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Véronique Lhéritier
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Journal Articles

NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients

Clinical Trials & Observations
Mathieu Simonin, Loïc Vasseur, Etienne Lengliné, Ludovic Lhermitte, Aurélie Cabannes-Hamy, Marie Balsat, Aline Schmidt, Marie-Emilie Dourthe, Aurore Touzart, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Françoise Huguet, Stéphane Ducassou, Véronique Lhéritier, Yves Chalandon, Norbert Ifrah, Hervé Dombret, Elizabeth Macintyre, Arnaud Petit, Philippe Rousselot, Jérôme Lambert, André Baruchel, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2024) 144 (15): 1570–1580.
https://doi.org/10.1182/blood.2023023754
Published: 2024
Includes: Supplemental data
Journal Articles

Nilotinib with or without cytarabine for Philadelphia-positive acute lymphoblastic leukemia

Clinical Trials & Observations
Yves Chalandon, Philippe Rousselot, Sylvie Chevret, Jean-Michel Cayuela, Rathana Kim, Françoise Huguet, Patrice Chevallier, Carlos Graux, Anne Thiebaut-Bertrand, Sylvain Chantepie, Xavier Thomas, Laure Vincent, Céline Berthon, Yosr Hicheri, Emmanuel Raffoux, Martine Escoffre-Barbe, Isabelle Plantier, Magalie Joris, Pascal Turlure, Florence Pasquier, Amine Belhabri, Gabrielle Roth Guepin, Sabine Blum, Michael Gregor, Marina Lafage-Pochitaloff, Julie Quessada, Véronique Lhéritier, Emmanuelle Clappier, Nicolas Boissel, Hervé Dombret
Journal: Blood
Blood (2024) 143 (23): 2363–2372.
https://doi.org/10.1182/blood.2023023502
Published: 2024
Includes: Supplemental data
Journal Articles

Genetic alterations and MRD refine risk assessment for KMT2A -rearranged B-cell precursor ALL in adults: a GRAALL study

Rathana Kim, Hugo Bergugnat, Cédric Pastoret, Florence Pasquier, Emmanuel Raffoux, Lise Larcher, Marie Passet, Nathalie Grardel, Eric Delabesse, Susanne Kubetzko, Aurélie Caye-Eude, Claus Meyer, Rolf Marschalek, Marine Lafage-Pochitaloff, Anne Thiebaut-Bertrand, Marie Balsat, Martine Escoffre-Barbe, Sabine Blum, Michael Baumann, Anne Banos, Nicole Straetmans, Maria-Pilar Gallego-Hernanz, Yves Chalandon, Carlos Graux, Jean Soulier, Thibaut Leguay, Mathilde Hunault, Françoise Huguet, Véronique Lhéritier, Hervé Dombret, Nicolas Boissel, Emmanuelle Clappier
Journal: Blood
Blood (2023) 142 (21): 1806–1817.
https://doi.org/10.1182/blood.2023021501
Published: 2023
Includes: Supplemental data
Journal Articles

NGS-Based Stratification Refines the Risk Stratification in T-ALL and Identifies a Very High-Risk Subgroup of Patients

Mathieu Simonin, Loïc Vasseur, Etienne Lengline, Ludovic Lhermitte, Aurelie Cabannes-Hamy, Marie Balsat, Aline Schmidt, Marie Emilie Dourthe, Aurore Touzart, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Françoise Huguet, Stephane Ducassou, Véronique Lhéritier, Yves Chalandon, Norbert Ifrah, Herve Dombret, Elizabeth A. Macintyre, Arnaud Petit, Philippe Rousselot, Jerome Lambert, André Baruchel, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2023) 142 (Supplement 1): 844.
https://doi.org/10.1182/blood-2023-179298
Published: 2023
Journal Articles

Oncogenetic-Driven Targeted Therapy for Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia : A French ALL-Target Observatory Report

