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Journal Articles

Novel Therapeutics Targeting Acute Myeloid Leukemia (AML) Stem Cells Identified through High-Throughput Screening

Isabella Iasenza, Safia Safa, Frederic Barabe, Sonia Cellot, Brian T. Wilhelm, Kolja Eppert

Blood (2023) 142 (Supplement 1): 5011.

https://doi.org/10.1182/blood-2023-189351

Published: 2023

Journal Articles

The Role of Histone H3-K27M Mutation in Preleukemic HSC Expansion

Hassan Dakik, Meaghan Boileau, Samantha Worme, Selin Jessa, Isabella Iasenza, Andrea Neumann, Yi Ling Sun, Manon Saby, Morgan Craig, Claudia L Kleinman, Kolja Eppert

Blood (2022) 140 (Supplement 1): 5839.

https://doi.org/10.1182/blood-2022-167571

Published: 2022

Journal Articles

High-Throughput Chemical Screen on Acute Myeloid Leukemia Stem Cells Identifies Novel Anti-LSC Compounds

Isabella Angela Iasenza, Safia Safa, Frederic Barabe, Sonia Cellot, Brian T. Wilhelm, Kolja Eppert

Blood (2021) 138 (Supplement 1): 1871.

https://doi.org/10.1182/blood-2021-145369

Published: 2021

Journal Articles

Single-Cell Transcriptomic Profiling of De Novo and Relapsed Acute Myeloid Leukemia Identifies a Leukemic Stemness Program Shared across Diverse Phenotypes

Samantha Worme, BSc, Selin Jessa, BSc, William Poon, BSc, Maja Jankovic, MSc, Gabriela Galicia Vazquez, PhD, Alexandre Bazinet, MD, Katharine Fooks, BSc, Isabella Iasenza, BSc, Patricia Arreba-Tutusaus, PhD, Kolja Eppert, PhD, Ioannis Ragoussis, PhD, Yu Chang Wang, PhD, Nathalie A Johnson, MD PhD, Sarit E Assouline, MD MSc, Claudia L Kleinman, PhD, François E Mercier, MD

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-143221

Published: 2020

Journal Articles

Novel Therapeutics That Can Target and Eradicate Leukemic Stem Cells in Acute Myeloid Leukemia: Investigating FDA-Approved Anti-Inflammatory Compounds

Isabella Iasenza, Meaghan Boileau, BSc, Andrea Neumann, BSc., Héloïse Frison, MSc., Mark D. Minden, MD PhD, Isabelle Laverdiere, BPharm, MSc, PhD, Kolja Eppert, MSc, PhD

Blood (2019) 134 (Supplement_1): 5052.

https://doi.org/10.1182/blood-2019-125338

Published: 2019

Journal Articles

Single Cell Transcriptomic Analysis of the Histone H3 K27M Mutation in Pre-Leukemic Hematopoietic Stem Cells

Meaghan Boileau, BSc, Selin Jessa, BSc, Samantha Worme, BSc, Damien Faury, Nada Jabado, MD PhD, François Mercier, MD, Claudia Kleinman, PhD, Kolja Eppert, MSc, PhD

Blood (2019) 134 (Supplement_1): 3773.

https://doi.org/10.1182/blood-2019-123769

Published: 2019

Journal Articles

Isolation of CD34 − and CD34 + Leukemia Stem Cells from Acute Myeloid Leukemia Blasts Using CD200

Jenny M. Ho, MD, Stephanie M. Dobson, PhD, Jessica McLeod, BSc, Veronique Voisin, PhD, Alex Murison, James Kennedy, MD PhD, Sasan Zandi, MD PhD, Kolja Eppert, MSc, PhD, Mark D. Minden, MD PhD, Mathieu Lupien, John E. Dick, PhD, Jean C.Y. Wang, MD PhD

Blood (2018) 132 (Supplement 1): 2790.

https://doi.org/10.1182/blood-2018-99-119318

Published: 2018

Journal Articles

Leukemic Stem Cell Expression Signatures Identify Novel Therapeutics for Acute Myeloid Leukemia

Meaghan Boileau, BSc, Isabelle Laverdiere, BPharm, MSc, PhD, Amanda Mitchell, PhD, Stanley W.K. Ng, Jean Wang, MD PhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Kolja Eppert, MSc, PhD

Blood (2017) 130 (Supplement 1): 3815.

