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Journal Articles

Whole-genome analysis reveals shared early genetic alterations and subtype-specific immune evasion pathways in intravascular large B-cell lymphoma and immune-privileged large B-cell lymphoma

Takuto Mori, Kazuyuki Shimada, Kaito Mimura, Suguru Fukuhara, Koji Izutsu, Daisuke Kawauchi, Yoshitaka Narita, Akiko Miyagi Maeshima, Ryosuke Koyamada, Nobuhiro Hiramoto, Nobuyuki Kakiuchi, Hirona Maeda, Ai Okada, Kenichi Chiba, Yuichi Shiraishi, Akifumi Takaori-Kondo, Seishi Ogawa, Akihiro Tomita, Kenichi Yoshida

Blood (2025) 146 (Supplement 1): 7061.

https://doi.org/10.1182/blood-2025-7061

Published: 2025

Journal Articles

Repertoire of driver events in coding and non-coding regions identified by whole-genome sequencing of myeloid neoplasms

Blood (2025) 146 (Supplement 1): 1450.

https://doi.org/10.1182/blood-2025-1450

Published: 2025

Journal Articles

A combination strategy of inotuzumab ozogamicin (InO) and BCL-2 family inhibitors prevents the emergence of PGP+ ino-resistant MRD in B-cell acute lymphoblastic leukemia

Anna Akaogi, Kenichi Ishiyama, Toshio Kitawaki, Hiroshi Arima, Tadahiko Matsumoto, Ernesto Diaz-Flores, Mignon Loh, Akifumi Takaori-Kondo

Blood (2025) 146 (Supplement 1): 1527.

https://doi.org/10.1182/blood-2025-1527

Published: 2025

Journal Articles

Single-cell multi-omics uncovers differentiation-dependent transcriptional programs shaping epigenetic subgroups in AML

Blood (2025) 146 (Supplement 1): 5005.

https://doi.org/10.1182/blood-2025-5005

Published: 2025

Journal Articles

SLF2 and SMC5 are novel causative genes for inherited bone marrow failure syndromes, driving HSC aging and predisposing to MDS

Sho Shibata, Kazuhisa Chonabayashi, Hirofumi Nakamura, Akitsu Hotta, Yuri Uchiyama, Yukiko Oh, Naomichi Matsumoto, Yotaro Ochi, Seishi Ogawa, Akifumi Takaori-Kondo, Yoshinori Yoshida

Blood (2025) 146 (Supplement 1): 4989.

https://doi.org/10.1182/blood-2025-4989

Published: 2025

Journal Articles

Inhibition of lysine acetyltransferases p300/CBP overcomes BTK inhibitor resistance in a xenograft model of Mantle Cell Lymphoma by suppressing MYC signaling

Yusuke Tashiro, Kotaro Shirakawa, Hiroshi Arima, Jelagat Carolline, Yoshinobu Konishi, Hiroyuki Matsui, Tadahiko Matsumoto, Yusuke Okamoto, Kazunari Aoki, Kosuke Yusa, Akifumi Takaori-Kondo

Blood (2025) 146 (Supplement 1): 438.

https://doi.org/10.1182/blood-2025-438

Published: 2025

Journal Articles

Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages

Blood (2025) 145 (11): 1149–1163.

https://doi.org/10.1182/blood.2024025402

Published: 2025

Includes: Supplemental data

Journal Articles

Whole-Genome Analysis Revealed the Genetic Landscape of Intravascular Large B-Cell Lymphoma

Takuto Mori, Kazuyuki Shimada, Kaito Mimura, Nobuyuki Kakiuchi, Hirona Maeda, Akifumi Takaori-Kondo, Seishi Ogawa, Akihiro Tomita, Kenichi Yoshida

Blood (2024) 144 (Supplement 1): 2983.

https://doi.org/10.1182/blood-2024-204466

Published: 2024

Journal Articles

Inhibition of p300/CBP Overcomes BTK Inhibitor Resistance in MCL By Counteracting IL-6/JAK/STAT3 Signaling

Yusuke Tashiro, Kotaro Shirakawa, Hiroshi Arima, Ryosuke Nomura, Yoshihito Horisawa, Stanford Emani, Suguru Takeuchi, Jelagat Caroline, Yasuhiro Kazuma, Hiroyuki Matsui, Tadahiko Matsumoto, Kosuke Yusa, Akifumi Takaori-Kondo

Blood (2024) 144 (Supplement 1): 5843.

https://doi.org/10.1182/blood-2024-206382

Published: 2024

Journal Articles

Deciphering the Heterogeneity of Acute Myeloid Leukemia through Chromatin Accessibility Profiling

Blood (2024) 144 (Supplement 1): 639.

https://doi.org/10.1182/blood-2024-200415

Published: 2024

Journal Articles

Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia

Kazunari Aoki, Mizuki Hyuga, Yusuke Tarumoto, Gohei Nishibuchi, Atsushi Ueda, Yotaro Ochi, Seiichi Sugino, Takashi Mikami, Hirokazu Kobushi, Itaru Kato, Koshi Akahane, Takeshi Inukai, Akifumi Takaori-Kondo, Junko Takita, Seishi Ogawa, Kosuke Yusa

Blood (2024) 143 (7): 604–618.

https://doi.org/10.1182/blood.2023020857

Published: 2024

Includes: Supplemental data

Journal Articles

CNOT4 Knockout Induces Proteasome Inhibitor Resistance in Multiple Myeloma Cells

Yoshihito Horisawa, Kotaro Shirakawa, Suguru Takeuchi, Ryosuke Nomura, Yusuke Tashiro, Stanford Emani, Jelagat Caroline, Yasuhiro Kazuma, Kosuke Yusa, Akifumi Takaori-Kondo