Aurelie Cabannes-Hamy, Lucien Courtois, Marie Balsat, Mathieu Simonin, Françoise Huguet, Martine Escoffre-Barbe, Florence Pasquier, Caroline Bonmati, Pascal Turlure, Thomas Cluzeau, Delphine Lebon, Eve Gehlkopf, Eolia Brissot, Justine Decroocq, Patrice Chevallier, Sylvain Chantepie, Victoria Cacheux, Sebastien Maury, Safia Chebrek, Thibaut Leguay, Melody Fort, Natacha Mauz, Mathlide Lamarque, Hunault-Berger Mathilde, Stefan Wickenhauser, Jamilé Frayfer, Anne Banos, Emmanuelle Tavernier, Denis Caillot, Anne Marie Ronchetti, Celine Berthon, Etienne Lengline, Véronique Lhéritier, Hervé Dombret, Ambroise Marçais, Antoine Pinton, Guillaume P Andrieu, Nicolas Boissel, Ludovic Lhermitte, Vahid Asnafi, Philippe Rousselot
Journal: Blood
Blood (2023) 142 (Supplement 1): 518.
https://doi.org/10.1182/blood-2023-179192
Published: 2023
Journal Articles

Efficacy and Tolerance of Brexucabtagene Autoleucel in Adults with Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia : A Graall Study from the Descar-T Registry

Florence Rabian, David Beauvais, Tony Marchand, Sabine Furst, Anne Huynh, Eolia Brissot, Sebastien Maury, Ludovic Gabellier, Patrice Chevallier, Michael Loschi, Stéphanie Nguyen Quoc, Marie Balsat, Ingrid Lafon, Amandine Fayard, Vincent Camus, Célestine Simand, Niels Moya, Cristina Castilla-Llorente, Magalie Joris, Ana Berceanu, Anne Thiebaut, Véronique Lhéritier, Eve Gehlkopf, Gabrielle Roth-Guepin, Thibaut Leguay, Nicolas Boissel
Journal: Blood
Blood (2023) 142 (Supplement 1): 3498.
https://doi.org/10.1182/blood-2023-180575
Published: 2023
Journal Articles

Exploring the Heterogeneity of Response to Blinatumomab in High-Risk Philadelphia-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: An Analysis from the QUEST Sub-Study of the Graall-2014/B Trial

Nicolas Boissel, Francoise Huguet, Thibaut Leguay, Mathilde Hunault, Rathana KIM, Yosr Hicheri, Marie Passet, Patrice Chevallier, Marie Balsat, Sebastien Maury, Anne Thiebaut, Florence Van Obbergh, Thomas Cluzeau, Martine Escoffre Barbe, Nicole Straetmans, Johanna Konopacki, Amine Belhabri, Alban Villate, Florence Pasquier, Didier Bouscary, Thorsten Braun, Sabine Blum, Victoria Cacheux, Caroline Bonmati, Sebastian Wittnebel, Véronique Lhéritier, Norbert Ifrah, Carlos Graux, Yves Chalandon, Emmanuelle Clappier, Herve Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 4349.
https://doi.org/10.1182/blood-2023-177847
Published: 2023
Journal Articles

Frontline Consolidation with Nelarabine for Adults with High-Risk T-Cell Acute Lymphoblastic Leukemia. Results of the Graall-2014/T Atriall Phase 2 Study

Nicolas Boissel, Carlos Graux, Francoise Huguet, Florence Pasquier, Aurore Touzart, Thomas Cluzeau, Ludovic Lhermitte, Eric Delabesse, Patrice Chevallier, Mathilde Hunault, Cedric Pastoret, Sebastien Maury, Nathalie Grardel, Martine Escoffre Barbe, Pascal Turlure, Beat Schafer, Marie Balsat, Philippe Rousselot, Thibaut Leguay, Eric Jourdan, Delphine Pranger, Michael Gregor, Emilie Lemasle, Anne Marie Ronchetti, Ana Berceanu, Ingrid Lafon, Madalina Uzunov, Etienne Lengline, Norbert Ifrah, Yves Chalandon, Véronique Lhéritier, Vahid Asnafi, Herve Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 962.
https://doi.org/10.1182/blood-2023-177696
Published: 2023
Journal Articles

