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Frederique Orsini
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Journal Articles

RAS/RAF landscape in monoclonal plasma cell conditions

Brief Report
Anais Schavgoulidze, Jill Corre, Mehmet Kemal Samur, Celine Mazzotti, Luka Pavageau, Aurore Perrot, Titouan Cazaubiel, Xavier Leleu, Margaret Macro, Karim Belhadj, Murielle Roussel, Sabine Brechignac, Lydia Montes, Denis Caillot, Laurent Frenzel, Philippe Rey, Jean-Marc Schiano de Colella, Thomas Chalopin, Caroline Jacquet, Valentine Richez, Frederique Orsini-Piocelle, Jean Fontan, Salomon Manier, Ludovic Martinet, Adam Sciambi, Mohamad Mohty, Herve Avet-Loiseau
Journal: Blood
Blood (2024) 144 (2): 201–205.
https://doi.org/10.1182/blood.2023022295
Published: 2024
Includes: Supplemental data
Journal Articles

The phase 2 LYSA study of prednisone, vinblastine, doxorubicin, and bendamustine for untreated Hodgkin lymphoma in older patients

Clinical Trials & Observations
Hervé Ghesquières, Daphné Krzisch, Emmanuelle Nicolas-Virelizier, Salim Kanoun, Anne Claire Gac, Stéphanie Guidez, Mohamed Touati, Kamel Laribi, Franck Morschhauser, Christophe Bonnet, Agathe Waultier-Rascalou, Frédérique Orsini-Piocelle, Marc André, Marguerite Fournier, Fabienne Morand, Alina Berriolo-Riedinger, Barbara Burroni, Diane Damotte, Alexandra Traverse-Glehen, Philippe Quittet, Olivier Casasnovas
Journal: Blood
Blood (2024) 143 (11): 983–995.
https://doi.org/10.1182/blood.2023021564
Published: 2024
Includes: Supplemental data
Journal Articles

Multicenter Open Label Phase 2 Study of Quadruplet-Based Regimen Iskpd (isatuximab plus pomalidomide and dexamethasone with carfilzomib) in Early Relapsed or Refractory Multiple Myeloma - IFM2018-03

Arthur Bobin, Jerome Lambert, Stéfanie Ragot, Aurore Perrot, Salomon Manier, Lionel Karlin, Denis Caillot, Lotfi Benboubker, Thomas Chalopin, Carla Araujo, Jean Fontan, Thorsten Braun, Clara Mariette, Elodie Scherman, Olivier Decaux, jean Sebastien Blade, Faiza Keddar, Christophe Roul, Mamoun Dib, Jill Corre, Frederique Orsini Piocelle, Laure Vincent, Cyrille Touzeau, Philippe Moreau, Herve Avet Loiseau, Xavier Leleu
Journal: Blood
Blood (2023) 142 (Supplement 1): 6742.
https://doi.org/10.1182/blood-2023-185792
Published: 2023
Journal Articles

Multicenter Open Label Phase 3 Benefit Study of Isatuximab Plus Lenalidomide and Dexamethasone with/without Bortezomib in the Treatment of Newly Diagnosed Non-Frail Transplant Ineligible Multiple Myeloma Elderly Patients. IFM2020-05

Arthur Bobin, Cyrille Hulin, Jerome Lambert, Aurore Perrot, Salomon Manier, Lydia Montes, Arnaud Jaccard, Lionel Karlin, Pascal Godmer, Denis Caillot, Thomas Chalopin, Christophe Roul, Clara Mariette, Sophie Rigaudeau, Jacques Delaunay, Claire Dingremont, Alberto Santagostino, Mamoun Dib, Margaret Macro, Mourad Tiab, Kamel Laribi, Emmanuelle Bourgeois Petit, Claire Calmettes, Frederique Orsini Piocelle, Benoit Bareau, Reza Tabrizi, Laure Vincent, Mohamad Mohty, Cyrille Touzeau, Jill Corre, Philippe Moreau, Thierry Facon, Herve Avet Loiseau, Xavier Leleu
Journal: Blood
Blood (2023) 142 (Supplement 1): 6741.
https://doi.org/10.1182/blood-2023-185699
Published: 2023
Journal Articles

Biallelic deletion of 1p32 defines ultra-high-risk myeloma, but monoallelic del(1p32) remains a strong prognostic factor

