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Journal Articles

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

Blood (2020) 136 (Supplement 1): 4.

https://doi.org/10.1182/blood-2020-137658

Published: 2020

Journal Articles

Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinases Exerts Synergistic Effect Against Chronic Myeloid Leukemia Cells

Sylwia Flis, Ewelina Bratek, Tomasz Chojnacki, Marlena Piskorek, Tomasz Skorski, MD PhD

Blood (2019) 134 (Supplement_1): 4143.

https://doi.org/10.1182/blood-2019-129093

Published: 2019

Journal Articles

ASXL1 Mutations Detectable at Diagnosis May Predict Response to Imatinib in Patients with Chronic Myeloid Leukemia

Marcin M Machnicki, MSc, Monika Pepek, MSc, Iwona Solarska, PhD, Joanna Niesiobedzka-Krezel, MD PhD, Ilona Seferynska, MD PhD, Joanna Gora Tybor, MD PhD, Magdalena Zawada, PhD, Tomasz Sacha, MD PhD, Waldemar Sawicki, MD PhD, Ewa Wasilewska, MD PhD, Katarzyna Pruszczyk, MD, Malgorzata Rydzanicz, PhD, Rafal Ploski, MD PhD, Tomasz Skorski, MD PhD, Tomasz Stoklosa, MD PhD

Blood (2019) 134 (Supplement_1): 4148.

https://doi.org/10.1182/blood-2019-129834

Published: 2019

Journal Articles

PARP1 Inhibitors Eliminated Imatinib-Refractory Chronic Myeloid Leukemia Cells in Bone Marrow Microenvironment Conditions

Margaret Nieborowska-Skorska, Paulina Podszywalow-Bartnicka, Silvia Maifrede, Bac Viet Le, Monika Toma, Peter Valent, Tomasz Sliwinski, Wayne Childers, Katarzyna Piwocka, Alexei Tulin, Tomasz Skorski, MD PhD

Blood (2018) 132 (Supplement 1): 3000.

https://doi.org/10.1182/blood-2018-99-115041

Published: 2018

Journal Articles

GADD45a Is a Tumor Suppressor in BCR-ABL-Driven Leukemogenesis

Kaushiki Mukherjee, Xiaojin Sha, MD PhD, Tomasz Skorski, MD PhD, Ravi Bhatia, MD, Barbara Hoffman, PhD, Dan Liebermann, PhD

Blood (2014) 124 (21): 4530.

https://doi.org/10.1182/blood.V124.21.4530.4530

Published: 2014

Journal Articles

Downregulation of BRCA1 Protein in BCR-ABL1–positive Cells Depends on Tiar-Mediated Repression of BRCA1 mRNA Translation

Paulina Podszywalow-Bartnicka, PhD, Magdalena Wolczyk, MSc, Monika Kusio-Kobialka, PhD, Kamila Wolanin, PhD, Krzysztof Skowronek, PhD, Margaret Nieborowska-Skorska, MD PhD, Yashodhara Dasgupta, PhD, Tomasz Skorski, MD PhD, Katarzyna Piwocka, PhD

Blood (2014) 124 (21): 3129.

https://doi.org/10.1182/blood.V124.21.3129.3129

Published: 2014

Journal Articles

Chronic Myeloid Leukemia Stem Cells (LSCs) and Leukemia Progenitor Cells (LPCs) Display Overlapping and Unique Mechanisms of Genomic Instability: The Role of PI3k-AKT and PI3k-Rac2-PAK Pathways

Margaret Nieborowska-Skorska, MD PhD, Sylwia Flis, PhD, Tomasz Skorski, MD PhD

Blood (2014) 124 (21): 1791.

https://doi.org/10.1182/blood.V124.21.1791.1791

Published: 2014

Journal Articles

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD PhD, Katherine Sullivan, Paulina Podszywalow-Bartnicka, Grazyna Hoser, PhD, Elisabeth Bolton-Gillespie, Kimberly Cramer-Morales, Artur Slupianek, PhD, Chun Zhou, PhD, Sabine Cerny-Reiterer, DVM, Tomasz Stoklosa, MD PhD, Stephen M. Sykes, PhD, Peter Valent, MD, Curt I. Civin, MD, Markus Muschen, MD PhD, Mark D. Minden, MD PhD, Kolja Eppert, PhD, Tomasz Skorski, MD PhD

