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Journal Articles

Motive and opportunity: MYC rearrangements in high-grade B-cell lymphoma with MYC and BCL2 rearrangements (an LLMPP study)

Laura K. Hilton, Brett Collinge, Susana Ben-Neriah, Waleed Alduaij, Haya Shaalan, Andrew P. Weng, Manuela Cruz, Graham W. Slack, Pedro Farinha, Tomoko Miyata-Takata, Merrill Boyle, Barbara Meissner, James R. Cook, Sarah L. Ondrejka, German Ott, Andreas Rosenwald, Elias Campo, Catalina Amador, Timothy C. Greiner, Philipp W. Raess, Joo Y. Song, Giorgio Inghirami, Elaine S. Jaffe, Dennis D. Weisenburger, Wing C. Chan, Klaus Beiske, Kai Fu, Jan Delabie, Stefania Pittaluga, Javeed Iqbal, George Wright, Laurie H. Sehn, Kerry J. Savage, Andrew J. Mungall, Andrew L. Feldman, Louis M. Staudt, Christian Steidl, Lisa M. Rimsza, Ryan D. Morin, David W. Scott
Journal: Blood
Blood (2024) 144 (5): 525–540.
https://doi.org/10.1182/blood.2024024251
Published: 2024
Includes: Supplemental data
Journal Articles

Gene Expression Profiling Reveals Two Overarching Types of Anaplastic Large Cell Lymphoma with Distinct Targetable Biology: An L.L.M.P.P. Study

Andrew L. Feldman, Surendra Dasari, Lisa M. Rimsza, David W. Scott, Naoki Oishi, Catalina Amador, Elias Campo, Wing C. Chan, James R. Cook, Jan Delabie, Pedro Farinha, Kai Fu, Timothy C. Greiner, Giorgio Inghirami, Javeed Iqbal, Elaine S. Jaffe, Sarah L. Ondrejka, German Ott, Stefania Pittaluga, Phil Raess, Andreas Rosenwald, Kerry J. Savage, Graham Slack, Susan L. Slager, Joo Y. Song, Louis M. Staudt, George Wright, Hao-Wei Wang, Yu Zeng, Tadashi Yoshino, Xiaojun Wu, Ryan A. Wilcox, Xueju Wang, Akira Satou, Anamarija M. Perry, Roberto Miranda, L. Jeffrey Medeiros, Matthew J. Maurer, Eric Mou, Young Hyeh Ko, Kennosuke Karube, Brad S. Kahl, Liuyan Jiang, David L Jaye, Laurence de Leval, Weina Chen, Jennifer R. Chapman-Fredricks, James R. Cerhan, Carlos Barrionuevo, Stephen M Ansell, Ahmed Aljudi
Journal: Blood
Blood (2023) 142 (Supplement 1): 847.
https://doi.org/10.1182/blood-2023-186969
Published: 2023
Journal Articles

Exceptional Response to BTK Inhibitors in Aggressive Lymphomas Linked to Chronic Selective Autophagy

James D Phelan, Sebastian Scheich, Jaewoo Choi, George Wright, Björn Häupl, Ryan M. Young, Sara Rieke, Martine Pape, Yanlong Ji, Henning Urlaub, Carmen Doebele, Alena Zindel, Tanja Wotapek, Monica Kasbekar, Da Wei Huang, Zana Coulibaly, Vivian M Morris, Xin Yu, Weihong Xu, Yandan Yang, Hong Zhao, Christopher J. Shoemaker, Zhuo Wang, Arthur Shaffer, Louis M. Staudt, Thomas Oellerich
Journal: Blood
Blood (2023) 142 (Supplement 1): 850.
https://doi.org/10.1182/blood-2023-190851
Published: 2023
Journal Articles

Molecular Determinants of Sensitivity to Polatuzumab-Vedotin in Diffuse Large B-Cell Lymphoma

Sean R Corcoran, Jaewoo Choi, Rachel E Fenner, Xin Yu, Sebastian Scheich, Tony Hsiao, Galina Schevchenko, Vivian M Morris, James D Phelan, Evangelia K Papachristou, Kamal Kishore, Clive S D'Santos, Yanlong Ji, Stefania Pittaluga, George Wright, Henning Urlaub, Kuan-Ting Pan, Thomas Oellerich, Jagan R. Muppidi, Daniel James Hodson, Louis M. Staudt
Journal: Blood
Blood (2023) 142 (Supplement 1): 2819.
https://doi.org/10.1182/blood-2023-178059
Published: 2023
Journal Articles

