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Journal Articles

Development of ALL-Hematotox (ALL-HT): Predicting post CAR T-cell hematotoxicity in B-cell acute lymphoblastic leukemia

Clinical Trials & Observations
Monica S Nair, Sara K Silbert, Kai Rejeski, Karilynn A Wilson, Adam Joseph Lamble, Yannis K. Valtis, Bonnie Yates, Alexa Morales Arana, Roni Shouval, Kevin J. Curran, Rebecca A Gardner, Haneen Shalabi, Colleen Annesley, Jae H. Park, Marion Subklewe, Nirali N Shah
Journal: Blood
Blood blood.2024025910.
https://doi.org/10.1182/blood.2024025910
Published: 2024
Includes: Supplemental data
Journal Articles

Risk Factors and Outcomes for Hematotoxicity Following Tisagenlecleucel for Pediatric B-Acute Lymphoblastic Leukemia

Kevin O. McNerney, Vanessa A. Fabrizio, Aimee C. Talleur, Stephanie Si Lim, Alexandra Dreyzin, Christina Baggott, Anant Vatsayan, Jenna Rossoff, Snehit Prabhu, Holly L. Pacenta, Christine L Phillips, Julie-An Talano, Amy Moskop, Michael R Verneris, Douglas Myers, Nicole Karras, Challice L. Bonifant, Muna Qayed, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Amy Keating, Susanne H.C. Baumeister, Vasant Chinnabhandar, Emily Egeler, Kevin J Curran, Crystal L. Mackall, Theodore W. Laetsch, Liora Michal Schultz, Swati Naik
Journal: Blood
Blood (2023) 142 (Supplement 1): 2133.
https://doi.org/10.1182/blood-2023-189921
Published: 2023
Journal Articles

Long Term Follow-up after Treatment with Allogeneic Off-the-Shelf CAR T Cell Therapy for Relapsed or Refractory B-Cell Malignancies

Sanam Shahid, Georgia C Flynn, Audrey Mauguen, Jennifer Bieler, Susan E Prockop, Andromachi Scaradavou, Jaap Jan Boelens, Craig S Sauter, Miguel-Angel Perales, Sergio A. Giralt, Xiuyan Wang, Isabelle Riviere, Michel Sadelain, Renier Brentjens, Nancy A Kernan, Richard J O'Reilly, Kevin J Curran
Journal: Blood
Blood (2023) 142 (Supplement 1): 3476.
https://doi.org/10.1182/blood-2023-180753
Published: 2023
Journal Articles

Updated Results of the Phase I BALLI-01 Trial of UCART22 Process 2 (P2), an Anti-CD22 Allogeneic CAR-T Cell Product Manufactured By Cellectis Biologics, in Patients with Relapsed or Refractory (R/R) CD22+ B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Nitin Jain, Patrice Chevallier, Hongtao Liu, Gary J. Schiller, Jean-Baptiste Méar, Daniel J. DeAngelo, Kevin J Curran, Stephan Grupp, Andre Baruchel, Marie Balsat, Alexandra LaCroce, Caroline Roudet, Ana B. Korngold, Kathryn J. Newhall, Eric Laille, Daniel J. Lee, Mark G. Frattini, Richard A. Larson, Nicolas Boissel
Journal: Blood
Blood (2023) 142 (Supplement 1): 4847.
https://doi.org/10.1182/blood-2023-187252
Published: 2023
Journal Articles

Peripheral Blast Count at Apheresis Acts Independent of Disease Burden As a Risk Factor for Survival Following Tisagenlecleucel in Children and Young Adults

Vanessa A. Fabrizio, Kristen Miller, Christina Baggott, Snehit Prabhu, Holly Pacenta, Christine L. Phillips, Jenna Rossoff, Heather E. Stefanski, Julie Talano, Amy Moskop, Susanne H.C. Baumeister, Gary Douglas Myers, Nicole Karras, Patrick A. Brown, Muna Qayed, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Rachel Wilcox, Vasant Chinnabhandar, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Amy K. Keating, Michael R. Verneris, Liora M. Schultz
Journal: Blood
Blood (2022) 140 (Supplement 1): 4661–4663.
https://doi.org/10.1182/blood-2022-169603
Published: 2022
Journal Articles

Obesity Associates with Inferior Outcomes and Toxicity in Pediatric and Young Adult Patient with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia Treated with Commercially Manufactured Tisagenlecleucel

Anthony J Ross, Christina Baggott, Snehit Prabhu, Holly Pacenta, Christine Philips, Jenna Rossoff, Heather E Stefanski, Julie Talano, Amy Moskop, Susanne H.C. Baumeister, Michael R Verneris, Gary Douglas Myers, Nicole Karras, Muna Qayed, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Amy K. Keating, Rachel Wilcox, Vanessa A Fabrizio, Vasant Chinnabhandar, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Sandra K Althouse, Shannon L. Maude, Curtis J Henry, Liora M. Schultz, Jodi L. Skiles
Journal: Blood
Blood (2022) 140 (Supplement 1): 10419–10421.
https://doi.org/10.1182/blood-2022-163336
Published: 2022
Journal Articles

