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Ghayas C Issa
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Journal Articles

FLAG-IDA plus venetoclax for children, adolescents, and young adults with newly diagnosed AML

Available to Purchase
Reeja Raj, Samanta Catueno, Amber Gibson, David McCall, Miriam B. Garcia, César Nunez, Michael Roth, Koji Sasaki, Priti Tewari, Ghayas C. Issa, Aziz Farhat, Jeremy Connors, Irtiza Sheikh, Yuki Nishida, Joanna S. Yi, Alexandra M. Stevens, Alex Bataller, Kapil Bhalla, Demetrios Petropoulos, Naval Daver, Tapan Kadia, Branko Cuglievan, Courtney D. DiNardo
Journal: Blood
Blood (2025) 146 (21): 2608–2611.
https://doi.org/10.1182/blood.2025029391
Published: 2025
Includes: Supplemental data
Journal Articles

Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy

Available to Purchase
Sven Turkalj, Felix A. Radtke, Bilyana Stoilova, Rabea Mecklenbrauck, Angus J. Groom, Niels Asger Jakobsen, Curtis A. Lachowiez, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Zhihong Zeng, Sanam Loghavi, Jennifer Marvin-Peek, Verena Körber, Farhad Ravandi, Ghayas C. Issa, Tapan M. Kadia, Vasiliki Symeonidou, Anne P. de Groot, Hagop M Kantarjian, Koichi Takahashi, Marina Konopleva, Courtney D. DiNardo, Paresh Vyas
Journal: Blood
Blood blood.2024027948.
https://doi.org/10.1182/blood.2024027948
Published: 2025
Includes: Supplemental data
Journal Articles

Menin inhibition with revumenib for NPM1 -mutated relapsed or refractory acute myeloid leukemia: the AUGMENT-101 study

Open Access
Clinical Trials & Observations
Martha L. Arellano, Michael J. Thirman, John F. DiPersio, Maël Heiblig, Eytan M. Stein, Andre C. Schuh, Andrius Žučenka, Stephane de Botton, Carolyn S. Grove, Gabriel N. Mannis, Cristina Papayannidis, Alexander E. Perl, Ghayas C. Issa, Ibrahim Aldoss, Ashish Bajel, David S. Dickens, Michael W. M. Kühn, Ioannis Mantzaris, Emmanuel Raffoux, Elie Traer, Irina Amitai, Hartmut Döhner, Corinna Greco, Tibor Kovacsovics, Christine M. McMahon, Pau Montesinos, Arnaud Pigneux, Paul J. Shami, Richard M. Stone, Ofir Wolach, John G. Harpel, Yakov Chudnovsky, Li Yu, Rebecca G. Bagley, Angela R. Smith, James S. Blachly
Journal: Blood
Blood (2025) 146 (9): 1065–1077.
https://doi.org/10.1182/blood.2025028357
Published: 2025
Includes: Supplemental data
Journal Articles

How I treat acute myeloid leukemia with differentiation therapy

Available to Purchase
Ghayas C. Issa, Eytan M. Stein, Courtney D. DiNardo
Journal: Blood
Blood (2025) 145 (12): 1251–1259.
https://doi.org/10.1182/blood.2024024008
Published: 2025
Journal Articles

Phase 1b/2 Study of Magrolimab (Magro), Azacitidine (AZA) and Venetoclax (VEN) in Patients (pts) with Newly Diagnosed (ND) Older/Unfit or High Risk Acute Myeloid Leukemia (AML) and Relapsed Refractory (R/R) AML: Final Clinical Data and Genomic Markers of Resistance/Relapse

Free
Sankalp Arora, Jayastu Senapati, Sanam Loghavi, Patrick K. Reville, Bofei Wang, Tapan M. Kadia, Courtney D. DiNardo, Naveen Pemmaraju, Musa Yilmaz, Joseph E. Jabbour, Nicholas J. Short, Guillermo Montalban-Bravo, Abhishek Maiti, Guilin Tang, Koji Sasaki, Gautam Borthakur, Joie Alvarez, Sherry Pierce, Graciela M. Nogueras González, Jing Ning, Ghayas C. Issa, Michael Andreeff, Farhad Ravandi, Guillermo Garcia-Manero, Hussein A. Abbas, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 735.
https://doi.org/10.1182/blood-2024-203706
Published: 2024
Journal Articles

