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Journal Articles

Disruption of cotranscriptional splicing suggests that RBM39 is a therapeutic target in acute lymphoblastic leukemia

Blood blood.2024024281.

https://doi.org/10.1182/blood.2024024281

Published: 2024

Includes: Supplemental data

Journal Articles

PRC2-Mediated Apoptosis Evasion Is a Therapeutic Target of MDS/AML Harboring Inv(3)/t(3;3) and -7

Hiroyoshi Kunimoto, Ayaka Miura, Maiko Sagisaka, Mieko Ito, Daisuke Honma, Shinji Tsutsumi, Takayuki Sakuma, Takuma Ohashi, Hiroshi Teranaka, Junji Ikeda, Takashi Toya, Yuka Harada, Noriko Doki, Sheng F. Cai, Akihide Yoshimi, Hiroaki Goto, Ross L Levine, Hideaki Nakajima

Blood (2023) 142 (Supplement 1): 2803.

https://doi.org/10.1182/blood-2023-178436

Published: 2023

Journal Articles

Regulation of Alternative Splicing in B-Cell ALL By DYRK1A

Qi Jin, Ethan Harris, Jacquelyn A. Myers, Anitria Cotton, Jeremy Wen, Johanna Melo-Cardenas, Akihide Yoshimi, Omar Abdel-Wahab, Esther A. Obeng, John D. Crispino

Blood (2023) 142 (Supplement 1): 39.

https://doi.org/10.1182/blood-2023-174923

Published: 2023

Journal Articles

Efficient production of human neutrophils from iPSCs that prevent murine lethal infection with immune cell recruitment

Masashi Miyauchi, Yusuke Ito, Fumio Nakahara, Toshiya Hino, Fumi Nakamura, Yuki Iwasaki, Taiki Kawagoshi, Junji Koya, Akihide Yoshimi, Shunya Arai, Yuki Kagoya, Mineo Kurokawa

Blood (2021) 138 (24): 2555–2569.

https://doi.org/10.1182/blood.2021011576

Published: 2021

Includes: Supplemental data

Journal Articles

Spliceosomal Disruption of the Non-Canonical SWI/SNF Chromatin Remodeling Complex in SF3B1 Mutant Leukemias

Daichi Inoue, MD PhD, Chew Guo-Liang, Bo Liu, PhD, Stanley C Lee, PhD, Brittany C Michel, Joey Pangallo, B.S., Andrew R D'Avino, Khrystyna North, Lillian E Bitner, BSc, Muran Xiao, Susumu Kobayashi, Akihide Yoshimi, MD PhD, Hana Cho, MSc, Sydney X Lu, MD PhD, Justin Taylor, MD, Cigall Kadoch, PhD, Robert K. Bradley, PhD, Omar Abdel-Wahab, MD

Blood (2019) 134 (Supplement_1): 637.

https://doi.org/10.1182/blood-2019-124616

Published: 2019

Journal Articles

Aberrant RNA Splicing Contributes to the Pathogenesis of EVI-Rearranged Myeloid Leukemias

Daichi Inoue, MD PhD, Stanley C Lee, PhD, Akihide Yoshimi, MD PhD, Justin Taylor, MD, Lillian E Bitner, BSc, Atsushi Tanaka, MD, Yasutaka Hayashi, MD PhD, Hana Cho, MSc, Chie Fukui, Ruth Saganty, Alexander V Penson, PhD, Omar Abdel-Wahab, MD

Blood (2019) 134 (Supplement_1): 917.

https://doi.org/10.1182/blood-2019-124722

Published: 2019

Journal Articles

Mutations in the RNA Splicing Factor SF3B1 Promote Transformation through MYC Stabilization

Akihide Yoshimi, MD, Zhaoqi Liu, PhD, Wang Jiguang, Hana Cho, MSc, Stanley C Lee, PhD, Michelle Ki, BSc, Lillian E Bitner, BSc, Timothy Chu, Anthony R Mato, MD, Peter P. Ruvolo, PhD, Giulia Fabbri, Laura Pasqualucci, MD, Raul Rabadan, PhD, Omar I Abdel-Wahab, MD

Blood (2018) 132 (Supplement 1): 882.

https://doi.org/10.1182/blood-2018-99-110328

Published: 2018

Journal Articles

Therapeutic Targeting of an RNA Splicing Factor Network for the Treatment of Myeloid Neoplasms