Blinatumomab during Consolidation in High-Risk Philadelphia Chromosome (Ph)-Negative B-Cell Precursor (BCP) Acute Lymphoblastic Leukemia (ALL) Adult Patients: A Two-Cohort Comparison within the Graall-2014/B Study

Nicolas Boissel, Francoise Huguet, Thibaut Leguay, Mathilde Hunault, Rathana KIM, Yosr Hicheri, Patrice Chevallier, Marie Balsat, Sébastien Maury, Anne Thiebaut-Bertrand, Florence Van Obbergh, Thomas Cluzeau, Martine Escoffre-Barbe, Nicole Straetmans, Johanna Konopacki, Amine Belhabri, Alban Villate, Florence Pasquier, Ioana Vaida, Laurence Sanhes, Magda Alexis, Cedric Pastoret, Mathlide Lamarque, Laure Farnault, Nathalie Grardel, Celine Berthon, Eric Delabesse, Veronique Lheritier, Norbert Ifrah, Carlos Graux, Yves Chalandon, Emmanuelle Clappier, Herve Dombret
Journal: Blood
Blood (2022) 140 (Supplement 1): 507–509.
https://doi.org/10.1182/blood-2022-159397
Published: 2022
Journal Articles

In Adults with Ph-Negative Acute Lymphoblastic Leukemia (ALL), Age-Adapted Chemotherapy Intensity and MRD-Driven Transplant Indication Significantly Reduces Treatment-Related Mortality (TRM) and Improves Overall Survival - Results from the Graall-2014 Trial

Nicolas Boissel, Francoise Huguet, Thibaut Leguay, Hunault-Berger Mathilde, Carlos Graux, Yves Chalandon, Eric Delabesse, Yosr Hicheri, Patrice Chevallier, Marie Balsat, Cedric Pastoret, Martine Escoffre-Barbe, Florence Pasquier, Jean-Pierre Marolleau, Anne Thiebaut-Bertrand, Anne Huynh, Nathalie Dhedin, Emilie Lemasle, Caroline Bonmati, Sébastien Maury, Gaëlle Guillerm, Anna Berceanu, Urs Schanz, Thomas Cluzeau, Pascal Turlure, Philippe Rousselot, Bernard J.M. De Prijck, Nathalie Grardel, Marie C Bene, Marine Lafage, Norbert Ifrah, Veronique Lheritier, Vahid Asnafi, Emmanuelle Clappier, Herve Dombret
Journal: Blood
Blood (2022) 140 (Supplement 1): 112–114.
https://doi.org/10.1182/blood-2022-157903
Published: 2022
Journal Articles

Concurrent CDX2 cis -deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL

Marie Passet, Rathana Kim, Stéphanie Gachet, François Sigaux, Julie Chaumeil, Ava Galland, Thomas Sexton, Samuel Quentin, Lucie Hernandez, Lise Larcher, Hugo Bergugnat, Tao Ye, Nezih Karasu, Aurélie Caye, Beate Heizmann, Isabelle Duluc, Patrice Chevallier, Philippe Rousselot, Françoise Huguet, Thibaut Leguay, Mathilde Hunault, Françoise Pflumio, Jean-Noël Freund, Camille Lobry, Véronique Lhéritier, Hervé Dombret, Claire Domon-Dell, Jean Soulier, Nicolas Boissel, Emmanuelle Clappier
Journal: Blood
Blood (2022) 139 (24): 3505–3518.
https://doi.org/10.1182/blood.2021014723
Published: 2022
Includes: Supplemental data
Journal Articles

PRC2 loss of function confers a targetable vulnerability to BET proteins in T-ALL

