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Issue Archive

Volume 114, Issue 17
October 22 2009
Issue Cover

Table of Contents

INSIDE BLOOD

GENE THERAPY
Peaceful coexistence or clonal dominance?
Dorothee von Laer
View Articletitled, Peaceful coexistence or clonal dominance?
INSIDE BLOOD
CLL: promiscuity leads to risks
Kostas Stamatopoulos
View Articletitled, CLL: promiscuity leads to risks
TRANSFUSION MEDICINE
Transfused B19V: B-nign, B-ware, B-gone?
Harvey G. Klein
View Articletitled, Transfused B19V: B-nign, B-ware, B-gone?

REVIEW ARTICLES

Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells
Dan S. Kaufman
View Articletitled, Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells

HOW I TREAT

How I treat ADA deficiency
H. Bobby Gaspar,Alessandro Aiuti,Fulvio Porta,Fabio Candotti,Michael S. Hershfield,Luigi D. Notarangelo
View Articletitled, How I treat ADA deficiency

CLINICAL TRIALS AND OBSERVATIONS

MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy
Clinical Trials & Observations
Kerry J. Savage,Nathalie A. Johnson,Susana Ben-Neriah,Joseph M. Connors,Laurie H. Sehn,Pedro Farinha,Douglas E. Horsman,Randy D. Gascoyne
View Articletitled, <em>MYC</em> gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy
Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis
Clinical Trials & Observations
Luca Malcovati,Matteo G. Della Porta,Daniela Pietra,Emanuela Boveri,Andrea Pellagatti,Anna Gallì,Erica Travaglino,Angela Brisci,Elisa Rumi,Francesco Passamonti,Rosangela Invernizzi,Laura Cremonesi,Jacqueline Boultwood,James S. Wainscoat,Eva Hellström-Lindberg,Mario Cazzola
View Articletitled, Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis

GENE THERAPY

Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy
Barbara Cassani,Eugenio Montini,Giulietta Maruggi,Alessandro Ambrosi,Massimiliano Mirolo,Silvia Selleri,Erika Biral,Ilaria Frugnoli,Vivian Hernandez-Trujillo,Clelia Di Serio,Maria Grazia Roncarolo,Luigi Naldini,Fulvio Mavilio,Alessandro Aiuti
View Articletitled, Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential
Haiming Xu,Satyam Eleswarapu,Hartmut Geiger,Kathleen Szczur,Deidre Daria,Yi Zheng,Jeffrey Settleman,Edward F. Srour,David A. Williams,Marie-Dominique Filippi
View Articletitled, Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential
Supplemental data
CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis
Wooseok Seo,Hermann J. Ziltener
View Articletitled, CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis
Supplemental data

IMMUNOBIOLOGY

Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice
Partha Dutta,Melanie Molitor-Dart,Joseph L. Bobadilla,Drew A. Roenneburg,Zhen Yan,Jose R. Torrealba,William J. Burlingham
View Articletitled, Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice
Supplemental data
HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1
Appakkudal R. Anand,Anil Prasad,Ritu R. Bradley,Yadwinder S. Deol,Tirumuru Nagaraja,Xianghui Ren,Ernest F. Terwilliger,Ramesh K. Ganju
View Articletitled, HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1
Reduced immunoglobulin class switch recombination in the absence of Artemis
Paola Rivera-Munoz,Pauline Soulas-Sprauel,Gwenaël Le Guyader,Vincent Abramowski,Sylvia Bruneau,Alain Fischer,Frédéric Pâques,Jean-Pierre de Villartay
View Articletitled, Reduced immunoglobulin class switch recombination in the absence of Artemis
Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production
Brief Report
Elisabetta Volpe,Maxime Touzot,Nicolas Servant,Marie-Annick Marloie-Provost,Philippe Hupé,Emmanuel Barillot,Vassili Soumelis
View Articletitled, Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production
Supplemental data

LYMPHOID NEOPLASIA

Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells
Till Seiler,Manuela Woelfle,Sophia Yancopoulos,Rosa Catera,Wentian Li,Katerina Hatzi,Carol Moreno,Marcela Torres,Santanu Paul,Hartmut Dohner,Stephan Stilgenbauer,Matthew S. Kaufman,Jonathan E. Kolitz,Steven L. Allen,Kanti R. Rai,Charles C. Chu,Nicholas Chiorazzi
View Articletitled, Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells
Supplemental data
Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug–induced apoptosis
Brief Report
Yuhuan Zheng,Zhen Cai,Siqing Wang,Xiang Zhang,Jianfei Qian,Sungyoul Hong,Haiyan Li,Michael Wang,Jing Yang,Qing Yi
View Articletitled, Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug–induced apoptosis

