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Volume 128, Issue 5

August 4 2016

In this Issue

Blood Flashback
Inside Blood Commentaries
Plenary Paper
Blood Spotlight
Clinical Trials and Observations
Hematopoiesis and Stem Cells
Immunobiology
Lymphoid Neoplasia
Myeloid Neoplasia
Platelets and Thrombopoiesis
Red Cells, Iron, and Erythropoiesis
Thrombosis and Hemostasis
Letters to Blood
Blood Work

Blood Flashback

Freireich EJ, Miller A, Emerson CP, Ross JF. The effect of inflammation on the utilization of erythrocyte and transferrin bound radioiron for red cell production. Blood. 1957;12(11):972-983.

View Articletitled, Freireich EJ, Miller A, Emerson CP, Ross JF. The effect of inflammation on the utilization of erythrocyte and transferrin bound radioiron for red cell production. <em>Blood</em>. 1957;12(11):<span class="related-article">972-983</span>.

Inside Blood Commentaries

INSIDE BLOOD COMMENTARY

I’m TORC1-ing platelets and thromboembolism

Adam D. Munday

View Articletitled, I’m TORC1-ing platelets and thromboembolism

INSIDE BLOOD COMMENTARY

FBXO11: a novel germinal center B-cell regulator?

Kojo S. J. Elenitoba-Johnson

View Articletitled, FBXO11: a novel germinal center B-cell regulator?

INSIDE BLOOD COMMENTARY

Versican vs versikine: tolerance vs attack

Michael Schmitt

View Articletitled, Versican vs versikine: tolerance vs attack

INSIDE BLOOD COMMENTARY

ROS: novel regulators of thrombopoiesis

Bing Zhang,James L. Zehnder

View Articletitled, ROS: novel regulators of thrombopoiesis

Plenary Paper

THROMBOSIS AND HEMOSTASIS

mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation

Jun Yang,Xuan Zhou,Xiaorong Fan,Min Xiao,Dinghua Yang,Bo Liang,Meng Dai,Lanlan Shan,Jingbo Lu,Zhiqi Lin,Rong Liu,Jun Liu,Liping Wang,Mei Zhong,Yu Jiang,Xiaochun Bai

View Articletitled, mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation

Supplemental data

Blood Spotlight

Mechanisms of platelet-mediated liver regeneration

Ton Lisman,Robert J. Porte

View Articletitled, Mechanisms of platelet-mediated liver regeneration

Clinical Trials and Observations

Efficacy and safety of rVIII-SingleChain: results of a phase 1/3 multicenter clinical trial in severe hemophilia A
Clinical Trials & Observations

Johnny Mahlangu,Kazimierz Kuliczkowski,Faraizah Abdul Karim,Oleksandra Stasyshyn,Marina V. Kosinova,Lynda Mae Lepatan,Aleksander Skotnicki,Lisa N. Boggio,Robert Klamroth,Johannes Oldenburg,Andrzej Hellmann,Elena Santagostino,Ross I. Baker,Kathelijn Fischer,Joan C. Gill,Stephanie P’Ng,Pratima Chowdary,Miguel A. Escobar,Claudia Djambas Khayat,Luminita Rusen,Debra Bensen-Kennedy,Nicole Blackman,Tharin Limsakun,Alex Veldman,Katie St. Ledger,Ingrid Pabinger,for the AFFINITY Investigators

View Articletitled, Efficacy and safety of rVIII-SingleChain: results of a phase 1/3 multicenter clinical trial in severe hemophilia A

Supplemental data

Hematopoiesis and Stem Cells

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Shuhei Koide,Motohiko Oshima,Keiyo Takubo,Satoshi Yamazaki,Eriko Nitta,Atsunori Saraya,Kazumasa Aoyama,Yuko Kato,Satoru Miyagi,Yaeko Nakajima-Takagi,Tetsuhiro Chiba,Hirotaka Matsui,Fumio Arai,Yutaka Suzuki,Hiroshi Kimura,Hiromitsu Nakauchi,Toshio Suda,Yoichi Shinkai,Atsushi Iwama

View Articletitled, Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Supplemental data

