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Issue Archive

Volume 126, Issue 11
September 10 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
More than one way to shrink
Ryszard Grygorczyk,Narla Mohandas
View Articletitled, More than one way to shrink
INSIDE BLOOD COMMENTARY
“Blood feuds”
Siddhartha Mukherjee
View Articletitled, “Blood feuds”
INSIDE BLOOD COMMENTARY
GVHD and miR: good things in small packages
Jonathan Serody
View Articletitled, GVHD and miR: good things in small packages
INSIDE BLOOD COMMENTARY
Directing CLL-cell traffic
Federico Caligaris-Cappio
View Articletitled, Directing CLL-cell traffic
INSIDE BLOOD COMMENTARY
Exploiting AML vulnerability: glutamine dependency
Ashkan Emadi
View Articletitled, Exploiting AML vulnerability: glutamine dependency
INSIDE BLOOD COMMENTARY
New players in Trousseau syndrome
Nigel S. Key
View Articletitled, New players in Trousseau syndrome

PLENARY PAPER

Red Cells, Iron, and Erythropoiesis
A mutation in the Gardos channel is associated with hereditary xerocytosis
Raphael Rapetti-Mauss,Caroline Lacoste,Véronique Picard,Corinne Guitton,Elise Lombard,Marie Loosveld,Vanessa Nivaggioni,Nathalie Dasilva,David Salgado,Jean-Pierre Desvignes,Christophe Béroud,Patrick Viout,Monique Bernard,Olivier Soriani,Henri Vinti,Valérie Lacroze,Madeleine Feneant-Thibault,Isabelle Thuret,Hélène Guizouarn,Catherine Badens
View Articletitled, A mutation in the Gardos channel is associated with hereditary xerocytosis

PLENARY PAPER

Red Cells, Iron, and Erythropoiesis
Mutations in the Gardos channel (KCNN4) are associated with hereditary xerocytosis
Brief Report
Edyta Glogowska,Kimberly Lezon-Geyda,Yelena Maksimova,Vincent P. Schulz,Patrick G. Gallagher
View Articletitled, Mutations in the Gardos channel (<em>KCNN4</em>) are associated with hereditary xerocytosis

HOW I TREAT

How I treat catastrophic thrombotic syndromes
Clinical Trials & Observations
Thomas L. Ortel,Doruk Erkan,Craig S. Kitchens
View Articletitled, How I treat catastrophic thrombotic syndromes

CLINICAL TRIALS AND OBSERVATIONS

Melphalan, prednisone, and thalidomide vs melphalan, prednisone, and lenalidomide (ECOG E1A06) in untreated multiple myeloma
Clinical Trials & Observations
A. Keith Stewart,Susanna Jacobus,Rafael Fonseca,Matthias Weiss,Natalie S. Callander,Asher A. Chanan-Khan,S. Vincent Rajkumar
View Articletitled, Melphalan, prednisone, and thalidomide vs melphalan, prednisone, and lenalidomide (ECOG E1A06) in untreated multiple myeloma
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation
Hui Cheng,Sha Hao,Yanfeng Liu,Yakun Pang,Shihui Ma,Fang Dong,Jing Xu,Guoguang Zheng,Shaoguang Li,Weiping Yuan,Tao Cheng
View Articletitled, Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation
Supplemental data

IMMUNOBIOLOGY

MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice
Yongxia Wu,Jessica Heinrichs,David Bastian,Jianing Fu,Hung Nguyen,Steven Schutt,Yuejun Liu,Junfei Jin,Chen Liu,Qi-Jing Li,Changqing Xia,Xue-Zhong Yu
View Articletitled, MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice
Supplemental data

LYMPHOID NEOPLASIA

NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity
Katarina Ochodnicka-Mackovicova,Mahnoush Bahjat,Timon A. Bloedjes,Chiel Maas,Alexander M. de Bruin,Richard J. Bende,Carel J. M. van Noesel,Jeroen E. J. Guikema
View Articletitled, NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity
Supplemental data
L-selectin controls trafficking of chronic lymphocytic leukemia cells in lymph node high endothelial venules in vivo
Fanny Lafouresse,Elisabeth Bellard,Camille Laurent,Christine Moussion,Jean-Jacques Fournié,Loïc Ysebaert,Jean-Philippe Girard
View Articletitled, L-selectin controls trafficking of chronic lymphocytic leukemia cells in lymph node high endothelial venules in vivo
Supplemental data

MYELOID NEOPLASIA

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition
Nathalie Jacque,Anne Marie Ronchetti,Clément Larrue,Godelieve Meunier,Rudy Birsen,Lise Willems,Estelle Saland,Justine Decroocq,Thiago Trovati Maciel,Mireille Lambert,Laury Poulain,Marie Anne Hospital,Pierre Sujobert,Laure Joseph,Nicolas Chapuis,Catherine Lacombe,Ivan Cruz Moura,Susan Demo,Jean Emmanuel Sarry,Christian Recher,Patrick Mayeux,Jérôme Tamburini,Didier Bouscary
View Articletitled, Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages
Sophie L. Gibbings,Rajni Goyal,A. Nicole Desch,Sonia M. Leach,Miglena Prabagar,Shaikh M. Atif,Donna L. Bratton,William Janssen,Claudia V. Jakubzick
View Articletitled, Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages
Supplemental data

