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James A Kennedy
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Journal Articles

Stem Cell-Derived Gene Expression Scores Predict Survival and Leukemic Transformation in Myelofibrosis

Jessie J.F. Medeiros, Andy G.X. Zeng, Michelle Chan-Seng-Yue, Tristan Woo, Jessica L McLeod, Andrea Arruda, Hubert Tsui, Burhan Goraya, Jaime O. Claudio, Jenny M. Ho, James A. Kennedy, Dawn Maze, Hassan Sibai, Mark D. Minden, Jean C.Y. Wang, John E. Dick, Vikas Gupta
Journal: Blood
Blood (2022) 140 (Supplement 1): 9681–9682.
https://doi.org/10.1182/blood-2022-163722
Published: 2022
Journal Articles

Comparison of Clinical Outcomes between Transplant and Non-Transplant Therapies in Myelofibrosis Following Failure of First-Line JAK-Inhibitor

James T. England, Eshetu G. Atenafu, James A. Kennedy, Burhan Goraya, Verna Cheung, Taylor Nye, Karine Gauthier, Marta B. Davidson, Aniket Bankar, Hassan Sibai, Dawn Maze, Auro Viswabandya, Vikas Gupta
Journal: Blood
Blood (2022) 140 (Supplement 1): 9724–9725.
https://doi.org/10.1182/blood-2022-165272
Published: 2022
Journal Articles

Lenalidomide promotes the development of TP53 -mutated therapy-related myeloid neoplasms

Clinical Trials & Observations
Adam S. Sperling, Veronica A. Guerra, James A. Kennedy, Yuanqing Yan, Joanne I. Hsu, Feng Wang, Andrew T. Nguyen, Peter G. Miller, Marie E. McConkey, Vanessa A. Quevedo Barrios, Ken Furudate, Linda Zhang, Rashmi Kanagal-Shamanna, Jianhua Zhang, Latasha Little, Curtis Gumbs, Naval Daver, Courtney D. DiNardo, Tapan Kadia, Farhad Ravandi, Hagop Kantarjian, Guillermo Garcia-Manero, P. Andrew Futreal, Benjamin L. Ebert, Koichi Takahashi
Journal: Blood
Blood (2022) 140 (16): 1753–1763.
https://doi.org/10.1182/blood.2021014956
Published: 2022
Includes: Supplemental data
Journal Articles

KDM6 Demethylases Integrate DNA Repair Gene Regulation: Loss of KDM6A Sensitizes AML to PARP Inhibition and Potentiates with BCL2 Blockade

Liberalis Debraj Boila, Liqing Jin, Alex Murison, Subham K. Bandyopadhyay, Subhadeep Ghosh, Siva Sai Naga Anurag Muddineni, Andy G.X. Zeng, Sayantani Sinha, Shankha Subhra Chatterjee, Mayukh Biswas, Nathan Mbong, Olga I. Gan, Andrea Arruda, Wasim Shaikh, Anwesha Bose, Satyaki Bhowmik, Sayan Chakraborty, James A. Kennedy, Amanda Mitchell, Eric R. Lechman, Debasis Banerjee, Michael Milyavsky, Mark D. Minden, John E. Dick, Amitava Sengupta
Journal: Blood
Blood (2021) 138 (Supplement 1): 25.
https://doi.org/10.1182/blood-2021-145491
Published: 2021
Journal Articles

Modeling and targeting of erythroleukemia by hematopoietic genome editing

Ilaria Iacobucci, Chunxu Qu, Elena Varotto, Laura J. Janke, Xu Yang, Aman Seth, Anang Shelat, Jake D. Friske, Reiji Fukano, Jiyang Yu, Burgess B. Freeman, III, James A. Kennedy, Adam S. Sperling, Rena Zheng, Yingzhe Wang, Harini Jogiraju, Kirsten M. Dickerson, Debbie Payne-Turner, Sarah M. Morris, Emily S. Hollis, Nina Ghosn, Georgia E. Haggard, R. Coleman Lindsley, Benjamin L. Ebert, Charles G. Mullighan
Journal: Blood
Blood (2021) 137 (12): 1628–1640.
https://doi.org/10.1182/blood.2020009103
Published: 2021
Includes: Supplemental data
Journal Articles

Clinical Significance of Emergent Leukocytosis in Patients with Myelofibrosis Receiving JAK Inhibitor Therapy