Immunobiology

XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination

Hanna IJspeert,Jacob Rozmus,Klaus Schwarz,René L. Warren,David van Zessen,Robert A. Holt,Ingrid Pico-Knijnenburg,Erik Simons,Isabel Jerchel,Angela Wawer,Myriam Lorenz,Turkan Patıroğlu,Himmet Haluk Akar,Ricardo Leite,Nicole S. Verkaik,Andrew P. Stubbs,Dik C. van Gent,Jacques J. M. van Dongen,Mirjam van der Burg

View Articletitled, XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination

Supplemental data

Lymphoid Neoplasia

FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease

Christof Schneider,Ning Kon,Letizia Amadori,Qiong Shen,Friederike H. Schwartz,Benjamin Tischler,Marion Bossennec,David Dominguez-Sola,Govind Bhagat,Wei Gu,Katia Basso,Riccardo Dalla-Favera

View Articletitled, FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease

Supplemental data

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Marina Bolzoni,Martina Chiu,Fabrizio Accardi,Rosanna Vescovini,Irma Airoldi,Paola Storti,Katia Todoerti,Luca Agnelli,Gabriele Missale,Roberta Andreoli,Massimiliano G. Bianchi,Manfredi Allegri,Amelia Barilli,Francesco Nicolini,Albertina Cavalli,Federica Costa,Valentina Marchica,Denise Toscani,Cristina Mancini,Eugenia Martella,Valeria Dall’Asta,Gaetano Donofrio,Franco Aversa,Ovidio Bussolati,Nicola Giuliani

View Articletitled, Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Supplemental data

Immunoregulatory roles of versican proteolysis in the myeloma microenvironment
Brief Report

Chelsea Hope,Simon Foulcer,Justin Jagodinsky,Sarah X. Chen,Jeffrey L. Jensen,Sanjay Patel,Catherine Leith,Ioanna Maroulakou,Natalie Callander,Shigeki Miyamoto,Peiman Hematti,Suneel S. Apte,Fotis Asimakopoulos

View Articletitled, Immunoregulatory roles of versican proteolysis in the myeloma microenvironment

Supplemental data

Myeloid Neoplasia

Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia

Klaus H. Metzeler,Tobias Herold,Maja Rothenberg-Thurley,Susanne Amler,Maria C. Sauerland,Dennis Görlich,Stephanie Schneider,Nikola P. Konstandin,Annika Dufour,Kathrin Bräundl,Bianka Ksienzyk,Evelyn Zellmeier,Luise Hartmann,Philipp A. Greif,Michael Fiegl,Marion Subklewe,Stefan K. Bohlander,Utz Krug,Andreas Faldum,Wolfgang E. Berdel,Bernhard Wörmann,Thomas Büchner,Wolfgang Hiddemann,Jan Braess,Karsten Spiekermann

View Articletitled, Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia

Supplemental data

Platelets and Thrombopoiesis

BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans

Song Wu,Zongdong Li,Dmitri V. Gnatenko,Beibei Zhang,Lu Zhao,Lisa E. Malone,Nedialka Markova,Timothy J. Mantle,Natasha M. Nesbitt,Wadie F. Bahou

View Articletitled, BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans

Supplemental data

Red Cells, Iron, and Erythropoiesis

Critical requirement of VEGF-C in transition to fetal erythropoiesis

Shentong Fang,Harri Nurmi,Krista Heinolainen,Shuo Chen,Essi Salminen,Pipsa Saharinen,Hanna K. A. Mikkola,Kari Alitalo

View Articletitled, Critical requirement of VEGF-C in transition to fetal erythropoiesis

Supplemental data

Thrombosis and Hemostasis

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice

Maureen A. Shaw,Keith W. Kombrinck,Kathryn E. McElhinney,David R. Sweet,Matthew J. Flick,Joseph S. Palumbo,Mei Cheng,Naomi L. Esmon,Charles T. Esmon,Alexander Brill,Denisa D. Wagner,Jay L. Degen,Eric S. Mullins

View Articletitled, Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice

Supplemental data

Letters to Blood

A pharmacogenetic analysis of the Canadian Cancer Trials Group MY.10 clinical trial of maintenance therapy for multiple myeloma
Clinical Trials & Observations

Ming Han,Alli Murugesan,Nizar J. Bahlis,Kevin Song,Darrell White,Christine Chen,Matthew D. Seftel,Kang Howsen-Jan,Donna Reece,Keith Stewart,Yagang Xie,Annette E. Hay,Lois Shepherd,Marina Djurfeldt,Liting Zhu,Ralph M. Meyer,Bingshu E. Chen,Tony Reiman

