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Journal Articles

Disruption of cotranscriptional splicing suggests that RBM39 is a therapeutic target in acute lymphoblastic leukemia

Blood blood.2024024281.

https://doi.org/10.1182/blood.2024024281

Published: 2024

Includes: Supplemental data

Journal Articles

Hematopoietic Stem Cells from Mice and Individuals with Sickle Cell Disease Display Premature Senescence and Loss of Function That Is Targetable By Senolytic Therapy

Aditya Barve, Mahmoud Dabbah, Emilia Kooienga, Esther A. Obeng, Jacquelyn Myers, Akshay Sharma, Shannon McKinney-Freeman

Blood (2023) 142 (Supplement 1): 33.

https://doi.org/10.1182/blood-2023-190264

Published: 2023

Journal Articles

SF3B1 K700E Alters the Splicing of Metabolism and Stress Response Genes, Attenuating the Effect of DNMT3A Mutations in MDS

Lashanale Wallace, Jacquelyn A. Myers, Mark Engelken, David Cullins, Heather Sheppard, Esther A. Obeng

Blood (2023) 142 (Supplement 1): 3215.

https://doi.org/10.1182/blood-2023-190288

Published: 2023

Journal Articles

Regulation of Alternative Splicing in B-Cell ALL By DYRK1A

Qi Jin, Ethan Harris, Jacquelyn A. Myers, Anitria Cotton, Jeremy Wen, Johanna Melo-Cardenas, Akihide Yoshimi, Omar Abdel-Wahab, Esther A. Obeng, John D. Crispino

Blood (2023) 142 (Supplement 1): 39.

https://doi.org/10.1182/blood-2023-174923

Published: 2023

Journal Articles

Engineering naturally occurring CD7 − T cells for the immunotherapy of hematological malignancies

Blood (2022) 140 (25): 2684–2696.

https://doi.org/10.1182/blood.2021015020

Published: 2022

Includes: Supplemental data

Journal Articles

A Murine Model Harboring Cooperating DNMT3A and SF3B1 Mutations Phenocopies SF3B1 Driven Myelodysplastic Syndrome

Lashanale Wallace, Ana Leal-Cervantes, Amina Metidji, Jacquelyn Myers, Chandra Rolle, Heather Tillman, Esther A. Obeng

Blood (2022) 140 (Supplement 1): 5862–5863.

https://doi.org/10.1182/blood-2022-170535

Published: 2022

Journal Articles

Mutant SF3B1 splices a more leukemogenic EVI1

Esther A. Obeng

Blood (2022) 140 (8): 800–801.

https://doi.org/10.1182/blood.2022017380

Published: 2022

Journal Articles

CD45RA-Depleted Haploidentical Transplantation Combined with NK Cell Addback Results in Promising Long-Term Outcomes in Pediatric Patients with High-Risk Hematologic Malignancies

Swati Naik, Aimee C Talleur, Ying Li, Renee M. Madden, Ewelina Mamcarz, Amr Qudeimat, Akshay Sharma, Ashok Srinivasan, Ali Y Suliman, Rebecca Epperly, Esther A. Obeng, Mireya Paulina Velasquez, Diego Hijano, Gabriela Maron, Stephen Gottschalk, Brandon M Triplett

Blood (2021) 138 (Supplement 1): 172.

https://doi.org/10.1182/blood-2021-149655

Published: 2021

Journal Articles

CD45RO+ T-Cell Add Back and Prophylactic Blinatumomab Administration Post Tcrαβ/CD19-Depleted Haploidentical Transplantation in Pediatric Patients with High Risk Acute Leukemia

Swati Naik, Renee M. Madden, Ewelina Mamcarz, Ashok Srinivasan, Akshay Sharma, Aimee C Talleur, Rebecca Epperly, Amr Qudeimat, Ali Y Suliman, Esther A. Obeng, Mireya Paulina Velasquez, Diego Hijano, Gabriela Maron, Ying Li, Stephen Gottschalk, Brandon M Triplett

Blood (2021) 138 (Supplement 1): 2897.

https://doi.org/10.1182/blood-2021-149671

Published: 2021

Journal Articles

Selective Targeting of Splicing Factor Mutant Hematopoietic Stem and Progenitor Cells Via STAT3 Inhibition

Kathryn S Potts, Rosannah C. Cameron, Noura Ghazale, Varun Gupta, Juan Martin Barajas, LaShanale Wallace, Ana Leal-Cervantes, Srinivas Aluri, Kith Pradhan, Mia McKinstry, Xiaoying Bai, Gaurav S Choudhary, Aditi Shastri, Amit Verma, Esther A. Obeng, Teresa V. Bowman

Blood (2021) 138 (Supplement 1): 1509.

https://doi.org/10.1182/blood-2021-151338

Published: 2021

Journal Articles

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice

Blood (2018) 132 (13): 1399–1412.

https://doi.org/10.1182/blood-2017-08-802769

Published: 2018

Includes: Supplemental data

Journal Articles

Congenital Thrombocytopenia and Myelofibrosis Due to Germline Mutations in G6b-B— a Megakaryocyte-Specific Immunoreceptor Tyrosine-Based Inhibitory Motif (ITIM) Receptor