Radovan Vasic, MD MHS, Yuliang Shi, Andrea Arruda, MSc, Sarah Malik, Jaime Claudio, PhD, Jose-Mario Capo-Chichi, PhD, Aniket Bankar, MBBS, MD DM, Hassan Sibai, MBBS, Dawn Maze, MDFRCPC,MSc, James A. Kennedy, MDPhD, Wei Xu, PhD, Vikas Gupta, MD FRCP, FRCPath
Journal: Blood
Blood (2020) 136 (Supplement 1): 22.
https://doi.org/10.1182/blood-2020-139936
Published: 2020
Journal Articles

Variation in Stem Cell Driven Hierarchies Underlies Clinical Outcome and Drug Response in AML

Andy G.X. Zeng, BSc, Amanda Mitchell, PhD, Oleksandr Galkin, PhD, Jean C.Y. Wang, MD PhD, James A. Kennedy, MDPhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
https://doi.org/10.1182/blood-2020-140895
Published: 2020
Journal Articles

Sirpαfc Treatment Targets Human Acute Myeloid Leukemia Stem Cells

Oleksandr Galkin, PhD, Jessica McLeod, BSc, James A Kennedy, MD PhD, Liqing Jin, MD, Nathan Mbong, Mark Wong, PhD, Bob Uger, PhD, Mark D. Minden, MD PhD, Jayne S Danska, PhD, Jean C.Y. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3906.
https://doi.org/10.1182/blood-2019-131018
Published: 2019
Journal Articles

HSCs Fated to Progress to Blast Phase Can be Detected in Myelofibrosis Patients Several Years Prior to Leukemic Transformation

Jenny M. Ho, MD, Jessie J.F. Medeiros, BSc, Michelle Chan-Seng-Yue, Lauren Hummel, BSc, Andrea Arruda, Amanda Mitchell, PhD, Caroline J McNamara, MBBS, James A Kennedy, MD PhD, Anne Tierens, MD PhD, Dawn Maze, MDFRCPC,MSc, Hubert Tsui, MD PhD, Mark D. Minden, MD PhD, Vikas Gupta, MD FRCP, FRCPath, John E. Dick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1676.
https://doi.org/10.1182/blood-2019-130923
Published: 2019
Journal Articles

Distinct patterns of clonal evolution in patients with concurrent myelo- and lymphoproliferative neoplasms

James A. Kennedy, Jessie J. F. Medeiros, Stephanie M. Dobson, Andrea Arruda, Mahadeo A. Sukhai, Tracy Stockley, Anne Tierens, Mark D. Minden, Suzanne Kamel-Reid, John E. Dick, Vikas Gupta
Journal: Blood
Blood (2018) 132 (20): 2201–2205.
https://doi.org/10.1182/blood-2018-04-845065
Published: 2018
Includes: Supplemental data
Journal Articles

Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice

Emma C. Fink, Marie McConkey, Dylan N. Adams, Saurav D. Haldar, James A. Kennedy, Andrew A. Guirguis, Namrata D. Udeshi, D. R. Mani, Michelle Chen, Brian Liddicoat, Tanya Svinkina, Andrew T. Nguyen, Steven A. Carr, Benjamin L. Ebert
Journal: Blood
Blood (2018) 132 (14): 1535–1544.
https://doi.org/10.1182/blood-2018-05-852798
Published: 2018
Includes: Supplemental data
Journal Articles

Donor-engrafted CHIP is common among stem cell transplant recipients with unexplained cytopenias

Christopher J. Gibson, James A. Kennedy, Sarah Nikiforow, Frank C. Kuo, Edwin P. Alyea, Vincent Ho, Jerome Ritz, Robert Soiffer, Joseph H. Antin, R. Coleman Lindsley
Journal: Blood
Blood (2017) 130 (1): 91–94.
https://doi.org/10.1182/blood-2017-01-764951
Published: 2017
Includes: Supplemental data
Journal Articles

Impact of Genomic Alterations on Outcomes in Myelofibrosis Patients Undergoing JAK1/2 Inhibitor Therapy

Jay Spiegel, MD, Caroline Jane McNamara, MBBS, Andrea Arruda, MSc., Tony Panzarella, BSc MSc, James A. Kennedy, MD PhD, Tracy L. Stockley, PhD, Mahadeo Sukhai, BSc, MSc, PhD, Mariam Thomas, PhD, Justyna Bartoszko, MD, Jenny M. Ho, MD, Nancy Siddiq, RN, BScN, Aaron D. Schimmer, MD PhD, Andre C. Schuh, MD FRCPC, Hassan Sibai, MD, Karen W.L. Yee, MD, Jaime O. Claudio, PhD, Rebecca Devlin, PhD, Mark D. Minden, MD PhD, Suzanne Kamel-Reid, PhD DABMG, FACMG, Vikas Gupta, MD FRCP, FRCPath
Journal: Blood
Blood (2016) 128 (22): 4263.
https://doi.org/10.1182/blood.V128.22.4263.4263
Published: 2016
Journal Articles