https://doi.org/10.1182/blood.V130.Suppl_1.3815.3815

Published: 2017

Journal Articles

CD200 Is a Marker of LSC Activity in Acute Myeloid Leukemia

Jenny M. Ho, MD, Stephanie M. Dobson, Jessica McLeod, Liqing Jin, MD PhD, Stanley W.K. Ng, MSc, Amanda Mitchell, PhD, Liran I. Shlush, MD PhD, Sasan Zandi, MD PhD, Kolja Eppert, PhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD

Blood (2016) 128 (22): 1705.

https://doi.org/10.1182/blood.V128.22.1705.1705

Published: 2016

Journal Articles

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo

Blood (2016) 127 (16): 2018–2027.

https://doi.org/10.1182/blood-2015-11-683649

Published: 2016

Includes: Supplemental data

Journal Articles

G Protein-Coupled Receptor 56 As a Potential Regulator of Normal and Leukemic Stem Cells

Heather Duncan, MSc, Karin G. Hermans, PhD, Sara Chisling, Isabelle Laverdiere, B.Pharm, PhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Kolja Eppert, PhD

Blood (2015) 126 (23): 4267.

https://doi.org/10.1182/blood.V126.23.4267.4267

Published: 2015

Journal Articles

Identification of Existing Bioactive Compounds That Target Acute Myeloid Leukemia Stem Cells

Isabelle Laverdiere, B.Pharm, PhD, Andrea L. Neumann, BSc, Meaghan Boileau, BSc, Heather Duncan, MSc, Sara Chisling, Amanda Mithchell, PhD, Stanley W.K. Ng, MSc, Jean C.Y. Wang, MDPhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Kolja Eppert, PhD

Blood (2015) 126 (23): 3681.

https://doi.org/10.1182/blood.V126.23.3681.3681

Published: 2015

Journal Articles

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD PhD, Katherine Sullivan, Paulina Podszywalow-Bartnicka, Grazyna Hoser, PhD, Elisabeth Bolton-Gillespie, Kimberly Cramer-Morales, Artur Slupianek, PhD, Chun Zhou, PhD, Sabine Cerny-Reiterer, DVM, Tomasz Stoklosa, MD PhD, Stephen M. Sykes, PhD, Peter Valent, MD, Curt I. Civin, MD, Markus Muschen, MD PhD, Mark D. Minden, MD PhD, Kolja Eppert, PhD, Tomasz Skorski, MD PhD

Blood (2014) 124 (21): 480.

https://doi.org/10.1182/blood.V124.21.480.480

Published: 2014

Journal Articles

Mir-126 Governs Human Leukemia Stem Cell Quiescence and Chemotherapy Resistance

Eric R. Lechman, PhD, Bernhard Gentner, MD, Peter van Galen, Stanley Wai-Kwong Ng, Kolja Eppert, PhD, Rene Marke, Liran Slush, MD, James A. Kennedy, MD PhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Veronique Voisin, PhD, Gary Bader, PhD, Mark D. Minden, MD, PhD, Jun Lu, PhD, Jean C.Y. Wang, MD PhD, Luigi Naldini, John E. Dick, PhD

Blood (2013) 122 (21): 1647.

https://doi.org/10.1182/blood.V122.21.1647.1647

Published: 2013

Journal Articles

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside

Sean P. McDermott, Kolja Eppert, Faiyaz Notta, Methvin Isaac, Alessandro Datti, Rima Al-awar, Jeff Wrana, Mark D. Minden, John E. Dick

Blood (2012) 119 (5): 1200–1207.

https://doi.org/10.1182/blood-2011-01-330019

Published: 2012

Includes: Supplemental data

Journal Articles

Identification and Characterization of Human Leukemia Stem Cell Functional Regulators

Kolja Eppert, PhD, Karin G Hermans, PhD, John E. Dick, PhD

Blood (2011) 118 (21): 2955.

