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Journal Articles

Prognostic factors for CNS control in children with acute lymphoblastic leukemia treated without cranial irradiation

Clinical Trials & Observations
Jingyan Tang, Jie Yu, Jiaoyang Cai, Li Zhang, Shaoyan Hu, Ju Gao, Hua Jiang, Yongjun Fang, Changda Liang, Xiuli Ju, Runming Jin, Xiaowen Zhai, Xuedong Wu, Xin Tian, Qun Hu, Ningling Wang, Hui Jiang, Lirong Sun, Alex W. K. Leung, Minghua Yang, Kaili Pan, Cheng Cheng, Yiping Zhu, Hui Zhang, Chunfu Li, Jun J. Yang, Chi-kong Li, Xiaofan Zhu, Shuhong Shen, Ching-Hon Pui
Journal: Blood
Blood (2021) 138 (4): 331–343.
https://doi.org/10.1182/blood.2020010438
Published: 2021
Includes: Supplemental data
Journal Articles

Genetics of osteonecrosis in pediatric acute lymphoblastic leukemia and general populations

Wenjian Yang, Meenakshi Devidas, Yiwei Liu, Colton Smith, Yunfeng Dai, Naomi Winick, Stephen P. Hunger, Mignon L. Loh, Elizabeth A. Raetz, Eric C. Larsen, William L. Carroll, Stuart S. Winter, Kimberly P. Dunsmore, Leonard A. Mattano, Jr, Mary V. Relling, Seth E. Karol
Journal: Blood
Blood (2021) 137 (11): 1550–1552.
https://doi.org/10.1182/blood.2020008471
Published: 2021
Includes: Supplemental data
Journal Articles

Identification of functional cooperative mutations of GNAO1 in human acute lymphoblastic leukemia

Lili Song, Bo Yu, Yi Yang, Jianwei Liang, Yingwen Zhang, Lixia Ding, Tianyi Wang, Xinyu Wan, Xiaomin Yang, Jingyan Tang, Shengyue Wang, Benshang Li, Yanxin Li, Haizhong Feng
Journal: Blood
Blood (2021) 137 (9): 1181–1191.
https://doi.org/10.1182/blood.2020005622
Published: 2021
Includes: Supplemental data
Journal Articles

Enshaei A, O’Connor D, Bartram J, et al. A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia. Blood. 2020;135(17):1438-1446.

Journal: Blood
Blood (2020) 136 (12): 1468.
https://doi.org/10.1182/blood.2020008578
Published: 2020
Journal Articles

A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia

Clinical Trials & Observations
Amir Enshaei, David O’Connor, Jack Bartram, Jeremy Hancock, Christine J. Harrison, Rachael Hough, Sujith Samarasinghe, Monique L. den Boer, Judith M. Boer, Hester A. de Groot-Kruseman, Hanne V. Marquart, Ulrika Noren-Nystrom, Kjeld Schmiegelow, Claire Schwab, Martin A. Horstmann, Gabriele Escherich, Mats Heyman, Rob Pieters, Ajay Vora, John Moppett, Anthony V. Moorman
Journal: Blood
Blood (2020) 135 (17): 1438–1446.
https://doi.org/10.1182/blood.2019003191
Published: 2020
Includes: Supplemental data
Journal Articles

Reduced–dose intensity therapy for pediatric lymphoblastic leukemia: long-term results of the Recife RELLA05 pilot study

Clinical Trials & Observations
Francisco Pedrosa, Elaine Coustan-Smith, Yinmei Zhou, Cheng Cheng, Arli Pedrosa, Mecneide Mendes Lins, Marcia Pedrosa, Norma Lucena-Silva, Alessandra Maria de Luna Ramos, Ester Vinhas, Gaston K. Rivera, Dario Campana, Raul C. Ribeiro
Journal: Blood
Blood (2020) 135 (17): 1458–1466.
https://doi.org/10.1182/blood.2019004215
Published: 2020
Includes: Supplemental data
Journal Articles

Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia

Clinical Trials & Observations
Malwine J. Barz, Jana Hof, Stefanie Groeneveld-Krentz, Jui Wan Loh, Annabell Szymansky, Kathy Astrahantseff, Arend von Stackelberg, Hossein Khiabanian, Adolfo A. Ferrando, Cornelia Eckert, Renate Kirschner-Schwabe
Journal: Blood
Blood (2020) 135 (12): 921–933.
https://doi.org/10.1182/blood.2019002499
Published: 2020
Includes: Supplemental data
Journal Articles

IKZF1 deletions in pediatric acute lymphoblastic leukemia: still a poor prognostic marker?