Standard Cytogenetic Risk Stratification Is Not Predictive of CD19 CAR Outcomes and Impact of Disease Burden Varies between Cytogenetic Risk Groups

John C. Molina, Vasant Chinnabhandar, Vanessa A Fabrizio, Michael Kunicki, Holly Pacenta, Jenna Rossoff, Heather E Stefanski, Julie Talano, Amy Moskop, Michael R Verneris, Gary Douglas Myers, Nicole Karras, Christina Baggott, Muna Qayed, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Amy K. Keating, Susanne H.C. Baumeister, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Liora M. Schultz, Stephanie M. Smith
Journal: Blood
Blood (2022) 140 (Supplement 1): 10386–10388.
https://doi.org/10.1182/blood-2022-165951
Published: 2022
Journal Articles

Antigen Directed Therapy Pre-Transplant Confers Superior Post-Transplant Survival Outcome Compared to Conventional Chemotherapy in Pediatric Patients with Relapsed and Refractory B-ALL

Jessica Stiefel, Allyson M. Flower, Marissa Botwinick, Maegan Ford, Alycia Foti, Mital Gandhi, Justin Slovin, Elana Smilow, Ashley Bowers, Hannah Karpel, Leya Y Schwartz, Ellen Fraint, Lisa M. Gennarini, Sharon L. Gardner, Elizabeth A. Raetz, Niketa C. Shah, Jing Chen, Jennifer Krajewski, Nobuko Hijiya, Prakash Satwani, Jessica C Hochberg, Audrey Mauguen, Kevin J. Curran, Maria Luisa Sulis
Journal: Blood
Blood (2022) 140 (Supplement 1): 7763–7765.
https://doi.org/10.1182/blood-2022-160272
Published: 2022
Journal Articles

Out-of-specification tisagenlecleucel does not compromise safety or efficacy in pediatric acute lymphoblastic leukemia

Clinical Trials & Observations
Jenna Rossoff, Christina Baggott, Snehit Prabhu, Holly Pacenta, Christine L. Phillips, Heather Stefanski, Julie-An Talano, Amy Moskop, Steven P. Margossian, Michael R. Verneris, Gary Douglas Myers, Nicole Karras, Patrick A. Brown, Muna Qayed, Michelle Hermiston, Prakash Satwani, Christa Krupski, Amy K. Keating, Rachel Wilcox, Cara A. Rabik, Vanessa A. Fabrizio, Michael Kunicki, Vasant Chinnabhandar, A. Yasemin Goksenin, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Liora M. Schultz
Journal: Blood
Blood (2021) 138 (21): 2138–2142.
https://doi.org/10.1182/blood.2021012392
Published: 2021
Journal Articles

Interventions and outcomes of adult patients with B-ALL progressing after CD19 chimeric antigen receptor T-cell therapy

Clinical Trials & Observations
Kitsada Wudhikarn, Jessica R. Flynn, Isabelle Rivière, Mithat Gönen, Xiuyan Wang, Brigitte Senechal, Kevin J. Curran, Mikhail Roshal, Peter G. Maslak, Mark B. Geyer, Elizabeth F. Halton, Claudia Diamonte, Marco L. Davila, Michel Sadelain, Renier J. Brentjens, Jae H. Park
Journal: Blood
Blood (2021) 138 (7): 531–543.
https://doi.org/10.1182/blood.2020009515
Published: 2021
Includes: Supplemental data
Journal Articles

Real-World Treatment of Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia Using Tisagenlecleucel That Is out of Specification for Commercial Release

Jenna Rossoff, MD, Christina Baggott, RN, PhD, Snehit Prabhu, PhD, Holly Pacenta, MD, Christine L Phillips, MD, Heather Stefanski, MDPhD, Julie-An Talano, MD, Amy Moskop, MD, Steven P. Margossian, MD PhD, Michael R Verneris, MD, Gary Douglas Myers, MD, Nicole Karras, MD, Patrick A. Brown, MD, Muna Qayed, MDMSc, Michelle Hermiston, MD PhD, Prakash Satwani, MD, Christa Krupski, DO, MPH, Amy Keating, MD, Rachel Wilcox, Cara A Rabik, MDPhD, Vanessa Fabrizio, MD, Michael Kunicki, Vasant Chinnabhandar, MD, A. Yasemin Goksenin, MD PhD MA, MPH, Kevin J. Curran, MD, Crystal L. Mackall, MD, Theodore W. Laetsch, MD, Liora M. Schultz, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–44.
https://doi.org/10.1182/blood-2020-136674
Published: 2020
Journal Articles