Blood (2023) 142 (Supplement 1): 1444.

https://doi.org/10.1182/blood-2023-185862

Published: 2023

Journal Articles

Single-Cell RNA Sequencing Revealed the YY1/EZH2/MLH1 Axis As a Possible Therapeutic Target of Intractable Adult T-Cell Leukemia

Takuya Shimizu, Takero Shindo, Akira Watanabe, Akifumi Takaori-Kondo

Blood (2023) 142 (Supplement 1): 6084.

https://doi.org/10.1182/blood-2023-185712

Published: 2023

Journal Articles

Prognostic Impact of Chromosomal Abnormalities in TP53 -Mutated Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes

Blood (2023) 142 (Supplement 1): 4328.

https://doi.org/10.1182/blood-2023-180291

Published: 2023

Journal Articles

Identification of Novel Transcripts and Potential Therapeutic Targets for Acute Leukemia

Fumiya Wada, Shoya Kato, Shruti Bhagat, Shigeki Hirabayashi, Raku Son, Akiko Oguchi, Kazuhiro Takeuchi, Sho Sekito, Tomoya Hirai, Zhiwei Zhang, Yoshihito Horisawa, Makoto Iwasaki, June Takeda, Junya Kanda, Takashi Sakamoto, Kotaro Shirakawa, Akifumi Takaori-Kondo, Yasuhiro Murakawa

Blood (2023) 142 (Supplement 1): 1583.

https://doi.org/10.1182/blood-2023-188008

Published: 2023

Journal Articles

Development of a Stacked Ensemble Model for Risk Stratification of Chronic Gvhd after Allogeneic HSCT: Trump Cohort Study

Blood (2023) 142 (Supplement 1): 3561.

https://doi.org/10.1182/blood-2023-173779

Published: 2023

Journal Articles

Epigenetic Classification of Acute Myeloid Leukemia Revealed By Genome-Wide Chromatin Profiling

Blood (2023) 142 (Supplement 1): 836.

https://doi.org/10.1182/blood-2023-180336

Published: 2023

Journal Articles

Inhibition of Lysine Acetyltransferases p300/CBP Overcomes BTK Inhibitor Resistance in Mantle Cell Lymphoma Cells

Yusuke Tashiro, Kotaro Shirakawa, Ryosuke Nomura, Yoshihito Horisawa, Stanford Emani, Suguru Takeuchi, Jelagat Caroline, Yasuhiro Kazuma, Kosuke Yusa, Akifumi Takaori-Kondo

Blood (2023) 142 (Supplement 1): 2816.

https://doi.org/10.1182/blood-2023-179993

Published: 2023

Journal Articles

Donor NK Cell Education By KIR3DL1 and HLA-B Associates with Reduced Relapse in Unrelated Bone Marrow Transplantation for Adult T-Cell Leukemia

Blood (2023) 142 (Supplement 1): 4982.

https://doi.org/10.1182/blood-2023-185474

Published: 2023

Journal Articles

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro M. Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin G. Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa

Blood (2023) 141 (5): 534–549.

https://doi.org/10.1182/blood.2022018221

Published: 2023

Includes: Supplemental data

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Whole-genome analysis reveals shared early genetic alterations and subtype-specific immune evasion pathways in intravascular large B-cell lymphoma and immune-privileged large B-cell lymphoma

Repertoire of driver events in coding and non-coding regions identified by whole-genome sequencing of myeloid neoplasms

A combination strategy of inotuzumab ozogamicin (InO) and BCL-2 family inhibitors prevents the emergence of PGP+ ino-resistant MRD in B-cell acute lymphoblastic leukemia

Single-cell multi-omics uncovers differentiation-dependent transcriptional programs shaping epigenetic subgroups in AML

SLF2 and SMC5 are novel causative genes for inherited bone marrow failure syndromes, driving HSC aging and predisposing to MDS

Inhibition of lysine acetyltransferases p300/CBP overcomes BTK inhibitor resistance in a xenograft model of Mantle Cell Lymphoma by suppressing MYC signaling

Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages

Whole-Genome Analysis Revealed the Genetic Landscape of Intravascular Large B-Cell Lymphoma

Inhibition of p300/CBP Overcomes BTK Inhibitor Resistance in MCL By Counteracting IL-6/JAK/STAT3 Signaling

Deciphering the Heterogeneity of Acute Myeloid Leukemia through Chromatin Accessibility Profiling

Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia

CNOT4 Knockout Induces Proteasome Inhibitor Resistance in Multiple Myeloma Cells

Single-Cell RNA Sequencing Revealed the YY1/EZH2/MLH1 Axis As a Possible Therapeutic Target of Intractable Adult T-Cell Leukemia

Prognostic Impact of Chromosomal Abnormalities in TP53 -Mutated Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes

Identification of Novel Transcripts and Potential Therapeutic Targets for Acute Leukemia

Development of a Stacked Ensemble Model for Risk Stratification of Chronic Gvhd after Allogeneic HSCT: Trump Cohort Study

Epigenetic Classification of Acute Myeloid Leukemia Revealed By Genome-Wide Chromatin Profiling

Inhibition of Lysine Acetyltransferases p300/CBP Overcomes BTK Inhibitor Resistance in Mantle Cell Lymphoma Cells

Donor NK Cell Education By KIR3DL1 and HLA-B Associates with Reduced Relapse in Unrelated Bone Marrow Transplantation for Adult T-Cell Leukemia

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

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