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Issue Archive

Volume 120, Issue 25
December 13 2012
Issue Cover

Table of Contents

Inside Blood

IMMUNOBIOLOGY
Human CD27+IgM+IgD+ B cells: T-cell or TLR-dependent?
Menno C. van Zelm
View Articletitled, Human CD27<sup>+</sup>IgM<sup>+</sup>IgD<sup>+</sup> B cells: T-cell or TLR-dependent?
CLINICAL TRIALS
MDS: unraveling the mystery
David A. Rizzieri
View Articletitled, MDS: unraveling the mystery
PLATELETS & THROMBOPOIESIS
α-granules: a story in the making
Robert Flaumenhaft
View Articletitled, α-granules: a story in the making

Blood Work

First needle marrow biopsy to diagnose a systemic illness
Simion Chiosea,Robert E. Lee
View Articletitled, First needle marrow biopsy to diagnose a systemic illness
Human granulocytic anaplasmosis
Olga Pozdnyakova,David M. Dorfman
View Articletitled, Human granulocytic anaplasmosis

Perspectives

Interim FDG-PET in Hodgkin lymphoma: a compass for a safe navigation in clinical trials?
Andrea Gallamini,Lale Kostakoglu
View Articletitled, Interim FDG-PET in Hodgkin lymphoma: a compass for a safe navigation in clinical trials?

Review Article

Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis
Jasper H. Smalberg,Lidia R. Arends,Dominique C. Valla,Jean-Jacques Kiladjian,Harry L. A. Janssen,Frank W. G. Leebeek
View Articletitled, Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis
Supplemental data

Clinical Trials and Observations

Prediagnosis biomarkers of insulin-like growth factor-1, insulin, and interleukin-6 dysregulation and multiple myeloma risk in the Multiple Myeloma Cohort Consortium
Clinical Trials & Observations
Brenda M. Birmann,Marian L. Neuhouser,Bernard Rosner,Demetrius Albanes,Julie E. Buring,Graham G. Giles,Qing Lan,I-Min Lee,Mark P. Purdue,Nathaniel Rothman,Gianluca Severi,Jian-Min Yuan,Kenneth C. Anderson,Michael Pollak,Nader Rifai,Patricia Hartge,Ola Landgren,Lawrence Lessin,Jarmo Virtamo,Robert B. Wallace,JoAnn E. Manson,Graham A. Colditz
View Articletitled, Prediagnosis biomarkers of insulin-like growth factor-1, insulin, and interleukin-6 dysregulation and multiple myeloma risk in the Multiple Myeloma Cohort Consortium
Supplemental data
Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel
Clinical Trials & Observations
Ban B. Dawood,Gillian C. Lowe,Marie Lordkipanidzé,Danai Bem,Martina E. Daly,Mike Makris,Andrew Mumford,Jonathan T. Wilde,Steve P. Watson
View Articletitled, Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel
Supplemental data

Hematopoiesis and Stem Cells

In situ production of innate immune cells in murine white adipose tissue
Sandrine Poglio,Fabienne De Toni,Daniel Lewandowski,Adeline Minot,Emmanuelle Arnaud,Vilma Barroca,Patrick Laharrague,Louis Casteilla,Béatrice Cousin
View Articletitled, In situ production of innate immune cells in murine white adipose tissue
Supplemental data
Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells
Fatih Kocabas,Junke Zheng,Suwannee Thet,Neal G. Copeland,Nancy A. Jenkins,Ralph J. DeBerardinis,Chengcheng Zhang,Hesham A. Sadek
View Articletitled, Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells
Supplemental data
Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress
Zeenath Unnisa,Jason P. Clark,Jayeeta Roychoudhury,Elizabeth Thomas,Lino Tessarollo,Neal G. Copeland,Nancy A. Jenkins,H. Leighton Grimes,Ashish R. Kumar
View Articletitled, Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress
Supplemental data