A Phase II Trial of Venetoclax in Combination with Cladribine, Idarubicin, and Cytarabine in Newly Diagnosed Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome

Free
Ian M. Bouligny, Hagop M. Kantarjian, Musa Yilmaz, Naval Daver, Gautam Borthakur, Courtney D. DiNardo, Guillermo Montalban-Bravo, Nicholas J. Short, Yesid Alvarado Valero, Elias Jabbour, Nitin Jain, Naveen Pemmaraju, Danielle Hammond, Kelly S. Chien, Koichi Takahashi, Ghayas C. Issa, Hussein A. Abbas, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2024) 144 (Supplement 1): 734.
https://doi.org/10.1182/blood-2024-203459
Published: 2024
Journal Articles

Establishing Benchmarks for Relapse-Free and Overall Survival Among Patients (Pts) with Newly Diagnosed AML Not Undergoing Allogeneic Stem Cell Transplantation (SCT) in First Remission

Free
Eitan Kugler, Hagop M. Kantarjian, Alexandre Bazinet, Wei-Ying Jen, Naval Daver, Courtney D. DiNardo, Nicholas J. Short, Jayastu Senapati, Gautam Borthakur, Naveen Pemmaraju, Ghayas C. Issa, Alex Bataller, Patrick K. Reville, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2024) 144 (Supplement 1): 2861.
https://doi.org/10.1182/blood-2024-199903
Published: 2024
Journal Articles

Incidence, Characteristics, and Outcomes of Patients with Newly Diagnosed, De Novo KIT -Mutated Non-Core Binding Factor Acute Myeloid Leukemia without Systemic Mastocytosis

Free
Eitan Kugler, Sanam Loghavi, Farhad Ravandi, Courtney D. DiNardo, Naval Daver, Tapan M. Kadia, Gautam Borthakur, Ghayas C. Issa, Hussein A. Abbas, Prithviraj Bose, Jayastu Senapati, Hagop M. Kantarjian, Nicholas J. Short
Journal: Blood
Blood (2024) 144 (Supplement 1): 2857.
https://doi.org/10.1182/blood-2024-199917
Published: 2024
Journal Articles

Clinical Outcomes Associated with NPM1 Mutations in Newly Diagnosed AML

Free
Aziz Farhat, Hagop M. Kantarjian, Koji Sasaki, Nicholas J. Short, Branko Cuglievan, Sanam Loghavi, Keyur P. Patel, Alex Bataller, Musa Yilmaz, Guillermo Montalban-Bravo, Danielle Hammond, Naveen Pemmaraju, Naval Daver, Farhad Ravandi, Elias Jabbour, Tapan M. Kadia, Gautam Borthakur, Guillermo Garcia-Manero, Courtney D. DiNardo, Ghayas C. Issa
Journal: Blood
Blood (2024) 144 (Supplement 1): 2853.
https://doi.org/10.1182/blood-2024-205504
Published: 2024
Journal Articles

Older Age and TP53 Mutations Are Predictors for the Development of Therapy-Related Myeloid Neoplasms in Adults Undergoing Frontline Therapy for Acute Lymphoblastic Leukemia

Free
Roberta Santos Azevedo, Hagop M. Kantarjian, Koichi Takahashi, Cedric Christophe Nasnas, Sanam Loghavi, Nitin Jain, Fadi G. Haddad, Jayastu Senapati, Ghayas C. Issa, Hussein A. Abbas, Tapan M. Kadia, Kelly S. Chien, Guillermo Montalban-Bravo, Rebecca Garris, Farhad Ravandi, Elias Jabbour, Nicholas J. Short
Journal: Blood
Blood (2024) 144 (Supplement 1): 728.
https://doi.org/10.1182/blood-2024-207745
Published: 2024
Journal Articles

