Treatment Patterns and Outcomes Among Newly Diagnosed Patients (pts) with Acute Myeloid Leukemia (AML) Who Present with Hyperleukocytosis: Findings from a Large International Patient Cohort

Maximilian Stahl, MD, Wei Wei, MD PhD, Pau Montesinos, MD PhD, Etienne Lengline, MD, Rory M Shallis, MD, Judith Neukirchen, MD, Vijaya R. Bhatt, MD, Mikkael A. Sekeres, MD MS, Amir T. Fathi, MD, Heiko Konig, MD PhD, Selina Luger, MD, Irum Khan, MBBS, Gail J. Roboz, MD, Thomas Cluzeau, MD PhD, David Martínez-Cuadron, MD, Emmanuel Raffoux, MD, Ulrich Germing, MD, Jayadev Manikkam Umakanthan, MBBS, Sudipto Mukherjee, MD PhD MPH, Andrew M. Brunner, MD, Adam M. Miller, BS, MD, Christine M. McMahon, MD, Ellen K. Ritchie, MD, Rebeca Rodríguez-Veiga, MD, Raphael Itzykson, MD PhD, Blanca Boluda, MD, Florence Rabian, MD, Mar Tormo, MD, Evelyn Gloria Acuna Cruz, MD, Emma Rabinovich, MD, Brendan Yoo, Nikolai A. Podoltsev, MD PhD, Steven D. Gore, MD, Amer M. Zeidan, MBBS, MHS
Journal: Blood
Blood (2018) 132 (Supplement 1): 4040.
https://doi.org/10.1182/blood-2018-99-112974
Published: 2018
Journal Articles

Outcomes of Patients with Newly-Diagnosed Acute Myeloid Leukemia and Hyperleukocytosis Who Did Not Undergo Intensive Chemotherapy: Results from a Large International Database

Rory M Shallis, MD, Maximilian Stahl, MD, Wei Wei, MD PhD, Pau Montesinos, MD PhD, Etienne Lengline, MD, Judith Neukirchen, MD, Vijaya R. Bhatt, MD, Mikkael A. Sekeres, MD MS, Amir T. Fathi, MD, Heiko Konig, MD PhD, Selina Luger, MD, Irum Khan, MBBS, Gail J. Roboz, MD, Thomas Cluzeau, MD PhD, David Martínez-Cuadron, MD, Emmanuel Raffoux, MD, Ulrich Germing, MD, Jayadev Manikkam Umakanthan, MBBS, Sudipto Mukherjee, MD PhD MPH, Andrew M. Brunner, MD, Adam M. Miller, BS, MD, Christine M. McMahon, MD, Ellen K. Ritchie, MD, Rebeca Rodríguez-Veiga, MD, Raphael Itzykson, MD PhD, Blanca Boluda, MD, Florence Rabian, MD, Mar Tormo, MD PhD, Evelyn Gloria Acuna Cruz, MD, Nikolai Podoltsev, MD PhD, Steven D. Gore, MD, Amer M. Zeidan, MBBS, MHS
Journal: Blood
Blood (2018) 132 (Supplement 1): 3999.
https://doi.org/10.1182/blood-2018-99-119755
Published: 2018