Immunobiology

PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function
Lianne van de Laar,Aniek van den Bosch,André Boonstra,Rekha S. Binda,Miranda Buitenhuis,Harry L. A. Janssen,Paul J. Coffer,Andrea M. Woltman
View Articletitled, PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function
Supplemental data
IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4–, MyD88-, and TIRAP- but not UNC-93B–deficient patients
Sandra Weller,Mélanie Bonnet,Héloïse Delagreverie,Laura Israel,Maya Chrabieh,László Maródi,Carlos Rodriguez-Gallego,Ben-Zion Garty,Chaim Roifman,Andrew C. Issekutz,Simona Eva Zitnik,Cyrille Hoarau,Yildiz Camcioglu,Júlia Vasconcelos,Carlos Rodrigo,Peter D. Arkwright,Andrea Cerutti,Eric Meffre,Shen-Ying Zhang,Alexandre Alcais,Anne Puel,Jean-Laurent Casanova,Capucine Picard,Jean-Claude Weill,Claude-Agnès Reynaud
View Articletitled, IgM<sup>+</sup>IgD<sup>+</sup>CD27<sup>+</sup> B cells are markedly reduced in IRAK-4–, MyD88-, and TIRAP- but not UNC-93B–deficient patients
Supplemental data
Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia
Capucine Daridon,Christoph Loddenkemper,Simone Spieckermann,Anja A. Kühl,Abdulgabar Salama,Gerd R. Burmester,Peter E. Lipsky,Thomas Dörner
View Articletitled, Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia
Supplemental data

Lymphoid Neoplasia

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma
Simona Blotta,Jana Jakubikova,Teresa Calimeri,Aldo M. Roccaro,Nicola Amodio,Abdel Kareem Azab,Umberto Foresta,Constantine S. Mitsiades,Marco Rossi,Katia Todoerti,Stefano Molica,Fortunato Morabito,Antonino Neri,Piersandro Tagliaferri,Pierfrancesco Tassone,Kenneth C. Anderson,Nikhil C. Munshi
View Articletitled, Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

Myeloid Neoplasia

Phase 2 study of the lenalidomide and azacitidine combination in patients with higher-risk myelodysplastic syndromes
Clinical Trials & Observations
Mikkael A. Sekeres,Ramon V. Tiu,Rami Komrokji,Jeffrey Lancet,Anjali S. Advani,Manuel Afable,Ricki Englehaupt,Joyce Juersivich,David Cuthbertson,Jennifer Paleveda,Ali Tabarroki,Valeria Visconte,Hideki Makishima,Andres Jerez,Ronald Paquette,Alan F. List,Jaroslaw P. Maciejewski
View Articletitled, Phase 2 study of the lenalidomide and azacitidine combination in patients with higher-risk myelodysplastic syndromes
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

The biology of nematode- and IL4Rα-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics
e-blood
Graham D. Thomas,Dominik Rückerl,Benjamin H. Maskrey,Phillip D. Whitfield,Mark L. Blaxter,Judith E. Allen
View Articletitled, The biology of nematode- and IL4Rα-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics
Supplemental data

Platelets and Thrombopoiesis

A case-control study to assess the risk of immune thrombocytopenia associated with vaccines
Clinical Trials & Observations
Lamiae Grimaldi-Bensouda,Marc Michel,Elodie Aubrun,Pamela Leighton,Jean-Francois Viallard,Daniel Adoue,Nadine Magy-Bertrand,Guillaume Tisserand,Mehdi Khellaf,Jean-Marc Durand,Philippe Quittet,Olivier Fain,Bernard Bonnotte,Anne Sophie Morin,Nicolas Limal,Nathalie Costedoat-Chalumeau,Nathalie Morel,Brigitte Pan-Petesch,Olivier Decaux,Matthieu Mahevas,Michel Ruel,Karim Sacre,Francois Lefrere,Lucien Abenhaim,Bertrand Godeau,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group,for the PGRx Immune Thrombocytopenia Study Group
View Articletitled, A case-control study to assess the risk of immune thrombocytopenia associated with vaccines
Supplemental data
Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets
Bjoern F. Kraemer,Robert A. Campbell,Hansjörg Schwertz,Zechariah G. Franks,Adriana Vieira de Abreu,Katharina Grundler,Benjamin T. Kile,Bijaya K. Dhakal,Matthew T. Rondina,Walter H. A. Kahr,Matthew A. Mulvey,Robert C. Blaylock,Guy A. Zimmerman,Andrew S. Weyrich
View Articletitled, Bacteria differentially induce degradation of Bcl-x<sub>L</sub>, a survival protein, by human platelets
Supplemental data
The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet α-granule biogenesis
Denisa Urban,Ling Li,Hilary Christensen,Fred G. Pluthero,Shao Zun Chen,Michael Puhacz,Parvesh M. Garg,Kiran K. Lanka,James J. Cummings,Helmut Kramer,James D. Wasmuth,John Parkinson,Walter H. A. Kahr
View Articletitled, The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet α-granule biogenesis
Supplemental data

