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Journal Articles

Integrated Immunological Analysis of the Bone Marrow Tumor Microenvironment in Myeloproliferative Neoplasms to Determine Potential Efficacy of Immune Checkpoint Blockade

Robert Orlowski, MD, Alexander Huang, Mercy Gohil, James Mangan, MD PhD, Marissa Vignali, PhD, Ryan O Emerson, PhD, Harlan Robins, PhD, Erik Yusko, PhD, Martha S Jordan, PhD, Martin Carroll, MD, D. Gary Gilliland, MD PhD, Elizabeth O Hexner, MD

Blood (2015) 126 (23): 2766.

https://doi.org/10.1182/blood.V126.23.2766.2766

Published: 2015

Journal Articles

The p110alpha and p110delta Isoforms of PI3 Kinase Are Dispensable for Hematopoietic Stem Cell Self-Renewal but Have Redundant Roles in B Cell Differentiation.

Kira Gritsman, MD, PhD, Linda Clayton, PhD, D. Gary Gilliland, MD, PhD, Thomas M. Roberts, PhD, Jean Zhao, PhD

Blood (2012) 120 (21): 2322.

https://doi.org/10.1182/blood.V120.21.2322.2322

Published: 2012

Journal Articles

Mtor Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

Demetrios Kalaitzidis, PhD, Stephen M. Sykes, Natalie Punt, Yuefeng Tang, PhD, Steven W. Lane, Clary Clish, PhD, D. Gary Gilliland, MD, PhD, David T. Scadden, MD, David Guertin, PhD, Scott A. Armstrong, MD, PhD

Blood (2011) 118 (21): 391.

https://doi.org/10.1182/blood.V118.21.391.391

Published: 2011

Journal Articles

An ENU Mutagenesis Screen to Identify Genes Involved in the Induction of FLT3-ITD Positive Acute Myeloid Leukemia

Anna L Brown, PhD, Robert Tunningley, PhD, Grant A Engler, BSc(Hons), D. Gary Gilliland, MD, PhD, Ian D Lewis, MBBS, PhD, Thomas Gonda, PhD, Richard J D'Andrea, PhD

Blood (2011) 118 (21): 1400.

https://doi.org/10.1182/blood.V118.21.1400.1400

Published: 2011

Journal Articles

KIT with D816 Mutations Cooperates with CBFB-MYH11 for Leukemogenesis in Mice

Ling Zhao, MD, PhD, J. Joseph Melenhorst, PhD, Lemlem Alemu, Stacie Anderson, Martha Kirby, Shelley Hoogstraten-Miller, Lauren Brinster, Maggie Kench, Yasuhiko Kamikubo, D. Gary Gilliland, MD, PhD, Pu Paul Liu, MD, PhD

Blood (2011) 118 (21): 867.

https://doi.org/10.1182/blood.V118.21.867.867

Published: 2011

Journal Articles

Leukemogenic Tyrosine Kinases Inhibit PKM2 to Promote the Warburg Effect and Tumor Growth

Blood (2010) 116 (21): 3142.

https://doi.org/10.1182/blood.V116.21.3142.3142

Published: 2010

Journal Articles

Longer-Term Follow up with TG101348 Therapy In Myelofibrosis Confirms Sustained Improvement In Splenomegaly, Disease-Related Symptoms, and JAK2 V617F Allele Burden

Animesh Pardanani, MBBS, PhD, Jason R Gotlib, MD, MS, Catriona Jamieson, MD, PhD, Jorge E. Cortes, MD, Moshe Talpaz, MD, Richard M Stone, M.D., Michael H Silverman, MD, FACP, Jolene Shorr, D. Gary Gilliland, MD, PhD, Ayalew Tefferi, MD

Blood (2010) 116 (21): 459.

https://doi.org/10.1182/blood.V116.21.459.459

Published: 2010

Journal Articles

Leukemia Stem Cells Are Resistant to In Vivo, Cell Non-Autonomous Wnt Inhibition.

Steven W. Lane, MD, Cristina Lo Celso, Stephen M Sykes, Sebastian Shterental, Mahnaz Paktinat, Charles P Lin, David A. Williams, MD, David T. Scadden, MD, D. Gary Gilliland, MD, PhD

Blood (2009) 114 (22): 1025.

https://doi.org/10.1182/blood.V114.22.1025.1025

Published: 2009

Journal Articles

Prevalence and Prognostic Impact of Allelic Imbalances Associated with Leukemic Transformation of Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.

Blood (2009) 114 (22): 1280.

https://doi.org/10.1182/blood.V114.22.1280.1280

Published: 2009

Journal Articles

A Phase I Evaluation of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis: Clinical Response Is Accompanied by Significant Reduction in JAK2 V617F Allele Burden.

