Issue Archive
Table of Contents
BLOOD COMMENTARIES
TFH lymphomas: the times they aza-changin’?
Clinical Trials & Observations
Oral 5-azacytidine and romidepsin exhibit marked activity in patients with PTCL: a multicenter phase 1 study
Clinical Trials & Observations
The authors report a phase 1 study of romidepsin combined with oral 5-azacytidine in patients with relapsed/refractory lymphomas, including complete remissions in 3 patients with angioimmunoblastic T-cell lymphoma.
A sobering “check” on immune checkpoint inhibitors
Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade
The investigators present their analysis of primary cells from patients with human T-cell leukemia virus 1–associated adult T-cell leukemia/lymphoma treated in a phase 2 clinical trial with nivolumab to elucidate mechanisms of hyperprogression that halted the trial after just 3 patients received a single treatment.
Nurturing a diet rich in PTCL
Targeted inhibition of CD47-SIRPα requires Fc-FcγR interactions to maximize activity in T-cell lymphomas
This study reveals that successful therapeutic targeting of the CD47-SIRPα axis in peripheral T-cell lymphoma is highly dependent on the Fc-FcγR interaction and is augmented by cotreatment with the anti-CCR4–targeted monoclonal antibody mogamulizumab.
Lifting the veil on germline DDX41 mutations
Germline DDX41 mutations define a significant entity within adult MDS/AML patients
Brief Report
This report presents the intriguing observation that cases with germline DEAD-box helicase 41 (DDX41) mutations represent a unique entity among adult myeloid neoplasms.
Resolvin the clot: DVT resolution through RvD4
Resolvin D4 attenuates the severity of pathological thrombosis in mice
The authors discovered the important role that lipid mediators (resolvin D4 in this study) play in both formation and resolution of clots in deep vein thrombosis.
PLENARY PAPER
Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis
In this Plenary Paper, the investigators demonstrate that the two monoferric forms of transferrin, the major plasma glycoprotein involved in cellular iron delivery, have functionally distinct effects on erythropoiesis and systemic iron regulation.
REVIEW ARTICLE
Optimizing treatment of HIV-associated lymphoma
This review discusses the pathogenesis and current treatment of HIV-related lymphomas.
CLINICAL TRIALS AND OBSERVATIONS
Oral 5-azacytidine and romidepsin exhibit marked activity in patients with PTCL: a multicenter phase 1 study
Clinical Trials & Observations
The authors report a phase 1 study of romidepsin combined with oral 5-azacytidine in patients with relapsed/refractory lymphomas, including complete remissions in 3 patients with angioimmunoblastic T-cell lymphoma.
IMMUNOBIOLOGY AND IMMUNOTHERAPY
Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade
The investigators present their analysis of primary cells from patients with human T-cell leukemia virus 1–associated adult T-cell leukemia/lymphoma treated in a phase 2 clinical trial with nivolumab to elucidate mechanisms of hyperprogression that halted the trial after just 3 patients received a single treatment.
LYMPHOID NEOPLASIA
Targeted inhibition of CD47-SIRPα requires Fc-FcγR interactions to maximize activity in T-cell lymphomas
This study reveals that successful therapeutic targeting of the CD47-SIRPα axis in peripheral T-cell lymphoma is highly dependent on the Fc-FcγR interaction and is augmented by cotreatment with the anti-CCR4–targeted monoclonal antibody mogamulizumab.
MYELOID NEOPLASIA
Germline DDX41 mutations define a significant entity within adult MDS/AML patients
Brief Report
This report presents the intriguing observation that cases with germline DEAD-box helicase 41 (DDX41) mutations represent a unique entity among adult myeloid neoplasms.
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling
This study unveils an unanticipated role of L-selectin downstream of integrin outside-in signaling in important neutrophil effector functions, including the clearance of bacteria in infected tissues.
THROMBOSIS AND HEMOSTASIS
Resolvin D4 attenuates the severity of pathological thrombosis in mice
The authors discovered the important role that lipid mediators (resolvin D4 in this study) play in both formation and resolution of clots in deep vein thrombosis.
VASCULAR BIOLOGY
BLOOD WORK
ERRATUM
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Cover Image
Cover Image
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Ex vivo confocal image of recruited neutrophils (green) in the lung tissue (red) after Klebsiella pneumoniae–induced pneumonia in Sell−/− mice. Neutrophil migration and effector functions are dependent on L-selectin shedding from the neutrophil surface. See the article by Cappenberg et al on page 1445.
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Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis
In this Plenary Paper, the investigators demonstrate that the two monoferric forms of transferrin, the major plasma glycoprotein involved in cellular iron delivery, have functionally distinct effects on erythropoiesis and systemic iron regulation.