Molecular Mechanism of Action of Glucocorticoids in Lymphoma Therapy

Jaewoo Choi, Michele Ceribelli, James D Phelan, Björn Häupl, Da Wei Huang, George Wright, Tony Hsiao, Vivian M Morris, Francesco Ciccarese, Boya Wang, Sean R Corcoran, Sebastian Scheich, Xin Yu, Weihong Xu, Yandan Yang, Joyce Zhou, Grace Zhang, Jagan R. Muppidi, Giorgio Inghirami, Thomas Oellerich, Craig J. Thomas, Louis M. Staudt
Journal: Blood
Blood (2023) 142 (Supplement 1): 2986.
https://doi.org/10.1182/blood-2023-174325
Published: 2023
Journal Articles

Phase Ib/II Study of Multi-Targeted Therapy with Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Lenalidomide (ViPOR) in Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL)

Christopher Melani, Rahul Lakhotia, Stefania Pittaluga, James D Phelan, Da Wei Huang, George Wright, Jillian Simard, Jagan R. Muppidi, Craig J. Thomas, Michele Ceribelli, Frances A Tosto, Yandan Yang, Weihong Xu, Theresa Davies-Hill, Svetlana Pack, Cody J Peer, Oluwatobi Arisa, Esther Mena, Maria L. Lindenberg, Ethan Bergvall, Craig A. Portell, Rafic J Farah, Seung Tae Lee, Amynah Pradhan, Candis Morrison, Atekelt Tadese, Anna M Juanitez, Crystal Lu, Allison P. Jacob, Heidi Simmons, William D Figg, Seth M. Steinberg, Elaine S Jaffe, Mark Roschewski, Louis M. Staudt, Wyndham H Wilson
Journal: Blood
Blood (2023) 142 (Supplement 1): 434.
https://doi.org/10.1182/blood-2023-180173
Published: 2023
Journal Articles

Preliminary Analysis of an Ongoing Phase II Study of Response-Adapted Therapy with Copanlisib and Rituximab for Untreated Follicular Lymphoma

Rahul Lakhotia, Christopher Melani, Jagan R. Muppidi, Stefania Pittaluga, James D Phelan, Colleen Ramsower, Lisa M. Rimsza, Ryan S Robertorye, George Wright, Mark Meerson, Ekaterina Postovalova, Alexander Bagaev, Nathan Fowler, Liza Lindenberg, Esther Mena, Ethan Bergvall, Amynah Pradhan, Atekelt Tadese, Candis Morrison, Sarah Evans, Sumaya Berg, Seth M. Steinberg, William Figg, Elaine S. Jaffe, Louis M. Staudt, Wyndham H. Wilson, Mark Roschewski
Journal: Blood
Blood (2023) 142 (Supplement 1): 1676.
https://doi.org/10.1182/blood-2023-185038
Published: 2023
Journal Articles

Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens

Brief Report
Anja Mottok, George Wright, Andreas Rosenwald, German Ott, Colleen Ramsower, Elias Campo, Rita M. Braziel, Jan Delabie, Dennis D. Weisenburger, Joo Y. Song, Wing C. Chan, James R. Cook, Kai Fu, Tim Greiner, Erlend Smeland, Harald Holte, Kerry J. Savage, Betty J. Glinsmann-Gibson, Randy D. Gascoyne, Louis M. Staudt, Elaine S. Jaffe, Joseph M. Connors, David W. Scott, Christian Steidl, Lisa M. Rimsza
Journal: Blood
Blood (2018) 132 (22): 2401–2405.
https://doi.org/10.1182/blood-2018-05-851154
Published: 2018
Includes: Supplemental data
Journal Articles

Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T-Cell Leukemia/Lymphoma

Masao Nakagawa, MD, Arthur L Shaffer, Michele Ceribelli, Meili Zhang, PhD, George Wright, Da Wei Huang, Wenming Xiao, John Powell, Michael N Petrus, Yibin Yang, James D Phelan, Holger Kohlhammer, Hee Min Yoo, Yandan Yang, Weihong Xu, Xin Yu, Hong Zhao, Bonita R Bryant, Michiyuki Maeda, Thomas A Waldmann, MD, Lou Staudt, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 731.
https://doi.org/10.1182/blood.V130.Suppl_1.731.731
Published: 2017
Journal Articles

Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma

Javeed Iqbal, Yulei Shen, Xin Huang, Yanyan Liu, Laura Wake, Cuiling Liu, Karen Deffenbacher, Cynthia M. Lachel, Chao Wang, Joseph Rohr, Shuangping Guo, Lynette M. Smith, George Wright, Sharathkumar Bhagavathi, Karen Dybkaer, Kai Fu, Timothy C. Greiner, Julie M. Vose, Elaine Jaffe, Lisa Rimsza, Andreas Rosenwald, German Ott, Jan Delabie, Elias Campo, Rita M. Braziel, James R. Cook, Raymond R. Tubbs, James O. Armitage, Dennis D. Weisenburger, Louis M. Staudt, Randy D. Gascoyne, Timothy W. McKeithan, Wing C. Chan
Journal: Blood
Blood (2015) 125 (7): 1137–1145.
https://doi.org/10.1182/blood-2014-04-566778
Published: 2015
Includes: Supplemental data
Journal Articles