Early Achievement of Deep Measurable Residual Disease (MRD) Negativity Identifies Patients with B-Cell Acute Lymphoblastic Leukemia (ALL) Who Have Excellent Long-Term Outcomes and Do Not Benefit from Allogeneic Stem Cell Transplant, Irrespective of Baseline High-Risk Cytomolecular Features

Free
Walid Macaron, Elias Jabbour, Nitin Jain, Fadi G. Haddad, Jayastu Senapati, Partow Kebriaei, Eitan Kugler, Kelly S. Chien, Ghayas C. Issa, Jairo Matthews, Rebecca Garris, Farhad Ravandi, Hagop M. Kantarjian, Nicholas J. Short
Journal: Blood
Blood (2024) 144 (Supplement 1): 727.
https://doi.org/10.1182/blood-2024-203929
Published: 2024
Journal Articles

Treatment Intensity in Acute Myeloid Leukemia with Extramedullary Disease

Free
Jennifer Marvin-Peek, Wei-Ying Jen, Nicholas J. Short, Ghayas C. Issa, Musa Yilmaz, Guillermo Montalban-Bravo, Alexandre Bazinet, Koji Sasaki, Abhishek Maiti, Gautam Borthakur, Danielle Hammond, Kelly S. Chien, Hussein A. Abbas, Naveen Pemmaraju, Guillermo Garcia-Manero, Elias Jabbour, Farhad Ravandi, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo
Journal: Blood
Blood (2024) 144 (Supplement 1): 2851.
https://doi.org/10.1182/blood-2024-202429
Published: 2024
Journal Articles

Asciminib (ASC) Demonstrates Favorable Safety and Tolerability Compared with Each Investigator-Selected Tyrosine Kinase Inhibitor (IS TKI) in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CML-CP) in the Pivotal Phase 3 ASC4FIRST Study

Free
Jorge E. Cortes, Andreas Hochhaus, Timothy P Hughes, Jianxiang Wang, Dong-Wook Kim, Dennis Dong Hwan Kim, Jiri Mayer, Yeow Tee Goh, Philipp le Coutre, Gabriel Etienne, Naoto Takahashi, Inho Kim, David Andorsky, Ghayas C. Issa, Felice Bombaci, Shruti Kapoor, Rajendra Jinwal, Lillian Yau, Richard Larson
Journal: Blood
Blood (2024) 144 (Supplement 1): 475.
https://doi.org/10.1182/blood-2024-203757
Published: 2024
Journal Articles

A Phase II Study of Time-Limited Treatment with Acalabrutinib Plus Obinutuzumab in Patients with Treatment-Naïve Chronic Lymphocytic Leukemia

Free
Jan A. Burger, Ekaterina Kim, Gitanjali Jayachandran, Wanda Lopez, Ghayas C. Issa, Musa Yilmaz, Mahesh Swaminathan, Jo Ishizawa, Alexandre Bazinet, Yesid Alvarado Valero, Nitin Jain, William G. Wierda, Alessandra Ferrajoli
Journal: Blood
Blood (2024) 144 (Supplement 1): 1868.
https://doi.org/10.1182/blood-2024-200331
Published: 2024
Journal Articles

Phase Ib/II Study of CPX-351 Plus Venetoclax in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)

Free
Vanthana Bharathi, Alex Bataller, Alexandre Bazinet, Gautam Borthakur, Elias Jabbour, Naval Daver, Nicholas J. Short, Koichi Takahashi, Ghayas C. Issa, Courtney D. DiNardo, Naveen Pemmaraju, Nitin Jain, Guillermo Montalban-Bravo, William G. Wierda, Farhad Ravandi, Hagop M. Kantarjian, Tapan M. Kadia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4272.
https://doi.org/10.1182/blood-2024-209157
Published: 2024
Journal Articles

