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Journal Articles

Genomic Landscape Including Novel Mutational Drivers in Relapsed/Refractory Diffuse Large B Cell Lymphoma

Kerstin Wenzl, PhD, Maria Ortiz, Nicholas Stong, PhD, C. Chris Huang, PhD, Matthew J. Maurer, MS, Fadi Towfic, PhD, Patrick R. Hagner, PhD, Hamid Nikbakht, PhD, Matthew Stokes, PhD, Sneh Lata, PhD, Sitharthan Kamalakaran, PhD, Konstantinos Mavrommatis, PhD, Matthew Trotter, PhD, Rebecca L. King, MD, Brian K. Link, MD, Susan L. Slager, PhD, Yan Asmann, PhD, Myron Czuczman, Stephen M Ansell, MD PhD, Thomas M. Habermann, MD, James R. Cerhan, MD PhD, Grzegorz Nowakowski, MD, Anne J Novak, PhD, Anita K Gandhi
Journal: Blood
Blood (2019) 134 (Supplement_1): 919.
https://doi.org/10.1182/blood-2019-123694
Published: 2019
Journal Articles

Clustering of Transcriptomic Signatures in Newly Diagnosed Diffuse Large B-Cell Lymphoma Identifies Two High-Risk Subgroups Which Increase in Prevalence at Relapse

Maria Ortiz, Kerstin Wenzl, PhD, Matthew Stokes, PhD, C. Chris Huang, PhD, Matthew J. Maurer, MS, Fadi Towfic, PhD, Patrick R. Hagner, PhD, Alexander Ratushny, PhD, Mark McConnell, PhD, Samuel A Danziger, PhD, Nicholas Stong, PhD, Sneh Lata, PhD, Sitharthan Kamalakaran, PhD, Konstantimos Mavrommatis, PhD, Matthew Trotter, PhD, Rebecca L. King, MD, Brian K. Link, MD, Susan L. Slager, PhD, Yan Asmann, PhD, Myron Czuczman, Stephen M Ansell, MD PhD, James R. Cerhan, MD PhD, Grzegorz Nowakowski, MD, Thomas M. Habermann, MD, Anita K Gandhi, Anne J Novak, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 923.
https://doi.org/10.1182/blood-2019-122756
Published: 2019
Journal Articles

Gene Expression and Genomic Markers Identify a Subpopulation of Poor Prognosis t(4;14) Patients in Newly Diagnosed Multiple Myeloma

Maria Ortiz, Fadi Towfic, PhD, Erin Flynt, Nicholas Stong, PhD, Sneh Lata, PhD, Dharanya Sampath, Dan Rozelle, PhD, Matthew Trotter, PhD, Jill Corre, PharmD, PhD, Hervé Avet-Loiseau, MD PhD, Anjan Thakurta
Journal: Blood
Blood (2019) 134 (Supplement_1): 366.
https://doi.org/10.1182/blood-2019-128907
Published: 2019
Journal Articles

Crowdsourced High-Risk Classifiers for Multiple Myeloma Patients Commonly Identify PHF19 As a Robust Progression Biomarker

Michael J Mason, PhD, Carolina D. Schinke, MD, Christine Eng, PhD, Fadi Towfic, PhD, Fred Gruber, PhD, Brian S. White, Yi Cui, PhD, Bailiang Li, PhD, Thomas Yu, BS, William S. Dalton, PhDMD, Hartmut Goldschmidt, MD, Herve Avet-Loiseau, MD PhD, Mehmet Samur, PhD, Maria Ortiz, Matthew Trotter, PhD, Boris Hayete, PhD, Andrew Dervan, Erin Flynt, Hongyue Dai, PhD, Douglas Bassett, PhD, Pieter Sonneveld, Kenneth H. Shain, MD PhD, Nikhil C. Munshi, MD, Daniel Auclair, Dirk Hose, MD, Gareth Morgan, MDPhDFRCP, Jonathan Göke, PhD, Brian A Walker, PhD, Anjan Thakurta, Justin Guinney, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4370.
https://doi.org/10.1182/blood-2019-127362
Published: 2019
Journal Articles