Clinical Trials & Observations
Martin Stanulla, Hélène Cavé, Anthony V. Moorman
Journal: Blood
Blood (2020) 135 (4): 252–260.
https://doi.org/10.1182/blood.2019000813
Published: 2020
Journal Articles

Beat pediatric ALL MRD: CD28 CAR T and transplant

Clinical Trials & Observations
Marco Ruella, Frederick L. Locke
Journal: Blood
Blood (2019) 134 (26): 2333–2335.
https://doi.org/10.1182/blood.2019003821
Published: 2019
Journal Articles

ROR1 Targeted Immunoliposomal Delivery of OSU-2S Show Selective Cytotoxicity in t(1;19) Translocated B-ALL

Swagata Goswami, MSc, Chi-Ling Chiang, PhD, Kevan Zapolnik, BS, Zhiliang Xie, James L. Lee, PhD, Sivasubramanian Baskar, Christoph Rader, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Bhavana Bhatnagar, DO, Natarajan Muthusamy, DVM,PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3798.
https://doi.org/10.1182/blood-2019-128828
Published: 2019
Journal Articles

Whole-Genome CRISPR Screen Reveals the Mechanism of Relapse in Patient-Derived Cells Representing High-Risk Paediatric ALL

Katarzyna Szoltysek, PhD, Helen Blair, Sirintra Nakjang, Ricky Tirtakusuma, Mankaran Singh, Ryan Nelson, Hesta McNeill, Catherine Dodd, Melanie Beckett, Lynsey McKenzie, Edward Law, Josef Vormoor, MD PhD, Deepali Pal, Olaf Heidenreich
Journal: Blood
Blood (2019) 134 (Supplement_1): 3952.
https://doi.org/10.1182/blood-2019-124818
Published: 2019
Journal Articles

Genetic Ancestry and Skeletal Toxicities Among Childhood Acute Lymphoblastic Leukemia Patients in the DFCI 05-001 Cohort

Qianqian Zhu, PhD, Song Yao, PhD, Peter D Cole, MD, Justine M. Kahn, MD MS, Marian H. Harris, MD PhD, Emily Schiller, MS, Uma Athale, MDMBBS,MSc, Luis A. Clavell, MD, Caroline Laverdiere, MD FRCPC, Jean-Marie Leclerc, MDFRCPC, Bruno Michon, MD FRCPC, Marshall A. Schorin, MD, Jennifer J.G. Welch, MD, Stephen E. Sallan, MD, Lewis B. Silverman, MD, Kara M. Kelly, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3811.
https://doi.org/10.1182/blood-2019-126814
Published: 2019
Journal Articles

The Adherence to MRD Time Points Is a Significantly Prognostic Predictor in an MRD-Directed Therapy for Childhood Acute Lymphoblastic Leukemia in Taiwan

Hsi-Che Liu, MD, Ting-Chi Yeh, MD, Tang-Her Jaing, MD, Shih-Hsiang Chen, MD, Chih-Cheng Hsiao, MD, Shih-Chung Wang, MD, Kang-Hsi Wu, MD, Fang-Liang Huang, MD, Shyh-Shin Chiou, MD PhD, Hsiu-Ju Yen, MD, Yu-Hsiang Chang, MD, Shu-Huey Chen, MD, Yu-Hua Chao, MD PhD, Shin-Nan Cheng, MD, Jinn-Li Wang, MD PhD, Rong-Long Chen, MD, Chao-Ping Yang, MD, Iou-Jih Hung, MD, Jen-Yin Hou, MD, Ting-Huan Huang, MD, Jiunn-Ming Sheen, MD, Yu-Chieh Chen, MD, Ching-Tien Peng, MD PhD, Pei-Chin Lin, MD PhD, Yu-Mei Liao, MD, Te-Kau Chang, MD, Chien-Hui Hung, MD, Lee-Yung Shih, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3813.
https://doi.org/10.1182/blood-2019-124432
Published: 2019
Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