Cell-of-Origin Subtype Classification of Diffuse Large B-Cell Lymphoma Using the Lymph2Cx Assay Retains Relevance in the Context of BCL2 and MYC Expression Status

Samantha L. Kendrick, PhD, Katalin Tus, MD, David W. Scott, MBChB, PhD, George Wright, PhD, Elaine S. Jaffe, MD, Andreas Rosenwald, MD, Elías Campo, MD PhD, Wing Chung Chan, MD, Joseph M. Connors, MD, Rita M. Braziel, MD, German Ott, MD, Jan Delabie, MD PhD, James R. Cook, MD PhD, Dennis D. Weisenburger, MD, Timothy C. Greiner, MS, MD, Kai Fu, MD PhD, Louis M. Staudt, MD PhD, Randy D. Gascoyne, MD, Lisa M. Rimsza, MD
Journal: Blood
Blood (2014) 124 (21): 1667.
https://doi.org/10.1182/blood.V124.21.1667.1667
Published: 2014
Journal Articles

Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma

Javeed Iqbal, George Wright, Chao Wang, Andreas Rosenwald, Randy D. Gascoyne, Dennis D. Weisenburger, Timothy C. Greiner, Lynette Smith, Shuangping Guo, Ryan A. Wilcox, Bin Tean Teh, Soon Thye Lim, Soon Yong Tan, Lisa M. Rimsza, Elaine S. Jaffe, Elias Campo, Antonio Martinez, Jan Delabie, Rita M. Braziel, James R. Cook, Raymond R. Tubbs, German Ott, Eva Geissinger, Philippe Gaulard, Pier Paolo Piccaluga, Stefano A. Pileri, Wing Y. Au, Shigeo Nakamura, Masao Seto, Francoise Berger, Laurence de Leval, Joseph M. Connors, James Armitage, Julie Vose, Wing C. Chan, Louis M. Staudt
Journal: Blood
Blood (2014) 123 (19): 2915–2923.
https://doi.org/10.1182/blood-2013-11-536359
Published: 2014
Includes: Supplemental data
Journal Articles

EZH2 mutations are frequent and represent an early event in follicular lymphoma

Brief Report
Csaba Bödör, Vera Grossmann, Nikolay Popov, Jessica Okosun, Ciarán O’Riain, King Tan, Jacek Marzec, Shamzah Araf, Jun Wang, Abigail M. Lee, Andrew Clear, Silvia Montoto, Janet Matthews, Sameena Iqbal, Hajnalka Rajnai, Andreas Rosenwald, German Ott, Elias Campo, Lisa M. Rimsza, Erlend B. Smeland, Wing C. Chan, Rita M. Braziel, Louis M. Staudt, George Wright, T. Andrew Lister, Olivier Elemento, Robert Hills, John G. Gribben, Claude Chelala, András Matolcsy, Alexander Kohlmann, Torsten Haferlach, Randy D. Gascoyne, Jude Fitzgibbon
Journal: Blood
Blood (2013) 122 (18): 3165–3168.
https://doi.org/10.1182/blood-2013-04-496893
Published: 2013
Includes: Supplemental data
Journal Articles

The Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib (PCI-32765), Has Preferential Activity in the ABC Subtype of Relapsed/Refractory De Novo Diffuse Large B-Cell Lymphoma (DLBCL): Interim Results of a Multicenter, Open-Label, Phase 2 Study

Wyndham H. Wilson, MD, PhD, John F. Gerecitano, MD, PhD, Andre Goy, MD, Sven de Vos, MD, PhD, Vaishalee P. Kenkre, MD, Paul M. Barr, MD, Kristie A. Blum, MD, Andrei R. Shustov, MD, Ranjana H. Advani, MD, Jason Lih, PhD, Mickey Williams, PhD, Roland Schmitz, PhD, Yandan Yang, PhD, Stefania Pittaluga, MD, PhD, George Wright, PhD, Lori A. Kunkel, MD, Jesse McGreivy, MD, Sriram Balasubramanian, PhD, Mei Cheng, PhD, Davina Moussa, Joseph J. Buggy, PhD, Louis M. Staudt, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 686.
https://doi.org/10.1182/blood.V120.21.686.686
Published: 2012
Journal Articles

High Incidence of EZH2 Mutations with Variable Mutation Load in Follicular Lymphoma and Its Consequences for EZH2 Targeted Therapy

