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Journal Articles

Efficacy and Safety of Marstacimab Prophylaxis in Hemophilia A/B With Inhibitors: Results from the Phase 3 BASIS Trial

Open Access
Clinical Trials & Observations
Davide Matino, Suchitra Acharya, Carrie Turich Taylor, Pengling Sun, Delphine Agathon, Sangeeta Raje, Travis Gould, Andrew Palladino, Johnny Mahlangu
Journal: Blood
Blood blood.2025031065.
https://doi.org/10.1182/blood.2025031065
Published: 2025
Includes: Supplemental data
Journal Articles

Donor-derived CD7 CAR T cells for pediatric and adult relapsed/refractory T-ALL/LBL: a phase 2 trial

Available to Purchase
Clinical Trials & Observations
Jing Pan, Liping Zhao, Yibing Zhang, Samuel Seery, Yue Tan, Biping Deng, Lingling Shan, Zhuojun Ling, Fan Wu, Zelin Wang, Quangang Wang, Xinjian Yu, Qinlong Zheng, Xiuwen Xu, Ying Yuan, Zhenglong Tian, Yanlei Zhang, Shuixiu Peng, Alex Hongsheng Chang, Xiaoming Feng
Journal: Blood
Blood (2025) 146 (23): 2745–2757.
https://doi.org/10.1182/blood.2025029299
Published: 2025
Includes: Supplemental data
Journal Articles

The origin, diagnosis, and prognosis of oligomannose-type diffuse large B-cell lymphoma

Available to Purchase
Dylan J. Tatterton, Maddy L. Newby, Joel D. Allen, Benjamin Sale, Giorgia Chiodin, Patrick J. Duriez, John Butler, Katy J. McCann, David W. Scott, Ryan D. Morin, Kostiantyn Dreval, Andrew J. Davies, Dean J. Bryant, Max Crispin, Francesco Forconi
Journal: Blood
Blood (2025) 146 (23): 2808–2820.
https://doi.org/10.1182/blood.2025029163
Published: 2025
Includes: Supplemental data
Journal Articles

Nanoromidepsin, a polymer nanoparticle of the HDAC inhibitor, improves safety and efficacy in models of T-cell lymphoma

Available to Purchase
Ipsita Pal, Anuradha Illendula, Andrea Joyner, John Sanil Manavalan, Tess M. Deddens, Ariana Sabzevari, Deepthi P. Damera, Samir Zuberi, Enrica Marchi, Todd E. Fox, Marya E. Dunlap-Brown, Kallesh D. Jayappa, Jihane Khalife, Jeffrey W. Craig, Thomas P. Loughran, Jr., David J. Feith, Owen A. O’Connor
Journal: Blood
Blood (2025) 146 (23): 2794–2807.
https://doi.org/10.1182/blood.2024027997
Published: 2025
Includes: Supplemental data
Journal Articles

Impact of ASXL1 at diagnosis in patients with CML receiving frontline potent TKIs: high risk of kinase domain mutations

Available to Purchase
Naranie Shanmuganathan, David T. Yeung, Carol Wadham, Adelina Fernandes, Muneeza Maqsood, NurHezrin Shahrin, Verity Saunders, Rosalie R. Kenyon, Ming Lin, John Toubia, Joe McConnell, Dominic Kaczorowski, David M. Ross, Agnes S. M. Yong, Lynette Chee, Jake Shortt, Nicholas Viiala, Jodi Braley, Chung Hoow Kok, Timothy P. Hughes, Susan Branford
Journal: Blood
Blood (2025) 146 (23): 2821–2832.
https://doi.org/10.1182/blood.2025030259
Published: 2025
Includes: Supplemental data
Journal Articles

Leukemia escapes immunity by imposing a type 1 regulatory program on neoantigen-specific CD4 + T cells

Available to Purchase
Hrishi Venkatesh, Enoc Granados Centeno, Qianyun Luo, Miriam Arroyo, Lynn Heltemes-Harris, Todd P. Knutson, Yinjie Qiu, Allison Haaning, Beau R. Webber, Veronika Bachanova, Michael A. Farrar, Sean I. Tracy
Journal: Blood
Blood (2025) 146 (23): 2779–2793.
https://doi.org/10.1182/blood.2024028194
Published: 2025
Includes: Supplemental data
Journal Articles

Impact of immunochemotherapy regimens on outcomes of patients with primary mediastinal B-cell lymphoma in the IELSG37 trial

Available to Purchase
Clinical Trials & Observations Brief Report
Emanuele Zucca, Luca Ceriani, Giovannino Ciccone, Alice Di Rocco, Maria Cristina Pirosa, Iryna Kriachok, Barbara Botto, Monica Balzarotti, Alessandra Tucci, Sara Veronica Usai, Vittorio Ruggero Zilioli, Elsa Pennese, Luca Arcaini, Anna Dabrowska-Iwanicka, Andrés J. M. Ferreri, Francesco Merli, Weili Zhao, Luigi Rigacci, Claudia Cellini, David Hodgson, Codruta Ionescu, Carla Minoia, Elisa Lucchini, Michele Spina, Alexander Fosså, Andrea Janikova, Kate Cwynarski, N. George Mikhaeel, Mats Jerkeman, Anastasios Stathis, Kelly Cozens, Nicoletta Ielmini, Iolanda De Martino, Jan Walewski, Marek Trneny, Franco Cavalli, Umberto Ricardi, Peter W. M. Johnson, Andrew Davies, Maurizio Martelli
Journal: Blood
Blood (2025) 146 (23): 2758–2764.
https://doi.org/10.1182/blood.2025028823
Published: 2025
Includes: Supplemental data
Journal Articles