CME Clinical Trials & Observations
Anaïs Schavgoulidze, Alexis Talbot, Aurore Perrot, Titouan Cazaubiel, Xavier Leleu, Salomon Manier, Laure Buisson, Sabrina Mahéo, Laura Do Souto Ferreira, Luka Pavageau, Cyrille Hulin, Jean-Pierre Marolleau, Laurent Voillat, Karim Belhadj, Marion Divoux, Borhane Slama, Sabine Brechignac, Margaret Macro, Anne-Marie Stoppa, Laurence Sanhes, Frédérique Orsini-Piocelle, Jean Fontan, Marie-Lorraine Chretien, Hélène Demarquette, Mohamad Mohty, Hervé Avet-Loiseau, Jill Corre
Journal: Blood
Blood (2023) 141 (11): 1308–1315.
https://doi.org/10.1182/blood.2022017863
Published: 2023
Includes: Supplemental data
Journal Articles

Multicenter Open Label Phase 2 Study of Isatuximab Plus Pomalidomide and Dexamethasone with Carfilzomib in Relapsed or Refractory Multiple Myeloma. Iskpd - IFM2018-03

Arthur Bobin, Jerome Lambert, Stéphanie Ragot, Aurore Perrot, Salomon Manier, Lionel Karlin, Denis Caillot, Cyrille Hulin, Lotfi Benboubker, Carla Araujo, Jean Fontan, Thorsten Braun, Clara Mariette, Elodie Scherman, Olivier Decaux, jean Sebastien Blade, Faida Keddar, Christophe Roul, Mamoun Dib, Jill Corre, Frederique Orsini, Laure Vincent, Mohamad Mohty, Cyrille Touzeau, Philippe Moreau, Herve Avet Loiseau, Xavier Leleu
Journal: Blood
Blood (2022) 140 (Supplement 1): 4452–4453.
https://doi.org/10.1182/blood-2022-166870
Published: 2022
Journal Articles

Multicenter Open Label Phase 3 Study of Isatuximab Plus Lenalidomide and Dexamethasone with/without Bortezomib in the Treatment of Newly Diagnosed Non-Frail Transplant Ineligible Multiple Myeloma Elderly Patients (≥ 65; < 80 Years). IFM2020-05/Benefit

Arthur Bobin, Jerome Lambert, Aurore Perrot, Salomon Manier, Lydia Montes, Arnaud Jaccard, Lionel Karlin, Pascal Godmer, Denis Caillot, Cyrille Hulin, Thomas Chalopin, Christophe Roul, Clara Mariette, Sophie Rigaudeau, Claire Dingremont, Alberto Santagostino, Mamoun Dib, Margaret Macro, Mourad Tiab, Kamel Laribi, Emmanuelle Bourgeois-Petit, Claire Calmettes, Frederique Orsini, Reza Tabrizi, Laure Vincent, Mohamad Mohty, Cyrille Touzeau, Jill Corre, Philippe Moreau, Thierry Facon, Herve Avet Loiseau, Xavier Leleu
Journal: Blood
Blood (2022) 140 (Supplement 1): 4423–4425.
https://doi.org/10.1182/blood-2022-168742
Published: 2022
Journal Articles

A Fixed-Duration Immunochemotherapy Approach Combined with Ibrutinib in CLL Produces Deep and Sustained MRD Responses: 5.5-Year Results from the Icll-07 Filo Trial

Anne-Sophie Michallet, Rémi Letestu, Magali Le Garff-Tavernier, Carmen Aanaei, Michel Ticchioni, Marie-Sarah Dilhuydy, Stephane Morisset, Valérie Rouille, Béatrice Mahé, Kamel Laribi, Bruno Villemagne, Emmanuelle Ferrant, Olivier Tournilhac, Alain Delmer, Christelle Portois, Lysiane Molina, Véronique Leblond, Cécile Tomowiak, Sophie de Guibert, Frederique Orsini, Anne Banos, Philippe Carassou, Guillaume Cartron, Luc Mathieu Fornecker, Loic Ysebaert, Caroline Dartigeas, Margot Truchan, Jean-Pierre Vilque, Therese Aurran Schleinitz, Cymbalista Florence, Stéphane Leprêtre, Vincent Lévy, Florence Nguyen Khac, Pierre Feugier
Journal: Blood
Blood (2022) 140 (Supplement 1): 7013–7015.
https://doi.org/10.1182/blood-2022-157963
Published: 2022
Journal Articles

