Mechanisms of GPRC5D loss mediating resistance to anti-GPRC5D CAR T therapy. In the T-cell therapy–naive setting, GPRC5D is highly expressed on multiple myeloma (MM) tumor cells, enabling effective targeting by anti-GPRC5D CAR T cells (arrows hitting the bullseye). After relapse, tumor cells eva... More about this image found in Mechanisms of GPRC5D loss mediating resistance to anti-GPRC5D CAR T thera...

Evolution of prognostic systems in LCH. (Left) Traditional risk-organ–based prognostication categorizes patients based on the presence or absence of risk-organ involvement, affecting overall survival. Patients with risk-organ involvement exhibit poorer survival compared with those without. (Right) M... More about this image found in Evolution of prognostic systems in LCH. (Left) Traditional risk-organ–based...

Enhancing PD-1 blockade efficacy through CD38 inhibition. The figure illustrates potential mechanisms through which combining the PD-1 inhibitor cemiplimab (orange) with the CD38 monoclonal antibody isatuximab (black) may amplify immune checkpoint blockade in ENKTL. (I) Direct CD38-mediated cell kil... More about this image found in Enhancing PD-1 blockade efficacy through CD38 inhibition. The figure illust...