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Jean C.Y. Wang, MD PhD
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Journal Articles

Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3

Qiang Liu, PhD BSc, Olga I. Gan, PhD, Gabriela Krivdova, BSc, Aaron Trotman-Grant, Stephanie M. Dobson, PhD, Karin G. Hermans, Mark D. Minden, Shai Izraeli, MD, John E. Dick, PhD FRS, Jean C.Y. Wang, MD PhD, Eric R. Lechman,, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-141733
Published: 2020
Journal Articles

Variation in Stem Cell Driven Hierarchies Underlies Clinical Outcome and Drug Response in AML

Andy G.X. Zeng, BSc, Amanda Mitchell, PhD, Oleksandr Galkin, PhD, Jean C.Y. Wang, MD PhD, James A. Kennedy, MDPhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
https://doi.org/10.1182/blood-2020-140895
Published: 2020
Journal Articles

A Stemness-Based Screen Identifies PLK1 Inhibitors for Targeting Leukemia Stem Cells in AML

Qiang Liu, PhD BSc, Amit Subedi, PhD, Samantha Yao, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Steven M Chan, MD PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-141740
Published: 2020
Journal Articles

Identification of Gene Regulatory Networks Governing Stemness Properties of Human HSC and LSC

Stanley W.K. Ng, Stephanie Zhi-Juan Xie, PhD, Elvin Wagenblast, PhD, Naoya Takayama, MD PhD, Liqing Jin, MD, Nathan Mbong, Alex Murison, Schoof E Erwin, Amanda Mitchell, PhD, Peter Van Galen, PhD, Mathieu Lupien, PhD, Mark D. Minden, MD PhD, Jean C.Y. Wang, MD PhD, Peter W. Zandstra, PhD, John E. Dick
Journal: Blood
Blood (2018) 132 (Supplement 1): 3832.
https://doi.org/10.1182/blood-2018-99-114314
Published: 2018
Journal Articles

Identification of Compounds That Target Acute Myeloid Leukemia Stem Cells Using a Scalable Next-Generation Screening Platform

Qiang Liu, PhD BSc, Amit Subedi, PhD, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Steven M Chan, MD PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 259.
https://doi.org/10.1182/blood-2018-99-115323
Published: 2018
Journal Articles

A Novel Predictor of Response to Gemtuzumab Ozogamicin Therapy in AML Provides Strategies for Sensitization of Leukemia Stem Cells in Individual Patients

Stanley W.K. Ng, Schoof E Erwin, Amanda Mitchell, PhD, Mark D. Minden, MD PhD, Lars Bullinger, MD, Hartmut Döhner, MD, Hervé Dombret, Claude Preudhomme, Meyling Cheok, BSPharm, PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2765.
https://doi.org/10.1182/blood-2018-99-114275
Published: 2018
Journal Articles

Isolation of CD34 − and CD34 + Leukemia Stem Cells from Acute Myeloid Leukemia Blasts Using CD200

Jenny M. Ho, MD, Stephanie M. Dobson, PhD, Jessica McLeod, BSc, Veronique Voisin, PhD, Alex Murison, James Kennedy, MD PhD, Sasan Zandi, MD PhD, Kolja Eppert, MSc, PhD, Mark D. Minden, MD PhD, Mathieu Lupien, John E. Dick, PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2790.
https://doi.org/10.1182/blood-2018-99-119318
Published: 2018
Journal Articles

Sphingosine-1-Phosphate Receptor 3 (S1PR3) Promotes Myeloid Commitment of Human Hematopoietic and Leukemic Stem Cells

Stephanie Zhi-Juan Xie, PhD, Kerstin Kaufmann, PhD, Olga I. Gan, PhD, Elisa Laurenti, PhD, Stanley W.K. Ng, Qiang Liu, Melissa Kleinau, Joseph Jargostf, Gareth Holmes, Chiara Luberto, PhD, Lina M Obeid, MD, Yusuf A. Hannun, MD, Jean C.Y. Wang, MD PhD, Mark D. Minden, MD PhD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1329.
https://doi.org/10.1182/blood-2018-99-119128
Published: 2018
Journal Articles

