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Issue Archive

Volume 9, Issue 21
November 11 2025
In Progress
Blood Advances Cover Image for Volume 9, Issue 21

Volume 9 Issue 21 | Blood Advances | American Society of Hematology

Lymphoid Neoplasia

Familial forms of chronic lymphocytic leukemia have a worse prognosis than sporadic forms: an Italian case-control study
Alberto Fresa,Idanna Innocenti,Annamaria Tomasso,Candida Vitale,Alessandro Sanna,Anna Maria Frustaci,Andrea Visentin,Azzurra Romeo,Paolo Sportoletti,Annamaria Giordano,Francesca Perutelli,Roberta Murru,Francesca Romana Mauro,Antonio Mosca,Francesca Morelli,Roberta Laureana,Andrea Galitzia,Ilaria Angeletti,Esmeralda Conte,Riccardo Moia,Giovanni D’Arena,Raffaella Pasquale,Francesco Autore,Jacopo Olivieri,Luca Stirparo,Giulia Benintende,Francesco Angotzi,Florenzia Vuono,Andrea Corbingi,Maria Ilaria Del Principe,Diana Giannarelli,Alessandra Tedeschi,Marta Coscia,Eugenio Sangiorgi,Dimitar G. Efremov,Luca Laurenti
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High-grade B-cell lymphoma, not otherwise specified: an LLMPP study
Brett Collinge,Laura K. Hilton,Jasper Wong,Waleed Alduaij,Susana Ben-Neriah,Graham W. Slack,Pedro Farinha,Merrill Boyle,Barbara Meissner,James R. Cook,German Ott,Andreas Rosenwald,Elias Campo,Catalina Amador,Timothy C. Greiner,Philipp W. Raess,Joo Y. Song,Giorgio Inghirami,Sarah L. Ondrejka,Elaine S. Jaffe,Dennis D. Weisenburger,Wing C. Chan,Harald Holte,Klaus Beiske,Kai Fu,Jan Delabie,Stefania Pittaluga,Javeed Iqbal,George Wright,Kerry J. Savage,Andrew J. Mungall,Louis M. Staudt,Christian Steidl,Andrew L. Feldman,Ryan D. Morin,Lisa M. Rimsza,David W. Scott
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Routine prophylaxis with levetiracetam offers no benefit in CD19 CAR-T for LBCL: a multicenter propensity-matched study
Eugenio Galli,Roberta Di Blasi,Alice Di Rocco,Caterina Cristinelli,Ilaria Pansini,Côme Bommier,Alessandro Corrente,Ilenia De Bernardis,Marcello Viscovo,Stefan Hohaus,Anna Modoni,Federica Sorà,Patrizia Chiusolo,Maurizio Martelli,Simona Sica,Catherine Thieblemont
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Measurable residual disease detection after CAR-T may predict response in patients with large B-cell lymphoma
Clinical Trials & Observations
Nira Krasnow,Katie Maurer,Catherine Song,Justin Rhoades,Kan Xiong,Andjela Crnjac,Timothy Blewett,Lily Gao,Heather Jacene,Reid Merryman,Satyen H. Gohil,Caitlyn Duffy,Liliana I. Guerrero,Jamie Dela Cruz,Mikaela McDonough,Jacquelyn O. Wolff,Robert Redd,Mike Mattie,Brodie Miles,G. Mike Makrigiorgos,Donna S. Neuberg,Scott J. Rodig,Philippe Armand,Caron Jacobson,Viktor A. Adalsteinsson,Catherine J. Wu
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THROMBOSIS AND HEMOSTASIS

A disrupted adenosinergic axis facilitates platelet activation in APS: exploring a novel therapeutic target
Somanathapura K. NaveenKumar,Thalia G. Newman,Bruna Mazetto Fonseca,Srilakshmi Yalavarthi,Mariane C. Flores Nascimento,Kaitlyn Sabb,Katarina Kmetova,Emily Chong,Kavya Sugur,Caroline H. Ranger,Megan P. Tompkins,Cyrus Sarosh,Jacqueline A. Madison,Ajay Tambralli,Jordan K. Schaefer,Michael Holinstat,Yu Zuo,Jason S. Knight
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IMMUNOBIOLOGY AND IMMUNOTHERAPY