MYELOID NEOPLASIA

Nf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in mice
Brief Report
Briony A. Cutts,Anna-Karin M. Sjogren,Karin M. E. Andersson,Annika M. Wahlstrom,Christin Karlsson,Birgitta Swolin,Martin O. Bergo
View Articletitled, <em>Nf1</em> deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in mice
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Colony-stimulating factor-1–induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages
Arnaud Jacquel,Naïma Benikhlef,Jérôme Paggetti,Najoua Lalaoui,Leslie Guery,Erick K. Dufour,Marion Ciudad,Cindy Racoeur,Olivier Micheau,Laurent Delva,Nathalie Droin,Eric Solary
View Articletitled, Colony-stimulating factor-1–induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages
Supplemental data
Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2
Manfred Nairz,Igor Theurl,Andrea Schroll,Milan Theurl,Gernot Fritsche,Ewald Lindner,Markus Seifert,Marie-Laure V. Crouch,Klaus Hantke,Shizuo Akira,Ferric C. Fang,Günter Weiss
View Articletitled, Absence of functional Hfe protects mice from invasive <em>Salmonella enterica</em> Serovar Typhimurium infection via induction of lipocalin-2
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Stage-specific susceptibility of human erythroblasts to Plasmodium falciparum malaria infection
Brief Report
Pamela A. Tamez,Hui Liu,Sebastian Fernandez-Pol,Kasturi Haldar,Amittha Wickrema
View Articletitled, Stage-specific susceptibility of human erythroblasts to <em>Plasmodium falciparum</em> malaria infection

THROMBOSIS AND HEMOSTASIS

Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men
Bas de Laat,Philip G. de Groot,Ronald H. W. M. Derksen,Rolf T. Urbanus,Koen Mertens,Frits R. Rosendaal,Carine J. M. Doggen
View Articletitled, Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men
Crystal structure of protein Z–dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X
Zhenquan Wei,Yahui Yan,Robin W. Carrell,Aiwu Zhou
View Articletitled, Crystal structure of protein Z–dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X
Supplemental data

TRANSFUSION MEDICINE

ABO blood group glycans modulate sialic acid recognition on erythrocytes
Miriam Cohen,Nancy Hurtado-Ziola,Ajit Varki
View Articletitled, ABO blood group glycans modulate sialic acid recognition on erythrocytes
Supplemental data
A linked donor-recipient study to evaluate parvovirus B19 transmission by blood component transfusion
Steven H. Kleinman,Simone A. Glynn,Tzong-Hae Lee,Leslie H. Tobler,Karen S. Schlumpf,Deborah S. Todd,Hannah Qiao,Mei-ying W. Yu,Michael P. Busch,for the National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study-II (NHLBI REDS-II)
View Articletitled, A linked donor-recipient study to evaluate parvovirus B19 transmission by blood component transfusion
Supplemental data

TRANSPLANTATION

Identification of 4 new HLA-DR–restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity
Anita N. Stumpf,Edith D. van der Meijden,Cornelis A. M. van Bergen,Roel Willemze,J. H. Frederik Falkenburg,Marieke Griffioen
View Articletitled, Identification of 4 new HLA-DR–restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity
Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease
Jimmy A. Rotolo,Branka Stancevic,Sydney X. Lu,Jianjun Zhang,David Suh,Christopher G. King,Lucy W. Kappel,George F. Murphy,Chen Liu,Zvi Fuks,Marcel R. van den Brink,Richard Kolesnick
View Articletitled, Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease
Supplemental data

VASCULAR BIOLOGY

Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1
Kohei Yamamizu,Kyoko Kawasaki,Shiori Katayama,Tetsuro Watabe,Jun K. Yamashita
View Articletitled, Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1
Supplemental data

CORRESPONDENCE

New GATA1 mutation in codon 2 leads to the earliest known premature stop codon in transient myeloproliferative disorder
Sylvia Hoeller,Michel P. Bihl,Alexandar Tzankov,Thomas Kuehne,Christian Potthoff,Elisabeth Bruder
View Articletitled, New <em>GATA1</em> mutation in codon 2 leads to the earliest known premature stop codon in transient myeloproliferative disorder
Limited efficacy of imatinib in severe pulmonary chronic graft-versus-host disease
Michael Stadler,Renate Ahlborn,Haytham Kamal,Helmut Diedrich,Stefanie Buchholz,Matthias Eder,Arnold Ganser
View Articletitled, Limited efficacy of imatinib in severe pulmonary chronic graft-versus-host disease
Response: Imatinib in lung cGVHD of mild to moderate severity
Attilio Olivieri,Michele Cimminiello,Franco Locatelli
View Articletitled, Response: Imatinib in lung cGVHD of mild to moderate severity
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