Rabbit Anti-Thymocyte Globulin Exposure (rATG) in CD34+ Selected Hematopoietic Cell Transplantation and Its Impact on Immune Reconstitution and Outcomes in Children and Adults

Madhavi Lakkaraja, MDMPH, Michael Scordo, MD, Audrey Mauguen, PhD, Christina Cho, MD, Sean Devlin, PhD, Scott T Avecilla, MDPhD, Farid Boulad, MD, Maria I. Cancio, MD, Kevin J. Curran, MD, Ann A. Jakubowski, MDPhD, Nancy A. Kernan, Andrew L. Kung, MD PhD, Richard J O'Reilly, MD, Esperanza B. Papadopoulos, MD, Susan Prockop, MD, Ichelle Roessel, Josel D Ruiz, MPH, Andromachi Scaradavou, MD, Brian C. Shaffer, MD, Gunjan Shah, MD, Barbara Spitzer, MD, Roni Tamari, MD, Sergio A. Giralt, MD, Miguel-Angel Perales, MD, Jaap Jan Boelens, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136341
Published: 2020
Journal Articles

Disease Burden Impacts Outcomes in Pediatric and Young Adult B-Cell Acute Lymphoblastic Leukemia after Commercial Tisagenlecleucel: Results from the Pediatric Real World CAR Consortium (PRWCC)

Liora M. Schultz, MD, Christina Baggott, RN, PhD, Snehit Prabhu, PhD, Holly Pacenta, MD, Christine L Phillips, MD, Jenna Rossoff, MD, Heather Stefanski, MDPhD, Julie-An Talano, MD, Amy Moskop, MD, Steven P. Margossian, MD PhD, Michael R Verneris, MD, Gary Douglas Myers, MD, Nicole Karras, MD, Patrick A. Brown, MD, Muna Qayed, MDMSc, Michelle Hermiston, MD PhD, Prakash Satwani, MD, Christa Krupski, DO, MPH, Amy Keating, MD, Rachel Wilcox, Cara A Rabik, MDPhD, Vanessa Fabrizio, MD, Michael Kunicki, Vasant Chinnabhandar, MD, A. Yasemin Goksenin, MD PhD MA, MPH, Kevin J. Curran, MD, Crystal L. Mackall, MD, Theodore W. Laetsch, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-134472
Published: 2020
Journal Articles

Toxicity and response after CD19-specific CAR T-cell therapy in pediatric/young adult relapsed/refractory B-ALL

Clinical Trials & Observations
Kevin J. Curran, Steven P. Margossian, Nancy A. Kernan, Lewis B. Silverman, David A. Williams, Neerav Shukla, Rachel Kobos, Christopher J. Forlenza, Peter Steinherz, Susan Prockop, Farid Boulad, Barbara Spitzer, Maria I. Cancio, Jaap Jan Boelens, Andrew L. Kung, Yasmin Khakoo, Victoria Szenes, Jae H. Park, Craig S. Sauter, Glenn Heller, Xiuyan Wang, Brigitte Senechal, Richard J. O’Reilly, Isabelle Riviere, Michel Sadelain, Renier J. Brentjens
Journal: Blood
Blood (2019) 134 (26): 2361–2368.
https://doi.org/10.1182/blood.2019001641
Published: 2019
Includes: Supplemental data
Journal Articles

Allogeneic CD34-Selected HSCT Following CAR T-Cells Is Associated with Low TRM and Favorable OS in Pediatric/Young Adult Patients with Relapsed/Refractory B-ALL

Vanessa Fabrizio, MD, Farid Boulad, MD, Maria I. Cancio, MD, Meghan A. Higman, MD PhD, Steven P. Margossian, MD PhD, Audrey Mauguen, PhD, Susan Prockop, MD, Andromachi Scaradavou, MD, Niketa C. Shah, MD, Barbara Spitzer, MD, Nick Yeager, Nancy A. Kernan, Richard O'Reilly, MD, Jaap Jan Boelens, MD PhD, Kevin J. Curran, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4582.
https://doi.org/10.1182/blood-2019-121767
Published: 2019
Journal Articles

Tisagenlecleucel Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Children and Young Adults with Acute Lymphoblastic Leukemia (ALL): Real World Experience from the Center for International Blood and Marrow Transplant Research (CIBMTR) and Cellular Therapy (CT) Registry

Stephan Grupp, MD PhD, Zhen-Huan Hu, MPH, Yiyun Zhang, PhD, Amy Keating, MD, Michael A. Pulsipher, MD, Christine Philips, Steven P. Margossian, MD PhD, Joseph Rosenthal, MD MS, Dana Salzberg, MD, Deborah E. Schiff, MD, Gregory Yanik, MD, Kevin J. Curran, MD, Andrew C. Harris, MD, Peiman Hematti, MD, Sarah Nikiforow, MD PhD, Patricia Steinert, PhD, Lan Yi, PhD, Raghav Chawla, MD PhD, Mary M. Horowitz, Eric Bleickardt, MD, Marcelo C. Pasquini, MDMS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2619.
https://doi.org/10.1182/blood-2019-129279
Published: 2019
Journal Articles