Blood (2014) 124 (21): 480.

https://doi.org/10.1182/blood.V124.21.480.480

Published: 2014

Journal Articles

Normal ABL1 Is a Tumor Suppressor and Therapeutic Target In BCR-ABL1–positive Leukemias

Yashodhara Dasgupta, Mateusz Koptyra, PhD, Margaret Nieborowska-Skorska, MD, PhD, Elisabeth Bolton Gillespie, PhD, Tomasz Stoklosa, MD, PhD, Grazyna Hoser, PhD, Mariusz Wasik, MD, Markus Muschen, Christine Richardson, PhD, Tomasz Skorski, MD, PhD

Blood (2013) 122 (21): 1466.

https://doi.org/10.1182/blood.V122.21.1466.1466

Published: 2013

Journal Articles

GADD45a Is a Tumor Suppressor In BCR-ABL-Driven Leukemogenesis

Kaushiki Mukherjee, Xiaojin Sha, MD, PhD, Ravi Bhatia, MD, Tomasz Skorski, MD, PhD, Barbara Hoffman, PhD, Dan Liebermann

Blood (2013) 122 (21): 1467.

https://doi.org/10.1182/blood.V122.21.1467.1467

Published: 2013

Journal Articles

Oncogene-Induced DNA Repair Defects Promote PARP1-Mediated “Dual Synthetic Lethality” To Eradicate Quiescent and Proliferating Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD, PhD, Artur Slupianek, PhD, Grazyna Hoser, PhD, Elisabeth Bolton-Gillespie, PhD, Alexei Tulin, Sabine Cerny-Reiterer, D.V.M, Peter Valent, Markus Muschen, Stephen M. Sykes, PhD, Tomasz Skorski, MD, PhD

Blood (2013) 122 (21): 810.

https://doi.org/10.1182/blood.V122.21.810.810

Published: 2013

Journal Articles

RAD52-Dependent Synthetic Lethality Eradicates Leukemia Stem Cells

Kimberly Cramer, Ph.D., Margaret Nieborowska-Skorska, MD, PhD, Artur Slupianek, PhD, Tomasz Sliwinski, David Irvine, Mhairi Copland, PhD, BSc, MRCP, FRCPath, Tomasz Skorski, MD, PhD

Blood (2012) 120 (21): 3.

https://doi.org/10.1182/blood.V120.21.3.3

Published: 2012

Journal Articles

BCR-ABL1 Kinase Inhibits DNA Glycosylases to Enhance Oxidative DNA Damage and Stimulate Genomic Instability

Artur Slupianek, PhD, Rafal Falinski, PhD, Pawel Znojek, Tomasz Stoklosa, MD, PhD, Sylwia Flis, Valentina Doneddu, Ewelina Synowiec, Janusz Blasiak, Alfonso Bellacosa, Tomasz Skorski, MD, PhD

Blood (2012) 120 (21): 520.

https://doi.org/10.1182/blood.V120.21.520.520

Published: 2012

Journal Articles

Genomic Instability in CML-CP originates From the Most Primitive Imatinib-Refractory Leukemia Stem Cells

Elisabeth Bolton, Mirle Schemionek, PhD, Hans-Urlich Klein, Grazyna Hoser, PhD, Sylwia Flis, Thoralf Lange, Linda Kerstiens, Margaret Nieborowska-Skorska, MD, PhD, Martin C. Müller, MD, Hardik Modi, Ravi Bhatia, MD, Steffen Koschmieder, MD, Tomasz Skorski, MD, PhD

Blood (2012) 120 (21): 909.

https://doi.org/10.1182/blood.V120.21.909.909

Published: 2012

Journal Articles

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Blood (2011) 118 (21): 2736.

https://doi.org/10.1182/blood.V118.21.2736.2736

Published: 2011

Journal Articles

Targeting DNA Repair Gene, RAD52, Induces Exhaustion of the Proliferating CML-CP Leukemia Stem Cells Carrying Oxidative DNA Damage

Kimberly Cramer, Elisabeth Bolton, Margaret Nieborowska-Skorska, MD, PhD, Sylwia Flis, Tomasz Skorski, MD, PhD

Blood (2011) 118 (21): 447.

https://doi.org/10.1182/blood.V118.21.447.447

Published: 2011

Journal Articles

Genomic Instability Originates From Leukemia Stem Cells in a Mouse Model of CML-CP

Elisabeth Bolton, Mirle Schemionek, PhD, Hans-Ulrich Klein, Linda Kerstiens, Steffen Koschmieder, MD, Tomasz Skorski, MD, PhD

Blood (2011) 118 (21): 445.

https://doi.org/10.1182/blood.V118.21.445.445

Published: 2011

Journal Articles

Sensitivity to Imatinib In BCR-ABL1-Positive Chronic Myeloid Leukemia Cells Depends on the Presence of Normal ABL1.

