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Issue Archive

Volume 122, Issue 3
July 18 2013
Issue Cover

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS & OBSERVATIONS
Modified antibody in fetal alloimmunization
Clinical Trials & Observations
James B. Bussel,Janice G. McFarland
View Articletitled, Modified antibody in fetal alloimmunization
GENE THERAPY
Trick to treat: tricking the thymus to treat cancer
Chiara Bonini,Anna Mondino
View Articletitled, Trick to treat: tricking the thymus to treat cancer
INSIDE BLOOD
Scouting out the neighborhood in AIDS-related lymphoma
Kieron Dunleavy,Catherine M. Bollard
View Articletitled, Scouting out the neighborhood in AIDS-related lymphoma
PLATELETS & THROMBOPOIESIS
A platelet cover-up
Donald M. Arnold
View Articletitled, A platelet cover-up

BLOOD WORK

Massive intravascular hemolysis with organ failure due to Clostridium perfringens: evidence of intracytoplasmic C. perfringens
David Dutton,Natalia Gavrilova
View Articletitled, Massive intravascular hemolysis with organ failure due to <em>Clostridium perfringens</em>: evidence of intracytoplasmic <em>C. perfringens</em>
Sideroblastic anemia secondary to zinc toxicity
Jawad Sheqwara,Yaser Alkhatib
View Articletitled, Sideroblastic anemia secondary to zinc toxicity

PLENARY PAPER

Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopenia: proof of principle in human volunteers
Cedric Ghevaert,Nina Herbert,Louise Hawkins,Nicola Grehan,Philip Cookson,Steve F. Garner,Abigail Crisp-Hihn,Paul Lloyd-Evans,Amanda Evans,Kottekkattu Balan,Willem H. Ouwehand,Kathryn L. Armour,Mike R. Clark,Lorna M. Williamson
View Articletitled, Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopenia: proof of principle in human volunteers
Supplemental data

PLENARY PAPER

Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti–HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia
Tamam Bakchoul,Andreas Greinacher,Ulrich J. Sachs,Annika Krautwurst,Harald Renz,Habi Harb,Gregor Bein,Peter J. Newman,Sentot Santoso
View Articletitled, Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti–HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia
Supplemental data

REVIEW ARTICLE

EBV-positive diffuse large B-cell lymphoma of the elderly
Chi Young Ok,Thomas G. Papathomas,L. Jeffrey Medeiros,Ken H. Young
View Articletitled, EBV-positive diffuse large B-cell lymphoma of the elderly

CLINICAL TRIALS AND OBSERVATIONS

The lupus anticoagulant: results from 2257 patients attending a high-risk pregnancy clinic
CME
Christine A. Clark,Judith Davidovits,Karen A. Spitzer,Carl A. Laskin
View Articletitled, The lupus anticoagulant: results from 2257 patients attending a high-risk pregnancy clinic

GENE THERAPY

Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection
Thomas M. Schmitt,David H. Aggen,Ingunn M. Stromnes,Michelle L. Dossett,Sarah A. Richman,David M. Kranz,Philip D. Greenberg
View Articletitled, Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment
V. Lokesh Battula,Ye Chen,Maria da Graca Cabreira,Vivian Ruvolo,Zhiqiang Wang,Wencai Ma,Sergej Konoplev,Elizabeth Shpall,Karen Lyons,Dirk Strunk,Carlos Bueso-Ramos,Richard Eric Davis,Marina Konopleva,Michael Andreeff
View Articletitled, Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment
Supplemental data
Fev regulates hematopoietic stem cell development via ERK signaling
Lu Wang,Tianhui Liu,Linjie Xu,Ya Gao,Yonglong Wei,Caiwen Duan,Guo-Qiang Chen,Shuo Lin,Roger Patient,Bo Zhang,Dengli Hong,Feng Liu
View Articletitled, Fev regulates hematopoietic stem cell development via ERK signaling
Supplemental data
The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation
Brenden W. Smith,Sarah S. Rozelle,Amy Leung,Jessalyn Ubellacker,Ashley Parks,Shirley K. Nah,Deborah French,Paul Gadue,Stefano Monti,David H. K. Chui,Martin H. Steinberg,Andrew L. Frelinger,Alan D. Michelson,Roger Theberge,Mark E. McComb,Catherine E. Costello,Darrell N. Kotton,Gustavo Mostoslavsky,David H. Sherr,George J. Murphy
View Articletitled, The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation
Supplemental data

