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Journal Articles

Remission conversion drives outcomes after CAR T-cell therapy for multiple myeloma: a registry analysis from the DRST

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Clinical Trials & Observations
Maximilian Merz, Nico Gagelmann, Samih Smaili, Sarah Flossdorf, Sandra Sauer, Christof Scheid, Bastian von Tresckow, Gerald Wulf, Katja Weisel, Igor Wolfgang Blau, Monika Engelhardt, Ralph Wäsch, Natalie Schub, Raphael Teipel, Judith Hecker, Johannes Waldschmidt, Britta Besemer, Ben-Niklas Baermann, Simon Call, Leo Hansmann, Francis Ayuketang Ayuk, Marc S. Raab, Hermann Einsele, Uwe Platzbecker, Nicolaus Kröger
Journal: Blood
Blood (2025) 146 (14): 1677–1686.
https://doi.org/10.1182/blood.2025028330
Published: 2025
Includes: Supplemental data
Journal Articles

IPSS-M risk and specific sex-associated somatic mutations predict response to ESA therapy in LR-MDS: building a new score

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Clinical Trials & Observations
Marco G. Raddi, Sophie Park, Michaela Fontenay, Olivier Kosmider, Maria Diez Campelo, Juan C. Berrocal, Marie Sebert, Lionel Adès, Uwe Platzbecker, Matteo G. Della Porta, Giorgio Mattiuz, Sven De Pourcq, Lorenzo Tofani, Giulia Maggioni, Elena Tofacchi, Angela Consagra, Luca Rigodanza, Gloria Andreossi, Cristina Amato, Mathieu Meunier, Celia Orlando, Emmanuelle Clappier, Nicolas Chapuis, Pierre Walczak, Katharina Zoldan, Anne Sophie Kubasch, Valeria Santini
Journal: Blood
Blood (2025) 146 (14): 1693–1706.
https://doi.org/10.1182/blood.2024027540
Published: 2025
Includes: Supplemental data
Journal Articles

The endothelial mTORC2-Foxo1 axis serves as an iron-responsive sensor governing systemic iron homeostasis

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Wenting Zhao, Peina Wang, Zhengxun Liu, Dongyuan Zhang, Yi Xia, Teng Xu, Fei Wang, Mingyang Cui, Xu Zhang, Shuaishuai Zhou, Zhixi Wei, Min Ma, Sitong Wan, Jingyi Qi, Zhengyang Zhang, Juan Chen, Libing Liu, Yinhua Zhu, Junjie Luo, Yongting Luo, Peng An
Journal: Blood
Blood (2025) 146 (14): 1722–1736.
https://doi.org/10.1182/blood.2025028454
Published: 2025
Includes: Supplemental data
Journal Articles

Marstacimab prophylaxis in hemophilia A/B without inhibitors: results from the phase 3 BASIS trial

Open Access
Clinical Trials & Observations
Davide Matino, Andrew Palladino, Carrie Turich Taylor, Eunhee Hwang, Sangeeta Raje, Satyaprakash Nayak, Regina McDonald, Suchitra S. Acharya, Johnny Mahlangu, Victor Jiménez-Yuste, Nirmalkumar Choraria, Renchi Yang, Chi-kong Li, Murtadha Al-Khabori, Yasser Wali, Javier Morales Adrián, Young-Shil Park, O. Bülent Zülfikar, John Teeter
Journal: Blood
Blood (2025) 146 (14): 1654–1663.
https://doi.org/10.1182/blood.2024027468
Published: 2025
Includes: Supplemental data
Journal Articles

Matched donor allogeneic CAR-T for adult B-ALL: toxicity, efficacy, repeat dosing, and the importance of lymphodepletion

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Clinical Trials & Observations
Claire Roddie, Juliana Dias, Maeve A. O’Reilly, Mahnaz Abbasian, Amaia Cadinanos-Garai, Ketki Vispute, Leticia Bosshard-Carter, Marina Mitsikakou, Eftychia Charalambous, Vedika Mehra, Harriet Roddy, Gordon Weng-Kit Cheung, John A. Hartley, Nasir Mahmoud, Leah Ensell, Yashma Patel, Maria A. V. Marzolini, Farzin Farzaneh, Lauren Nickolay, Nourredine Himoudi, Farhatullah Syed, Bilyana Popova, Sevasti Galani, Alexander Day, Mark W. Lowdell, Karl S. Peggs
Journal: Blood
Blood (2025) 146 (14): 1664–1676.
https://doi.org/10.1182/blood.2025028790
Published: 2025
Includes: Supplemental data
Journal Articles