PLATELETS AND THROMBOPOIESIS

Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia
Clinical Trials & Observations
Anja J. Gerrits,Emily A. Leven,Andrew L. Frelinger, III,Sophie L. Brigstocke,Michelle A. Berny-Lang,W. Beau Mitchell,Shoshana Revel-Vilk,Hannah Tamary,Sabrina L. Carmichael,Marc R. Barnard,Alan D. Michelson,James B. Bussel
View Articletitled, Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia

THROMBOSIS AND HEMOSTASIS

The polyphosphate–factor XII pathway drives coagulation in prostate cancer-associated thrombosis
Katrin F. Nickel,Göran Ronquist,Florian Langer,Linda Labberton,Tobias A. Fuchs,Carsten Bokemeyer,Guido Sauter,Markus Graefen,Nigel Mackman,Evi X. Stavrou,Gunnar Ronquist,Thomas Renné
View Articletitled, The polyphosphate–factor XII pathway drives coagulation in prostate cancer-associated thrombosis
Supplemental data
Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF
e-blood
Jennifer E. Huffman,Paul S. de Vries,Alanna C. Morrison,Maria Sabater-Lleal,Tim Kacprowski,Paul L. Auer,Jennifer A. Brody,Daniel I. Chasman,Ming-Huei Chen,Xiuqing Guo,Li-An Lin,Riccardo E. Marioni,Martina Müller-Nurasyid,Lisa R. Yanek,Nathan Pankratz,Megan L. Grove,Moniek P. M. de Maat,Mary Cushman,Kerri L. Wiggins,Lihong Qi,Bengt Sennblad,Sarah E. Harris,Ozren Polasek,Helene Riess,Fernando Rivadeneira,Lynda M. Rose,Anuj Goel,Kent D. Taylor,Alexander Teumer,André G. Uitterlinden,Dhananjay Vaidya,Jie Yao,Weihong Tang,Daniel Levy,Melanie Waldenberger,Diane M. Becker,Aaron R. Folsom,Franco Giulianini,Andreas Greinacher,Albert Hofman,Chiang-Ching Huang,Charles Kooperberg,Angela Silveira,John M. Starr,Konstantin Strauch,Rona J. Strawbridge,Alan F. Wright,Barbara McKnight,Oscar H. Franco,Neil Zakai,Rasika A. Mathias,Bruce M. Psaty,Paul M. Ridker,Geoffrey H. Tofler,Uwe Völker,Hugh Watkins,Myriam Fornage,Anders Hamsten,Ian J. Deary,Eric Boerwinkle,Wolfgang Koenig,Jerome I. Rotter,Caroline Hayward,Abbas Dehghan,Alex P. Reiner,Christopher J. O’Donnell,Nicholas L. Smith
View Articletitled, Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF
Supplemental data

BLOOD WORK

Bing-Neel syndrome: a rare complication of Waldenström macroglobulinemia
Sergio Sánchez-Guerrero,Jorge J. Castillo
View Articletitled, Bing-Neel syndrome: a rare complication of Waldenström macroglobulinemia
Extreme dyserythropoiesis in the setting of acute erythroid leukemia
Francisco J. Ortuño,Maria Sola
View Articletitled, Extreme dyserythropoiesis in the setting of acute erythroid leukemia

CORRESPONDENCE

Dexamethasone, rituximab, and cyclophosphamide as primary treatment of Waldenström macroglobulinemia: final analysis of a phase 2 study
Efstathios Kastritis,Maria Gavriatopoulou,Marie-Christine Kyrtsonis,Maria Roussou,Evdoxia Hadjiharissi,Argyris Symeonidis,Panagiotis Repoussis,Evridiki Michalis,Sosana Delimpasi,Konstantinos Tsatalas,Panagiotis Tsirigotis,Amalia Vassou,Elina Vervessou,Eirini Katodritou,Dimitra Gika,Evangelos Terpos,Meletios A. Dimopoulos
View Articletitled, Dexamethasone, rituximab, and cyclophosphamide as primary treatment of Waldenström macroglobulinemia: final analysis of a phase 2 study
Supplemental data
Preclinical activity of the repurposed drug auranofin in classical Hodgkin lymphoma
Marta Celegato,Cinzia Borghese,Naike Casagrande,Maurizio Mongiat,Xaver U. Kahle,Alice Paulitti,Michele Spina,Alfonso Colombatti,Donatella Aldinucci
View Articletitled, Preclinical activity of the repurposed drug auranofin in classical Hodgkin lymphoma
Supplemental data
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