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Issue Archive

Volume 119, Issue 9
March 1 2012
Issue Cover

Table of Contents

Inside Blood

INSIDE BLOOD
Taking it up a notch in MCL
Samir Parekh
View Articletitled, Taking it up a notch in MCL
MYELOID NEOPLASIA
Unveiling the complexity of CK+ AML
Bruno C. Medeiros
View Articletitled, Unveiling the complexity of CK+ AML
THROMBOSIS & HEMOSTASIS
VWF sequence variants: innocent until proven guilty
Daria Babushok,Adam Cuker
View Articletitled, VWF sequence variants: innocent until proven guilty

Blood Work

Aleukemic variant of mast cell leukemia
Sacha Zeerleder,Marinus van Oers
View Articletitled, Aleukemic variant of mast cell leukemia

Plenary Paper

PLENARY PAPER
Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma
Robert Kridel,Barbara Meissner,Sanja Rogic,Merrill Boyle,Adele Telenius,Bruce Woolcock,Jay Gunawardana,Catherine E. Jenkins,Chris Cochrane,Susana Ben-Neriah,King Tan,Ryan D. Morin,Stephen Opat,Laurie H. Sehn,Joseph M. Connors,Marco A. Marra,Andrew P. Weng,Christian Steidl,Randy D. Gascoyne
View Articletitled, Whole transcriptome sequencing reveals recurrent <em>NOTCH1</em> mutations in mantle cell lymphoma

Review Article

Selection of optimal alternative graft source: mismatched unrelated donor, umbilical cord blood, or haploidentical transplant
Karen K. Ballen,John Koreth,Yi-Bin Chen,Bimalangshu R. Dey,Thomas R. Spitzer
View Articletitled, Selection of optimal alternative graft source: mismatched unrelated donor, umbilical cord blood, or haploidentical transplant

Clinical Trials And Observations

Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: a single-institution historical experience
Clinical Trials & Observations
Hagop Kantarjian,Susan O'Brien,Elias Jabbour,Guillermo Garcia-Manero,Alfonso Quintas-Cardama,Jenny Shan,Mary Beth Rios,Farhad Ravandi,Stefan Faderl,Tapan Kadia,Gautam Borthakur,Xuelin Huang,Richard Champlin,Moshe Talpaz,Jorge Cortes
View Articletitled, Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: a single-institution historical experience
Fludarabine and rituximab for relapsed or refractory hairy cell leukemia
Brief Report
Alina S. Gerrie,Leslie N. Zypchen,Joseph M. Connors
View Articletitled, Fludarabine and rituximab for relapsed or refractory hairy cell leukemia
Interim 18-FDG-PET/CT failed to predict the outcome in diffuse large B-cell lymphoma patients treated at the diagnosis with rituximab-CHOP
Clinical Trials & Observations
Patrizia Pregno,Annalisa Chiappella,Marilena Bellò,Barbara Botto,Simone Ferrero,Silvia Franceschetti,Francesca Giunta,Marco Ladetto,Giorgio Limerutti,Massimo Menga,Maura Nicolosi,Giorgio Priolo,Benedetta Puccini,Luigi Rigacci,Flavia Salvi,Luca Vaggelli,Roberto Passera,Gianni Bisi,Umberto Vitolo
View Articletitled, Interim 18-FDG-PET/CT failed to predict the outcome in diffuse large B-cell lymphoma patients treated at the diagnosis with rituximab-CHOP
Comparative outcome of initial therapy for younger patients with mantle cell lymphoma: an analysis from the NCCN NHL Database
Clinical Trials & Observations
Ann S. LaCasce,Jonathan L. Vandergrift,Maria A. Rodriguez,Gregory A. Abel,Allison L. Crosby,Myron S. Czuczman,Auayporn P. Nademanee,Douglas W. Blayney,Leo I. Gordon,Michael Millenson,Ann Vanderplas,Eva M. Lepisto,Andrew D. Zelenetz,Joyce Niland,Jonathan W. Friedberg
View Articletitled, Comparative outcome of initial therapy for younger patients with mantle cell lymphoma: an analysis from the NCCN NHL Database
Trisomies in multiple myeloma: impact on survival in patients with high-risk cytogenetics
Clinical Trials & Observations
Shaji Kumar,Rafael Fonseca,Rhett P. Ketterling,Angela Dispenzieri,Martha Q. Lacy,Morie A. Gertz,Suzanne R. Hayman,Francis K. Buadi,David Dingli,Ryan A. Knudson,Alexandra Greenberg,Stephen J. Russell,Steven R. Zeldenrust,John A. Lust,Robert A. Kyle,Leif Bergsagel,S. Vincent Rajkumar
View Articletitled, Trisomies in multiple myeloma: impact on survival in patients with high-risk cytogenetics