Yashodhara Dasgupta, Anna Virgili, Mateusz Koptyra, Elisabeth P. Nacheva, MD, PhD, Tomasz Skorski, MD, PhD

Blood (2010) 116 (21): 3405.

https://doi.org/10.1182/blood.V116.21.3405.3405

Published: 2010

Journal Articles

CML-CP Mouse Model of Genomic Instability.

Elisabeth Bolton, Linda Kamp, Hardik Modi, Ravi Bhatia, MD, Steffen Koschmieder, MD, Tomasz Skorski, MD, PhD

Blood (2010) 116 (21): 1210.

https://doi.org/10.1182/blood.V116.21.1210.1210

Published: 2010

Journal Articles

Mitochondrial Respiratory Chain Complex III Causes Genomic Instability In CML-CP.

Piotr Kopinski, Margaret Nieborowska-Skorska, MD, PhD, Grazyna Hoser, PhD, Danielle Ngaba, Regina Ray, Mateusz Koptyra, PhD, Elisabeth Bolton, Ilona Seferynska, MD, PhD, Tomasz Stoklosa, MD, PhD, Artur Slupianek, PhD, Mamatha R. Reddy, Martin Sattler, PhD, Tomasz Skorski, MD, PhD

Blood (2010) 116 (21): 1211.

https://doi.org/10.1182/blood.V116.21.1211.1211

Published: 2010

NARROW

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinases Exerts Synergistic Effect Against Chronic Myeloid Leukemia Cells

ASXL1 Mutations Detectable at Diagnosis May Predict Response to Imatinib in Patients with Chronic Myeloid Leukemia

PARP1 Inhibitors Eliminated Imatinib-Refractory Chronic Myeloid Leukemia Cells in Bone Marrow Microenvironment Conditions

GADD45a Is a Tumor Suppressor in BCR-ABL-Driven Leukemogenesis

Downregulation of BRCA1 Protein in BCR-ABL1–positive Cells Depends on Tiar-Mediated Repression of BRCA1 mRNA Translation

Chronic Myeloid Leukemia Stem Cells (LSCs) and Leukemia Progenitor Cells (LPCs) Display Overlapping and Unique Mechanisms of Genomic Instability: The Role of PI3k-AKT and PI3k-Rac2-PAK Pathways

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

Normal ABL1 Is a Tumor Suppressor and Therapeutic Target In BCR-ABL1–positive Leukemias

GADD45a Is a Tumor Suppressor In BCR-ABL-Driven Leukemogenesis

Oncogene-Induced DNA Repair Defects Promote PARP1-Mediated “Dual Synthetic Lethality” To Eradicate Quiescent and Proliferating Leukemia Stem and Progenitor Cells

RAD52-Dependent Synthetic Lethality Eradicates Leukemia Stem Cells

BCR-ABL1 Kinase Inhibits DNA Glycosylases to Enhance Oxidative DNA Damage and Stimulate Genomic Instability

Genomic Instability in CML-CP originates From the Most Primitive Imatinib-Refractory Leukemia Stem Cells

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Targeting DNA Repair Gene, RAD52, Induces Exhaustion of the Proliferating CML-CP Leukemia Stem Cells Carrying Oxidative DNA Damage

Genomic Instability Originates From Leukemia Stem Cells in a Mouse Model of CML-CP

Sensitivity to Imatinib In BCR-ABL1-Positive Chronic Myeloid Leukemia Cells Depends on the Presence of Normal ABL1.

CML-CP Mouse Model of Genomic Instability.

Mitochondrial Respiratory Chain Complex III Causes Genomic Instability In CML-CP.

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American Society of Hematology

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American Society of Hematology

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