Guillaume P. Andrieu, Milena Kohn, Mathieu Simonin, Charlotte L. Smith, Agata Cieslak, Marie-Émilie Dourthe, Guillaume Charbonnier, Carlos Graux, Françoise Huguet, Véronique Lhéritier, Hervé Dombret, Salvatore Spicuglia, Philippe Rousselot, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2021) 138 (19): 1855–1869.
https://doi.org/10.1182/blood.2020010081
Published: 2021
Includes: Supplemental data
Journal Articles

The Omission of High-Dose Cytarabine during Consolidation Therapy of Ph-Positive ALL Patients Treated with Nilotinib and Low-Intensity Chemotherapy Results in an Increased Risk of Relapses Despite Non-Inferior Levels of Late BCR-ABL1 MRD Response. First Results of the Randomized Graaph-2014 Study

Philippe Rousselot, Yves Chalandon, Sylvie Chevret, Jean-Michel Cayuela, Francoise Huguet, Patrice Chevallier, Carlos Graux, Anne Thiebaut-Bertrand, Sylvain Chantepie, Xavier Thomas, Laure Vincent, Celine Berthon, Norbert Vey, Emmanuel Raffoux, Martine Escoffre-Barbe, Isabelle Plantier, Jean Pierre Marolleau, Pascal Turlure, Florence Pasquier, Amine Belhabri, Gabrielle Roth Guepin, Olivier Spertini, Veronique Lheritier, Emmanuelle Clappier, Nicolas Boissel, Hervé Dombret
Journal: Blood
Blood (2021) 138 (Supplement 1): 512.
https://doi.org/10.1182/blood-2021-148843
Published: 2021
Journal Articles

Frequency and Outcome of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with BCR-ABL1 Clonal Hematopoiesis after Blast Clearance: Results from the Graaph-2014 Trial

Rathana KIM, Philippe Rousselot, Jean-Michel Cayuela, Yves Chalandon, Marie Passet, Xavier Thomas, Nicole Straetmans, Patrice Chevallier, Francoise Huguet, Celine Berthon, Georg Stüssi, Sébastien Maury, Sylvain Chantepie, Jean-Baptiste Micol, Isabelle Plantier, Sylvie Chevret, Jean Soulier, Norbert Ifrah, Veronique Lheritier, Hervé Dombret, Nicolas Boissel, Emmanuelle Clappier
Journal: Blood
Blood (2021) 138 (Supplement 1): 3478.
https://doi.org/10.1182/blood-2021-150126
Published: 2021
Journal Articles

Frontline Consolidation with Blinatumomab for High-Risk Philadelphia-Negative Acute Lymphoblastic Adult Patients. Early Results from the Graall-2014-QUEST Phase 2

Nicolas Boissel, Francoise Huguet, Carlos Graux, Yosr Hicheri, Patrice Chevallier, Rathana KIM, Marie Balsat, Thibaut Leguay, Mathilde Hunault, Sébastien Maury, Anne Thiebaut-Bertrand, Martine Escoffre-Barbe, Thomas Cluzeau, Alban Villate, Florence Pasquier, Laure Farnault, Florence Van Obbergh, Philippe Rousselot, Yves Chalandon, Eric Delabesse, Cedric Pastoret, Emmanuelle Clappier, Veronique Lheritier, Herve Dombret
Journal: Blood
Blood (2021) 138 (Supplement 1): 1232.
https://doi.org/10.1182/blood-2021-146163
Published: 2021
Journal Articles

Impact of Central Nervous System Involvement in Adult Patients with Acute Lymphoblastic Leukemia Treated in a Pediatrics-Inspired Protocol - a Graall Study

Corentin Orvain, Sylvain Chantepie, Xavier Thomas, Martine Escoffre-Barbe, Francoise Huguet, Yohan Desbrosses, Gaelle Guillerm, Thibaut Leguay, Sarah Barbieux, Norbert Vey, Patrice Chevallier, Jean Valere Malfuson, Stephane Lepretre, Jean Pierre Marolleau, Hacene Zerazhi, Diana Carp, Ambroise Marçais, Maria Pilar Gallego Hernanz, Iona Vaida, Florence Pasquier, Veronique Lheritier, Norbert Ifrah, Hervé Dombret, Nicolas Boissel, Hunault-Berger Mathilde
Journal: Blood
Blood (2021) 138 (Supplement 1): 215.
https://doi.org/10.1182/blood-2021-150705
Published: 2021
Journal Articles