https://doi.org/10.1182/blood.V118.21.2955.2955

Published: 2011

Journal Articles

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Jinghui Zhang, PhD, Li Ding, PhD, Linda Holmfeldt, PhD, Gang Wu, PhD, Susan L. Heatley, Ph.D., Debbie Payne-Turner, John Easton, PhD, Xiang Chen, PhD, Jianmin Wang, PhD, Michael Rusch, BA, Charles Lu, PhD, Shann-Ching Chen, PhD, Racquel Collins-Underwood, PhD, Jing Ma, PhD, Kathryn G. Roberts, PhD, Stanley Pounds, PhD, Lei Wei, PhD, Anatoly Ulyanov, PhD, Jared Becksfort, Pankaj Gupta, Robert Huether, PhD, Richard Kriwacki, PhD, Daniel McGoldrick, David Zhao, Daniel Alford, Stephen Espy, Kiran Chand Bobba, Guangchun Song, Deqing Pei, MS, Cheng Cheng, PhD, Stefan Roberts, Michael Barbato, Dario Campana, MD, PhD, Elaine Coustan-Smith, MS, William E. Evans, PharmD, Sheila A Shurtleff, PhD, Maria Kleppe, Jan Cools, PhD, Kristin Shimano, Michelle L. Hermiston, MD, PhD, Sergei Doulatov, PhD, Kolja Eppert, PhD, Elisa Laurenti, PhD, Faiyaz Notta, PhD, John E Dick, PhD, Giuseppe Basso, MD PhD, Stephen P. Hunger, MD, Mignon L Loh, MD, Meenakshi Devidas, PhD, Brent L. Wood, MD, PhD, Stuart S. Winter, MD, Kimberly Dunsmore, MD, Robert S. Fulton, MS, Lucinda A. Fulton, MS, Xin Hong, PhD, Christopher C. Harris, BS, David J. Dooling, PhD, Kerri Ochoa, Kimberly J Johnson, John C Obenauer, Ching-Hon Pui, MD, Susana C. Raimondi, PhD, Clayton W Naeve, PhD, Timothy J Ley, MD, Elaine R Mardis, PhD, Richard K Wilson, PhD, James R Downing, MD, Charles G Mullighan, MBBS, MD, FRACP, FRCPA, MSc

Blood (2011) 118 (21): 68.

https://doi.org/10.1182/blood.V118.21.68.68

Published: 2011

Journal Articles

Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production

Blood (2011) 118 (21): 61.

https://doi.org/10.1182/blood.V118.21.61.61

Published: 2011

Journal Articles

Enriched MicroRNA-126 Bioactivity Marks the Primitive Compartment In AML and Regulates LSC Numbers

Eric Lechman, PhD, Bernhard Gentner, MD, Hidefumi Hiramatsu, MD, Kristin J Hope, PhD, Katsuto Takenaka, MD, Kolja Eppert, PhD, Mark D. Minden, MD, PhD, Luigi Naldini, MD, PhD, John E. Dick, PhD

Blood (2010) 116 (21): 94.

https://doi.org/10.1182/blood.V116.21.94.94

Published: 2010

Journal Articles

Comparison of human cord blood engraftment between immunocompromised mouse strains

Sean P. McDermott, Kolja Eppert, Eric R. Lechman, Monica Doedens, John E. Dick

Blood (2010) 116 (2): 193–200.

https://doi.org/10.1182/blood-2010-02-271841

Published: 2010

Includes: Supplemental data

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Novel Therapeutics Targeting Acute Myeloid Leukemia (AML) Stem Cells Identified through High-Throughput Screening

The Role of Histone H3-K27M Mutation in Preleukemic HSC Expansion

High-Throughput Chemical Screen on Acute Myeloid Leukemia Stem Cells Identifies Novel Anti-LSC Compounds

Single-Cell Transcriptomic Profiling of De Novo and Relapsed Acute Myeloid Leukemia Identifies a Leukemic Stemness Program Shared across Diverse Phenotypes

Novel Therapeutics That Can Target and Eradicate Leukemic Stem Cells in Acute Myeloid Leukemia: Investigating FDA-Approved Anti-Inflammatory Compounds

Single Cell Transcriptomic Analysis of the Histone H3 K27M Mutation in Pre-Leukemic Hematopoietic Stem Cells

Isolation of CD34 − and CD34 + Leukemia Stem Cells from Acute Myeloid Leukemia Blasts Using CD200

Leukemic Stem Cell Expression Signatures Identify Novel Therapeutics for Acute Myeloid Leukemia

CD200 Is a Marker of LSC Activity in Acute Myeloid Leukemia

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo

G Protein-Coupled Receptor 56 As a Potential Regulator of Normal and Leukemic Stem Cells

Identification of Existing Bioactive Compounds That Target Acute Myeloid Leukemia Stem Cells

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

Mir-126 Governs Human Leukemia Stem Cell Quiescence and Chemotherapy Resistance

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside

Identification and Characterization of Human Leukemia Stem Cell Functional Regulators

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production

Enriched MicroRNA-126 Bioactivity Marks the Primitive Compartment In AML and Regulates LSC Numbers

Comparison of human cord blood engraftment between immunocompromised mouse strains

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