Red Cells, Iron, and Erythropoiesis

Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease
Stéphane M. Camus,Blandine Gausserès,Philippe Bonnin,Laurent Loufrani,Linda Grimaud,Dominique Charue,Joao A. De Moraes,Jean-Marie Renard,Alain Tedgui,Chantal M. Boulanger,Pierre-Louis Tharaux,Olivier P. Blanc-Brude
View Articletitled, Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease
Supplemental data

Thrombosis and Hemostasis

Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S
Brief Report
Josefin Ahnström,Helena M. Andersson,Verity Hockey,Yiran Meng,Thomas A. J. McKinnon,Tsutomu Hamuro,James T. B. Crawley,David A. Lane
View Articletitled, Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S
Supplemental data

Vascular Biology

The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis
Gemma Bridge,Rui Monteiro,Stephen Henderson,Victoria Emuss,Dimitris Lagos,Dimitra Georgopoulou,Roger Patient,Chris Boshoff
View Articletitled, The microRNA-30 family targets <em>DLL4</em> to modulate endothelial cell behavior during angiogenesis
Supplemental data
The vitamin K–dependent anticoagulant factor, protein S, inhibits multiple VEGF-A–induced angiogenesis events in a Mer- and SHP2-dependent manner
Sylvain Fraineau,Arnaud Monvoisin,Jonathan Clarhaut,Julie Talbot,Claire Simonneau,Chryso Kanthou,Sandip M. Kanse,Michel Philippe,Omar Benzakour
View Articletitled, The vitamin K–dependent anticoagulant factor, protein S, inhibits multiple VEGF-A–induced angiogenesis events in a Mer- and SHP2-dependent manner
Supplemental data

Correspondence

The revised IPSS is a powerful tool to evaluate the outcome of MDS patients treated with azacitidine: the GFM experience
Mathilde Lamarque,Sophie Raynaud,Raphael Itzykson,Sylvain Thepot,Bruno Quesnel,Francois Dreyfus,Odile Beyne Rauzy,Pascal Turlure,Norbert Vey,Christian Recher,Caroline Dartigeas,Laurence Legros,Jacques Delaunay,Sorin Visanica,Aspasia Stamatoullas,Pierre Fenaux,Lionel Adès
View Articletitled, The revised IPSS is a powerful tool to evaluate the outcome of MDS patients treated with azacitidine: the GFM experience
CD8+ T cells far predominate over CD4+ T cells in healthy immune response to Epstein-Barr virus infected lymphoblastoid cell lines
Michael P. Pender,Peter A. Csurhes,Casey M. M. Pfluger,Scott R. Burrows
View Articletitled, CD8<sup>+</sup> T cells far predominate over CD4<sup>+</sup> T cells in healthy immune response to Epstein-Barr virus infected lymphoblastoid cell lines
Significant weight gain in patients with chronic myeloid leukemia after imatinib therapy
Elvis Aduwa,Richard Szydlo,David Marin,Letizia Foroni,Alistair Reid,John Goldman,Jane F. Apperley,Dragana Milojkovic
View Articletitled, Significant weight gain in patients with chronic myeloid leukemia after imatinib therapy
Limited efficacy and tolerance of imatinib mesylate in steroid-refractory sclerodermatous chronic GVHD
Adèle de Masson,Jean-David Bouaziz,Régis Peffault de Latour,Sebastian Wittnebel,Patricia Ribaud,Marie-Thérèse Rubio,Jean-Baptiste Micol,Felipe Suarez,Stéphanie Nguyen,Jean-Hugues Dalle,Karima Yakouben,Marie Robin,Aliénor Xhaard,Lionel Adès,Jean-Henri Bourhis,Michel Rybojad,Martine Bagot,Gérard Socié
View Articletitled, Limited efficacy and tolerance of imatinib mesylate in steroid-refractory sclerodermatous chronic GVHD

Blood Reflections

Venous Return
Adam Possner
View Articletitled, Venous Return
All Issues

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