1-20 of 20
Rajeswaran Mani
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia

Swagata Goswami, Rajeswaran Mani, Jessica Nunes, Chi-Ling Chiang, Kevan Zapolnik, Eileen Hu, Frank Frissora, Xiaokui Mo, Logan A. Walker, Pearlly Yan, Ralf Bundschuh, Larry Beaver, Raymond Devine, Yo-Ting Tsai, Ann Ventura, Zhiliang Xie, Min Chen, Rosa Lapalombella, Alison Walker, Alice Mims, Karilyn Larkin, Nicole Grieselhuber, Chad Bennett, Mitch Phelps, Erin Hertlein, Gregory Behbehani, Sumithira Vasu, John C. Byrd, Natarajan Muthusamy
Journal: Blood
Blood (2022) 139 (9): 1340–1358.
https://doi.org/10.1182/blood.2020010344
Published: 2022
Includes: Supplemental data
Journal Articles

Aurora Kinase Inhibition Overcomes Primary Venetoclax Failure and Leads to Synthetic Lethality in BCL2-Positive Lymphomas Via Upregulation of P53/P21/BAX Axis

Rajeswaran Mani, Samon Benrashid, Sarah E Teague, Scott C Jaros, Hsih-Te Yang, Lawrence J Druhan, David M Foureau, Nury M Steuerwald, Nilanjan Ghosh, Edward A. Copelan, Donald L. Durden, Belinda Avalos, Steven I. Park
Journal: Blood
Blood (2021) 138 (Supplement 1): 682.
https://doi.org/10.1182/blood-2021-146064
Published: 2021
Journal Articles

CSF3R Splicing Regulates Granulopoiesis Via Splice Variant Specific Responses to G-CSF

Amanda Lance, Rajeswaran Mani, Sara L. Seegers, Belinda R Avalos, Lawrence J Druhan
Journal: Blood
Blood (2021) 138 (Supplement 1): 3130.
https://doi.org/10.1182/blood-2021-154322
Published: 2021
Journal Articles

The Novel Multitarget Small-Molecule Inhibitor SRX3177 Overcomes Ibrutinib Resistance in Mantle Cell Lymphoma

Dhananjaya Pal, Cody C. McHale, Samon Benrashid, Poornima Gourabathini, Krishnaiah Maddeboina, Kendra R. Vann, Rajeswaran Mani, Tatiana Kutateladze, Peter Martin, Maurizio Di Liberto, Selina Chen-Kiang, Steven I. Park, Donald L. Durden
Journal: Blood
Blood (2021) 138 (Supplement 1): 2262.
https://doi.org/10.1182/blood-2021-154253
Published: 2021
Journal Articles

ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model

Chi-Ling Chiang, Swagata Goswami, Frank W. Frissora, Zhiliang Xie, Pearlly S. Yan, Ralf Bundschuh, Logan A. Walker, Xiaomeng Huang, Rajeswaran Mani, Xiaokui M. Mo, Sivasubramanian Baskar, Christoph Rader, Mitch A. Phelps, Guido Marcucci, John C. Byrd, L. James Lee, Natarajan Muthusamy
Journal: Blood
Blood (2019) 134 (5): 432–444.
https://doi.org/10.1182/blood.2018882290
Published: 2019
Includes: Supplemental data
Journal Articles

Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemia

Mary K. McKenna, Sunil K. Noothi, Sara S. Alhakeem, Karine Z. Oben, Joseph T. Greene, Rajeswaran Mani, Kathryn L. Perry, James P. Collard, Jacqueline R. Rivas, Gerhard C. Hildebrandt, Roger A. Fleischman, Eric B. Durbin, John C. Byrd, Chi Wang, Natarajan Muthusamy, Vivek M. Rangnekar, Subbarao Bondada
Journal: Blood
Blood (2018) 131 (26): 2943–2954.
https://doi.org/10.1182/blood-2017-10-813931
Published: 2018
Includes: Supplemental data
Journal Articles

Evaluation of ROR1 Targeted Antibody Drug Conjugates in Acute and Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

Eileen Hu, BS, Priscilla Do, Rajeswaran Mani, DVM,PhD, Frank Frissora, MS, Haiyong Peng, PhD, Lorenz Waldmeier, PhD, Roger Beerli, PhD, Christoph Rader, PhD, Ulf Grawunder, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM,PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3017.
https://doi.org/10.1182/blood.V130.Suppl_1.3017.3017
Published: 2017
Journal Articles

Tumor Antigen ROR1 Targeted Delivery of MiR-29b in Chronic Lymphocytic Leukemia Induces Epigenetic Reprograming Resulting in Cell Cycle Arrest

