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Issue Archive

Volume 117, Issue 25
June 23 2011
Blood Cover Image for Volume 117, Issue 25

Table of Contents

Inside Blood

CLINICAL TRIALS
Ph: not bad at all
François Guilhot
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IMMUNOBIOLOGY
Self-enabling T cells
Terry J. Fry
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THROMBOSIS & HEMOSTASIS
A new fish for the β2GPI hook: LPS!
Jacob H. Rand
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TRANSPLANTATION
ATG and RIC: not such a good match?
Sergio Giralt
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Perspectives

New sources of drugs for hematologic malignancies
Clinical Trials & Observations
Mahadeo A. Sukhai,Paul A. Spagnuolo,Scott Weir,James Kasper,Lavonne Patton,Aaron D. Schimmer
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Review Articles

Peripheral T-cell lymphoma
Francine M. Foss,Pier Luigi Zinzani,Julie M. Vose,Randy D. Gascoyne,Steven T. Rosen,Kensei Tobinai
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How I Treat

How I treat the acquired von Willebrand syndrome
Andreas Tiede,Jacob H. Rand,Ulrich Budde,Arnold Ganser,Augusto B. Federici
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Hematopoiesis and Stem Cells

Inhibition of cellular senescence by developmentally regulated FGF receptors in mesenchymal stem cells
Daniel L. Coutu,Moïra François,Jacques Galipeau
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Supplemental data
SNP array–based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes
Clinical Trials & Observations
Manuel G. Afable, II,Marcin Wlodarski,Hideki Makishima,Mohammed Shaik,Mikkael A. Sekeres,Ramon V. Tiu,Matt Kalaycio,Christine L. O'Keefe,Jaroslaw P. Maciejewski
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Supplemental data

Immunobiology

Thymic T-cell development in allogeneic stem cell transplantation
Werner Krenger,Bruce R. Blazar,Georg A. Holländer
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Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination
Constandina Pospori,Shao-An Xue,Angelika Holler,Cecile Voisine,Mario Perro,Judith King,Farnaz Fallah-Arani,Barry Flutter,Ronjon Chakraverty,Hans J. Stauss,Emma C. Morris
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Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived β-glucans
Chunjian Qi,Yihua Cai,Lacey Gunn,Chuanlin Ding,Bing Li,Goetz Kloecker,Keqing Qian,John Vasilakos,Shinobu Saijo,Yoichiro Iwakura,John R. Yannelli,Jun Yan
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Supplemental data

Lymphoid Neoplasia

Constitutive Notch pathway activation in murine ZMYM2-FGFR1–induced T-cell lymphomas associated with atypical myeloproliferative disease
MingQiang Ren,John K. Cowell
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Supplemental data
Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia
Vikki Rand,Helen Parker,Lisa J. Russell,Claire Schwab,Hannah Ensor,Julie Irving,Lisa Jones,Dino Masic,Lynne Minto,Heather Morrison,Sarra Ryan,Hazel Robinson,Paul Sinclair,Anthony V. Moorman,Jonathan C. Strefford,Christine J. Harrison
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Supplemental data
Development and characterization of APRIL antagonistic monoclonal antibodies for treatment of B-cell lymphomas
Marco Guadagnoli,Fiona C. Kimberley,Uyen Phan,Katherine Cameron,Paul M. Vink,Hans Rodermond,Eric Eldering,Arnon P. Kater,Hans van Eenennaam,Jan Paul Medema
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Supplemental data