A Dexamethasone Sparing-Regimen with Daratumumab and Lenalidomide in Frail Patients with Newly-Diagnosed Multiple Myeloma: Efficacy and Safety Analysis of the Phase 3 IFM2017-03 Trial

Salomon Manier, Jill Corre, Cyrille Hulin, Kamel Laribi, Carla Araujo, Gian-Matteo Pica, Cyrille Touzeau, Pascal Godmer, Bohrane Slama, Lionel Karlin, Frederique Orsini-Piocelle, Mamoun Dib, Margaret Macro, Laurence Sanhes, Aurore Perrot, Jean Yves Mary, Jerome Lambert, Herve Avet-Loiseau, Philippe Moreau, Xavier Leleu, Thierry Facon
Journal: Blood
Blood (2022) 140 (Supplement 1): 1369–1370.
https://doi.org/10.1182/blood-2022-159933
Published: 2022
Journal Articles

Primary plasma cell leukemias displaying t(11;14) have specific genomic, transcriptional, and clinical features

Brief Report
Titouan Cazaubiel, Xavier Leleu, Aurore Perrot, Salomon Manier, Laure Buisson, Sabrina Maheo, Laura Do Souto Ferreira, Romain Lannes, Luka Pavageau, Cyrille Hulin, Jean-Pierre Marolleau, Laurent Voillat, Karim Belhadj, Marion Divoux, Borhane Slama, Sabine Brechignac, Margaret Macro, Anne-Marie Stoppa, Laurence Sanhes, Frédérique Orsini-Piocelle, Jean Fontan, Marie-Lorraine Chretien, Hélène Demarquette, Mohamad Mohty, Anais Schavgoulidze, Herve Avet-Loiseau, Jill Corre
Journal: Blood
Blood (2022) 139 (17): 2666–2672.
https://doi.org/10.1182/blood.2021014968
Published: 2022
Includes: Supplemental data
Journal Articles

In Multiple Myeloma, High-Risk Secondary Genetic Events Observed at Relapse Are Present from the Diagnosis in Tiny Undetectable Subclones

Herve Avet-Loiseau, Romain Lannes, Aurore Perrot, Céline Mazzotti, Marion Divoux, Titouan Cazaubiel, Xavier Leleu, Anaïs Schavgoulidze, Marie-Lorraine Chretien, Salomon Manier, Didier Adiko, Frédérique Orsini-Piocelle, Francois Lifermann, Sabine Brechignac, Lauris Gastaud, Didier Bouscary, Magaret Macro, Mohamad Mohty, Nikhil C. Munshi, Jill Corre
Journal: Blood
Blood (2021) 138 (Supplement 1): 77.
https://doi.org/10.1182/blood-2021-146869
Published: 2021
Journal Articles

Phase II Study of the Combination of Pomalidomide with Dexamethasone As Maintenance Therapy after First Relapse Treatment with PCD Followed or Not By Autologous Stem Cell Transplant in Multiple Myeloma Patients

Laurent Garderet, Frédérique Kuhnowski, Benoit Berge, Murielle Roussel, Martine Escoffre-Barbe, Ingrid Lafon, Thierry Facon, Xavier Leleu, Lionel Karlin, Aurore Perrot, Philippe Moreau, Gerald Marit, Anne-Marie Stoppa, Bruno Royer, Carine Chaleteix, Mourad Tiab, Carla Araujo, Pascal Lenain, Margaret Macro, Eric G. Voog, Lotfi Benboubker, Olivier Thierry Allangba, Eric Jourdan, Frédérique Orsini-Piocelle, Sabine Brechignac, Jean-Richard Eveillard, Karim Belhadj, Marc Wetterwald, Brigitte Pegourie, Arnaud Jaccard, Jean Claude Eisenmann, Sylvie Glaisner, Mohamad Mohty, Cyrille Hulin, Herve Avet Loiseau, Claire Mathiot, Michel Attal
Journal: Blood
Blood (2021) 138 (Supplement 1): 2753.
https://doi.org/10.1182/blood-2021-152136
Published: 2021
Journal Articles

RD Vs. VRD: What Is the First-Line, Real-Life Management of Multiple Myeloma Patients Ineligible for Stem Cell Auto Transplantation in the Emmy Cohort?