HLA-E[pHLA-G] complex–specific monoclonal antibody enhancing NK activity in multiple myeloma
Muhammad Abu Ahmad,Olga Radinsky,Bar Kaufman,Kamran Waidha,Eman Gharra,Sharon Dim,Dinesh Babu Manikandan,Noa Ofir,Dirk Jäger,Marten Meyer,Moshe Elkabets,Kerry S. Campbell,Miri Zektser,Roi Gazit,Ory Rouvio,Frank Momburg,Angel Porgador
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Real-world outcomes of infections following tisagenlecleucel in patients with B-cell ALL: a CIBMTR analysis
Clinical Trials & Observations
Hemalatha G. Rangarajan,Prakash Satwani,Megan M. Herr,Min Chen,Michael J. Martens,Kitsada Wudhikarn,Samuel John,Vanessa A. Fabrizio,Emily M. Hsieh,Amar H. Kelkar,Erin Doherty,David I. Marks,Olle Ringden,Brian Friend,Matthew S. Kelly,Nosha Farhadfar,Tim Prestidge,Nasheed M. Hossain,Hongtao Liu,Shahrukh Hashmi,Dipenkumar Modi,Lena E. Winestone,Zeinab El Boghdadly,Hemant S. Murthy,Miguel-Angel Perales,Roy F. Chemaly,Christopher E. Dandoy,Joshua A. Hill,Anna Huppler,Marcie Riches,Jeffery J. Auletta
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Comparative real-world outcomes of CD19-directed CAR T-cell therapies in large B-cell lymphoma
Xavier Deschênes-Simard,Maria Bromberg,Sean M. Devlin,Mithat Gonen,Ofrat Beyar-Katz,Andrew Ip,Ronit Marcus,Abraham Avigdor,Annamaria Ballweg,Emma Rabinovich,Mohammad Alhomoud,Alfredo Rivas Delgado,Magdalena Corona De Lapuerta,Alejandro Luna De Abia,Maria Lia Palomba,Gunjan L. Shah,Richard Lin,Alexander P. Boardman,Lorenzo Falchi,Jennifer Lue,Gilles Salles,Miguel-Angel Perales,Roni Shouval,Parastoo B. Dahi,Michael Scordo
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RESEARCH LETTER

Adult thymectomy is associated with increased mortality risk from cancer but not cardiovascular disease
Kameron A. Kooshesh,Brody H. Foy,Richard A. Baylis,Karin Gustafsson,Daniel A. Zlotoff,Tomas G. Neilan,David T. Scadden
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Late effects after thymectomy
Chintan Parekh
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Next-generation flow cytometry analysis of clonal bone marrow plasma cells identifies an indolent subset of MGUS
Jón Þórir Óskarsson,Sigrun Thorsteinsdottir,Sæmundur Rögnvaldsson,Andri Ólafsson,Gunnhildur Viðarsdóttir,Elfa Rún Guðmundsdóttir,Elias Eythorsson,Ásbjörn Jónsson,Brynjar Viðarsson,Páll T. Önundarson,Bjarni A. Agnarsson,Margrét Sigurðardóttir,Ingunn Þorsteinsdóttir,Ísleifur Ólafsson,Stephen J. Harding,Brian GM Durie,Thorvardur Jon Love,Sigurdur Y. Kristinsson
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Impact of radiotherapy site, modality, and dose on subsequent clonal hematopoiesis
Alexander G. Goglia,Griffen R. Mustion,Leslie A. Modlin,Ross L. Levine,Kelly L. Bolton,Lior Z. Braunstein
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Inside Blood Advances

Late effects after thymectomy
Chintan Parekh
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After the fog has lifted: infections with CD19 CAR-T therapy
Catherine Orla Morrissey
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ctDNA MRD after CAR-T
Clinical Trials & Observations
Salvatore Fiorenza,Mark R. Dowling
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CLINICAL TRIALS AND OBSERVATIONS

