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Issue Archive

Volume 123, Issue 14
April 3 2014
Issue Cover

Table of Contents

INSIDE BLOOD

PHAGOCYTES, GRANULOCYTES, & MYELOPOIESIS
STIM1 for stimulation of phagocyte NADPH oxidase
Richard D. Ye
View Articletitled, STIM1 for stimulation of phagocyte NADPH oxidase
INSIDE BLOOD
CLLonal selection: survival of the fittest?
Claire Dearden
View Articletitled, CLLonal selection: survival of the fittest?
INSIDE BLOOD
An E3 ubiquitin ligase-independent role of LUBAC
Rudi Beyaert
View Articletitled, An E3 ubiquitin ligase-independent role of LUBAC
MYELOID NEOPLASIA
Many roads lead to MPN
Heike L. Pahl
View Articletitled, Many roads lead to MPN
RED CELLS, IRON, & ERYTHROPOIESIS
Toward unraveling heme regulation
Valentine Brousse,Wassim El Nemer
View Articletitled, Toward unraveling heme regulation

BLOOD WORK

Enteropathy-associated T-cell lymphoma, type II (monomorphic variant)
Adeel Raza,Yuli Zu
View Articletitled, Enteropathy-associated T-cell lymphoma, type II (monomorphic variant)
Bone marrow necrosis in de novo AML
Michael Daskalakis,Marcelo Caballero
View Articletitled, Bone marrow necrosis in de novo AML

PLENARY PAPER

Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia
Davide Rossi,Hossein Khiabanian,Valeria Spina,Carmela Ciardullo,Alessio Bruscaggin,Rosella Famà,Silvia Rasi,Sara Monti,Clara Deambrogi,Lorenzo De Paoli,Jiguang Wang,Valter Gattei,Anna Guarini,Robin Foà,Raul Rabadan,Gianluca Gaidano
View Articletitled, Clinical impact of small <em>TP53</em> mutated subclones in chronic lymphocytic leukemia
Supplemental data

BLOOD SPOTLIGHT

XMEN disease: a new primary immunodeficiency affecting Mg2+ regulation of immunity against Epstein-Barr virus
Feng-Yen Li,Benjamin Chaigne-Delalande,Helen Su,Gulbu Uzel,Helen Matthews,Michael J. Lenardo
View Articletitled, XMEN disease: a new primary immunodeficiency affecting Mg<sup>2+</sup> regulation of immunity against Epstein-Barr virus

CLINICAL TRIALS AND OBSERVATIONS

Active von Willebrand factor predicts 28-day mortality in patients with systemic inflammatory response syndrome
Clinical Trials & Observations Brief Report
Agon Hyseni,Hans Kemperman,Dylan W. de Lange,Jozef Kesecioglu,Philip G. de Groot,Mark Roest
View Articletitled, Active von Willebrand factor predicts 28-day mortality in patients with systemic inflammatory response syndrome
Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study
Clinical Trials & Observations Brief Report
Paola Guglielmelli,Flavia Biamonte,Giada Rotunno,Valentina Artusi,Lucia Artuso,Isabella Bernardis,Elena Tenedini,Lisa Pieri,Chiara Paoli,Carmela Mannarelli,Rajmonda Fjerza,Elisa Rumi,Viktoriya Stalbovskaya,Matthew Squires,Mario Cazzola,Rossella Manfredini,Claire Harrison,Enrico Tagliafico,Alessandro M. Vannucchi,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators,on behalf of the COMFORT-II Investigators and the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators
View Articletitled, Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation
Yu Lan,Wenyan He,Zhuan Li,Yu Wang,Jun Wang,Jiao Gao,Weili Wang,Tao Cheng,Bing Liu,Xiao Yang
View Articletitled, Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation
Supplemental data

IMMUNOBIOLOGY

Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice
Judith T. Murphy,Andre P. Burey,Amy M. Beebe,Danling Gu,Leonard G. Presta,Taha Merghoub,Jedd D. Wolchok
View Articletitled, Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice
Supplemental data