Hematopoiesis And Stem Cells

p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes
Praveen Anur,Jane Yates,Michael R. Garbati,Scott Vanderwerf,Winifred Keeble,Keaney Rathbun,Laura E. Hays,Jeffrey W. Tyner,Johanna Svahn,Enrico Cappelli,Carlo Dufour,Grover C. Bagby
View Articletitled, p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes
IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors
Amy M. Becker,Drew G. Michael,Ansuman T. Satpathy,Roger Sciammas,Harinder Singh,Deepta Bhattacharya
View Articletitled, IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors
Supplemental data
Functional characterization of CD4+ T cells in aplastic anemia
Shahram Kordasti,Judith Marsh,Sufyan Al-Khan,Jie Jiang,Alexander Smith,Azim Mohamedali,Pilar Perez Abellan,Caroline Veen,Benedetta Costantini,Austin G. Kulasekararaj,Nana Benson-Quarm,Thomas Seidl,Syed A. Mian,Farzin Farzaneh,Ghulam J. Mufti
View Articletitled, Functional characterization of CD4<sup>+</sup> T cells in aplastic anemia
Supplemental data

Immunobiology

HIV-1 envelope-dependent restriction of CXCR4-using viruses in child but not adult untransformed CD4+ T-lymphocyte lines
Samanta A. Mariani,Immacolata Brigida,Anna Kajaste-Rudnitski,Silvia Ghezzi,Alessia Rocchi,Anna Plebani,Elisa Vicenzi,Alessandro Aiuti,Guido Poli
View Articletitled, HIV-1 envelope-dependent restriction of CXCR4-using viruses in child but not adult untransformed CD4<sup>+</sup> T-lymphocyte lines
Supplemental data
Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection
Younes Zoughlami,Carlijn Voermans,Kim Brussen,Karel A. van Dort,Neeltje A. Kootstra,David Maussang,Martine J. Smit,Peter L. Hordijk,Paula B. van Hennik
View Articletitled, Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection
Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates
Marcin Kwissa,Helder I. Nakaya,Herold Oluoch,Bali Pulendran
View Articletitled, Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates
Supplemental data
T-cell immunity to Kaposi sarcoma–associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4+ T cells
Shereen Sabbah,Ya Jankey Jagne,Jianmin Zuo,Thushan de Silva,Mohammad M. Ahasan,Christian Brander,Sarah Rowland-Jones,Katie L. Flanagan,Andrew D. Hislop
View Articletitled, T-cell immunity to Kaposi sarcoma–associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4<sup>+</sup> T cells

Lymphoid Neoplasia

Conjugation of lymphoma idiotype to CD40 antibody enhances lymphoma vaccine immunogenicity and antitumor effects in mice
Jennifer Carlring,Marika J. Szabo,Robert Dickinson,Evy De Leenheer,Andrew W. Heath
View Articletitled, Conjugation of lymphoma idiotype to CD40 antibody enhances lymphoma vaccine immunogenicity and antitumor effects in mice
Supplemental data
Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function
Yu-Tzu Tai,Holly M. Horton,Sun-Young Kong,Erik Pong,Hsing Chen,Saso Cemerski,Matthew J. Bernett,Duc-Hanh T. Nguyen,Sher Karki,Seung Y. Chu,Greg A. Lazar,Nikhil C. Munshi,John R. Desjarlais,Kenneth C. Anderson,Umesh S. Muchhal
View Articletitled, Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function
Supplemental data
The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells
Brief Report
Francesco Forconi,Kathleen N. Potter,Elisa Sozzi,Isla Henderson,Emanuele Cencini,Davide Rossi,Riccardo Bomben,Valter Gattei,Gianluca Gaidano,Graham Packham,Freda K. Stevenson
View Articletitled, The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells
Supplemental data
MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia
Brief Report
Marek Mraz,Dasa Dolezalova,Karla Plevova,Katerina Stano Kozubik,Veronika Mayerova,Katerina Cerna,Katerina Musilova,Boris Tichy,Sarka Pavlova,Marek Borsky,Jan Verner,Michael Doubek,Yvona Brychtova,Martin Trbusek,Ales Hampl,Jiri Mayer,Sarka Pospisilova
View Articletitled, MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia
Supplemental data