Donor Chip Causes Donor-Derived Clonal Hematopoiesis As an Early Complication of Allogeneic Stem Cell Transplantation

Christopher J. Gibson, MD, James A. Kennedy, MDPhD, Sarah Nikiforow, MD PhD, John E. Dick, PhD, Jerome Ritz, MD, Robert J. Soiffer, MD, Joseph H. Antin, MD, R. Coleman Lindsley, MD PhD
Journal: Blood
Blood (2016) 128 (22): 987.
https://doi.org/10.1182/blood.V128.22.987.987
Published: 2016
Journal Articles

Chromatin Accessibility Identifies CTCF As a Gatekeeper of Stemness Functions in Human Hematopoietic Development

Naoya Takayama, MD PhD, Alex Murison, PhD, Shin-ichiro Takayanagi, PhD, Sasan Zandi, MD PhD, Nadia Penrod, PhD, Amanda Mitchel, James A. Kennedy, MD PhD, Stanley W.K. Ng, MSc, Stephanie Zhi-Juan Xie, PhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Mathieu Lupien, PhD
Journal: Blood
Blood (2016) 128 (22): 3873.
https://doi.org/10.1182/blood.V128.22.3873.3873
Published: 2016
Journal Articles

Mir-125a Confers Multi-Lineage Long-Term Repopulating Stem Cell Activity to Human Hematopoietic Committed Progenitors

Eric R. Lechman, PhD, Karin G. Hermans, PhD, Erwin M. Schoof, PhD, Aaron Trotman-Grant, BS, Stephanie M Dobson, MSc, Gabriela Krivdova, MS, Janneke J. Elzinga, James A. Kennedy, MDPhD, Olga I Gan, PhD, John E Dick, PhD
Journal: Blood
Blood (2015) 126 (23): 900.
https://doi.org/10.1182/blood.V126.23.900.900
Published: 2015
Journal Articles

Engraftment Patterns in NOD. SCID Mice Predict Outcome in Human AML

James A. Kennedy, MDPhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Liqing Jin, MD, Stanley Wai-Kwong Ng, BASc, Liran I. Shlush, MDPhD, Sasan Zandi, MDPhD, Jessica McLeod, BSc, Andreea C. Popescu, BSc, Nathan Mbong, BSc, Andrea Arruda, MSc, Mark D Minden, MDPhD, John E. Dick, PhD, Jean C.Y. Wang, MDPhD
Journal: Blood
Blood (2014) 124 (21): 16.
https://doi.org/10.1182/blood.V124.21.16.16
Published: 2014
Journal Articles

Modeling the Multi-Step Pathogenesis of Acute Myeloid Leukemia of Down Syndrome

Eric R. Lechman, PhD, Karin G. Hermans, PhD, Stephanie M. Dobson, BSc, Olga I. Gan, PhD, James A. Kennedy, MDPhD, John Chen, PhD, Johann K. Hitzler, MD, John E. Dick, PhD
Journal: Blood
Blood (2014) 124 (21): 3579.
https://doi.org/10.1182/blood.V124.21.3579.3579
Published: 2014
Journal Articles

Mir-126 Governs Human Leukemia Stem Cell Quiescence and Chemotherapy Resistance

Eric R. Lechman, PhD, Bernhard Gentner, MD, Peter van Galen, Stanley Wai-Kwong Ng, Kolja Eppert, PhD, Rene Marke, Liran Slush, MD, James A. Kennedy, MD PhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Veronique Voisin, PhD, Gary Bader, PhD, Mark D. Minden, MD, PhD, Jun Lu, PhD, Jean C.Y. Wang, MD PhD, Luigi Naldini, John E. Dick, PhD
Journal: Blood
Blood (2013) 122 (21): 1647.
https://doi.org/10.1182/blood.V122.21.1647.1647
Published: 2013
Journal Articles

Leukemic Engraftment In NOD. SCID Mice Is Correlated With Clinical Parameters and Predicts Outcome In Human AML

James A. Kennedy, MD PhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Jessica McLeod, Andreea C. Popescu, BSc, Andrea Arruda, MSc, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2013) 122 (21): 50.
https://doi.org/10.1182/blood.V122.21.50.50
Published: 2013