Sydney X. Lu, MD PhD, Eric Wang, Alessandro Pastore, Chen Xufeng, PhD, Jochen Imig, PhD, Stanley C Lee, PhD, Yohana Ghebrechristos, Akihide Yoshimi, MD, Lillian E Bitner, BSc, Michelle Ki, BSc, Andreas Kloetgen, Kuan-Ting Lin, PhD, Raoul Tibes, MD PhD, Adrian R. Krainer, PhD, Taisuke Uehara, Takashi Owa, PhD, Iannis Aifantis, PhD, Omar I Abdel-Wahab, MD

Blood (2018) 132 (Supplement 1): 427.

https://doi.org/10.1182/blood-2018-99-111430

Published: 2018

Journal Articles

Human Germline HLTF E259K Mutation Identified in Familial MDS Patients Accumulates DNA Damage through Impaired PCNA Polyubiquitination

Kensuke Takaoka, Masahito Kawazu, Junji Koya, Akihide Yoshimi, Yosuke Masamoto, MD PhD, Hiroaki Maki, Takashi Toya, Takashi Kobayashi, Yasuhito Nannya, MD PhD, Shunya Arai, MD PhD, Hironori Ueno, Kenshi Suzuki, Hironori Harada, Atsushi Manabe, Yasuhide Hayashi, Hiroyuki Mano, MDPhD, Mineo Kurokawa, MD PhD

Blood (2017) 130 (Supplement 1): 4238.

https://doi.org/10.1182/blood.V130.Suppl_1.4238.4238

Published: 2017

Journal Articles

Characterization of Ntrk fusions and Therapeutic Response to Ntrk Inhibition in Hematologic Malignancies

Blood (2017) 130 (Supplement 1): 794.

https://doi.org/10.1182/blood.V130.Suppl_1.794.794

Published: 2017

Journal Articles

Oncogenic Mutations in XPO1 Promote Lymphoid Transformation By Altering Nuclear/Cytoplasmic Localization of NFκB Signaling Intermediates

Justin Taylor, MD, Xiao Jing Zhang, Stella V Paffenholz, Alexander V Penson, PhD, Matthew Chang, Christina Marcelus, Lillian E Bitner, Young Rock Chung, MS, Akihide Yoshimi, MD, Stanley Chun-Wei Lee, PhD, Myriam Boukhali, MS, Rajesh K Soni, PhD, Ronald C Hendrickson, PhD, Barry S Taylor, PhD, Jose A Rodríguez, PhD, Wilhelm Haas, PhD, Omar Abdel-Wahab, MD

Blood (2017) 130 (Supplement 1): 879.

https://doi.org/10.1182/blood.V130.Suppl_1.879.879

Published: 2017

Journal Articles

Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis

Blood (2017) 130 (Supplement 1): 473.

https://doi.org/10.1182/blood.V130.Suppl_1.473.473

Published: 2017

Journal Articles

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML

Blood (2017) 130 (4): 397–407.

https://doi.org/10.1182/blood-2017-01-763219

Published: 2017

Includes: Supplemental data

Journal Articles

Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells

Blood (2017) 130 (2): 176–180.

https://doi.org/10.1182/blood-2016-12-757377

Published: 2017

Includes: Supplemental data

Journal Articles

Frequent Clinical Overlap of Histiocytic Neoplasms and WHO-Classified Myeloid Malignancies Leads to Functional Insights into the Cell-of-Origin of Histiocytoses

Benjamin Heath Durham, MD BS, Akihide Yoshimi, MD PhD, Matthias Papo, Young Rock Chung, MS, Neval Ozkaya, MD, Chezi Ganzel, Ahmet Dogan, David M. Hyman, Christopher Y. Park, MD PhD, Raajit K. Rampal, MD, PhD, Damien Roos Weil, Francois Michel Lemoine, MD PhD, Zahir Amoura, Olivier A. Bernard, PhD, Eli L. Diamond, MD, Jean-François Emile, MD PhD, Julien Haroche, MD PhD, Omar Abdel-Wahab, MD

Blood (2016) 128 (22): 951.

https://doi.org/10.1182/blood.V128.22.951.951

Published: 2016

Journal Articles

Patient-Derived Induced Pluripotent Stem Cells Identified SLITRK4 As a Causative Gene of Chronic Myelomonocytic Leukemia

Sho Yamazaki, MD, PhD, Kazuki Taoka, MD, PhD, Shunya Arai, MD, PhD, Masashi Miyauchi, MD, PhD, Keisuke Kataoka, MD PhD, Akihide Yoshimi, MD, PhD, Mineo Kurokawa, MD, PhD