Olivier Decaux, Aurore Perrot, Laurent Frenzel, Bruno Royer, Carla Araujo, Karim Belhadj, Philippe Moreau, Denis Caillot, Xavier Leleu, Agathe Farge, Anne Vekhoff, Samantha Schulmann, Jean Fontan, Frederique Orsini, Laurence Sanhes, Valentine Richez, Arnaud Jaccard, Ronan Garlantezec, Nathalie Texier, Raphael Germain, Catherine Boccaccio, Cyrille Hulin
Journal: Blood
Blood (2021) 138 (Supplement 1): 3766.
https://doi.org/10.1182/blood-2021-149480
Published: 2021
Journal Articles

Final Analysis of a Prospective Multicenter Phase II Trial of the Lymphoma Study Association (LYSA) Using Prednisone, Vinblastine, Doxorubicin and Bendamustine (PVAB) Regimen in First Line Therapy for Patients over 60 Years with Advanced-Stage Classical Hodgkin Lymphoma

Herve Ghesquieres, Rene-Olivier Casasnovas, Emmanuelle Nicolas-Virelizier, Salim Kanoun, Gandhi Laurent Damaj, Vincent Delwail, Arnaud Jaccard, Kamel Laribi, Franck Morschhauser, Christophe Bonnet, Agathe Waultier, Frederique Orsini-Piocelle, Marc Andre, Marguerite Fournier, Fabienne Morand, Alina Berriolo-Riedinger, Diane Damotte, Alexandra Traverse-Glehen, Philippe Quittet, Pauline Brice
Journal: Blood
Blood (2021) 138 (Supplement 1): 1370.
https://doi.org/10.1182/blood-2021-152346
Published: 2021
Journal Articles

del(17p) without TP53 mutation confers a poor prognosis in intensively treated newly diagnosed patients with multiple myeloma

Clinical Trials & Observations Brief Report
Jill Corre, Aurore Perrot, Denis Caillot, Karim Belhadj, Cyrille Hulin, Xavier Leleu, Mohamad Mohty, Thierry Facon, Laure Buisson, Laura Do Souto, Romain Lannes, Stephanie Dufrechou, Naïs Prade, Frederique Orsini-Piocelle, Laurent Voillat, Arnaud Jaccard, Lionel Karlin, Margaret Macro, Sabine Brechignac, Mamoun Dib, Laurence Sanhes, Jean Fontan, Lauriane Clement-Filliatre, Jean-Pierre Marolleau, Stephane Minvielle, Philippe Moreau, Hervé Avet-Loiseau
Journal: Blood
Blood (2021) 137 (9): 1192–1195.
https://doi.org/10.1182/blood.2020008346
Published: 2021
Includes: Supplemental data
Journal Articles

A fixed-duration, measurable residual disease–guided approach in CLL: follow-up data from the phase 2 ICLL-07 FILO trial

Clinical Trials & Observations Brief Report
Anne-Sophie Michallet, Rémi Letestu, Magali Le Garff-Tavernier, Carmen Aanei, Michel Ticchioni, Marie-Sarah Dilhuydy, Fabien Subtil, Valerie Rouille, Beatrice Mahe, Kamel Laribi, Bruno Villemagne, Gilles Salles, Olivier Tournilhac, Alain Delmer, Christelle Portois, Brigitte Pegourie, Veronique Leblond, Cecile Tomowiak, Sophie De Guibert, Frederique Orsini Piocelle, Anne Banos, Philippe Carassou, Guillaume Cartron, Luc-Matthieu Fornecker, Loic Ysebaert, Caroline Dartigeas, Malgorzata Truchan-Graczyk, Jean-Pierre Vilque, Thérèse Aurran, Florence Cymbalista, Stéphane Lepretre, Vincent Levy, Florence Nguyen-Khac, Pierre Feugier
Journal: Blood
Blood (2021) 137 (8): 1019–1023.
https://doi.org/10.1182/blood.2020008164
Published: 2021
Includes: Supplemental data
Journal Articles

Early Versus Late Autologous Stem Cell Transplant in Newly Diagnosed Multiple Myeloma: Long-Term Follow-up Analysis of the IFM 2009 Trial