LYMPHOID NEOPLASIA

Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells
Sebastian W. Hofbauer,Peter W. Krenn,Sylvia Ganghammer,Daniela Asslaber,Ulrike Pichler,Karin Oberascher,Reinhard Henschler,Michael Wallner,Hubert Kerschbaum,Richard Greil,Tanja N. Hartmann
View Articletitled, Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells
Supplemental data
Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma
Raphael Koch,Martin Demant,Thiha Aung,Nina Diering,Anna Cicholas,Bjoern Chapuy,Dirk Wenzel,Marlen Lahmann,Annemarie Güntsch,Christina Kiecke,Sabrina Becker,Timo Hupfeld,Vivek Venkataramani,Marita Ziepert,Lennart Opitz,Wolfram Klapper,Lorenz Trümper,Gerald G. Wulf
View Articletitled, Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma
Supplemental data
A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells
Brief Report
Sonia M. Dubois,Catherine Alexia,Youtong Wu,Héloïse M. Leclair,Claire Leveau,Emilie Schol,Thierry Fest,Karin Tarte,Zhijian J. Chen,Julie Gavard,Nicolas Bidère
View Articletitled, A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells
Supplemental data
Osteoblastic niche supports the growth of quiescent multiple myeloma cells
Brief Report
Zheng Chen,Robert Z. Orlowski,Michael Wang,Larry Kwak,Nami McCarty
View Articletitled, Osteoblastic niche supports the growth of quiescent multiple myeloma cells
Supplemental data

MYELOID NEOPLASIA

G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia
Hee Kyu Lee,Hong Woo Kim,In Yong Lee,Jungmi Lee,Jaekyoo Lee,Dong Sik Jung,Sang Yeop Lee,Sung Ho Park,Haejun Hwang,Jang-Sik Choi,Jung-Ho Kim,Se Won Kim,Jung Keun Kim,Jan Cools,Jong Sung Koh,Ho-Juhn Song
View Articletitled, G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia
Supplemental data
Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms
Pontus Lundberg,Axel Karow,Ronny Nienhold,Renate Looser,Hui Hao-Shen,Ina Nissen,Sabine Girsberger,Thomas Lehmann,Jakob Passweg,Martin Stern,Christian Beisel,Robert Kralovics,Radek C. Skoda
View Articletitled, Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms
Supplemental data
Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis
Julia Skokowa,Doris Steinemann,Jenny E. Katsman-Kuipers,Cornelia Zeidler,Olga Klimenkova,Maksim Klimiankou,Murat Ünalan,Siarhei Kandabarau,Vahagn Makaryan,Renee Beekman,Kira Behrens,Carol Stocking,Julia Obenauer,Susanne Schnittger,Alexander Kohlmann,Marijke G. Valkhof,Remco Hoogenboezem,Gudrun Göhring,Dirk Reinhardt,Brigitte Schlegelberger,Martin Stanulla,Peter Vandenberghe,Jean Donadieu,C. Michel Zwaan,Ivo P. Touw,Marry M. van den Heuvel-Eibrink,David C. Dale,Karl Welte
View Articletitled, Cooperativity of <em>RUNX1</em> and <em>CSF3R</em> mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense
Hong Zhang,Regina A. Clemens,Fengchun Liu,Yongmei Hu,Yoshihiro Baba,Pierre Theodore,Tomohiro Kurosaki,Clifford A. Lowell
View Articletitled, STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense
Supplemental data

PLATELETS AND THROMBOPOIESIS

hGH promotes megakaryocyte differentiation and exerts a complementary effect with c-Mpl ligands on thrombopoiesis
Yang Xu,Song Wang,Mingqiang Shen,Zhou Zhang,Shilei Chen,Fang Chen,Mo Chen,Dongfeng Zeng,Aiping Wang,Jinghong Zhao,Tianmin Cheng,Yongping Su,Junping Wang
View Articletitled, hGH promotes megakaryocyte differentiation and exerts a complementary effect with c-Mpl ligands on thrombopoiesis
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6
Claire Mayeur,Lisa K. Lohmeyer,Patricio Leyton,Sonya M. Kao,Alexandra E. Pappas,Starsha A. Kolodziej,Ester Spagnolli,Binglan Yu,Rita L. Galdos,Paul B. Yu,Randall T. Peterson,Donald B. Bloch,Kenneth D. Bloch,Andrea U. Steinbicker
View Articletitled, The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6
Supplemental data
Heme oxygenase 1 is expressed in murine erythroid cells where it controls the level of regulatory heme
Daniel Garcia-Santos,Matthias Schranzhofer,Monika Horvathova,Mehrad Mojtahed Jaberi,Jose Artur Bogo Chies,Alex D. Sheftel,Prem Ponka
View Articletitled, Heme oxygenase 1 is expressed in murine erythroid cells where it controls the level of regulatory heme
Supplemental data

THROMBOSIS AND HEMOSTASIS

Targeted mutation of zebrafish fga models human congenital afibrinogenemia
Brief Report
Richard J. Fish,Corinne Di Sanza,Marguerite Neerman-Arbez
View Articletitled, Targeted mutation of zebrafish <em>fga</em> models human congenital afibrinogenemia
Supplemental data
All Issues

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