Blood (2016) 128 (22): 1134.

https://doi.org/10.1182/blood.V128.22.1134.1134

Published: 2016

Journal Articles

Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity

Stanley Chun-Wei Lee, PhD, Khrystyna Dilai, Esther A. Obeng, MDPhD, Eunhee Kim, PhD, Jean-Baptiste Micol, MD PhD, Akihide Yoshimi, MD PhD, Christophe Willekens, MD, Daichi Inoue, Véronique Saada, PharmD, Hana Cho, Young Rock Chung, MS, James Palacino, PhD, Michael Seiler, PhD, Silvia Buonamici, PhD, Peter Smith, Benjamin L. Ebert, MD PhD, Robert Bradley, PhD, Omar Abdel-Wahab, MD

Blood (2016) 128 (22): 961.

https://doi.org/10.1182/blood.V128.22.961.961

Published: 2016

Journal Articles

The Nationwide Study of Erdheim-Chester Disease in Japan

Mizuki Ogura, MD, PhD, Takashi Toya, MD, PhD, Akihide Yoshimi, MD, PhD, Aya Shinozaki Ushiku, MD, PhD, Akira Honda, MD, PhD, Toyama Kazuhiro, MD, PhD, Kenjiro Honda, MD, PhD, Yasuhito Nannya, MD, PhD, Yusuke Shinoda, MD, PhD, Akiko M. Saito, MD PhD, Takashi Ogura, MD, Ichiro Katayama, MD, PhD, Kiyoshi Miyagawa, MD, PhD, Masaomi Nangaku, MD, PhD, Masashi Fukayama, MD, PhD, Mineo Kurokawa, MD, PhD

Blood (2016) 128 (22): 4879.

https://doi.org/10.1182/blood.V128.22.4879.4879

Published: 2016

Journal Articles

Identification of Somatic Mutation Contributing to Chemotherapy Resistance in Acute Myeloid Leukemia

Akira Honda, MD, PhD, Junji Koya, MD, PhD, Akihide Yoshimi, MD PhD, Keisuke Kataoka, MD PhD, Shunya Arai, MD, PhD, Mineo Kurokawa, MD, PhD

Blood (2016) 128 (22): 600.

https://doi.org/10.1182/blood.V128.22.600.600

Published: 2016

Journal Articles

H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies

Blood (2016) 128 (22): 966.

https://doi.org/10.1182/blood.V128.22.966.966

Published: 2016

NARROW

Disruption of cotranscriptional splicing suggests that RBM39 is a therapeutic target in acute lymphoblastic leukemia

PRC2-Mediated Apoptosis Evasion Is a Therapeutic Target of MDS/AML Harboring Inv(3)/t(3;3) and -7

Regulation of Alternative Splicing in B-Cell ALL By DYRK1A

Efficient production of human neutrophils from iPSCs that prevent murine lethal infection with immune cell recruitment

Spliceosomal Disruption of the Non-Canonical SWI/SNF Chromatin Remodeling Complex in SF3B1 Mutant Leukemias

Aberrant RNA Splicing Contributes to the Pathogenesis of EVI-Rearranged Myeloid Leukemias

Mutations in the RNA Splicing Factor SF3B1 Promote Transformation through MYC Stabilization

Therapeutic Targeting of an RNA Splicing Factor Network for the Treatment of Myeloid Neoplasms

Human Germline HLTF E259K Mutation Identified in Familial MDS Patients Accumulates DNA Damage through Impaired PCNA Polyubiquitination

Characterization of Ntrk fusions and Therapeutic Response to Ntrk Inhibition in Hematologic Malignancies

Oncogenic Mutations in XPO1 Promote Lymphoid Transformation By Altering Nuclear/Cytoplasmic Localization of NFκB Signaling Intermediates

Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML

Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells

Frequent Clinical Overlap of Histiocytic Neoplasms and WHO-Classified Myeloid Malignancies Leads to Functional Insights into the Cell-of-Origin of Histiocytoses

Patient-Derived Induced Pluripotent Stem Cells Identified SLITRK4 As a Causative Gene of Chronic Myelomonocytic Leukemia

Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity

The Nationwide Study of Erdheim-Chester Disease in Japan

Identification of Somatic Mutation Contributing to Chemotherapy Resistance in Acute Myeloid Leukemia

H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies

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American Society of Hematology

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ASH Publications

American Society of Hematology

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