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Journal Articles

A Phase 2 Study of Canakinumab in Patients with Lower-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia

Juan Jose Rodriguez Sevilla, Vera Adema, Kelly S. Chien, Irene Ganan-Gomez, Guillermo Montalban-Bravo, Samuel Urrutia, Joby Joseph, Hui Yang, Gautam Borthakur, Nicholas J. Short, Ghayas C. Issa, Tapan M. Kadia, Koichi Takahashi, Danielle E. Hammond, Guillermo Garcia-Manero

Blood (2023) 142 (Supplement 1): 1866.

https://doi.org/10.1182/blood-2023-185259

Published: 2023

Journal Articles

Myelodysplastic Syndrome Hematopoietic Stem Cells Can Undergo Differentiation Trajectory Rewiring to Escape Venetoclax Vulnerability

Juan Jose Rodriguez Sevilla, Irene Ganan-Gomez, Feiyang Ma, Kelly S. Chien, Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Sanam Loghavi, Vera Adema, Natthakan Thongon, Alexandre Bazinet, Guillermo Garcia-Manero, Simona Colla

Blood (2023) 142 (Supplement 1): 584.

https://doi.org/10.1182/blood-2023-180447

Published: 2023

Journal Articles

Clinical and Biological Effects of Canakinumab in Lower-Risk Myelodysplastic Syndromes (MDS): Results from a Phase 2 Clinical Trial

Guillermo Garcia-Manero, Vera Adema, Samuel Urrutia, Feiyang Ma, Hui Yang, Irene Ganan-Gomez, Gautam Borthakur, Koichi Takahashi, Nicholas Short, Ghayas C. Issa, Kelly S. Chien, Guillermo Montalban-Bravo, Joby Joseph, Simona Colla

Blood (2022) 140 (Supplement 1): 2078–2080.

https://doi.org/10.1182/blood-2022-167703

Published: 2022

Journal Articles

Myelodysplastic Syndromes without Detectable Mutations: Analysis of Clinical Presentation and Outcome

Alex Bataller, Rashmi Kanagal-Shamanna, Kelly S. Chien, Guillermo Montalban-Bravo, Tapan M. Kadia, Farhad Ravandi, Courtney D. DiNardo, Naval Daver, Nicholas Short, Gautam Borthakur, Elias Jabbour, Danielle Hammond, Lucia Masarova, Irene Ganan-Gomez, Vera Adema, Hagop Kantarjian, Guillermo Garcia-Manero, Koji Sasaki

Blood (2022) 140 (Supplement 1): 9793–9795.

https://doi.org/10.1182/blood-2022-164962

Published: 2022

Journal Articles

Deficiency of RPS14 Beyond the Haploinsufficient Loss in Del(5q)

Vera Adema, Sunisa Kongkiatkamon, Laura Palomo, Wencke Walter, Stephan Hutter, Thomas LaFramboise, Maria Diez-Campelo, Mar Mallo, Blanca Xicoy, Manja Meggendorfer, Hetty E. Carraway, Claudia Haferlach, Valeria Visconte, Francesc Sole, John Barnard, Torsten Haferlach, Jaroslaw P. Maciejewski

Blood (2021) 138 (Supplement 1): 2591.

https://doi.org/10.1182/blood-2021-151926

Published: 2021

Journal Articles

Single-Cell RNA Sequencing Analysis Reveals Mechanisms of Initiation and Progression in Chronic Myelomonocytic Leukemia

Guillermo Montalban-Bravo, Feiyang Ma, Irene Ganan-Gomez, Rashmi Kanagal-Shamanna, Vera Adema, Yue Wei, Kelly S. Chien, Natthakan Thongon, Hui Yang, Carlos E. Bueso-Ramos, Hagop Kantarjian, Guillermo Garcia-Manero, Simona Colla

Blood (2021) 138 (Supplement 1): 2588.

https://doi.org/10.1182/blood-2021-151340

Published: 2021

Journal Articles

Novel Synthetic Lethal Targets for Myeloid Neoplasms with Loss of Chromosome 7

Minako Mori, Vera Adema, Carmelo Gurnari, Simona Pagliuca, Laila Terkawi, Waled Bahaj, Tariq Kewan, John Barnard, Valeria Visconte, Torsten Haferlach, Jaroslaw P. Maciejewski

Blood (2021) 138 (Supplement 1): 3346.

https://doi.org/10.1182/blood-2021-152974

Published: 2021

Journal Articles

Germline MPO Variants Predispose to Myeloid Neoplasia: Potential Mechanisms Suggested By In Vivo and in Vitro Studies

Blood (2021) 138 (Supplement 1): 3662.

https://doi.org/10.1182/blood-2021-149598

Published: 2021

Journal Articles

Targeting DNA2 Overcomes Myeloma Cells' Metabolic Reprogramming in Response to DNA Damage

