Activation of FXR in hepatocytes by bile acids or tropifexor downregulates expression of Serpine 1 , the gene that encodes PAI-1. This results in decreased plasma levels of PAI-1 and enhancement of fibrin-clot lysis. Professional illustration by Patrick Lane, ScEYEnce Studios. More about this image found in Activation of FXR in hepatocytes by bile acids or tropifexor downregulates ...

Figure 6. In vivo efficacy of IC488743 treatment of human MM xenografts in SCID mice. (A) Mice injected with 5 × 10 6 LB cells were treated orally twice a day with control vehicle (●), and IC488743 10 mg/kg ( □ ) or 30 mg/kg (○). Mean tumor volume was calculated as in “Murine xenograft models o... More about this image found in In vivo efficacy of IC488743 treatment of human MM xenografts in SCID mice....