Animesh D. Pardanani, MBBS, PhD, Jason R Gotlib, MD, MS, Catriona Jamieson, MD, PhD, Jorge Cortes, MD, Moshe Talpaz, MD, Richard Stone, MD, Michael H Silverman, MD, FACP, Jolene Shorr, D. Gary Gilliland, MD, PhD, Ayalew Tefferi, MD

Blood (2009) 114 (22): 755.

https://doi.org/10.1182/blood.V114.22.755.755

Published: 2009

Journal Articles

C-KIT with D816Y/V Mutations Cooperate with CBFB-MYH11 to Accelerate Leukemogenesis in Mice.

Ling Zhao, J. Joseph Melenhorst, Ph.D., Lemlem Alemu, Martha Kirby, Stacie M Anderson, Shelley Hoogstraten-Miller, Yasuhiko Kamikubo, MD, PhD, D. Gary Gilliland, MD, PhD, Pu Paul Liu

Blood (2009) 114 (22): 274.

https://doi.org/10.1182/blood.V114.22.274.274

Published: 2009

Journal Articles

A Regulatory Network Between Notch and AKT Signaling Pathways Differentially Controls Megakaryocyte Development From Hematopoietic Stem or Committed Progenitor Cells.

Melanie G Cornejo, Stephen M Sykes, Cristina Lo Celso, Zuzana Tothova, Jon Aster, MD, PhD, Ronald A DePinho, MD, David T Scadden, MD, D. Gary Gilliland, MD, PhD, Thomas Mercher, Ph.D

Blood (2009) 114 (22): 384.

https://doi.org/10.1182/blood.V114.22.384.384

Published: 2009

Journal Articles

Hematopoietic Stem Cell Defects in Novel Fanconi Anemia Mouse Models

Kalindi Parmar, PhD, Jung Min Kim, PhD, Akiko Shimamura, MD, PhD, Anna Stuckert, Mary K DeLoach, Kaya Zhu, Peter M. Mauch, MD, Jeffery Kutok, MD, PhD, Jon Aster, MD, PhD, Koichi Akashi, MD, PhD, D. Gary Gilliland, MD, PhD, Alan D. D’Andrea, MD

Blood (2008) 112 (11): 440.

https://doi.org/10.1182/blood.V112.11.440.440

Published: 2008

Journal Articles

Runx1 Is Required for Notch-Induced Specification of Megakaryocyte Development from Early Hematopoietic Stem and Progenitor Cells

Melanie G Cornejo, Thomas Mercher, Ph.D, Joseph D. Growney, PhD, Jonathan Jesneck, Ivan Maillard, MD, PhD, Warren S. Pear, MD, PhD, Jon Aster, MD, PhD, D. Gary Gilliland, MD, PhD

Blood (2008) 112 (11): 1370.

https://doi.org/10.1182/blood.V112.11.1370.1370

Published: 2008

Journal Articles

NFIB: A Gene Consistently Upregulated in MPD and Frequently Co-Amplified with JAK2V617F Augments Growth of Erythropoietin Dependent Cells

Xiaoqing Lin, BS, Monica Buzzai, PhD, Ross L Levine, MD, Windy Berkofsky-Fessler, PhD, Weijia Zhang, PhD, Benjamin L. Ebert, MD, DPhil, D. Gary Gilliland, MD, PhD, Jonathan D. Licht, MD

Blood (2008) 112 (11): 3727.

https://doi.org/10.1182/blood.V112.11.3727.3727

Published: 2008

Journal Articles

Integrative Analysis of Genomic Aberration and Gene Expression Suggests That MPD with Loss of Heterozygosity or Gain of Chromosome 9 Represents a Distinct Entity

Weijia Zhang, PhD, Benjamin L. Ebert, MD, DPhil, Windy Berkofsky-Fessler, PhD, Monica Buzzai, PhD, Yezhou Sun, MSc, Caixia Xi, MSc, Ross L Levine, MD, D. Gary Gilliland, MD, PhD, Jonathan D. Licht, MD

Blood (2008) 112 (11): 3735.

https://doi.org/10.1182/blood.V112.11.3735.3735

Published: 2008

Journal Articles

Hedgehog Signaling Is Dispensable for Adult Murine Hematopoiesis and Leukemogenesis.