Myeloid Neoplasia

TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome
Frank G. Rücker,Richard F. Schlenk,Lars Bullinger,Sabine Kayser,Veronica Teleanu,Helena Kett,Marianne Habdank,Carla-Maria Kugler,Karlheinz Holzmann,Verena I. Gaidzik,Peter Paschka,Gerhard Held,Marie von Lilienfeld-Toal,Michael Lübbert,Stefan Fröhling,Thorsten Zenz,Jürgen Krauter,Brigitte Schlegelberger,Arnold Ganser,Peter Lichter,Konstanze Döhner,Hartmut Döhner
View Articletitled, <em>TP53</em> alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome
Supplemental data
Prognostic value of monosomal karyotype in comparison to complex aberrant karyotype in acute myeloid leukemia: a study on 824 cases with aberrant karyotype
Brief Report
Claudia Haferlach,Tamara Alpermann,Susanne Schnittger,Wolfgang Kern,Jörg Chromik,Christoph Schmid,Hermann Josef Pielken,Karl-Anton Kreuzer,Heinz-Gert Höffkes,Torsten Haferlach
View Articletitled, Prognostic value of monosomal karyotype in comparison to complex aberrant karyotype in acute myeloid leukemia: a study on 824 cases with aberrant karyotype
Supplemental data

Thrombosis And Hemostasis

Macrophage LRP1 contributes to the clearance of von Willebrand factor
Ghasem Rastegarlari,Julie N. Pegon,Caterina Casari,Soline Odouard,Ana-Maria Navarrete,Nathalie Saint-Lu,Bart J. van Vlijmen,Paulette Legendre,Olivier D. Christophe,Cécile V. Denis,Peter J. Lenting
View Articletitled, Macrophage LRP1 contributes to the clearance of von Willebrand factor
VWF mutations and new sequence variations identified in healthy controls are more frequent in the African-American population
Daniel B. Bellissimo,Pamela A. Christopherson,Veronica H. Flood,Joan Cox Gill,Kenneth D. Friedman,Sandra L. Haberichter,Amy D. Shapiro,Thomas C. Abshire,Cindy Leissinger,W. Keith Hoots,Jeanne M. Lusher,Margaret V. Ragni,Robert R. Montgomery
View Articletitled, <em>VWF</em> mutations and new sequence variations identified in healthy controls are more frequent in the African-American population

Transplantation

Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study
Clinical Trials & Observations
Junya Kanda,Masakatsu Hishizawa,Atae Utsunomiya,Shuichi Taniguchi,Tetsuya Eto,Yukiyoshi Moriuchi,Ryuji Tanosaki,Fumio Kawano,Yasushi Miyazaki,Masato Masuda,Koji Nagafuji,Masamichi Hara,Minoko Takanashi,Shunro Kai,Yoshiko Atsuta,Ritsuro Suzuki,Takakazu Kawase,Keitaro Matsuo,Tokiko Nagamura-Inoue,Shunichi Kato,Hisashi Sakamaki,Yasuo Morishima,Jun Okamura,Tatsuo Ichinohe,Takashi Uchiyama
View Articletitled, Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study
Supplemental data

Vascular Biology

Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane
Lea Scheppke,Eric A. Murphy,Alessandro Zarpellon,Jennifer J. Hofmann,Alona Merkulova,David J. Shields,Sara M. Weis,Tatiana V. Byzova,Zaverio M. Ruggeri,M. Luisa Iruela-Arispe,David A. Cheresh
View Articletitled, Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane
Supplemental data
Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells
Costanza Giampietro,Andrea Taddei,Monica Corada,Gian Maria Sarra-Ferraris,Myriam Alcalay,Ugo Cavallaro,Fabrizio Orsenigo,Maria Grazia Lampugnani,Elisabetta Dejana
View Articletitled, Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells
Supplemental data

Correspondence

Experience with obatoclax mesylate (GX15-070), a small molecule pan–Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma
Yasuhiro Oki,Amanda Copeland,Fredrick Hagemeister,Luis E. Fayad,Michelle Fanale,Jorge Romaguera,Anas Younes
View Articletitled, Experience with obatoclax mesylate (GX15-070), a small molecule pan–Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma
Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding
Theodore E. Warkentin,Peter Margetts,Stuart J. Connolly,Andre Lamy,Chris Ricci,John W. Eikelboom
View Articletitled, Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding
Circulating immune complexes do not affect microparticle flow cytometry analysis in acute coronary syndrome
Nicolas Amabile,Jean-Marie Renard,Christophe Caussin,Chantal M. Boulanger
View Articletitled, Circulating immune complexes do not affect microparticle flow cytometry analysis in acute coronary syndrome
Response: systematic use of Triton lysis as a control for microvesicle labeling
Bence György,Maria Pasztoi,Edit I. Buzas
View Articletitled, Response: systematic use of Triton lysis as a control for microvesicle labeling
Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice
Kristina Berg Lorvik,Bjarne Bogen,Alexandre Corthay
View Articletitled, Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice
CEBPE activation in PML-RARA cells by arsenic
Zhenbo Hu,Yogen Saunthararajah
View Articletitled, CEBPE activation in PML-RARA cells by arsenic
Supplemental data
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