Jianping Li, MD, Catalina Troche, PhD, Julia Hlavka Zhang, BS, Jonathan Shrimp, PhD, Jacob S. Roth, PhD, Duohui Jing, PhD, Alok Swaroop, PhD, Marta Kulis, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Amin Sobn, PhD, Sharon Norton, MS, Richard Lynn Bennett, PhD, Min Shen, PhD, Matthew D. Hall, PhD, Richard B. Lock, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3758.
https://doi.org/10.1182/blood-2019-126910
Published: 2019
Journal Articles

Transient Elevations in Markers of Hepatic Function during Pediatric Acute Lymphoblastic Leukemia Treatment Are Common but Do Not Influence Outcomes: A Study of 805 Patients from the Learn Consortium

Joanna S. Yi, MD, Tiffany Chambers, MPH, Kelly D Getz, Tamara P. Miller, MDMSc, Evanette Burrows, MPH, Marla Daves, MD, Philip J. Lupo, PhD MPH, Michael E. Scheurer, PhD MPH, Richard Aplenc, MD PhD, Karen R. Rabin, MD PhD, Maria Monica J. Gramatges, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3814.
https://doi.org/10.1182/blood-2019-123992
Published: 2019
Journal Articles

Targeting Neurotrophic Receptor Tyrosine Kinase (NTRK) Fusion Structural Homologs in Refractory Pediatric Acute Lymphoblastic Leukemia (ALL)

Son Tran, Mehul Gupta, Sunand Kannappan, Chunfen Zhang, MD, Aru Narendran, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3882.
https://doi.org/10.1182/blood-2019-132223
Published: 2019
Journal Articles

Pediatric Preclinical Testing Consortium Evaluation of the Novel Anti-Microtubule Drug E7130 in Xenograft Models of Early T-Cell Precursor Acute Lymphoblastic Leukemia

Richard B. Lock, PhD, Kathryn Evans, Connor D Jones, Narimanne El-Zein, Katerina Bendak, PhD, Cara E Toscan, PhD, Chelsea Mayoh, Stephen W Erickson, PhD, Beverly A Teicher, PhD, Malcolm A Smith, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3875.
https://doi.org/10.1182/blood-2019-123867
Published: 2019
Journal Articles

Socioeconomic Status Is Associated with Prognostic Factors in Childhood Acute Lymphoblastic Leukemia - Implications for Outcomes: A Report from the Children's Oncology Group

Taumoha Ghosh, Michaela Richardson, MPH, Logan G. Spector, PhD, Lucie M Turcotte, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3808.
https://doi.org/10.1182/blood-2019-125091
Published: 2019
Journal Articles

Trends in Inpatient and Intensive Care Resource Utilization after Chimeric Antigen Receptor T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia from 2012-2019

Regina M. Myers, MD, Julie C Fitzgerald, MD, Amanda M. DiNofia, MD, Lisa Wray, MD, Allison Barz Leahy, MD, Yimei Li, PhD, Laura Smith, RN, MSN, CRNP, Evanette Burrows, MPH, Mark Ramos, BS, Laura S Motley, BSc, BSN, RN, Raabia N Khan, MPH, Kelly D Getz, Richard Aplenc, MD PhD, Stephan Grupp, MD PhD, Shannon L. Maude, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 61.
https://doi.org/10.1182/blood-2019-126724
Published: 2019
Journal Articles

NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children

Masanori Yoshida, MD, Kazuhiko Nakabayashi, PhD, Aiko Sato-Otsubo, PhD, Shinichi Tsujimoto, MD PhD, Kaoru Yoshida, MD, Ryota Shirai, MD, Tomoo Osumi, MD, Yuki Yuza, MD PhD, Masatoshi Takagi, MD PhD, Hiroyuki Takahashi, MD PhD, Katsuyoshi Koh, MD, Akitoshi Kinoshita, MD PhD, Moeko Hino, MD, Toshihiko Imamura, MD PhD, Yozo Nakazawa, MD PhD, Okuya Mayuko, MD PhD, Harumi Kakuda, MD PhD, Masashi Sanada, MD, Kimikazu Matsumoto, MD, PhD, Daisuke Tomizawa, MD PhD, Nobutaka Kiyokawa, MD PhD, Akira Ohara, MD PhD, Atsushi Manabe, MD PhD, Kenichiro Hata, MD PhD, Jun J. Yang, PhD, Motohiro Kato, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2751.
https://doi.org/10.1182/blood-2019-125713
Published: 2019