CD200 Is a Marker of LSC Activity in Acute Myeloid Leukemia

Jenny M. Ho, MD, Stephanie M. Dobson, Jessica McLeod, Liqing Jin, MD PhD, Stanley W.K. Ng, MSc, Amanda Mitchell, PhD, Liran I. Shlush, MD PhD, Sasan Zandi, MD PhD, Kolja Eppert, PhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1705.
https://doi.org/10.1182/blood.V128.22.1705.1705
Published: 2016
Journal Articles

Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells

Julia Etchin, PhD, Bonnie Thi Le, M.S., Alex Kentsis, MD, PhD, Richard M. Stone, MD, Dilara McCauley, PhD, Michael Kauffman, MD, PhD, Sharon Shacham, PhD, MBA, Jean C.Y. Wang, MD PhD, Andrew L Kung, MD, PhD, A. Thomas Look, MD
Journal: Blood
Blood (2013) 122 (21): 3932.
https://doi.org/10.1182/blood.V122.21.3932.3932
Published: 2013
Journal Articles

Blockade Of CD47 Using SIRPαFc: Role Of The Fc Region In Anti-Leukemic Activity and Tolerability

Robert A. Uger, PhD, Xinli Pang, MD, PhD, Mark Wong, PhD, Violetta House, Karen Dodge, Stephane Viau, Noel T. Vigo, Debbie Tam, Tran Truong, Liqing Jin, MD, Andrei V. Malko, Jenny Ho, MD, Tatiana K. Prasolava, PhD, Jayne S. Danska, PhD, Jean C.Y. Wang, MD PhD, Penka S. Petrova, PhD
Journal: Blood
Blood (2013) 122 (21): 3935.
https://doi.org/10.1182/blood.V122.21.3935.3935
Published: 2013
Journal Articles

Mir-126 Governs Human Leukemia Stem Cell Quiescence and Chemotherapy Resistance

Eric R. Lechman, PhD, Bernhard Gentner, MD, Peter van Galen, Stanley Wai-Kwong Ng, Kolja Eppert, PhD, Rene Marke, Liran Slush, MD, James A. Kennedy, MD PhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Veronique Voisin, PhD, Gary Bader, PhD, Mark D. Minden, MD, PhD, Jun Lu, PhD, Jean C.Y. Wang, MD PhD, Luigi Naldini, John E. Dick, PhD
Journal: Blood
Blood (2013) 122 (21): 1647.
https://doi.org/10.1182/blood.V122.21.1647.1647
Published: 2013
Journal Articles

Functional and Phenotypic Characterization Of Acute Myeloid Leukemia By Analysis Of Diagnostic/Relapse Paired Samples

Jenny M. Ho, MD, Liran I. Shlush, MD, PhD, Amanda Mitchell, PhD, Rene Marke, Jessica McLeod, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2595.
https://doi.org/10.1182/blood.V122.21.2595.2595
Published: 2013
Journal Articles

Leukemic Engraftment In NOD. SCID Mice Is Correlated With Clinical Parameters and Predicts Outcome In Human AML

James A. Kennedy, MD PhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Jessica McLeod, Andreea C. Popescu, BSc, Andrea Arruda, MSc, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2013) 122 (21): 50.
https://doi.org/10.1182/blood.V122.21.50.50
Published: 2013
Journal Articles

DNMT3a Mutations Define a Pre-Leukemic Stem Cell Reservoir In Human Acute Myeloid Leukemia

Liran I. Shlush, MD, PhD, Sasan Zandi, PhD, MD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, McLeod Jessica, Monica Doedens, Medeiros Jessie, Marke Rene, McPherson J John, PhD, Thomas J Hudson, MD, Brown Andrew, PhD, Trinh M Quang, Lincoln D Stein, James A. Kennedy, MD PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD PhD, John E Dick, PhD
Journal: Blood
Blood (2013) 122 (21): 487.
https://doi.org/10.1182/blood.V122.21.487.487
Published: 2013
Journal Articles

