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Journal Articles

RNA Sequencing in Childhood B-Lymphoblastic Leukemia Improves Molecular and Risk Assignment

Allen Eng Juh Yeoh, MD, Zhenhua Li, PhD, Shawn Lee, MD, Winnie Hui Ni Chin, Nan Jiang, PhD, Yi Lu, PhD, Shirley Kow Yin Kham, BSc, Ah Moy Tan, MD, Hai_peng Lin, Thuan Chong Quah, Hany Ariffin, Jun J. Yang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 651.
https://doi.org/10.1182/blood-2019-131653
Published: 2019
Journal Articles

RNA-Seq Can Help Identify IGH Disease Clones for MRD Monitoring in Childhood B-Lymphoblastic Leukemia

Zhenhua Li, PhD, Nan Jiang, PhD, Evelyn Huizi Lim, Winnie Hui Ni Chin, Shirley Kow Yin Kham, BSc, Wentao Yang, Thuan Chong Quah, Hai_peng Lin, Ah Moy Tan, MD, Hany Ariffin, Jun J. Yang, PhD, Allen Eng Juh Yeoh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1471.
https://doi.org/10.1182/blood-2019-131548
Published: 2019
Journal Articles

Intensifying Treatment in Childhood B-Lymphoblastic Leukemia with IKZF1 Deletions Negates Its Adverse Outcome: Results of Ma-Spore ALL 2003 and 2010 Studies

Yi Lu, PhD, Winnie Hui Ni Chin, Evelyn Huizi Lim, Shirley Kow Yin Kham, BSc, Ah Moy Tan, MD, Hany Ariffin, MD PhD, Allen Eng Juh Yeoh, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 478.
https://doi.org/10.1182/blood.V130.Suppl_1.478.478
Published: 2017
Journal Articles

Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations

Shaoyan Hu, Maoxiang Qian, Hui Zhang, Yu Guo, Jin Yang, Xujie Zhao, Hailong He, Jun Lu, Jian Pan, Meimei Chang, Guoqing Du, Ting-Nien Lin, Shirley Kow-Yin Kham, Thuan Chong Quah, Hany Ariffin, Ah-Moy Tan, Yong Cheng, Chunliang Li, Allen Eng-Juh Yeoh, Ching-Hon Pui, Anders Jacobsen Skanderup, Jun J. Yang
Journal: Blood
Blood (2017) 129 (24): 3264–3268.
https://doi.org/10.1182/blood-2017-03-771162
Published: 2017
Includes: Supplemental data
Journal Articles

Whole Transcriptome Sequencing Identified a Distinct Subtype of Acute Lymphoblastic Leukemia with Abnormalities of CREBBP and EP300

Hui Zhang, MD, PhD, Maoxiang Qian, PhD, Shirley, Kow Yin Kham, MD, PhD, Shuguang Liu, PhD, Chuang Jiang, BS, Xujie Zhao, MS, Yi Lu, PhD, Ting-Nien Lin, Pharma D, Ranran Zhang, MD, Takaya Moriyama, MD PhD, Zhaohong Yin, MD, PhD, Lei Shi, PhD, Zhenhua Li, MD, Kean-Hui Chiew, MD, Zhiwei Chen, MD, Bhojwani Deepa, MD, Shuhong Shen, MD, PhD, Huyong Zheng, MD PhD, Ching-Hon Pui, MD, Allen Eng Juh Yeoh, MD, Jun J. Yang, PhD
Journal: Blood
Blood (2016) 128 (22): 3912.
https://doi.org/10.1182/blood.V128.22.3912.3912
Published: 2016
Journal Articles

Profiling of somatic mutations in acute myeloid leukemia with FLT3 -ITD at diagnosis and relapse

Clinical Trials & Observations
Manoj Garg, Yasunobu Nagata, Deepika Kanojia, Anand Mayakonda, Kenichi Yoshida, Sreya Haridas Keloth, Zhi Jiang Zang, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Ling-Wen Ding, Tamara Alpermann, Qiao-Yang Sun, De-Chen Lin, Wenwen Chien, Vikas Madan, Li-Zhen Liu, Kar-Tong Tan, Abhishek Sampath, Subhashree Venkatesan, Koiti Inokuchi, Satoshi Wakita, Hiroki Yamaguchi, Wee Joo Chng, Shirley-Kow Yin Kham, Allen Eng-Juh Yeoh, Masashi Sanada, Joanna Schiller, Karl-Anton Kreuzer, Steven M. Kornblau, Hagop M. Kantarjian, Torsten Haferlach, Michael Lill, Ming-Chung Kuo, Lee-Yung Shih, Igor-Wolfgang Blau, Olga Blau, Henry Yang, Seishi Ogawa, H. Phillip Koeffler
Journal: Blood
Blood (2015) 126 (22): 2491–2501.
https://doi.org/10.1182/blood-2015-05-646240
Published: 2015
Includes: Supplemental data
Journal Articles