Inga Hofmann Zhang, MD, Elizabeth H. Stover, Dana E. Cullen, Junhao Mao, PhD, Kelly J. Morgan, PhD, Benjamin H. Lee, MD, PhD, Michael G. Kharas, PhD, Peter G. Miller, Rachel Okabe, Scott A. Armstrong, MD, PhD, Nico Ghilardi, PhD, Stephen Gould, PhD, Fred J. deSauvage, PhD, Andrew P. McMahon, PhD, D. Gary Gilliland, MD, PhD

Blood (2008) 112 (11): 1391.

https://doi.org/10.1182/blood.V112.11.1391.1391

Published: 2008

Journal Articles

Ott1 (Rbm15) Is Required for the Large to Small Pre B-Cell Transition

Michael Kharas, John Manis, MD, D. Gary Gilliland, MD, PhD, Glen D. Raffel, MD, PhD

Blood (2008) 112 (11): 706.

https://doi.org/10.1182/blood.V112.11.706.706

Published: 2008

Journal Articles

Notch Signaling Induces Megakaryocytic Cell Fate.

Thomas Mercher, PhD, Melanie Cornejo, Christopher Sears, PhD, Thomas Kindler, MD PhD, Sandra Moore, Jon Aster, MD PhD, D. Gary Gilliland, MD PhD

Blood (2007) 110 (11): 200.

https://doi.org/10.1182/blood.V110.11.200.200

Published: 2007

Journal Articles

Primary Cell Experiments with TG101348, a JAK2-Selective Inhibitor, in the Presence of Myeloproliferative Disorder-Associated JAK2V617F, MPLW515L/K, and JAK2 Exon 12 Mutations.

Terra L. Lasho, MT, Christy Finke, John D. Hood, PhD, Richard Soll, PhD, Glenn Noronha, PhD, Ruben A. Mesa, MD, Catriona Jamieson, MD, PhD, Srdan Verstovsek, MD, PhD, Jorge Cortes, MD, Hagop Kantarjian, MD, D. Gary Gilliland, MD, PhD, Ayalew Tefferi, MD, Animesh Pardanani, MBBS, PhD

Blood (2007) 110 (11): 3541.

https://doi.org/10.1182/blood.V110.11.3541.3541

Published: 2007

NARROW

Integrated Immunological Analysis of the Bone Marrow Tumor Microenvironment in Myeloproliferative Neoplasms to Determine Potential Efficacy of Immune Checkpoint Blockade

The p110alpha and p110delta Isoforms of PI3 Kinase Are Dispensable for Hematopoietic Stem Cell Self-Renewal but Have Redundant Roles in B Cell Differentiation.

Mtor Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

An ENU Mutagenesis Screen to Identify Genes Involved in the Induction of FLT3-ITD Positive Acute Myeloid Leukemia

KIT with D816 Mutations Cooperates with CBFB-MYH11 for Leukemogenesis in Mice

Leukemogenic Tyrosine Kinases Inhibit PKM2 to Promote the Warburg Effect and Tumor Growth

Longer-Term Follow up with TG101348 Therapy In Myelofibrosis Confirms Sustained Improvement In Splenomegaly, Disease-Related Symptoms, and JAK2 V617F Allele Burden

Leukemia Stem Cells Are Resistant to In Vivo, Cell Non-Autonomous Wnt Inhibition.

Prevalence and Prognostic Impact of Allelic Imbalances Associated with Leukemic Transformation of Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.

A Phase I Evaluation of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis: Clinical Response Is Accompanied by Significant Reduction in JAK2 V617F Allele Burden.

C-KIT with D816Y/V Mutations Cooperate with CBFB-MYH11 to Accelerate Leukemogenesis in Mice.

A Regulatory Network Between Notch and AKT Signaling Pathways Differentially Controls Megakaryocyte Development From Hematopoietic Stem or Committed Progenitor Cells.

Hematopoietic Stem Cell Defects in Novel Fanconi Anemia Mouse Models

Runx1 Is Required for Notch-Induced Specification of Megakaryocyte Development from Early Hematopoietic Stem and Progenitor Cells

NFIB: A Gene Consistently Upregulated in MPD and Frequently Co-Amplified with JAK2V617F Augments Growth of Erythropoietin Dependent Cells

Integrative Analysis of Genomic Aberration and Gene Expression Suggests That MPD with Loss of Heterozygosity or Gain of Chromosome 9 Represents a Distinct Entity

Hedgehog Signaling Is Dispensable for Adult Murine Hematopoiesis and Leukemogenesis.

Ott1 (Rbm15) Is Required for the Large to Small Pre B-Cell Transition

Notch Signaling Induces Megakaryocytic Cell Fate.

Primary Cell Experiments with TG101348, a JAK2-Selective Inhibitor, in the Presence of Myeloproliferative Disorder-Associated JAK2V617F, MPLW515L/K, and JAK2 Exon 12 Mutations.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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