Baseline and on-Treatment Bone Marrow Microenvironments Predict Myeloma Patient Outcomes and Inform Potential Intervention Strategies

Samuel A Danziger, PhD, Mark McConnell, PhD, Jake Gockley, PhD, Mary Young, PhD, Adam Rosenthal, MS, Frank Schmitz, MD PhD, David Reiss, PhD, Phil Farmer, Cody Ashby, PhD, Michael A Bauer, PhD, Frits van Rhee, MD PhD, Faith E. Davies, MD, Maurizio Zangari, MD, Nathan Petty, MS, CCRP, Wilbert B. Copeland, PhD, Brian A. Fox, PhD, Antje Hoering, PhD, Alison Fitch, Katie Newhall, PhD, Bart Barlogie, MD PhD, Brian A Walker, PhD, Matthew Trotter, PhD, Rob Hershberg, MD PhD, Andrew Dervan, Alexander Ratushny, PhD, Gareth Morgan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1882.
https://doi.org/10.1182/blood-2018-99-113169
Published: 2018
Journal Articles

A High-Risk Multiple Myeloma Group Identified By Integrative Multi-Omics Segmentation of Newly Diagnosed Patients

Maria Ortiz, Fadi Towfic, PhD, Mehmet Kemal Samur, PhD, Erin Flynt, In Sock Jang, PhD, Kai Wang, PhD, Cody Ashby, PhD, Brian A Walker, PhD, Matthew Trotter, PhD, Gareth Morgan, MD, Nikhil Munshi, MD, Anjan Thakurta, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3165.
https://doi.org/10.1182/blood-2018-99-117114
Published: 2018
Journal Articles

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Brian A. Walker, Konstantinos Mavrommatis, Christopher P. Wardell, T. Cody Ashby, Michael Bauer, Faith E. Davies, Adam Rosenthal, Hongwei Wang, Pingping Qu, Antje Hoering, Mehmet Samur, Fadi Towfic, Maria Ortiz, Erin Flynt, Zhinuan Yu, Zhihong Yang, Dan Rozelle, John Obenauer, Matthew Trotter, Daniel Auclair, Jonathan Keats, Niccolo Bolli, Mariateresa Fulciniti, Raphael Szalat, Philippe Moreau, Brian Durie, A. Keith Stewart, Hartmut Goldschmidt, Marc S. Raab, Hermann Einsele, Pieter Sonneveld, Jesus San Miguel, Sagar Lonial, Graham H. Jackson, Kenneth C. Anderson, Herve Avet-Loiseau, Nikhil Munshi, Anjan Thakurta, Gareth J. Morgan
Journal: Blood
Blood (2018) 132 (6): 587–597.
https://doi.org/10.1182/blood-2018-03-840132
Published: 2018
Includes: Supplemental data
Journal Articles

MYC Rearrangements in Multiple Myeloma Are Complex, Can Involve More Than Five Different Chromosomes, and Correlate with Increased Expression of MYC and a Distinct Downstream Gene Expression Pattern

Aneta Mikulasova, PhD, Cody Cody Ashby, PhD, Ruslana G. Tytarenko, MS, Michael Bauer, PhD, Konstantimos Mavrommatis, PhD, Christopher P. Wardell, PhD, Matthew Trotter, PhD, Shayu Deshpande, Owen W. Stephens, Erming Tian, PhD MBA, Graham Jackson, Faith E. Davies, MD, Anjan Thakurta, PhD, Nikhil Munshi, MD, Gareth J. Morgan, MD PhD, Brian A Walker, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 65.
https://doi.org/10.1182/blood.V130.Suppl_1.65.65
Published: 2017
Journal Articles

Discovery of an Immune-Driven Gene Expression Signature That Predicts for Clinical Benefit to CC-122 in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (R/R DLBCL)

Alberto Risueño, PhD, Patrick R. Hagner, PhD, Celia Fontanillo, PhD, Amira Djebbari, DSc, Joel S. Parker, PhD, Clifton P. Drew, PhD, Fadi Towfic, PhD, Michael Pourdehnad, MD, Anita K. Gandhi, PhD, Matthew Trotter, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2830.
https://doi.org/10.1182/blood.V130.Suppl_1.2830.2830
Published: 2017
Journal Articles