Natthakan Thongon, Andrea Santoni, Jintan Liu, Natalia Baran, Feiyang Ma, Christopher Jackson, Pamela Lockyer, Irene Ganan-Gomez, Vera Adema, Ashley Rose, Matteo Marchesini, Yun Qing, Min Jin Ha, Caleb Class, Matteo Pellegrini, Lin Tan, Philip Lorenzi, Marina Konopleva, Simona Colla

Blood (2021) 138 (Supplement 1): 1573.

https://doi.org/10.1182/blood-2021-148992

Published: 2021

Journal Articles

Epigenetic Enzyme Mutations in Myeloid Malignancies Are Selected By Chromatin-Remodeling Requirements That Vary By Lineage- and Maturation-Stage

Sunisa Kongkiatkamon, Xiaorong Gu, Kwok Peng Ng, Simona Pagliuca, Vera Adema, Wencke Walter, Yasunobu Nagata, Cassandra M Kerr, Cassandra M Kerr, Manja Meggendorfer, Hassan Awada, Stephan Hutter, Carmelo Gurnari, Claudia Haferlach, Babal K. Jha, Valeria Visconte, Torsten Haferlach, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah

Blood (2021) 138 (Supplement 1): 1148.

https://doi.org/10.1182/blood-2021-153618

Published: 2021

Journal Articles

Molecular and Expression Characterization of Monosomy 7 and Del(7q)

Vera Adema, PhD, Cassandra M Kerr, MS, Hassan Awada, MD, Sunisa Kongkiatkamon, MD, Bhumika J. Patel, MD, Mikkael A. Sekeres, MD MS, Valeria Visconte, PhD, John Barnard, Jaroslaw P. Maciejewski, MD PhD, Torsten Haferlach, MD

Blood (2020) 136 (Supplement 1): 33.

https://doi.org/10.1182/blood-2020-142507

Published: 2020

Journal Articles

Co-Existence of Splicing Factor Mutations in Myeloid Malignancies

Vera Adema, PhD, Hassan Awada, MD, Laila Terkawi, Sunisa Kongkiatkamon, MD, Cassandra M Kerr, MS, Valeria Visconte, PhD

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-141582

Published: 2020

Journal Articles

Double Genetic Hits and Subclonal Mosaicism in the Ras Signaling Pathway in Myeloid Neoplasia

Sunisa Kongkiatkamon, MD, Yasunobu Nagata, MD PhD, Vera Adema, PhD, Hassan Awada, MD, Misam Zawit, MD, Laila Terkawi, Simona Pagliuca, MD, Carmelo Gurnari, MD, Cassandra M Kerr, MS, Mikkael A. Sekeres, MD MS, Hetty E. Carraway, MD MBA, Yogenthiran Saunthararajah, MD, Bhumika J. Patel, MD, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD

Blood (2020) 136 (Supplement 1): 34–35.

https://doi.org/10.1182/blood-2020-143210

Published: 2020

Journal Articles

Impact of Pathogenic Germ Line Variants in Adults with Acquired Bone Marrow Failure Syndromes Vs . Myeloid Neoplasia

Misam Zawit, MBBS, Jibran Durrani, MD, Wenyi Shen, MD, Vera Adema, PhD, Cassandra M Kerr, MS, Hassan Awada, MD, Sunisa Kongkiatkamon, MD, Carmelo Gurnari, MD, Simona Pagliuca, MD, Laila Terkawi, Bhumika J. Patel, MD, Valeria Visconte, PhD, Hetty E. Carraway, MD MBA, Thomas LaFramboise, PhD, Seth J. Corey, MD, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-142586

Published: 2020

Journal Articles

SF3B1 -Mutant Myelodysplastic Syndrome with Ringed Sideroblasts (MDS-RS) at the Single-Cell Level

Rashmi Kanagal-Shamanna, MD, Vera Adema, PhD, Feiyang Ma, Bs, Andrea Santoni, PhD, Hui Yang, MD PhD, Irene Ganan-Gomez, PhD, Natthakan Thongon, PhD, Guillermo Montalban-Bravo, MD, Matteo Pellegrini, PhD, Carlos E. Bueso-Ramos, MD PhD, Guillermo Garcia-Manero, MD, Simona Colla, PhD

Blood (2020) 136 (Supplement 1): 50–51.

https://doi.org/10.1182/blood-2020-141928

Published: 2020

Journal Articles

Type of TP53 Mutations Affects Subclonal Configuration and Selection Pressure for Acquisition of Additional Hits in Contralateral Alleles

Carmelo Gurnari, MD, Vera Adema, PhD, Hassan Awada, MD, Simona Pagliuca, MD, Cassandra M Kerr, MS, Sunisa Kongkiatkamon, MD, Thomas Laframboise, PhD, Valeria Visconte, PhD, Maria Teresa Voso, MD, Mikkael A. Sekeres, MD MS, Hetty E. Carraway, MD MBA, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD

