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Journal Articles

Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms

Sunil K. Joshi, Kristin Qian, William H. Bisson, Kevin Watanabe-Smith, Ariane Huang, Daniel Bottomly, Elie Traer, Jeffrey W. Tyner, Shannon K. McWeeney, Monika A. Davare, Brian J. Druker, Cristina E. Tognon

Blood (2020) 135 (24): 2159–2170.

https://doi.org/10.1182/blood.2019003691

Published: 2020

Includes: Supplemental data

Journal Articles

MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491

Gabriel Levy, Serge Carillo, Benjamin Papoular, Bruno Cassinat, Jean-Marc Zini, Emilie Leroy, Leila N. Varghese, Ilyas Chachoua, Jean-Philippe Defour, Steven O. Smith, Stefan N. Constantinescu

Blood (2020) 135 (12): 948–953.

https://doi.org/10.1182/blood.2019003240

Published: 2020

Includes: Supplemental data

Journal Articles

Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy

Blood (2019) 134 (Supplement_1): 247.

https://doi.org/10.1182/blood-2019-131024

Published: 2019

Journal Articles

New Paradigms for the Mechanisms of Thrombopoietin Receptor Activation and Dysregulation By the JAK2 V617F Mutation

Stephan Wilmes, PhD, Maximillian Hafer, BSc, Tess A Stanly, Ignacio Moraga, PhD, Joni Vuorio, PhD, Chetan Poojari, PhD, Vivek Sharma, PhD, Sara Löchte, PhD, Katiuska Pulgar Prieto, BSc, Julie A Tucker, PhD, Stevan R Hubbard, PhD, K.Christopher Garcia, PhD, Ilpo Vattulainen, PhD, Ian Hitchcock, PhD, Jacob Piehler, PhD

Blood (2019) 134 (Supplement_1): 2962.

https://doi.org/10.1182/blood-2019-129234

Published: 2019

Journal Articles

A Test to Quantify NOTCH Pathway Activity in T Cell Acute Lymphoblastic Leukemia Patients

Kirsten Canté-Barrett, PhD, Laurent Holtzer, PhD, Henk van Ooijen, PhD, Rico Hagelaar, Valentina Cordo', MSc, Wim Verhaegh, PhD, Anja van de Stolpe, MD PhD, Jules P.P. Meijerink, PhD

Blood (2019) 134 (Supplement_1): 4661.

https://doi.org/10.1182/blood-2019-122856

Published: 2019

Journal Articles

The von Willebrand factor D′D3 assembly and structural principles for factor VIII binding and concatemer biogenesis

Xianchi Dong, Nina C. Leksa, Ekta Seth Chhabra, Joseph W. Arndt, Qi Lu, Kevin E. Knockenhauer, Robert T. Peters, Timothy A. Springer

Blood (2019) 133 (14): 1523–1533.

https://doi.org/10.1182/blood-2018-10-876300

Published: 2019

Includes: Multimedia, Supplemental data

Journal Articles

Different Classes of ABL1 Fusions Activate Different Downstream Signalling Nodes

Lauren M Brown, BSc, Hannah Huckstep, BSc, Jarrod Sandow, PhD, Ray C Bartolo, PhD, Nadia Davidson, PhD, Breon Schmidt, BSc, Stefan Bjelosevic, BSc, Ricky W Johnstone, PhD, Alicia Oshlack, PhD, Melissa Davis, PhD, Paul G Ekert

Blood (2018) 132 (Supplement 1): 2628.

https://doi.org/10.1182/blood-2018-99-117844

Published: 2018

Journal Articles

JAK2 V617F Dimerizes Homodimeric Cytokine Receptors Cytosolic Domains By Requiring Pseudokinase Domain Residues That Promote JAK2 Dimerization and Oncogenic Activity

Emilie Leroy, Thomas Balligand, MD, Stefan N Constantinescu, MD

Blood (2018) 132 (Supplement 1): 50.

https://doi.org/10.1182/blood-2018-99-111336

Published: 2018

Journal Articles

Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response

Blood (2018) 132 (3): 307–320.