Csaba Böodöor, PhD, Grossmann Vera, Alexander Kohlmann, PhD, King Tan, MBBS, Jessica Okosun, MD, Nikolay Popov, PhD, Shamzah Araf, MD, Jacek Marzec, Ciaran O‘Riain, MD, PhD, Abigail Lee, MD, PhD, Andrew James Clear, BSc, Silvia Montoto, MD, Janet Matthews, Sameena Iqbal, Hajnalka Rajnai, MD, Andreas Rosenwald, MD, German Ott, MD, Elias Campo, MD, PhD, Erlend B. Smeland, MD, Wing C. Chan, MD, Rita M. Braziel, MD, Louis M. Staudt, MD, PhD, George Wright, PhD, Lisa M. Rimsza, MD, T. Andrew Lister, MD, Olivier Elemento, PhD, John G Gribben, Andras Matolcsy, MD, PhD, Torsten Haferlach, MD, Randy D. Gascoyne, MD, Jude Fitzgibbon, PhD
Journal: Blood
Blood (2012) 120 (21): 545.
https://doi.org/10.1182/blood.V120.21.545.545
Published: 2012
Journal Articles

A Constitutivly Active NFkB Non Canonical Pathway Is Maintained by RelB Repression of TRAF2 to Prevent Autophagy-Mediated Cell Death in Hodgkin Lymphomas

Stella M. Ranuncolo, MD., PhD, Wenming Xiao, PhD, George Wright, PhD, Mones S Abu-Asab, PhD, Stefania Pittaluga, MD, PhD, Elaine S. Jaffe, MD, Brian A Lewis, PhD
Journal: Blood
Blood (2011) 118 (21): 428.
https://doi.org/10.1182/blood.V118.21.428.428
Published: 2011
Journal Articles

Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling

Elena M. Hartmann, Elias Campo, George Wright, Georg Lenz, Itziar Salaverria, Pedro Jares, Wenming Xiao, Rita M. Braziel, Lisa M. Rimsza, Wing-Chung Chan, Dennis D. Weisenburger, Jan Delabie, Elaine S. Jaffe, Randy D. Gascoyne, Sandeep S. Dave, Hans-Konrad Mueller-Hermelink, Louis M. Staudt, German Ott, Sílvia Beà, Andreas Rosenwald
Journal: Blood
Blood (2010) 116 (6): 953–961.
https://doi.org/10.1182/blood-2010-01-263806
Published: 2010
Includes: Supplemental data
Journal Articles

OCT2 (Octamer Binding Protein 2): An Essential Role in Germinal Center B Cell Differentiation and the “Achilles Heel” of Derived Lymphomas.

Stella M Ranuncolo, MD., PhD, Vu Ngo, PhD, Georg Lenz, MD, Wenming Xiao, PhD, George Wright, Ph.D., Louis M. Staudt, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 362.
https://doi.org/10.1182/blood.V114.22.362.362
Published: 2009
Journal Articles

Accurate Classification of Diffuse Large B Cell Lymphoma Into Germinal Center and Activated B Cell Subtypes Using a Nuclease Protection Assay On Formalin Fixed Paraffin Embedded Tissue: A Study From the Lymphoma and Leukemia Molecular Profiling Project.

Lisa M. Rimsza, MD, George Wright, Ph.D., Mark Schwartz, PhD, Wing C. Chan, Elaine S Jaffe, MD, Randy D. Gascoyne, MD, Elias Campo, MD, PhD, Andreas Rosenwald, MD, German Ott, MD, James R. Cook, MD, PhD, Raymond R. Tubbs, DO, Rita M. Braziel, MD, Jan Delabie, MD, Thomas P. Miller, MD, Richard I Fisher, MD, Louis M. Staudt, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 620.
https://doi.org/10.1182/blood.V114.22.620.620
Published: 2009
Journal Articles

High Microvascular Density Correlates with Poor Outcome in Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Treated with Rituximab Plus Chemotherapy (R-CT).

Teresa M Cardesa-Salzmann, Luis Colomo, Fina Climent, Eva Gonzalez-Barca, Armando López-Guillermo, Gonzalo Gutierrez, Santiago Mercadal, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Rita M. Braziel, James R. Cook, Raymond R. Tubbs, Andreas Rosenwald, German Ott, José Luís Mate, Josep-Maria Ribera, Leonor Arenillas, Sergi Serrano, Neus Combalía, Jan Delabie, Georg Lenz, George Wright, Elaine S Jaffe, Louis M. Staudt, Wing C. Chan, Dennis Weissenburger, Elias Campo
Journal: Blood
Blood (2009) 114 (22): 1948.
https://doi.org/10.1182/blood.V114.22.1948.1948
Published: 2009