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Claes Wahlestedt
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Journal Articles

Preclinical efficacy of dual BET/HAT inhibitor–based combinations against post myeloproliferative neoplasm secondary AML cells

Free
Warren Fiskus, Christopher Mill, Lucia Masarova, Naveen Pemmaraju, Prithviraj Bose, Arnav Gupta, Hanxi Hou, Taghi Manshouri, Jayastu Senapati, Sanam Loghavi, Andrew Dunbar, Claes Wahlestedt, Courtney DiNardo, Kapil Bhalla
Journal: Blood
Blood (2025) 146 (Supplement 1): 5053.
https://doi.org/10.1182/blood-2025-5053
Published: 2025
Journal Articles

EP31670, a dual-BET + p300 inhibitor, demonstrates pre-clinical efficacy, including in combination with JAK inhibition, in the hMPLW515L adoptive transfer model of myelofibrosis (MF)

Free
Linda Fabris, Warren Fiskus, Kavi O'Connor, Zachary Zaroogian, Shishir Waghray, Gautam Borthakur, Prithviraj Bose, Naveen Pemmaraju, Lucia Masarova, Taghi Manshouri, Kapil Bhalla, Claes Wahlestedt, Ross Levine, Andrew Dunbar
Journal: Blood
Blood (2025) 146 (Supplement 1): 3759.
https://doi.org/10.1182/blood-2025-3759
Published: 2025
Journal Articles

Identifying novel 'druggable’ targets via Npm1A-turboid fusion and mass spectrometry to overcome genetic or adaptive resistance to menin inhibitors in mtNPM1 AML

Free
Christopher Mill, Warren Fiskus, John Davis, Christine Birdwell, Hanxi Hou, Claes Wahlestedt, Jayastu Senapati, Koji Sasaki, Sanam Loghavi, Branko Cuglievan, Tapan Kadia, Naval Daver, Courtney DiNardo, Kapil Bhalla
Journal: Blood
Blood (2025) 146 (Supplement 1): 1500.
https://doi.org/10.1182/blood-2025-1500
Published: 2025
Journal Articles

Targeting Aberrant DLK1 Re-Expression in ASXL1 -Mutant Chronic Myelomonocytic Leukemia with BRD4 / p300-Directed Epigenetic Small Molecule Therapy

Free
Terra L. Lasho, Jenna A. Fernandez, Jeong-Heon Lee, Linh D. Pham, Huihuang Yan, Christy Finke, Abhishek A. Mangaonkar, Aref Al-Kali, Naseema Gangat, Joseph Collard, Claes Wahlestedt, Mrinal M. Patnaik, Moritz Binder
Journal: Blood
Blood (2024) 144 (Supplement 1): 3197.
https://doi.org/10.1182/blood-2024-204070
Published: 2024
Journal Articles

Targeting Oncogenic Enhancers in ASXL1 -Mutant Chronic Myelomonocytic Leukemia

Free
Terra L Lasho, Christy M Finke, Jenna A. Fernandez, Christopher T. Schmitz, Karl J. Clark, Claes Wahlestedt, Judy Chiao, Abhishek A Mangaonkar, Mrinal M. Patnaik, Moritz Binder
Journal: Blood
Blood (2023) 142 (Supplement 1): 1413.
https://doi.org/10.1182/blood-2023-178083
Published: 2023
Journal Articles

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Free
Hui Yang, Stefan Kurtenbach, Ying Guo, Ines Lohse, Michael A. Durante, Jianping Li, Zhaomin Li, Hassan Al-Ali, Lingxiao Li, Zizhen Chen, Matthew G. Field, Peng Zhang, Shi Chen, Shohei Yamamoto, Zhuo Li, Yuan Zhou, Stephen D. Nimer, J. William Harbour, Claes Wahlestedt, Mingjiang Xu, Feng-Chun Yang
Journal: Blood
Blood (2018) 131 (3): 328–341.
https://doi.org/10.1182/blood-2017-06-789669
Published: 2018
Includes: Supplemental data
Journal Articles

Gain-of-Function of ASXL1 Truncating Protein in the Pathogenesis of Myeloid Malignancies

Free
Hui Yang, PhD, Stefan Kurtenbach, PhD, Ying Guo, MD PhD, Ines Lohse, PhD, Michael Durante, PhD candidate, Peng Zhang, PhD, Yuan Zhou, PhD, William Harbour, MDPhD, Claes Wahlestedt, Mingjiang Xu, MDPhD, Feng-Chun Yang, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 564.
https://doi.org/10.1182/blood.V130.Suppl_1.564.564
Published: 2017
Journal Articles

A Patient-Specific Ex Vivo Screening Platform for Personalized Acute Myeloid Leukemia (AML) Therapy

Free
Diana Azzam, PhD, Claude-Henry Volmar, PhD, Al-Ali Hassan, PhD, Aymee Perez, PhD, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Francisco Vega, MD PhD, Arthur Zelent, PhD, Christopher R. Cogle, MD, Claes Wahlestedt, PhD, Ronan T. Swords, MDPhDFRCPI FRCPath
Journal: Blood
Blood (2015) 126 (23): 1352.
https://doi.org/10.1182/blood.V126.23.1352.1352
Published: 2015
Journal Articles

The BET Bromodomain Inhibitors EP11313 and EP11336 Have Potent Anti-Leukemic Activity in Acute Myeloid Leukemia (AML) and Augment the Effects of All-Trans-Retinoic Acid (AtRA) in Vitro

Free
Ronan T. Swords, MDPhDFRCPI FRCPath, Shaun Brothers, PhD, Nagi Ayad, PhD, Aymee Perez, PhD, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Ana Rodriguez, Shawn Johnstone, PhD, Jeffrey Albert, Joseph Collard, Arthur Zelent, PhD, Claes Wahlestedt, PhD
Journal: Blood
Blood (2015) 126 (23): 2552.
https://doi.org/10.1182/blood.V126.23.2552.2552
Published: 2015
Journal Articles

Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression

Free
Olof Gidlöf, Marcel van der Brug, Jenny Öhman, Patrik Gilje, Björn Olde, Claes Wahlestedt, David Erlinge
Journal: Blood
Blood (2013) 121 (19): 3908–3917.
https://doi.org/10.1182/blood-2012-10-461798
Published: 2013
Includes: Supplemental data