Infection after CD19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma: real-world analysis from CIBMTR
Clinical Trials & Observations
Kitsada Wudhikarn,Megan M. Herr,Min Chen,Michael J. Martens,John H. Baird,Lohith Gowda,Hemalatha G. Rangarajan,Muhammad Bilal Abid,Mohamed A. Kharfan-Dabaja,Kirsten M. Williams,Siddhartha Ganguly,Jo-Anne H. Young,Akshay Sharma,Giancarlo Fatobene,Tania Jain,Christopher G. Kanakry,Dipenkumar Modi,Natalie S. Grover,Baheyeldin Salem,Marjorie Vieira Batista,Paschalis Vergidis,Dwight E. Yin,Amer M. Beitinjaneh,Amar H. Kelkar,Taiga Nishihori,Jennifer Holter Chakrabarty,Usama Gergis,Melody Smith,Zeinab El Boghdadly,Christopher E. Dandoy,Hemant S. Murthy,Anna R. Huppler,Miguel-Angel Perales,Roy F. Chemaly,Joshua A. Hill,Marcie Riches,Jeffery J. Auletta
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Supplemental data
After the fog has lifted: infections with CD19 CAR-T therapy
Catherine Orla Morrissey
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Outcomes of patients with suspected heparin-induced thrombocytopenia in a contemporary multicenter cohort
Clinical Trials & Observations
Henning Nilius,Ekaterina Sinitsa,Jan-Dirk Studt,Dimitrios A. Tsakiris,Andreas Greinacher,Adriana Mendez,Adrian Schmidt,Walter A. Wuillemin,Bernhard Gerber,Prakash Vishnu,Lukas Graf,Johanna A. Kremer Hovinga,Tamam Bakchoul,Michael Nagler
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Novel devimistat results in complete remissions in heavily pretreated Burkitt lymphoma in a phase 2 trial
Clinical Trials & Observations
Raphael Steiner,Liana Nikolaenko,Ranjit Nair,Venkatraman Seshan,Swetha Kambhampati Thiruvengadam,Niloufer Khan,Jeremy S. Abramson,Steven Horwitz,Matthew Matasar,Colette Owens,Ildefonso Ismael Rodriguez Rivera,David J. Straus,Timothy S. Pardee,Sanjeev Luther,Sabrina Saboukoulou,Win Su Thet,Shreya Vemuri,Ariela Noy
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MYELOID NEOPLASIA

Overcoming venetoclax resistance through heme-mediated NOXA/cyclin D1/Mcl-1 axis with a novel artemisinin conjugate
Jingyi Zhang,Zhenwei Zhang,Jinghua Liu,Shenglin Luan,Jiqiang Qu,Zi Wu,Yafei Kuang,Ping Gong,Yu Bao,Yuetong Wang,Xiaojing Yan,Samuel Waxman,Linxiang Zhao,Yongkui Jing
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SYSTEMATIC REVIEW

Efficacy and safety of thrombolysis for pediatric venous thromboembolism: a systematic review and meta-analysis
Hassan Kawtharany,Muayad Azzam,Aseel Alkhader,Marisol Betensky,Qais Hamarsha,Hadi K. Abou Zeid,Razan Mansour,Carine Tabak,Payal Patel,Sarah L. Baghdadi,Rachel S. Bercovitz,Rukhmi Bhat,Tina Biss,Brian R. Branchford,Leonardo R. Brandão,Anthony K. C. Chan,E. Vincent S. Faustino,Julie Jaffray,Sophie Jones,Bryce A. Kerlin,Nicole Kucine,Riten Kumar,Christoph Male,Marie-Claude Pelland-Marcotte,Leslie Raffini,Chittalsinh M. Raulji,Sarah E. Sartain,Clifford M. Takemoto,Cristina Tarango,C. Heleen van Ommen,Maria C. Velez,Sara K. Vesely,John Wiernikowski,Suzan Williams,Hope P. Wilson,Gary Woods,Ayesha Zia,Paul Monagle,Reem A. Mustafa
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TRANSPLANTATION

Ixazomib decreases the risk of chronic graft-versus-host disease: identification of cGVHD biomarkers
Clinical Trials & Observations
Teresa Caballero-Velázquez,Javier Delgado Serrano,Lucía López-Corral,Christelle Ferra-Coll,Clara Beatriz García-Calderón,David Valcárcel,Irene García-Cadenas,Estefanía Pérez López,María-José Jiménez Lorenzo,Francisco Manuel Martín-Domínguez,María de los Reyes Jiménez-León,Guillermo Orti,Virginia Escamilla Gómez,Cristina Blázquez-Goñi,Almudena Cabero Martínez,Henry Andrade Ruiz,Estefanía Menéndez-Pedregal,Fermín Sánchez-Guijo,José Antonio Pérez Simón
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Late effects after thymectomy
After the fog has lifted: infections with CD19 CAR-T therapy
ctDNA MRD after CAR-T
Next-generation flow cytometry analysis of clonal bone marrow plasma cells identifies an indolent subset of MGUS
Comparative real-world outcomes of CD19-directed CAR T-cell therapies in large B-cell lymphoma

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