Interim Results of the Phase II Study Investigating CPX-351 in Combination with Ivosidenib for Patients with IDH1-Mutated Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome

Free
Jennifer Croden, Danielle Hammond, Kelly S. Chien, Abhishek Maiti, George Donovan Tippett, Guillermo Montalban-Bravo, Michael Morales, Nicholas J. Short, Hussein A. Abbas, Ghayas C. Issa, Tapan M. Kadia, Gautam Borthakur, Farhad Ravandi, Courtney D. DiNardo
Journal: Blood
Blood (2024) 144 (Supplement 1): 4271.
https://doi.org/10.1182/blood-2024-207476
Published: 2024
Journal Articles

Phase 1b/2 Study of Decitabine and Venetoclax in Combination with the Targeted Mutant IDH1 Inhibitor Olutasidenib for Patients with Relapsed/Refractory AML, High Risk MDS, or Newly Diagnosed AML Not Eligible for Chemotherapy with an IDH1 Mutation

Free
Courtney D. DiNardo, Kelly S. Chien, Jillian Mullin, Danielle Hammond, Jeremy Ramdial, Tapan M. Kadia, Fadi G. Haddad, Musa Yilmaz, Koji Sasaki, Ghayas C. Issa, Koichi Takahashi, Elizabeth J. Shpall, Farhad Ravandi, Naval Daver, Hagop Kantarjian
Journal: Blood
Blood (2024) 144 (Supplement 1): 1527.2.
https://doi.org/10.1182/blood-2024-208771
Published: 2024
Journal Articles

A Phase I/II Study of Gilteritinib and Momelotinib for Patients with Relapsed/Refractory FLT3 -Mutated Acute Myeloid Leukemia: A Trial in Progress

Free
Nicholas J. Short, Farhad Ravandi, Naval Daver, Courtney D. DiNardo, Gautam Borthakur, Tapan M. Kadia, Musa Yilmaz, Ghayas C. Issa, Regina Abramova, Araceli Isabella Garza, Hagop M. Kantarjian, Hussein A. Abbas
Journal: Blood
Blood (2024) 144 (Supplement 1): 4288.1.
https://doi.org/10.1182/blood-2024-200923
Published: 2024
Journal Articles

Outcomes of Adult Patients with Newly Diagnosed IDH-Mutated Acute Myeloid Leukemia Receiving Intensive Chemotherapy Plus Venetoclax

Free
Jennifer Croden, Jennifer Marvin-Peek, Marina Konopleva, Gautam Borthakur, Naval Daver, Hussein A. Abbas, Koichi Takahashi, Koji Sasaki, Guillermo Garcia-Manero, Nitin Jain, Naveen Pemmaraju, Nicholas J. Short, Danielle Hammond, Elias Jabbour, Lucia Masarova, Kelly S. Chien, Ghayas C. Issa, Guillermo Montalban-Bravo, Musa Yilmaz, Abhishek Maiti, Yesid Alvarado Valero, Steven M. Kornblau, Farhad Ravandi, Hagop Kantarjian, Tapan M. Kadia, Courtney D. DiNardo
Journal: Blood
Blood (2024) 144 (Supplement 1): 6126.
https://doi.org/10.1182/blood-2024-207413
Published: 2024
Journal Articles

Impact of Flow Cytometry-Based Measurable Residual Disease Clearance Kinetics in Patients with Acute Myeloid Leukemia Undergoing Intensive Chemotherapy

Free
Wei-Ying Jen, Koji Sasaki, Farhad Ravandi, Tapan M. Kadia, Sa A. Wang, Wei Wang, Sanam Loghavi, Naval Daver, Courtney D. DiNardo, Ghayas C. Issa, Hussein A. Abbas, Cedric Nasnas, Alex Bataller, Samuel Urrutia, Sherry Pierce, Hagop M. Kantarjian, Nicholas J. Short
Journal: Blood
Blood (2024) 144 (Supplement 1): 1572.
https://doi.org/10.1182/blood-2024-212036
Published: 2024