Effective Response Metric (ERM-D8) Using Time-Series Gene Expression Profiling at Diagnosis and Day 8 of Remission-Induction Therapy Is a Novel Early Prognostic Marker to Predict Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) — a Malaysia-Singapore ALL Study

Allen Eng Juh Yeoh, MD, Zhenhua Li, PhD, Difeng Dong, PhD, Yi Lu, PhD, Jan Trka, MD, PhD, Prof., Shirley Kow Yin Kham, B.Sc., Ah Moy Tan, MD, Hany Ariffin, MD, Limsoon Wong, PhD
Journal: Blood
Blood (2014) 124 (21): 2393.
https://doi.org/10.1182/blood.V124.21.2393.2393
Published: 2014
Journal Articles

Genomic Profiling of Pharmacogenetic Variants Establishes a SNP-Based Predictor for Poor Outcome in Asian Children with Acute Lymphoblastic Leukemia (ALL): A Report from Malaysia-Singapore ALL Study Group

Yi Lu, PhD, Marc Hai Liang Wong, M.B.,B.S., Zhenhua Li, PhD, Shirley Kow Yin Kham, B.Sc., Ah Moy Tan, MD, Hany Ariffin, MD, Allen Eng Juh Yeoh, MD
Journal: Blood
Blood (2014) 124 (21): 1069.
https://doi.org/10.1182/blood.V124.21.1069.1069
Published: 2014
Journal Articles

Comprehensive Profiling of Somatic Mutations Which Define Primary Disease and Relapse in Various Acute Leukemia Subtypes

Vikas Madan, PhD, Wen-Wen Chien, PhD, Ding Ling Wen, PhD, Manoj Garg, PhD, Norimichi Hattori, Sun Qiaoyang, PhD, Henry Yang, PhD, Yasunobu Nagata, MD, Kenichi Yoshida, MD, Masashi Sanada, MD, Yusuke Okuno, MD, PhD, Tamara Alpermann, Ezhilarasi Chendamarai, Saravanan Ganesan, MSc, Daniel Nowak, MD, Tsuyoshi Nakamaki, MD, Norihiko Kawamata, Takayuki Ikezoe, Shirley, Kow Yin Kham, Jairo Matthews, Liu Lizhen, Meng Xuan, Lim Su Lin, Olga Blau, MD, PhD, Steven M. Kornblau, MD, PhD, Michael Andreeff, MD, PhD, Shigeru Tomoyasu, MD, Wolf-Karsten Hofmann, Allen Yeoh, Seishi Ogawa, MD, PhD, Vikram Mathews, Torsten Haferlach, MD, Lee-Yung Shih, MD, Phillip Koeffler, MD
Journal: Blood
Blood (2012) 120 (21): 783.
https://doi.org/10.1182/blood.V120.21.783.783
Published: 2012
Journal Articles

Host Pharmacogenetic Factors Significantly Contribute to Refinement of Prognosis in Children with Acute Lymphoblastic Leukemia (ALL): Result From the Malaysia-Singapore (Ma-Spore) ALL 2003 Study

Yi Lu, Ph.D., Shirley Kow Yin Kham, B.Sc., Arrifin Hany, M.D., Ah Moy Tan, M.D., Thuan Chong Quah, M.D., Allen Eng Juh Yeoh, M.D.
Journal: Blood
Blood (2011) 118 (21): 567.
https://doi.org/10.1182/blood.V118.21.567.567
Published: 2011
Journal Articles

BH3-Mimetics, ABT-737 and Obatoclax, Work Synergistically to Induce Cell Death In Leukemic Cell Lines

Grace Shimin Koh, Nan Jiang, Di Feng Dong, Joshua Yew Suang Lim, Shirley Kow Yin Kham, Fook Tim Chew, Lim Soon Wong, Allen Yeoh
Journal: Blood
Blood (2010) 116 (21): 1850.
https://doi.org/10.1182/blood.V116.21.1850.1850
Published: 2010
Journal Articles

Integrated Molecular and Pharmacogenetic Profiles in Prediction of Early Response to Therapy in Children with Acute Lymphoblastic Leukemia (ALL): A Report From Malaysia-Singapore ALL Study Group.