IMMUNOBIOLOGY

The Rac activator DOCK2 regulates natural killer cell–mediated cytotoxicity in mice through the lytic synapse formation
Yusuke Sakai,Yoshihiko Tanaka,Toyoshi Yanagihara,Mayuki Watanabe,Xuefeng Duan,Masao Terasawa,Akihiko Nishikimi,Fumiyuki Sanematsu,Yoshinori Fukui
View Articletitled, The Rac activator DOCK2 regulates natural killer cell–mediated cytotoxicity in mice through the lytic synapse formation
Supplemental data
Induction of B7-H6, a ligand for the natural killer cell–activating receptor NKp30, in inflammatory conditions
Jessica Matta,Myriam Baratin,Laurent Chiche,Jean-Marie Forel,Céline Cognet,Guillemette Thomas,Catherine Farnarier,Christelle Piperoglou,Laurent Papazian,Damien Chaussabel,Sophie Ugolini,Frédéric Vély,Eric Vivier
View Articletitled, Induction of B7-H6, a ligand for the natural killer cell–activating receptor NKp30, in inflammatory conditions
Supplemental data
CD40L expression permits CD8+ T cells to execute immunologic helper functions
Marco Frentsch,Regina Stark,Nadine Matzmohr,Sarah Meier,Sibel Durlanik,Axel R. Schulz,Ulrik Stervbo,Karsten Jürchott,Friedemann Gebhardt,Guido Heine,Morgan A. Reuter,Michael R. Betts,Dirk Busch,Andreas Thiel
View Articletitled, CD40L expression permits CD8<sup>+</sup> T cells to execute immunologic helper functions
Supplemental data

LYMPHOID NEOPLASIA

Runx1 is essential at two stages of early murine B-cell development
Birte Niebuhr,Neele Kriebitzsch,Meike Fischer,Kira Behrens,Thomas Günther,Malik Alawi,Ulla Bergholz,Ursula Müller,Susanne Roscher,Marion Ziegler,Frank Buchholz,Adam Grundhoff,Carol Stocking
View Articletitled, Runx1 is essential at two stages of early murine B-cell development
Supplemental data
The microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategies
Konstantinos Liapis,Andrew Clear,Andrew Owen,Rita Coutinho,Paul Greaves,Abigail M. Lee,Silvia Montoto,Maria Calaminici,John G. Gribben
View Articletitled, The microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategies
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients
Geneviève Galarneau,Sean Coady,Melanie E. Garrett,Neal Jeffries,Mona Puggal,Dina Paltoo,Karen Soldano,Antonio Guasch,Allison E. Ashley-Koch,Marilyn J. Telen,Abdullah Kutlar,Guillaume Lettre,George J. Papanicolaou
View Articletitled, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients

VASCULAR BIOLOGY

Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation
Guoqi Zhang,Li Yang,Gab Seok Kim,Kieran Ryan,Shulin Lu,Rebekah K. O’Donnell,Katherine Spokes,Nathan Shapiro,William C. Aird,Michael J. Kluk,Kiichiro Yano,Teresa Sanchez
View Articletitled, Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation
Supplemental data

CORRESPONDENCE

Mononuclear phagocytes and marker modulation: when CD16 disappears, CD38 takes the stage
Mario Picozza,Luca Battistini,Giovanna Borsellino
View Articletitled, Mononuclear phagocytes and marker modulation: when CD16 disappears, CD38 takes the stage
Non-Hodgkin lymphoma in familial amyloid polyneuropathy patients in Sweden
Kari Hemminki,Xinjun Li,Asta Försti,Jan Sundquist,Kristina Sundquist
View Articletitled, Non-Hodgkin lymphoma in familial amyloid polyneuropathy patients in Sweden
The microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategies
Antonino Carbone,Annunziata Gloghini
View Articletitled, The microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategies
No familial aggregation in chronic myeloid leukemia
Magnus Björkholm,Sigurdur Y. Kristinsson,Ola Landgren,Lynn R. Goldin
View Articletitled, No familial aggregation in chronic myeloid leukemia
A missense mutation in ANKRD26 segregates with thrombocytopenia
Saad A. Al Daama,Yousef H. Housawi,Walid Dridi,Mohammed Sager,F. George Otieno,Cuiping Hou,Lyam Vasquez,Cecilia Kim,Lifeng Tian,Patrick Sleiman,Hakon Hakonarson
View Articletitled, A missense mutation in ANKRD26 segregates with thrombocytopenia
Localized edema with sclerodermatous evolution: a possible form of skin chronic graft-versus-host disease associated with endothelial activation
Mathilde Tardieu,Michel Rybojad,Régis Peffault de Latour,Marie Robin,Adèle de Masson,Aliénor Xhaard,Hélène Le Buanec,Nathalie Parquet,Flore Sicre de Fontbrune,Anne Bergeron,Catherine Scieux,Valérie Dessirier,Armand Bensussan,Martine Bagot,Gérard Socié,Jean-David Bouaziz
View Articletitled, Localized edema with sclerodermatous evolution: a possible form of skin chronic graft-versus-host disease associated with endothelial activation

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

LAC: 6-year review of 2257 high-risk patients
CME
View Articletitled, LAC: 6-year review of 2257 high-risk patients
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