View Articletitled, A pharmacogenetic analysis of the Canadian Cancer Trials Group MY.10 clinical trial of maintenance therapy for multiple myeloma

Supplemental data

Allogeneic bone marrow transplantation for treatment of severe hemolytic anemia attributable to hexokinase deficiency
Clinical Trials & Observations

Sajad Khazal,Veronika Polishchuk,Deepa Manwani,Patrick G. Gallagher,Samantha Prinzing,Kris Michael Mahadeo

View Articletitled, Allogeneic bone marrow transplantation for treatment of severe hemolytic anemia attributable to hexokinase deficiency

Blood Work

Bone marrow smear examination in the diagnosis of Niemann-Pick B disease

Barbara Foucher,Liliana Vila

View Articletitled, Bone marrow smear examination in the diagnosis of Niemann-Pick B disease

Florid erythrophagocytosis by neutrophils in peripheral blood

Weijie Li,Naresh Reddivalla

View Articletitled, Florid erythrophagocytosis by neutrophils in peripheral blood

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Table of Contents

Blood Flashback

Freireich EJ, Miller A, Emerson CP, Ross JF. The effect of inflammation on the utilization of erythrocyte and transferrin bound radioiron for red cell production. Blood. 1957;12(11):972-983.

Inside Blood Commentaries

I’m TORC1-ing platelets and thromboembolism

FBXO11: a novel germinal center B-cell regulator?

Versican vs versikine: tolerance vs attack

ROS: novel regulators of thrombopoiesis

Plenary Paper

mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation

Blood Spotlight

Mechanisms of platelet-mediated liver regeneration

Clinical Trials and Observations

Efficacy and safety of rVIII-SingleChain: results of a phase 1/3 multicenter clinical trial in severe hemophilia A
Clinical Trials & Observations

Hematopoiesis and Stem Cells

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Immunobiology

XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination

Lymphoid Neoplasia

FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Immunoregulatory roles of versican proteolysis in the myeloma microenvironment
Brief Report

Myeloid Neoplasia

Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia

Platelets and Thrombopoiesis

BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans

Red Cells, Iron, and Erythropoiesis

Critical requirement of VEGF-C in transition to fetal erythropoiesis

Thrombosis and Hemostasis

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice

Letters to Blood

A pharmacogenetic analysis of the Canadian Cancer Trials Group MY.10 clinical trial of maintenance therapy for multiple myeloma
Clinical Trials & Observations

Allogeneic bone marrow transplantation for treatment of severe hemolytic anemia attributable to hexokinase deficiency
Clinical Trials & Observations

Blood Work

Bone marrow smear examination in the diagnosis of Niemann-Pick B disease

Florid erythrophagocytosis by neutrophils in peripheral blood

Email alerts

ASH Publications

American Society of Hematology

Issue Archive

Table of Contents

Blood Flashback

Inside Blood Commentaries

Plenary Paper

Blood Spotlight

Clinical Trials and Observations

Efficacy and safety of rVIII-SingleChain: results of a phase 1/3 multicenter clinical trial in severe hemophilia A Clinical Trials & Observations

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

Immunoregulatory roles of versican proteolysis in the myeloma microenvironment Brief Report

Myeloid Neoplasia

Platelets and Thrombopoiesis

Red Cells, Iron, and Erythropoiesis

Thrombosis and Hemostasis

Letters to Blood

A pharmacogenetic analysis of the Canadian Cancer Trials Group MY.10 clinical trial of maintenance therapy for multiple myeloma Clinical Trials & Observations

Allogeneic bone marrow transplantation for treatment of severe hemolytic anemia attributable to hexokinase deficiency Clinical Trials & Observations

Blood Work

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Efficacy and safety of rVIII-SingleChain: results of a phase 1/3 multicenter clinical trial in severe hemophilia A
Clinical Trials & Observations

Immunoregulatory roles of versican proteolysis in the myeloma microenvironment
Brief Report

A pharmacogenetic analysis of the Canadian Cancer Trials Group MY.10 clinical trial of maintenance therapy for multiple myeloma
Clinical Trials & Observations

Allogeneic bone marrow transplantation for treatment of severe hemolytic anemia attributable to hexokinase deficiency
Clinical Trials & Observations