https://doi.org/10.1182/blood-2017-10-810986

Published: 2018

Includes: Supplemental data

Journal Articles

Dual-Switch CAR-T Cells: Orthogonal Molecular Switches to Control Activation and Elimination of CAR-T Cells to Target CD123 + Cancer

J. Henri Bayle, PhD, MyLinh T Duong, PhD, An Lu, Eva Morschl, PhD, Matthew R. Collinson-Pautz, PhD, Kelly L Sharp, Slawomir Szymanski, PhD, Mary E. Brandt, Kevin M. Slawin, MD, Steven Toler, PhD, Eric Yvon, S., Aaron Foster, David M. Spencer

Blood (2017) 130 (Supplement 1): 3184.

https://doi.org/10.1182/blood.V130.Suppl_1.3184.3184

Published: 2017

Journal Articles

Leukocyte Adhesion Deficiency-I (LAD-I): A Comprehensive Review of Published Cases

Sanchali Kasbekar, PharmD, Juan Bueren, PhD, Adrian J Thrasher, MD PhD FMedSci, Donald B Kohn, MD, Julian Sevilla, MD PhD, Jonathan D Schwartz, MD, Elena Almarza, PhD

Blood (2017) 130 (Supplement 1): 4821.

https://doi.org/10.1182/blood.V130.Suppl_1.4821.4821

Published: 2017

Journal Articles

CDC37 As a Novel Target for the Treatment of NPM1-ALK Expressing Anaplastic Large Cell Lymphomas

Sudhakiranmayi Kuravi, M.S., Elizabeth Parrott, M.A., Siddhartha Ganguly, MD, Anusha Vallurupalli, MD, Yogenthiran Saunthararajah, MD, Brian S Blagg, PhD, Jensen Roy, MD, Joseph P. McGuirk, DO, Ramesh Balusu, PhD

Blood (2017) 130 (Supplement 1): 2758.

https://doi.org/10.1182/blood.V130.Suppl_1.2758.2758

Published: 2017

Journal Articles

Combining Effects of the SMO Inhibitor and Jak1 Inhibitor in Terminal Differentiation of MDS-Derived Induced Potent Stem Cells (iPSC)

Tetsuzo Tauchi, MDPhD, Seiichi Okabe, MD PhD, Seiichiro Katagiri, MD, Yuko Tanaka, MDPhD, Kazuma Ohyashiki, MD PhD

Blood (2016) 128 (22): 3150.

https://doi.org/10.1182/blood.V128.22.3150.3150

Published: 2016

Journal Articles

von Willebrand factor is dimerized by protein disulfide isomerase

Svenja Lippok, Katra Kolšek, Achim Löf, Dennis Eggert, Willem Vanderlinden, Jochen P. Müller, Gesa König, Tobias Obser, Karoline Röhrs, Sonja Schneppenheim, Ulrich Budde, Carsten Baldauf, Camilo Aponte-Santamaría, Frauke Gräter, Reinhard Schneppenheim, Joachim O. Rädler, Maria A. Brehm

Blood (2016) 127 (9): 1183–1191.

https://doi.org/10.1182/blood-2015-04-641902

Published: 2016

Includes: Multimedia, Supplemental data

Journal Articles

Molecular Basis of Von Willebrand Disease in Patients from India

Sumitha Elayaperumal, M.Sc, Eunice Sindhuvi Edison, PhD, Sankari Devi Govindanattar, B.Sc, Surendar Singh, B.Sc, Aby Abraham, MD DM, Biju George, DM, Auro Viswabandya, MD DM, Sukesh Nair, MD FRCPA, Alok Srivastava, MD FRACP

Blood (2015) 126 (23): 1102.

https://doi.org/10.1182/blood.V126.23.1102.1102

Published: 2015

Journal Articles

NOTCH1 Induces Differential Epigenomic Patterning and Genomic Organization in Fetal Liver- and Adult Bone Marrow-Derived Hematopoietic Progentiors

Vincenzo Giambra, PhD, Sonya H Lam, Miriam Belmonte, Sam Gusscott, Sohrab Salehi, Fong Chun Chan, Robert Kridel, MD MPH, Alireza Lorzadeh, Catherine Hoofd, PhD, Christian Steidl, MD, Connie J. Eaves, PhD, Martin Hirst, PhD, Andrew P. Weng, MD PhD