Chi-Ling Chiang, MS, Swagata Goswami, MS, Rajeswaran Mani, DVM,PhD, Frank Frissora, MS, Zhiliang Xie, Xiaomeng Huang, PhD, Sivasubramanian Baskar, PhD, Christoph Rader, PhD, Mitch A. Phelps, PhD, Guido Marcucci, MD, John C. Byrd, MD, James L. Lee, PhD, Natarajan Muthusamy, DVM,PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4981.
https://doi.org/10.1182/blood.V130.Suppl_1.4981.4981
Published: 2017
Journal Articles

OSU-2S, a Novel PKC Activator, Mediates PKC Dependent Cell Death, Differentiation and Cell Cycle Arrest in Acute Myeloid Leukemia

Swagata Goswami, MS, Rajeswaran Mani, DVM,PhD, Xiaokui Mo, PhD MAS, Pearlly S. Yan, PhD, Michael B Broe, PhD, Ralf Bundschuh, PhD, Larry State Beaver, Kevan Zapolnik, BS, Zhiliang Xie, Donna Bucci, David M. Lucas, PhD, Allison R. Walker, MD MPH, Alice S. Mims, MD MSCR, Rebecca B. Klisovic, MD, Ching-Shih Chen, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Sumithira Vasu, MDMBBS, Natarajan Muthusamy, DVM,PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1247.
https://doi.org/10.1182/blood.V130.Suppl_1.1247.1247
Published: 2017
Journal Articles

Par-4 Overexpression Impedes Leukemogenesis in the Eµ-TCL1 Leukemia Model

Joseph Thomas Greene, BS, Rahul Ramaswamy, Mary K McKenna, BS, Rajeswaran Mani, DVM,PhD, Frank Frissora, MS, Ronni Wasmuth, BS, Minh Tran, BS, Xiaokui Mo, PhD MAS, Carlo M. Croce, MD, Vivek Rangnekar, PhD, John C. Byrd, MD, Subbarao Bondada, PhD, Natarajan Muthusamy, DVM,PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1223.
https://doi.org/10.1182/blood.V130.Suppl_1.1223.1223
Published: 2017
Journal Articles

SL-401 Mediates Potent Cytotoxicity Against CD123+ AML and MDS with Excess Blasts and Demonstrates Therapeutic Benefit in PDX Model

Rajeswaran Mani, DVM PhD, Swagata Goswami, MS, Bhavani Gopalakrishnan, Rahul Ramaswamy, Ronni Wasmuth, Minh Tran, Xiaokui Mo, PhD MAS, Amber Gordon, MLS, Donna Bucci, David Lucas, PhD, Christopher L. Brooks, PhD, Alison R. Walker, MD MPH, William Blum, MD, John C. Byrd, MD, Gerard Lozanski, MD, Sumithra Vasu, MBBS, Natarajan Muthusamy, DVM, PhD
Journal: Blood
Blood (2016) 128 (22): 580.
https://doi.org/10.1182/blood.V128.22.580.580
Published: 2016
Journal Articles

CD33 Targeted Immunoliposomal Delivery of OSU-2S, a Non-Immunosuppressive FTY720 Derivative, Mediates Selective Cytotoxicity in Acute Myeloid Leukemia

Swagata Goswami, MS, Rajeswaran Mani, DVM PhD, Chi-Ling Chiang, MS, Frank W Frissora, M.S., Xiaokui Mo, PhD MAS, Zhiliang Xie, Donna Bucci, Amber Gordon, MLS, David M. Lucas, PhD, William Blum, MD, Alison R. Walker, MD MPH, Alice S. Mims, MD MSCR, Rebecca B Klisovic, MD, Ching-Shih Chen, PhD, Robert J Lee, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Sumithira Vasu, MBBS, Natarajan Muthusamy, DVM, PhD
Journal: Blood
Blood (2016) 128 (22): 2748.
https://doi.org/10.1182/blood.V128.22.2748.2748
Published: 2016
Journal Articles

Decitabine enhances anti-CD33 monoclonal antibody BI 836858–mediated natural killer ADCC against AML blasts

Sumithira Vasu, Shun He, Carolyn Cheney, Bhavani Gopalakrishnan, Rajeswaran Mani, Gerard Lozanski, Xiaokui Mo, Veronica Groh, Susan P. Whitman, Renate Konopitzky, Christian Kössl, Donna Bucci, David M. Lucas, Jianhua Yu, Michael A. Caligiuri, William Blum, Paul J. Adam, Eric Borges, Bjoern Rueter, Karl-Heinz Heider, Guido Marcucci, Natarajan Muthusamy
Journal: Blood
Blood (2016) 127 (23): 2879–2889.
https://doi.org/10.1182/blood-2015-11-680546
Published: 2016
Includes: Supplemental data
Journal Articles

Immunoliposomal Delivery of Mir-29b By Targeting Tumor Antigen ROR1 Induces Epigenetic Reprograming in Human-ROR1-Expressed Mouse Model of Chronic Lymphocytic Leukemia