Inga Hofmann, MD, Andrew Crispin, BS, Dean Campagna, BS, Monica Calicchio, Klaus Schmitz-Abe, Esther A. Obeng, MD PhD, Kyriacos Markianos, Yotis A. Senis, Mark D. Fleming, MD DPhil

Blood (2017) 130 (Supplement 1): 1630.

https://doi.org/10.1182/blood.V130.Suppl_1.1630.1630

Published: 2017

Journal Articles

Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity

Stanley Chun-Wei Lee, PhD, Khrystyna Dilai, Esther A. Obeng, MDPhD, Eunhee Kim, PhD, Jean-Baptiste Micol, MD PhD, Akihide Yoshimi, MD PhD, Christophe Willekens, MD, Daichi Inoue, Véronique Saada, PharmD, Hana Cho, Young Rock Chung, MS, James Palacino, PhD, Michael Seiler, PhD, Silvia Buonamici, PhD, Peter Smith, Benjamin L. Ebert, MD PhD, Robert Bradley, PhD, Omar Abdel-Wahab, MD

Blood (2016) 128 (22): 961.

https://doi.org/10.1182/blood.V128.22.961.961

Published: 2016

Journal Articles

Expressionof Sf3b1- K700Ein Murine B Cells Causes Pre-mRNA Splicing and Altered B Cell Differentiation and Function

Lili Wang, MD PhD, Rutendo Gambe, BS, Jean Fan, BS, Youzhong Wan, PhD, Angela N Brooks, PhD, Jing Sun, PhD, Esther A. Obeng, MD PhD, Donna S Neuberg, ScD, Matthew Meyerson, MD PhD, Mark D. Fleming, MD DPhil, Benjamin L. Ebert, MD, Ruben D. Carrasco, MD PhD, Catherine J Wu, MD

Blood (2015) 126 (23): 366.

https://doi.org/10.1182/blood.V126.23.366.366

Published: 2015

Journal Articles

Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells

Blood (2015) 126 (23): 1643.

https://doi.org/10.1182/blood.V126.23.1643.1643

Published: 2015

Journal Articles

Cancer-Associated Mutations in SF3B1 Exhibit Neomorphic Splicing Activity and Block Erythroid Differentiation

Blood (2014) 124 (21): 4615.

https://doi.org/10.1182/blood.V124.21.4615.4615

Published: 2014

Journal Articles

Mutant Splicing Factor 3b Subunit 1 (SF3B1) Causes Dysregulated Erythropoiesis and a Stem Cell Disadvantage

Esther A. Obeng, MDPhD, Marie E. McConkey, PhD, Dean Campagna, Rebekka K. Schneider, MD, Michelle C. Chen, Paul J Schmidt, PhD, Ann Mullally, MD, Mark D. Fleming, MD DPhil, Benjamin L. Ebert, MD DPhil

Blood (2014) 124 (21): 828.

https://doi.org/10.1182/blood.V124.21.828.828

Published: 2014

Journal Articles

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

Esther A. Obeng, Louise M. Carlson, Delia M. Gutman, William J. Harrington, Jr, Kelvin P. Lee, Lawrence H. Boise

Blood (2006) 107 (12): 4907–4916.

https://doi.org/10.1182/blood-2005-08-3531

Published: 2006

NARROW

Disruption of cotranscriptional splicing suggests that RBM39 is a therapeutic target in acute lymphoblastic leukemia

Hematopoietic Stem Cells from Mice and Individuals with Sickle Cell Disease Display Premature Senescence and Loss of Function That Is Targetable By Senolytic Therapy

SF3B1 K700E Alters the Splicing of Metabolism and Stress Response Genes, Attenuating the Effect of DNMT3A Mutations in MDS

Regulation of Alternative Splicing in B-Cell ALL By DYRK1A

Engineering naturally occurring CD7 − T cells for the immunotherapy of hematological malignancies

A Murine Model Harboring Cooperating DNMT3A and SF3B1 Mutations Phenocopies SF3B1 Driven Myelodysplastic Syndrome

Mutant SF3B1 splices a more leukemogenic EVI1

CD45RA-Depleted Haploidentical Transplantation Combined with NK Cell Addback Results in Promising Long-Term Outcomes in Pediatric Patients with High-Risk Hematologic Malignancies

CD45RO+ T-Cell Add Back and Prophylactic Blinatumomab Administration Post Tcrαβ/CD19-Depleted Haploidentical Transplantation in Pediatric Patients with High Risk Acute Leukemia

Selective Targeting of Splicing Factor Mutant Hematopoietic Stem and Progenitor Cells Via STAT3 Inhibition

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice

Congenital Thrombocytopenia and Myelofibrosis Due to Germline Mutations in G6b-B— a Megakaryocyte-Specific Immunoreceptor Tyrosine-Based Inhibitory Motif (ITIM) Receptor

Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity

Expressionof Sf3b1- K700Ein Murine B Cells Causes Pre-mRNA Splicing and Altered B Cell Differentiation and Function

Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells

Cancer-Associated Mutations in SF3B1 Exhibit Neomorphic Splicing Activity and Block Erythroid Differentiation

Mutant Splicing Factor 3b Subunit 1 (SF3B1) Causes Dysregulated Erythropoiesis and a Stem Cell Disadvantage

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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