Blood (2015) 126 (23): 3637.

https://doi.org/10.1182/blood.V126.23.3637.3637

Published: 2015

Journal Articles

A Dominant Negative Mutation (p.P214L) in ETV6 is Associated with Megakaryocyte and Erythroid Transcript Misregulation

Leila Noetzli, BS, Jesse W Rowley, PhD, Michael U Callaghan, MD, Madhvi Rajpurkar, MD, Alisa B. Lee-Sherick, MD, Christopher C. Porter, MD, Andrew S. Weyrich, PhD, Jorge A. Di Paola, MD

Blood (2015) 126 (23): 76.

https://doi.org/10.1182/blood.V126.23.76.76

Published: 2015

Journal Articles

Human Induced Pluripotent Stem Cells Incorporating Safe Harbor Loci Integrated Inducible Suicide Systems for Use in the Application of Cellular Therapeutics

Xiaosong Huang, PhD, Weijie Lan, PhD, Philippe Parone, PhD, Raedun Clarke, PhD, Ramzey Abujarour, PhD, Megan Robinson, BS, Miguel Meza, MS, Sarah Raynel, MS, Betsy Rezner, BS, David Robbins, BS, Tom Tong Lee, PhD, Daniel Shoemaker, PhD, Bahram Valamehr, PhD MBA

Blood (2015) 126 (23): 3237.

https://doi.org/10.1182/blood.V126.23.3237.3237

Published: 2015

Journal Articles

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia

Chen Shochat, Noa Tal, Vitalina Gryshkova, Yehudit Birger, Obul R. Bandapalli, Giovanni Cazzaniga, Nava Gershman, Andreas E. Kulozik, Andrea Biondi, Marc R. Mansour, Jean-Claude Twizere, Martina U. Muckenthaler, Nir Ben-Tal, Stefan N. Constantinescu, Dani Bercovich, Shai Izraeli

Blood (2014) 124 (1): 106–110.

https://doi.org/10.1182/blood-2013-10-529685

Published: 2014

Includes: Supplemental data

Journal Articles

Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor

Yan-Feng Zhou, Timothy A. Springer

Blood (2014) 123 (12): 1785–1793.

https://doi.org/10.1182/blood-2013-11-523639

Published: 2014

Includes: Supplemental data

NARROW

Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms

MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491

Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy

New Paradigms for the Mechanisms of Thrombopoietin Receptor Activation and Dysregulation By the JAK2 V617F Mutation

A Test to Quantify NOTCH Pathway Activity in T Cell Acute Lymphoblastic Leukemia Patients

The von Willebrand factor D′D3 assembly and structural principles for factor VIII binding and concatemer biogenesis

Different Classes of ABL1 Fusions Activate Different Downstream Signalling Nodes

JAK2 V617F Dimerizes Homodimeric Cytokine Receptors Cytosolic Domains By Requiring Pseudokinase Domain Residues That Promote JAK2 Dimerization and Oncogenic Activity

Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response

Dual-Switch CAR-T Cells: Orthogonal Molecular Switches to Control Activation and Elimination of CAR-T Cells to Target CD123 + Cancer

Leukocyte Adhesion Deficiency-I (LAD-I): A Comprehensive Review of Published Cases

CDC37 As a Novel Target for the Treatment of NPM1-ALK Expressing Anaplastic Large Cell Lymphomas

Combining Effects of the SMO Inhibitor and Jak1 Inhibitor in Terminal Differentiation of MDS-Derived Induced Potent Stem Cells (iPSC)

von Willebrand factor is dimerized by protein disulfide isomerase

Molecular Basis of Von Willebrand Disease in Patients from India

NOTCH1 Induces Differential Epigenomic Patterning and Genomic Organization in Fetal Liver- and Adult Bone Marrow-Derived Hematopoietic Progentiors

A Dominant Negative Mutation (p.P214L) in ETV6 is Associated with Megakaryocyte and Erythroid Transcript Misregulation

Human Induced Pluripotent Stem Cells Incorporating Safe Harbor Loci Integrated Inducible Suicide Systems for Use in the Application of Cellular Therapeutics

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia

Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor

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American Society of Hematology

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ASH Publications

American Society of Hematology

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