Crowdsourcing a High-Risk Classifier for Multiple Myeloma Patients

Andrew P Dervan, Michael Mason, PhD, Fadi Towfic, PhD, Michael Amatangelo, PhD, Daniel Auclair, PhD, Douglas Bassett, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Samuel Danziger, PhD, Erin Flynt, PhD, Hartmut Goldschmidt, MD, Justin Guinney, PhD, Dirk Hose, MD, Konstantimos Mavrommatis, PhD, Gareth J. Morgan, MD PhD, Nikhil Munshi, MD, Alexander Ratushny, PhD, Dan Rozelle, PhD, Mehmet Kemal Samur, PhD, Frank Schmitz, MD PhD, Kenneth H Shain, MD PhD, Matthew Trotter, PhD, Brian A Walker, PhD, Brian S. White, PhD, Thomas Yu, BS, Anjan Thakurta, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 265.
https://doi.org/10.1182/blood.V130.Suppl_1.265.265
Published: 2017
Journal Articles

Deconvolution of the Immune Microenvironment Can Predict the Outcome of Myeloma Patients and Inform Potential Intervention Strategies

Samuel Danziger, PhD, Andrew P Dervan, Frank Schmitz, MD PhD, Brian A Walker, PhD, Wilbert Copeland, PhD, Alison Fitch, BS, Kathryn Newhall, PhD, Cody Cody Ashby, PhD, Michael Bauer, PhD, Bart Barlogie, MD PhD, Teri Foy, PhD, Matthew Trotter, PhD, Rob Hershberg, MD PhD, Alexander Ratushny, PhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1751.
https://doi.org/10.1182/blood.V130.Suppl_1.1751.1751
Published: 2017
Journal Articles

Identification of Novel Oncogenes and Tumor Suppressor Genes in Newly Diagnosed Multiple Myeloma

Brian A Walker, PhD, Christopher P. Wardell, PhD, Konstantimos Mavrommatis, PhD, Cody Cody Ashby, PhD, Michael Bauer, PhD, Mehmet Kemal Samur, PhD, Fadi Towfic, PhD, Maria Ortiz, Erin Flynt, PhD, Matthew Trotter, PhD, Anjan Thakurta, PhD, Nikhil Munshi, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 60.
https://doi.org/10.1182/blood.V130.Suppl_1.60.60
Published: 2017
Journal Articles

FOXM1 Is Associated with Development of Therapeutic Resistance in Multiple Myeloma

Michael Amatangelo, PhD, Maria Ortiz, Paola Neri, MD, Fadi Towfic, PhD, Chad Bjorklund, Jian Kang, Erica Sternberg, Nizar J. Bahlis, MD, Matthew Trotter, PhD, Anjan Thakurta, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1261.
https://doi.org/10.1182/blood.V130.Suppl_1.1261.1261
Published: 2017
Journal Articles

The Multiple Myeloma Genome Project: Development of a Molecular Segmentation Strategy for the Clinical Classification of Multiple Myeloma

Brian A Walker, PhD, Mehmet K. Samur, PhD, Konstantinos Mavrommatis, Cody Ashby, PhD, Christopher P Wardell, PhD, Maria Ortiz, PhD, Fadi Towfic, Caleb K. Stein, MS, Michael A Bauer, PhD, Michael Amatangelo, PhD, Giovanni Parmigiani, PhD, Zhinuan Yu, PhD, Matthew Trotter, Herve Avet-Loiseau, MD PhD, Graham H Jackson, MD PhD, Kenneth C. Anderson, Anjan Thakurta, PhD, Nikhil C. Munshi, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 196.
https://doi.org/10.1182/blood.V128.22.196.196
Published: 2016
Journal Articles

Lenalidomide Exhibits Activity in Mantle Cell Lymphoma through Increased NK Cell Mediated Cytotoxicity