CD19 CAR T cells following autologous transplantation in poor-risk relapsed and refractory B-cell non-Hodgkin lymphoma

Clinical Trials & Observations
Craig S. Sauter, Brigitte Senechal, Isabelle Rivière, Ai Ni, Yvette Bernal, Xiuyan Wang, Terence Purdon, Malloury Hall, Ashvin N. Singh, Victoria Z. Szenes, Sarah Yoo, Ahmet Dogan, Yongzeng Wang, Craig H. Moskowitz, Sergio Giralt, Matthew J. Matasar, Miguel-Angel Perales, Kevin J. Curran, Jae Park, Michel Sadelain, Renier J. Brentjens
Journal: Blood
Blood (2019) 134 (7): 626–635.
https://doi.org/10.1182/blood.2018883421
Published: 2019
Includes: Supplemental data
Journal Articles

Clinical Responses and Pharmacokinetics of MCARH171, a Human-Derived Bcma Targeted CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma: Final Results of a Phase I Clinical Trial

Sham Mailankody, MBBS, Arnab Ghosh, MBBS, PhD, Mette Staehr, PhD, Terence J Purdon, MS, Mikhail Roshal, MD PhD, Elizabeth Halton, NP-BC AOCNP, Claudia Diamonte, RN, John Pineda, RN, Pavan Anant, BS, Yvette Bernal, MS, Analisa Wills, Neha Korde, MD, Nikoletta Lendvai, MDPhD, Alexander M. Lesokhin, MD, Hani Hassoun, MD, Malin Hultcrantz, MD PhD, Heather J. Landau, MD, Gunjan L. Shah, MD, Michael Scordo, MD, David J. Chung, MDPhD, Oscar B Lahoud, MD, Pallavi Khattar, MD, Carlos Fernandez de Larrea, MD PhD, Qi Gao, Achim Jungbluth, MDPhD, Jae H. Park, MD, Kevin J. Curran, MD, Craig S. Sauter, MD, Maria Lia Palomba, MD, Brigitte Senechal, PhD, Xiuyan Wang, PhD, Ahmet Dogan, MD PhD, Sergio Giralt, MD, Isabelle Riviere, PhD, Ola Landgren, MD PhD, Renier J. Brentjens, MD PhD, Eric L. Smith, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 959.
https://doi.org/10.1182/blood-2018-99-119717
Published: 2018
Journal Articles

High Dose Cyclophosphamide and Pre-Treatment Disease Burden Dictate Response and Survival in a Multicenter Clinical Trial Using CD19-Specific CAR T Cells for Relapsed/Refractory B-ALL

Kevin J. Curran, MD, Steven P. Margossian, MD PhD, Nancy A. Kernan, MD, Lewis B. Silverman, MD, Jae H. Park, MD, Craig S. Sauter, MD, Eric L Smith, MDPhD, Farid Boulad, MD, Maria I. Cancio, MD, Christopher Forlenza, Carolyn Jackson, Neerav Shukla, MD, Barbara Spitzer, Susan Prockop, MD, Peter G. Steinherz, MD, Andrew L. Kung, MD PhD, Richard J. O'Reilly, MD, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1326.
https://doi.org/10.1182/blood.V130.Suppl_1.1326.1326
Published: 2017
Journal Articles

Development and Evaluation of a Human Single Chain Variable Fragment (scFv) Derived Bcma Targeted CAR T Cell Vector Leads to a High Objective Response Rate in Patients with Advanced MM

Eric L Smith, MDPhD, Sham Mailankody, MBBS, Arnab Ghosh, MBBS, PhD, Reed Masakayan, MS, Mette Staehr, PhD, Terence J Purdon, MS, Elizabeth Halton, NP, Claudia Diamonte, RN, Pavan Anant, Yvette Bernal, MS, Xiuyan Wang, PhD, Yongzeng Wang, PhD, Sarah Garrett, Steven Almo, PhD, Pei Wang, PhD, Hong Liu, MD PhD, Yiyang Xu, PhD, Elena Mead, MD, Jae H. Park, MD, Kevin J. Curran, MD, Craig S. Sauter, MD, Sergio A. Giralt, MD, Ola Landgren, MD PhD, Ahmet Dogan, MD PhD, Mikhail Roshal, MDPhD, Cheng Liu, PhD, Isabelle Riviere, PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 742.
https://doi.org/10.1182/blood.V130.Suppl_1.742.742
Published: 2017