On the CHOPping block? Rethinking initial therapy for PMBCL

Free
Clinical Trials & Observations
Nitya Gulati, Lisa Giulino-Roth
Journal: Blood
Blood (2025) 146 (23): 2732–2734.
https://doi.org/10.1182/blood.2025031030
Published: 2025
Journal Articles

A structural spotlight on extrinsic Xase complex

Free
Lacramioara Ivanciu
Journal: Blood
Blood (2025) 146 (23): 2742–2743.
https://doi.org/10.1182/blood.2025030904
Published: 2025
Journal Articles

Donor-derived CD7 CAR-T in T-ALL/LBL: promise and pitfalls

Free
Clinical Trials & Observations
Ibrahim Aldoss, Lori Muffly
Journal: Blood
Blood (2025) 146 (23): 2731–2732.
https://doi.org/10.1182/blood.2025030672
Published: 2025
Journal Articles

Close V, Close W, Kugler SJ, et al. FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL. Blood . 2019;133(8):830-839.

Free
Journal: Blood
Blood (2025) 146 (23): 2845.
https://doi.org/10.1182/blood.2025031881
Published: 2025
Journal Articles

The secret to staying young: platelet factor 4

Free
James Ropa
Journal: Blood
Blood (2025) 146 (23): 2734–2736.
https://doi.org/10.1182/blood.2025031130
Published: 2025
Journal Articles

How can we chop CML with an ASXL1?

Free
Jorge Cortes
Journal: Blood
Blood (2025) 146 (23): 2741–2742.
https://doi.org/10.1182/blood.2025031031
Published: 2025
Journal Articles

Hijacked helpers: Tr1 cells fuel immune escape in B-ALL

Free
Martina Seiffert
Journal: Blood
Blood (2025) 146 (23): 2736–2737.
https://doi.org/10.1182/blood.2025030985
Published: 2025
Journal Articles

Atypical hyperlymphocytosis following CAR T-cell infusion

Open Access
Christopher J. Vossen, Angela M. B. Collie
Journal: Blood
Blood (2025) 146 (23): 2843.
https://doi.org/10.1182/blood.2025030448
Published: 2025
Journal Articles

Sweet stuff is dangerous in DLBCL

Free
Falko Fend, Leticia Quintanilla-Martínez
Journal: Blood
Blood (2025) 146 (23): 2739–2741.
https://doi.org/10.1182/blood.2025031082
Published: 2025
Journal Articles

Clinical revival of romidepsin with nanoparticles

Free
Wataru Munakata
Journal: Blood
Blood (2025) 146 (23): 2737–2739.
https://doi.org/10.1182/blood.2025031003
Published: 2025
Journal Articles

Marchand T, Lamy T, Loughran TP Jr. A modern view of LGL leukemia. Blood. 2024;144(18):1910-1923.

Free
Journal: Blood
Blood (2025) 146 (23): 2844.
https://doi.org/10.1182/blood.2025032105
Published: 2025
Images
In young mice, megakaryocytes produce PF4, which in turn drives the maintenance of lineage-balanced, potent HSCs. During aging, the megakaryocytic niche is altered. Megakaryocytes undergo changes in morphology, changes in number, and produce significantly less PF4. This reduction in PF4 contributes to myeloid-biased hematopoiesis and a loss of functionally potent HSCs. Both human and mouse HSC function can be partially restored through direct administration/treatment of recombinant PF4 protein.

In young mice, megakaryocytes produce PF4, which in turn drives the mainten...

Free
in The secret to staying young: platelet factor 4 > Blood
Published: 2025
In young mice, megakaryocytes produce PF4, which in turn drives the maintenance of lineage-balanced, potent HSCs. During aging, the megakaryocytic niche is altered. Megakaryocytes undergo changes in morphology, changes in number, and produce significantly less PF4. This reduction in PF4 contributes ... More about this image found in In young mice, megakaryocytes produce PF4, which in turn drives the mainten...
Images
Schematic representation of the role of N-glycosylation in the CDR of the immunoglobulin heavy chain in FL and Mann-type DLBCL. Of note, immunoglobulin light chain CDRs can also be glycosylated in these lymphomas. Mann-type DLBCL (upper right) shares the presence of a BCL2 translocation and/or an EZB-type mutational profile (middle panel) with conventional FL (upper left). Oligomannoses in the CDR of the surface immunoglobulin as part of the BCR bind to DC-SIGN expressed by macrophages or dendritic cells. This results in continuous BCR signaling via CD79a/b with activation of the downstream PI3K/AKT pathway. The difference between the generally indolent behavior of FL and Mann-type DLBCL, especially in comparison with other DLBCL of GCB type, warrants further studies. The figure was created, in part, with BioRender.com. Montes I. (2025) https://BioRender.com/r2fnrs7.

Schematic representation of the role of N-glycosylation in the CDR of the i...

Free
in Sweet stuff is dangerous in DLBCL > Blood
Published: 2025
Schematic representation of the role of N-glycosylation in the CDR of the immunoglobulin heavy chain in FL and Mann-type DLBCL. Of note, immunoglobulin light chain CDRs can also be glycosylated in these lymphomas. Mann-type DLBCL (upper right) shares the presence of a BCL2 translocation and/or an ... More about this image found in Schematic representation of the role of N-glycosylation in the CDR of the i...