Thromboembolism prophylaxis in adult patients with acute lymphoblastic leukemia treated in the GRAALL-2005 study

CME Clinical Trials & Observations
Corentin Orvain, Marie Balsat, Emmanuelle Tavernier, Jean-Pierre Marolleau, Thomas Pabst, Patrice Chevallier, Noémie de Gunzburg, Victoria Cacheux, Françoise Huguet, Sylvain Chantepie, Denis Caillot, Yves Chalandon, Jamilé Frayfer, Caroline Bonmati, Véronique Lheritier, Norbert Ifrah, Hervé Dombret, Nicolas Boissel, Mathilde Hunault-Berger
Journal: Blood
Blood (2020) 136 (3): 328–338.
https://doi.org/10.1182/blood.2020004919
Published: 2020
Includes: Supplemental data
Journal Articles

Sensitive Monitoring of BCR-ABL1 Kinase Domain Mutations By Next Generation Sequencing for Optimizing Clinical Decisions in Philadelphia-Positive Acute Lymphoblastic Leukemia in the Graaph-2014 Trial

Jean-Michel Cayuela, Francois Lay, MD, Yves Chalandon, Philippe Rousselot, MD PhD, Xavier Thomas, MD PhD, Violaine Havelange, MD, Francoise Huguet, MD, Patrice Chevallier, MD, Anne Thiebaut-Bertrand, Sylvain Chantepie, MD, Nicolas Boissel, MD PhD, Norbert Vey, MD PhD, Martine Escoffre-Barbe, MD, Franciane Paul, Celine Berthon, MD PhD, Isabelle Plantier, MD, Mathilde Hunault, MD PhD, Carlos Graux, Veronique Lheritier, Sylvie Chevret, MD PhD, Hervé Dombret
Journal: Blood
Blood (2019) 134 (Supplement_1): 1295.
https://doi.org/10.1182/blood-2019-124029
Published: 2019
Journal Articles

PAX5 P80R mutation identifies a novel subtype of B-cell precursor acute lymphoblastic leukemia with favorable outcome

Marie Passet, Nicolas Boissel, François Sigaux, Colombe Saillard, Mario Bargetzi, Ibrahima Ba, Xavier Thomas, Carlos Graux, Yves Chalandon, Thibaut Leguay, Etienne Lengliné, Johanna Konopacki, Samuel Quentin, Eric Delabesse, Marina Lafage-Pochitaloff, Cédric Pastoret, Nathalie Grardel, Vahid Asnafi, Véronique Lhéritier, Jean Soulier, Hervé Dombret, Emmanuelle Clappier
Journal: Blood
Blood (2019) 133 (3): 280–284.
https://doi.org/10.1182/blood-2018-10-882142
Published: 2019
Includes: Supplemental data
Journal Articles

Impact of cytogenetic abnormalities in adults with Ph-negative B-cell precursor acute lymphoblastic leukemia

Clinical Trials & Observations
Marina Lafage-Pochitaloff, Laurence Baranger, Mathilde Hunault, Wendy Cuccuini, Christine Lefebvre, Audrey Bidet, Isabelle Tigaud, Virginie Eclache, Eric Delabesse, Chrystèle Bilhou-Nabéra, Christine Terré, Elise Chapiro, Nathalie Gachard, Marie-Joelle Mozziconacci, Geneviève Ameye, Sarah Porter, Nathalie Grardel, Marie C. Béné, Yves Chalandon, Carlos Graux, Françoise Huguet, Véronique Lhéritier, Norbert Ifrah, Hervé Dombret
Journal: Blood
Blood (2017) 130 (16): 1832–1844.
https://doi.org/10.1182/blood-2017-05-783852
Published: 2017
Includes: Supplemental data