Aurore Perrot, Valerie Lauwers-Cances, Titouan Cazaubiel, Thierry Facon, MD, Denis Caillot, Lauriane Clement-Filliatre, Margaret Macro, Olivier Decaux, Karim Belhadj, Mohamad Mohty, Lionel Karlin, MD, Jean Claude Eisenmann, Mourad Tiab, Frederique Orsini, Cyrille Touzeau, Xavier Leleu, MD, Herve Avet-Loiseau, Nikhil C. Munshi, MD, Kenneth Anderson, MD, Paul G. Richardson, MD, Philippe Moreau, MD, Michel Attal
Journal: Blood
Blood (2020) 136 (Supplement 1): 39.
https://doi.org/10.1182/blood-2020-134538
Published: 2020
Journal Articles

Maintenance of Long-Term Undetectable Minimal Residual Disease after Combination of Ibrutinib with Abbreviated Chemotherapy in the Icll-07 Filo Trial

Anne-Sophie Michallet, MD PhD, Marie-Sarah Dilhuydy, MD, Fabien Subtil, Valérie Rouille, Beatrice Mahe, MD, Kamel Laribi, MD, Bruno Villemagne, MD, Gilles A. Salles, MD PhD, Olivier Tournilhac, Alain Jacques Delmer, MD PhD, Christelle Portois, Brigitte Pegourie, MD, Veronique Leblond, MD PhD, Cecile Tomowiak, MD, Sophie de Guibert, MD, Frederique Orsini, Anne Banos, MD, Philippe Carassou, Guillaume Cartron, Luc Mathieu Fornecker, MD PhD, Loic Ysebaert, MD PhD, Caroline Dartigeas, MD, Margot Truchan, Jean Pierre Vilque, Thérèse Aurran, MD, Florence Cymbalista, MD PhD, Stephane Lepretre, Vincent Levy, MD PhD, Florence Nguyen-Khac, MD PhD, Magali Le Garff-Tavernier, Carmen Aanaei, Michel Ticchioni, Remi Letestu, Pierre Feugier, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3038.
https://doi.org/10.1182/blood-2019-126720
Published: 2019
Journal Articles

Prednisone, Vinblastine, Doxorubicin and Bendamustine (PVAB) Regimen in First Line Therapy for Older Patients with Advanced-Stage Classical Hodgkin Lymphoma: Results of a Prospective Multicenter Phase II Trial of the Lymphoma Study Association (LYSA)

Herve Ghesquieres, MD PhD, Olivier Casasnovas, MD, Emmanuelle Nicolas-Virelizier, MD, Damaj Gandhi Laurent, MD PhD, Vincent Delwail, MD, Mohamed Touati, MD, Katell Le Du, MD, Franck Morschhauser, MD PhD, Christophe Bonnet, MD, Agathe Waultier-Rascalou, MD, Frederique Orsini-Piocelle, MD, Marc André, Myriam Ben Boutieb, Fabienne Morand, Diane Damotte, MD PhD, Alexandra Traverse-Glehen, MD PhD, Philippe Quittet, MD, Pauline Brice
Journal: Blood
Blood (2019) 134 (Supplement_1): 2832.
https://doi.org/10.1182/blood-2019-129016
Published: 2019
Journal Articles

Pomalidomide, cyclophosphamide, and dexamethasone for relapsed multiple myeloma

Clinical Trials & Observations
Laurent Garderet, Frederique Kuhnowski, Benoit Berge, Murielle Roussel, Martine Escoffre-Barbe, Ingrid Lafon, Thierry Facon, Xavier Leleu, Lionel Karlin, Aurore Perrot, Philippe Moreau, Gerald Marit, Anne-Marie Stoppa, Bruno Royer, Carine Chaleteix, Mourad Tiab, Carla Araujo, Pascal Lenain, Margaret Macro, Eric Voog, Lofti Benboubker, Olivier Allangba, Eric Jourdan, Frederique Orsini-Piocelle, Sabine Brechignac, Jean-Richard Eveillard, Karim Belhadj, Marc Wetterwald, Brigitte Pegourie, Arnaud Jaccard, Jean-Claude Eisenmann, Sylvie Glaisner, Mohamad Mohty, Cyrille Hulin, Herve Avet Loiseau, Claire Mathiot, Michel Attal
Journal: Blood
Blood (2018) 132 (24): 2555–2563.
https://doi.org/10.1182/blood-2018-07-863829
Published: 2018
Includes: Supplemental data