Patrick Hagner, PhD, Hsiling Chiu, Maria Ortiz-Estevez, Tsvetan Biyukov, Carrie Brachman, Marek Trneny, Luca Arcaini, Franck Morschhauser, MD, Antoine Thyss, Stephan Stilgenbauer, Noel Milpied, Reinhard Marks, Pellegrino Musto, Giovanni Martinelli, MD PhD, Carla Heise, Thomas Daniel, Rajesh Chopra, James Carmichael, Matthew Trotter, Anita K. Gandhi, PhD, Anjan Thakurta
Journal: Blood
Blood (2015) 126 (23): 821.
https://doi.org/10.1182/blood.V126.23.821.821
Published: 2015
Journal Articles

Resistance to Lenalidomide in Multiple Myeloma Is Associated with a Switch in Gene Expression Profile

Michael D. Amatangelo, PhD, Paola Neri, MD PhD, Maria Ortiz, PhD, Chad C. Bjorklund, Anita K. Gandhi, PhD, Anke Klippel, Nizar J Bahlis, MD, Tom Daniel, Rajesh Chopra, MBBS, PhD, Matthew Trotter, Anjan Thakurta
Journal: Blood
Blood (2015) 126 (23): 1789.
https://doi.org/10.1182/blood.V126.23.1789.1789
Published: 2015
Journal Articles

IMiD® Immunomodulatory Agents Promote Apoptosis in Multiple Myeloma Cells through Induction of TRAIL Expression

Michael D. Amatangelo, PhD, Chad C. Bjorklund, Anita K. Gandhi, PhD, Anke Klippel, Tom Daniel, Rajesh Chopra, MBBS, PhD, Matthew Trotter, Anjan Thakurta
Journal: Blood
Blood (2015) 126 (23): 5355.
https://doi.org/10.1182/blood.V126.23.5355.5355
Published: 2015
Journal Articles

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Patrick R. Hagner, Hon-Wah Man, Celia Fontanillo, Maria Wang, Suzana Couto, Mike Breider, Chad Bjorklund, Courtney G. Havens, Gang Lu, Emily Rychak, Heather Raymon, Rama Krishna Narla, Leo Barnes, Gody Khambatta, Hsiling Chiu, Jolanta Kosek, Jian Kang, Michael D. Amantangelo, Michelle Waldman, Antonia Lopez-Girona, Ti Cai, Michael Pourdehnad, Matthew Trotter, Thomas O. Daniel, Peter H. Schafer, Anke Klippel, Anjan Thakurta, Rajesh Chopra, Anita K. Gandhi
Journal: Blood
Blood (2015) 126 (6): 779–789.
https://doi.org/10.1182/blood-2015-02-628669
Published: 2015
Includes: Supplemental data
Journal Articles

CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways

Patrick Hagner, PhD, Maria Wang, PhD, Suzana Couto, PhD, Mike Breider, DVM, PhD DACVP, Celia Fontanillo, PhD, Matthew Trotter, PhD, Chad C Bjorklund, PhD, Courtney G. Havens, PhD, Heather K Raymon, PhD, Rama Krishna Narla, PhD, Leo Barnes, PhD, Michelle Waldman, MS, Tom Daniel, MD, Anke Klippel, PhD, Michael Pourdehnad, MD, Anjan Thakurta, PhD, Rajesh Chopra, MD, PhD, Anita K. Gandhi, PhD
Journal: Blood
Blood (2014) 124 (21): 3035.
https://doi.org/10.1182/blood.V124.21.3035.3035
Published: 2014
Journal Articles

In Vitro Production Of Megakaryocytes and Platelets From Human Induced Pluripotent Cells By GMP Compatible Methods

Thomas Moreau, PhD, Maria Colzani, Meera Arumugam, PhD, Amanda Evans, Marloes Renee Tijssen, PhD, Matthew Trotter, PhD, Willem H Ouwehand, Roger Pedersen, MD PhD, Cedric Ghevaert, MD PhD
Journal: Blood
Blood (2013) 122 (21): 2401.
https://doi.org/10.1182/blood.V122.21.2401.2401
Published: 2013