How I treat pediatric pulmonary embolism

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Ayesha Zia, Neil A. Goldenberg, Madhvi Rajpurkar
Journal: Blood
Blood (2025) 146 (14): 1643–1653.
https://doi.org/10.1182/blood.2024026599
Published: 2025
Includes: Supplemental data
Journal Articles

The acute myeloid leukemia microenvironment impairs neutrophil maturation and function through NF-κB signaling

Open Access
Paran Goel, Sajesan Aryal, Alana M. Franceski, Valeriya Kuznetsova, Amanda Costa, Francesca Luca, Ashley N. Connelly, Daniel W. Phillips, Caroline C. Ennis, Brittany M. Curtiss, Sourajeet Karfa, Brittany L. Crown, Christina R. Larson, Estelle Carminita, Virginia Camacho, Doug Welsch, Changde Cheng, Asumi Yokota, Isidoro Cobo, Hideyo Hirai, Rui Lu, Ravi Bhatia, Pran K. Datta, P. Brent Ferrell, Robert S. Welner
Journal: Blood
Blood (2025) 146 (14): 1707–1721.
https://doi.org/10.1182/blood.2024028199
Published: 2025
Includes: Supplemental data
Journal Articles

A new prognostic index (CLIPI) for advanced cutaneous lymphoma enables precise patient risk stratification

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Clinical Trials & Observations Brief Report
Julia J. Scarisbrick, Pietro Quaglino, Sean Whittaker, Martine Bagot, Emmanuella Guenova, Evangelia Papadavid, Henry Miles Prince, Jose A. Sanches, Denis R. Miyashiro, Octavio Servitje, Christiane Querfeld, Oleg Akilov, Arvind Arumainathan, Luke Bennett, Maxime Battistella, Kim Benstead, Emilio Berti, Marie Beylot-Barry, Anne-Marie Busschots, Richard Cowan, Reinhard Dummer, Giles Dunnill, Teresa Estrach, Felicity Evison, Abraham Bashir, Larisa Geskin, Ale Gru, Joan Guitart, Melba C. Herrera, Emillia Hodak, Steve Horwitz, Constanze Jonak, Claus-Detlev Klemke, Robert Knobler, Pam Mckay, Marta Marschalkó, Cesare Massone, Rubeta Matin, Christina Mitteldorf, Robert Novoa, Pablo Ortiz-Romero, Nicola Pimpinelli, Ramon M. Pujol, Annmari Ranki, Liisa Vakeva, Kerri E. Rieger, Rudolf Stadler, Franz Trautinger, Johanna Latzka, Maarten Vermeer, Rachel Wachsmuth, Sophie Weatherhead, Ulrike Wehkamp, Marion Wobser, Youn H. Kim
Journal: Blood
Blood (2025) 146 (14): 1687–1692.
https://doi.org/10.1182/blood.2025029628
Published: 2025
Includes: Supplemental data
Journal Articles

Foxo1 unlocks the liver endothelial code to iron sensing

Free
Kostas Pantopoulos
Journal: Blood
Blood (2025) 146 (14): 1639–1641.
https://doi.org/10.1182/blood.2025030281
Published: 2025
Journal Articles

In low-risk myelodysplastic syndrome, don’t shoot the STAG2

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Natasha Szuber, Lambert Busque
Journal: Blood
Blood (2025) 146 (14): 1636–1638.
https://doi.org/10.1182/blood.2025030114
Published: 2025
Journal Articles

DRiving STandard-of-care CAR T cells in real-world Germany

Free
Mark R. Dowling, Simon J. Harrison
Journal: Blood
Blood (2025) 146 (14): 1634–1635.
https://doi.org/10.1182/blood.2025029932
Published: 2025
Journal Articles

AML halts neutrophil maturation

Free
Lakshmi Sandhow, Diana Passaro
Journal: Blood
Blood (2025) 146 (14): 1638–1639.
https://doi.org/10.1182/blood.2025030403
Published: 2025
Journal Articles