Chi-Ling Chiang, Frank W Frissora, Zhiliang Xie, Xiaomeng Huang, Rajeswaran Mani, DVM, Sivasubramanian Baskar, Christoph Rader, Kenneth K. Chan, Guido Marcucci, MD, John C. Byrd, MD, L. James Lee, Natarajan Muthusamy, DVM, PhD
Journal: Blood
Blood (2015) 126 (23): 1743.
https://doi.org/10.1182/blood.V126.23.1743.1743
Published: 2015
Journal Articles

Tumor Antigen ROR1 Targeted Delivery Of FTY720 Derivative OSU-2S Prolongs Survival In ROR1 Engineered Mouse Model Of Chronic Lymphocytic Leukemia

Rajeswaran Mani, DVM, Yicheng Mao, PhD, Frank W Frissora, M.S., Chi-ling Chiang, Jiang Wang, Yuan Zhao, Yun Wu, Bo Yu, Ph.D., Ribai Yan, Xiaokui Mo, PhD, Sivasubramanian Baskar, PhD, Christoph Rader, Ph.D., Mitch A. Phelps, PhD, Robert J. Lee, Ph.D, Ching-Shih Chen, PhD, James Lee, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D
Journal: Blood
Blood (2013) 122 (21): 4168.
https://doi.org/10.1182/blood.V122.21.4168.4168
Published: 2013
Journal Articles

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

Rosa Lapalombella, Qingxiang Sun, Katie Williams, Larissa Tangeman, Shruti Jha, Yiming Zhong, Virginia Goettl, Emilia Mahoney, Caroline Berglund, Sneha Gupta, Alicia Farmer, Rajeswaran Mani, Amy J. Johnson, David Lucas, Xiaokui Mo, Dirk Daelemans, Vincent Sandanayaka, Sharon Shechter, Dilara McCauley, Sharon Shacham, Michael Kauffman, Yuh Min Chook, John C. Byrd
Journal: Blood
Blood (2012) 120 (23): 4621–4634.
https://doi.org/10.1182/blood-2012-05-429506
Published: 2012
Includes: Supplemental data
Journal Articles

FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death

Lapo Alinari, Emilia Mahoney, John Patton, Xiaoli Zhang, Lenguyen Huynh, Christian T. Earl, Rajeswaran Mani, Yicheng Mao, Bo Yu, Carl Quinion, William H. Towns, Ching-Shih Chen, David M. Goldenberg, Kristie A. Blum, John C. Byrd, Natarajan Muthusamy, Mette Prætorius-Ibba, Robert A. Baiocchi
Journal: Blood
Blood (2011) 118 (26): 6893–6903.
https://doi.org/10.1182/blood-2011-06-363879
Published: 2011
Includes: Multimedia, Supplemental data
Journal Articles

FTY720 Increases CD74 Expression and Sensitizes Mantle Cell Lymphoma Cells to Milatuzumab-Mediated Cell Death

Lapo Alinari, MD., Ph.D., Emilia Mahoney, MD, PhD, John T. Patton, Xiaoli Zhang, PhD, MS, Lenguyen Huynh, Christian Tyler Earl, Rajeswaran Mani, DVM, Yicheng Mao, Bo Yu, Ph.D., William H. Towns, Ching-Shih Chen, Ph.D, David M. Goldenberg, Kristie A. Blum, MD, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D, Mette Ibba, PhD, Robert A. Baiocchi, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 600.
https://doi.org/10.1182/blood.V118.21.600.600
Published: 2011
Journal Articles

OSU-2S, A Novel FTY720 derivative, Mediates Cytotoxicity In Chronic Lymphocytic Leukemia Through PKC Dependent Modulation of SHP1 Tyrosine Phosphatase

Rajeswaran Mani, DVM, Frank W Frissora, M.S., Ching-Shih Chen, Ph.D, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D
Journal: Blood
Blood (2011) 118 (21): 2499.
https://doi.org/10.1182/blood.V118.21.2499.2499
Published: 2011
Journal Articles

Targeting the Cyclin D - CDK4/6 - Rb Axis in Mantle Cell Lymphoma with the Novel Translation Inhibitor Silvestrol,

Lapo Alinari, MD., Ph.D., Ryan B. Edwards, Courtney J. Prince, William H. Towns, Rajeswaran Mani, DVM, Amy Lehman, Xiaoli Zhang, PhD, MS, David Jarjoura, PhD, Li Pan, PhD, A. Douglas Kinghorn, PhD, DSc, Michael R. Grever, M.D., Robert A. Baiocchi, M.D., Ph.D., David M. Lucas, PhD
Journal: Blood
Blood (2011) 118 (21): 3498.
https://doi.org/10.1182/blood.V118.21.3498.3498
Published: 2011