Myeloid Neoplasia

Variant Philadelphia translocations: molecular-cytogenetic characterization and prognostic influence on frontline imatinib therapy, a GIMEMA Working Party on CML analysis
Clinical Trials & Observations
Giulia Marzocchi,Fausto Castagnetti,Simona Luatti,Carmen Baldazzi,Monica Stacchini,Gabriele Gugliotta,Marilina Amabile,Giorgina Specchia,Mario Sessarego,Ursula Giussani,Laura Valori,Giancarlo Discepoli,Anna Montaldi,Alessandra Santoro,Laura Bonaldi,Giovanni Giudici,Anna Maria Cianciulli,Francesca Giacobbi,Francesca Palandri,Fabrizio Pane,Giuseppe Saglio,Giovanni Martinelli,Michele Baccarani,Gianantonio Rosti,Nicoletta Testoni,for the Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA) Working Party on Chronic Myeloid Leukemia
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Supplemental data
R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm
Kotaro Shide,Takuro Kameda,Vadim Markovtsov,Haruko K. Shimoda,Elizabeth Tonkin,Shuling Fang,Chian Liu,Marina Gelman,Wayne Lang,Jason Romero,John McLaughlin,Somasekhar Bhamidipati,Jeffrey Clough,Caroline Low,Andrea Reitsma,Stacey Siu,Polly Pine,Gary Park,Allan Torneros,Matt Duan,Rajinder Singh,Donald G. Payan,Takuya Matsunaga,Yasumichi Hitoshi,Kazuya Shimoda
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Supplemental data
p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemia
Shannon Elf,Dean Blevins,Lingtao Jin,Tae-Wook Chung,Ifor R. Williams,Benjamin H. Lee,Jian-Xin Lin,Warren J. Leonard,Jack Taunton,Hanna J. Khoury,Sumin Kang
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Supplemental data
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome
Qian-fei Wang,George Wu,Shuangli Mi,Fuhong He,Jun Wu,Jingfang Dong,Roger T. Luo,Ryan Mattison,Joseph J. Kaberlein,Shyam Prabhakar,Hongkai Ji,Michael J. Thirman
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Supplemental data
A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia
Dong Hwan (Dennis) Kim,Seung-Tae Lee,Hong-Hee Won,Seonwoo Kim,Min-Ji Kim,Hee-Jin Kim,Sun-Hee Kim,Jong-Won Kim,Hyeoung-Joon Kim,Yeo-Kyeoung Kim,Sang Kyun Sohn,Joon Ho Moon,Chul Won Jung,Jeffrey H. Lipton
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Supplemental data
DOT1L, the H3K79 methyltransferase, is required for MLL-AF9–mediated leukemogenesis
Anh Tram Nguyen,Olena Taranova,Jin He,Yi Zhang
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Supplemental data
Overexpression of microRNA-16-2 contributes to the abnormal erythropoiesis in polycythemia vera
Brief Report
Paola Guglielmelli,Lorenzo Tozzi,Costanza Bogani,Ilaria Iacobucci,Vanessa Ponziani,Giovanni Martinelli,Alberto Bosi,Alessandro M. Vannucchi,on behalf of the AGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative) Investigators
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Supplemental data

Red Cells, Iron, and Erythropoiesis

Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival
CME
Richard J. Kelly,Anita Hill,Louise M. Arnold,Gemma L. Brooksbank,Stephen J. Richards,Matthew Cullen,Lindsay D. Mitchell,Dena R. Cohen,Walter M. Gregory,Peter Hillmen
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Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1α localization in erythroblasts
Raffaele Renella,Nigel A. Roberts,Jill M. Brown,Marco De Gobbi,Louise E. Bird,Tasneem Hassanali,Jacqueline A. Sharpe,Jacqueline Sloane-Stanley,David J. P. Ferguson,Jacqueline Cordell,Veronica J. Buckle,Douglas R. Higgs,William G. Wood
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Supplemental data
Serum hepcidin: reference ranges and biochemical correlates in the general population
e-blood
Tessel E. Galesloot,Sita H. Vermeulen,Anneke J. Geurts-Moespot,Siem M. Klaver,Joyce J. Kroot,Dorlene van Tienoven,Jack F. M. Wetzels,Lambertus A. L. M. Kiemeney,Fred C. Sweep,Martin den Heijer,Dorine W. Swinkels
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Supplemental data

Thrombosis and Hemostasis

β2-Glycoprotein I: a novel component of innate immunity
Çetin Ağar,Philip G. de Groot,Matthias Mörgelin,Stephanie D. D. C. Monk,Gwendolyn van Os,Johannes H. M. Levels,Bas de Laat,Rolf T. Urbanus,Heiko Herwald,Tom van der Poll,Joost C. M. Meijers
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First-trimester low-dose prednisolone in refractory antiphospholipid antibody–related pregnancy loss
Brief Report
Kate Bramham,Mari Thomas,Catherine Nelson-Piercy,Munther Khamashta,Beverley J. Hunt
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Transplantation

Depletion of CD25+ T cells from hematopoietic stem cell grafts increases posttransplantation vaccine-induced immunity to neuroblastoma
Weiqing Jing,Xiaocai Yan,William H. D. Hallett,Jill A. Gershan,Bryon D. Johnson
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Supplemental data
Impact of immune modulation with anti–T-cell antibodies on the outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies
Clinical Trials & Observations
Robert J. Soiffer,Jennifer LeRademacher,Vincent Ho,Fangyu Kan,Andrew Artz,Richard E. Champlin,Steven Devine,Luis Isola,Hillard M. Lazarus,David I. Marks,David L. Porter,Edmund K. Waller,Mary M. Horowitz,Mary Eapen
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Supplemental data

Other Departments

Continuing Medical Education (CME) questions: survival of patients with PNH on eculizumab
CME
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All Issues

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