Rebalancing the hemophilia teeter-totter

Free
Clinical Trials & Observations
Thomas C. Abshire
Journal: Blood
Blood (2025) 146 (14): 1631–1632.
https://doi.org/10.1182/blood.2025030260
Published: 2025
Journal Articles

AML with mutated TP53, therapy-related, with basophilic differentiation, partial CD22, and ring sideroblasts

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Zhaodong Xu, Eric McGinnis
Journal: Blood
Blood (2025) 146 (14): 1737.
https://doi.org/10.1182/blood.2025029483
Published: 2025
Journal Articles

CAR-DLI for ALL, but not without lymphodepletion

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Clinical Trials & Observations
Lutz P. Müller
Journal: Blood
Blood (2025) 146 (14): 1632–1634.
https://doi.org/10.1182/blood.2025030291
Published: 2025
Journal Articles

More than skin deep

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Ryan A. Wilcox
Journal: Blood
Blood (2025) 146 (14): 1635–1636.
https://doi.org/10.1182/blood.2025030356
Published: 2025
Images
A model for iron sensing in LSECs. High intracellular iron levels, a consequence of the uptake of diferric transferrin via transferrin receptor 1 (Tfr1), NTBI via Zip8 or other transporter(s), or reduced iron efflux caused by hepcidin-mediated inhibition of ferroportin, promote lysosomal degradation of Rictor, a core component of mTORC2. Loss of mTORC2 activity leads to Akt inactivation, thereby enabling the nuclear translocation of Foxo1. Once in the nucleus, Foxo1 binds specific elements in the Bmp2 and Bmp6 promoters, thereby activating their transcription. Conversely, when intracellular iron levels are low because of reduced uptake and/or increased efflux, mTORC2 remains active, phosphorylating Akt. Activated Akt phosphorylates Foxo1, retaining it in the cytoplasm and thereby repressing Bmp2 and Bmp6 expression. Fpn, ferroportin; Tf, transferrin. Figure created with BioRender.com.

A model for iron sensing in LSECs. High intracellular iron levels, a conseq...

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in Foxo1 unlocks the liver endothelial code to iron sensing > Blood
Published: 2025
A model for iron sensing in LSECs. High intracellular iron levels, a consequence of the uptake of diferric transferrin via transferrin receptor 1 (Tfr1), NTBI via Zip8 or other transporter(s), or reduced iron efflux caused by hepcidin-mediated inhibition of ferroportin, promote lysosomal degradation... More about this image found in A model for iron sensing in LSECs. High intracellular iron levels, a conseq...
Images
Role of LD in CAR-T therapy after alloHSCT. EFS, event-free survival; OS, overall survival.

Role of LD in CAR-T therapy after alloHSCT. EFS, event-free survival; OS, o...

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in CAR-DLI for ALL, but not without lymphodepletion > Blood
Published: 2025
Role of LD in CAR-T therapy after alloHSCT. EFS, event-free survival; OS, overall survival. More about this image found in Role of LD in CAR-T therapy after alloHSCT. EFS, event-free survival; OS, o...
Images
AML disrupts neutrophil homeostatic balance in the BM, resulting in the accumulation of immature subsets aberrantly expressing CD14 on activation of NF-κB.

AML disrupts neutrophil homeostatic balance in the BM, resulting in the acc...

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in AML halts neutrophil maturation > Blood
Published: 2025
AML disrupts neutrophil homeostatic balance in the BM, resulting in the accumulation of immature subsets aberrantly expressing CD14 on activation of NF-κB. More about this image found in AML disrupts neutrophil homeostatic balance in the BM, resulting in the acc...
Images
Proposed approach to PE risk stratification in children. CBC, complete blood count; ECMO, extracorporeal membrane oxygenation.

Proposed approach to PE risk stratification in children. CBC, complete blo...

Available to Purchase
in How I treat pediatric pulmonary embolism > Blood
Published: 2025
Figure 1. Proposed approach to PE risk stratification in children. CBC, complete blood count; ECMO, extracorporeal membrane oxygenation. More about this image found in Proposed approach to PE risk stratification in children. CBC, complete blo...