Issue Archive
BLOOD COMMENTARIES
Genes driving bad luck
Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome
The authors report the interaction between Down syndrome, a major genetic leukemia predisposition condition, and inherited genetic alleles associated with increased susceptibility to childhood acute lymphoblastic leukemia.
PET-adapted treatment of Hodgkin lymphoma
Five-year follow-up of SWOG S0816: limitations and values of a PET-adapted approach with stage III/IV Hodgkin lymphoma
The investigators present results on the long-term value and limitations of early interim positron emission tomography (PET) scanning in advanced Hodgkin lymphoma.
REVIEW ARTICLE
Lentiviral and genome-editing strategies for the treatment of β-hemoglobinopathies
This review article summarizes the clinical outcomes and genotoxicity issues of gene therapy for hemoglobinopathies based on lentiviral vectors carrying a β-globin–like gene or genome editing to correct the erythropoietic defect.
HEMATOPOIESIS AND STEM CELLS
Prospective isolation of nonhematopoietic cells of the niche and their differential molecular interactions with HSCs
The bone marrow niche environment is essential for the control and maintenance of hematopoietic stem cells (HSCs). The investigators present the first global analysis of the communication between distinct niche cell types and HSCs.
LYMPHOID NEOPLASIA
Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome
The authors report the interaction between Down syndrome, a major genetic leukemia predisposition condition, and inherited genetic alleles associated with increased susceptibility to childhood acute lymphoblastic leukemia.
Five-year follow-up of SWOG S0816: limitations and values of a PET-adapted approach with stage III/IV Hodgkin lymphoma
The investigators present results on the long-term value and limitations of early interim positron emission tomography (PET) scanning in advanced Hodgkin lymphoma.
BLOOD WORK
ERRATUM
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Cover Image
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Calcified osteoblasts stained with alizarin red after in vitro differentiation of Lepr-cre− mesenchymal stromal cells from the bone marrow niche. See the article by Mende et al on page 1214.
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Prospective isolation of nonhematopoietic cells of the niche and their differential molecular interactions with HSCs
The bone marrow niche environment is essential for the control and maintenance of hematopoietic stem cells (HSCs). The investigators present the first global analysis of the communication between distinct niche cell types and HSCs.