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

Marko Skrtic, BSc, Shrivani Sriskanthadevan, PhD, Bozhena Livak, BSc, Marinella Gebbia, PhD, Xiaoming Wang, Zezhou Wang, PhD, Rose Hurren, BSc, Yulia Jitkova, PhD, Marcela Gronda, MSc, Neil Maclean, BSc, Courteney Lai, BSc, Yanina Eberhard, BSc, PhD, Justyna Bartoszko, BSc, Paul A. Spagnuolo, PhD, Angela Rutledge, PhD, Alessandro Datti, PhD, Troy Ketela, Jason Moffat, Brian H Robinson, PhD, Jessie M Cameron, PhD, Jeff L. Wrana, PhD, Connie J. Eaves, PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, R. Keith Humphries, MD, PhD, Corey Nislow, PhD, Guri Giaever, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 233.
https://doi.org/10.1182/blood.V118.21.233.233
Published: 2011
Journal Articles

Efficacy of SAR302503, a JAK2 Inhibitor, in the Treatment of a Primary Xenograft Model of Human Acute Myeloid Leukemia,

Weihsu Claire Chen, PhD, Andreea C. Popescu, Yan Xing, PhD, Gitte Gerhard, Julie S. Yuan, PhD, Mark D. Minden, MD, PhD, Cynthia Guidos, PhD, Donna E. Hogge, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD
Journal: Blood
Blood (2011) 118 (21): 3624.
https://doi.org/10.1182/blood.V118.21.3624.3624
Published: 2011
Journal Articles

Histone H3 Methylation Mediates All- Trans -Retinoic Acid Responsiveness in Acute Myeloid Leukemia

Tino Schenk, PhD, Stefanie Göllner, PhD, Weihsu Claire Chen, PhD, Louise Howell, BSc, Liqing Jin, MD, Katja Hebestreit, Hans-Ulrich Klein, PhD, Alan K Burnett, MD, Ken I. Mills, PhD, FRCPath, Laurence Marton, MD, Robert Casero, Jr., PhD, Patrick Woster, PhD, Martin Dugas, MD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, Carsten Müller-Tidow, MD, Kevin Petrie, PhD, Arthur Zelent, PhD
Journal: Blood
Blood (2011) 118 (21): 224.
https://doi.org/10.1182/blood.V118.21.224.224
Published: 2011
Journal Articles

Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production

Mahadeo A. Sukhai, PhD, Rose Hurren, BSc, Angela Rutledge, PhD, Bozena Livak, Xiaoming Wang, Ayesh Seneviratne, Maria Christine Cusimano, Marinella Gebbia, PhD, Marko Skrtic, Hong Sun, Marcela Gronda, MSc, Paul A. Spagnuolo, PhD, Malene Urbanus, PhD, Kolja Eppert, PhD, Dilan Dissanayake, Xiaoming Li, PhD, Thomas Sun, Frederick Vizeacoumar, Alessandro Datti, PhD, Pamela Ohashi, PhD, FRSC, Jeff L. Wrana, PhD, Ian M. Rogers, PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, Seth J. Corey, MD, Corey Nislow, PhD, Guri Giaever, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 61.
https://doi.org/10.1182/blood.V118.21.61.61
Published: 2011
Journal Articles

Acute Myeloid Leukemia Stem Cells Escape Innate Immune Surveillance by Macrophages through Interaction with SIRPα

Alexandre P.A. Theocharides, MD, Liqing Jin, MD, Po-Yan Cheng, Armando G. Poeppl, Tatiana K. Prasolava, PhD, Mark D. Minden, MD, PhD, John E. Dick, PhD, Jayne S. Danska, PhD, Jean C.Y. Wang, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 499.
https://doi.org/10.1182/blood.V116.21.499.499
Published: 2010