Yi Lu, Ph.D., Shirley Kow Yin Kham, B.Sc., Hany Ariffin, M.D., Ah Moy Tan, M.D., Hai Peng Lin, M.D., Thuan Chong Quah, M.D., Allen Eng Juh Yeoh, M.D.
Journal: Blood
Blood (2009) 114 (22): 2624.
https://doi.org/10.1182/blood.V114.22.2624.2624
Published: 2009
Journal Articles

BIM Regulates Prednisolone-Induced Apoptosis in B-Lineage ALL: A Potential Biomarker.

Nan Jiang, PhD, Grace Shi Min Koh, BSc, Shirley Kow Yin Kham, BSc, Yi Lu, PhD, Fook Tim Chew, PhD, Allen Eng Juh Yeoh, MD
Journal: Blood
Blood (2008) 112 (11): 1505.
https://doi.org/10.1182/blood.V112.11.1505.1505
Published: 2008
Journal Articles

Single IGH/TCR MRD Marker Is More Informative and Cost-Effective in Risk-Stratified Therapy for Childhood ALL: Prospective Treatment Trial Results from the Malaysia-Singapore (Ma-Spore) ALL 2003 Study

Allen Eng Juh Yeoh, MD, Hany Ariffin, MD, Ah Moy Tan, MD, Thi Thu Ha Truong, BSc, Hai Peng Lin, MD, Yiong Huak Chan, PhD, Shirley Kow Yin Kham, BSc, Thuan Chong Quah, MD
Journal: Blood
Blood (2008) 112 (11): 2551.
https://doi.org/10.1182/blood.V112.11.2551.2551
Published: 2008
Journal Articles

MDR1 C3435T Polymorphism Is Highly Correlated with Early Response to Therapy and Outcome in Childhood Acute Lymphoblastic Leukaemia: Malaysia-Singapore 2003 ALL Study.

Shirley Kow Yin Kham, BSc, Hany Ariffin, MD, Yiong Huak Chan, PhD, Thuan Chong Quah, MD, Allen Eng Juh Yeoh, MD
Journal: Blood
Blood (2007) 110 (11): 226.
https://doi.org/10.1182/blood.V110.11.226.226
Published: 2007
Journal Articles

Genetic Polymorphisms in the Folate Pathway and Risk of Childhood Acute Lymphoblastic Leukemia (ALL): MTHFR, MTHFD1, RFC1 and TS.

Allen Eng-Juh Yeoh, MD, Shirley Kow-Yin Kham, BSc, Yi Lu, PhD, Toon-Chai Foo, BSc, Hany Ariffin, MD, Thuan-Chong Quah, MD
Journal: Blood
Blood (2006) 108 (11): 2274.
https://doi.org/10.1182/blood.V108.11.2274.2274
Published: 2006
Journal Articles

Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism Decreases Risk of Childhood Acute Lymphoblastic Leukemia (ALL): A Study of the Chinese and Malay Population.

Shirley Kow Yin Kham, BSc, Toon Chai Foo, Ariffin Hany, MD, Yiong Huak Chan, PhD, Hai Peng Lin, MD, Thuan Chong Quah, MD, Allen Eng Juh Yeoh, MD
Journal: Blood
Blood (2005) 106 (11): 1459.
https://doi.org/10.1182/blood.V106.11.1459.1459
Published: 2005
Journal Articles

A New Genotyping Chip for Childhood ALL: Using a Novel Multiplex Allele-Specific Primer Extension Strategy To Detect Twelve Polymorphisms in Six Genes Encoding for Drug-Metabolizing Enzymes.

Yi Lu, Kow-Yin Kham, Eng-Juh Yeoh
Journal: Blood
Blood (2004) 104 (11): 4500.
https://doi.org/10.1182/blood.V104.11.4500.4500
Published: 2004
Journal Articles

SELDI Bone Marrow Profiling of B-Lineage Childhood Lymphoblastic Leukemia: Identity of Several Differential Markers.

Sioyong Lim, Liqun Huang, Shirley Kow Yin Kham, Fook Tim Chew, Allen Eng Juh Yeoh
Journal: Blood
Blood (2004) 104 (11): 1090.
https://doi.org/10.1182/blood.V104.11.1090.1090
Published: 2004