Blood (2020) 136 (Supplement 1): 25.

https://doi.org/10.1182/blood-2020-140058

Published: 2020

Journal Articles

Rare Germline Alterations of Myeloperoxidase Predispose to Myeloid Neoplasms and Are Associated with Increased Circulating Burden of Microbial DNA

Sunisa Kongkiatkamon, MD, Samuel Li, BA, Tatiana Dombrovski, Laila Terkawi, Cassandra M Kerr, MS, Vera Adema, PhD, Yasunobu Nagata, MD PhD, Wencke Walter, PhD, Hassan Awada, MD, Bartlomiej Przychodzen, Stephan Hutter, PhD, Carmelo Gurnari, MD, Simona Pagliuca, MD, Manja Meggendorfer, PhD, Claudia Haferlach, MD, Valeria Visconte, PhD, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD, Thomas LaFramboise, PhD

Blood (2020) 136 (Supplement 1): 2–3.

https://doi.org/10.1182/blood-2020-139972

Published: 2020

Journal Articles

The Clonal Trajectories of SF3B1 Mutations in Myeloid Neoplasia

Hassan Awada, MD, Cassandra M. Kerr, MS, Vera Adema, PhD, Carmelo Gurnari, MD, Simona Pagliuca, MD, Heesun J. Rogers, MD PhD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD

Blood (2020) 136 (Supplement 1): 8.

https://doi.org/10.1182/blood-2020-139528

Published: 2020

Journal Articles

Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms

Laura Palomo, Manja Meggendorfer, Stephan Hutter, Sven Twardziok, Vera Ademà, Irene Fuhrmann, Francisco Fuster-Tormo, Blanca Xicoy, Lurdes Zamora, Pamela Acha, Cassandra M. Kerr, Wolfgang Kern, Jaroslaw P. Maciejewski, Francesc Solé, Claudia Haferlach, Torsten Haferlach

Blood (2020) 136 (16): 1851–1862.

https://doi.org/10.1182/blood.2019004229

Published: 2020

Includes: Supplemental data

Journal Articles

Pharmacologic Normalization of Altered Transcriptome of SF3B1 Mutant Myeloid Neoplasia

Blood (2019) 134 (Supplement_1): 564.

https://doi.org/10.1182/blood-2019-129189

Published: 2019

NARROW

A Phase 2 Study of Canakinumab in Patients with Lower-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia

Myelodysplastic Syndrome Hematopoietic Stem Cells Can Undergo Differentiation Trajectory Rewiring to Escape Venetoclax Vulnerability

Clinical and Biological Effects of Canakinumab in Lower-Risk Myelodysplastic Syndromes (MDS): Results from a Phase 2 Clinical Trial

Myelodysplastic Syndromes without Detectable Mutations: Analysis of Clinical Presentation and Outcome

Deficiency of RPS14 Beyond the Haploinsufficient Loss in Del(5q)

Single-Cell RNA Sequencing Analysis Reveals Mechanisms of Initiation and Progression in Chronic Myelomonocytic Leukemia

Novel Synthetic Lethal Targets for Myeloid Neoplasms with Loss of Chromosome 7

Germline MPO Variants Predispose to Myeloid Neoplasia: Potential Mechanisms Suggested By In Vivo and in Vitro Studies

Targeting DNA2 Overcomes Myeloma Cells' Metabolic Reprogramming in Response to DNA Damage

Epigenetic Enzyme Mutations in Myeloid Malignancies Are Selected By Chromatin-Remodeling Requirements That Vary By Lineage- and Maturation-Stage

Molecular and Expression Characterization of Monosomy 7 and Del(7q)

Co-Existence of Splicing Factor Mutations in Myeloid Malignancies

Double Genetic Hits and Subclonal Mosaicism in the Ras Signaling Pathway in Myeloid Neoplasia

Impact of Pathogenic Germ Line Variants in Adults with Acquired Bone Marrow Failure Syndromes Vs . Myeloid Neoplasia

SF3B1 -Mutant Myelodysplastic Syndrome with Ringed Sideroblasts (MDS-RS) at the Single-Cell Level

Type of TP53 Mutations Affects Subclonal Configuration and Selection Pressure for Acquisition of Additional Hits in Contralateral Alleles

Rare Germline Alterations of Myeloperoxidase Predispose to Myeloid Neoplasms and Are Associated with Increased Circulating Burden of Microbial DNA

The Clonal Trajectories of SF3B1 Mutations in Myeloid Neoplasia

Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms

Pharmacologic Normalization of Altered Transcriptome of SF3B1 Mutant Myeloid Neoplasia

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