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The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status
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INSIDE BLOOD
BLOOD WORK
PLENARY PAPER
Leukemia cell–targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity
Dewan Md Sakib Hossain,Cedric Dos Santos,Qifang Zhang,Anna Kozlowska,Hongjun Liu,Chan Gao,Dayson Moreira,Piotr Swiderski,Agnieszka Jozwiak,Justin Kline,Stephen Forman,Ravi Bhatia,Ya-Huei Kuo,Marcin Kortylewski
REVIEW ARTICLE
HOW I TREAT
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1
Anneliese O. Speak,Danielle te Vruchte,Lianne C. Davis,Anthony J. Morgan,David A. Smith,Nicole M. Yanjanin,Louise Simmons,Ralf Hartung,Heiko Runz,Eugen Mengel,Michael Beck,Jackie Imrie,Elizabeth Jacklin,James E. Wraith,Christian Hendriksz,Robin Lachmann,Celine Cognet,Rohini Sidhu,Hideji Fujiwara,Daniel S. Ory,Antony Galione,Forbes D. Porter,Eric Vivier,Frances M. Platt
Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection
Chuka A. Didigu,Craig B. Wilen,Jianbin Wang,Jennifer Duong,Anthony J. Secreto,Gwenn A. Danet-Desnoyers,James L. Riley,Phillip D. Gregory,Carl H. June,Michael C. Holmes,Robert W. Doms
LYMPHOID NEOPLASIA
Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group
Trudy D. Buitenkamp,Shai Izraeli,Martin Zimmermann,Erik Forestier,Nyla A. Heerema,Marry M. van den Heuvel-Eibrink,Rob Pieters,Carin M. Korbijn,Lewis B. Silverman,Kjeld Schmiegelow,Der-Cheng Liang,Keizo Horibe,Maurizio Arico,Andrea Biondi,Giuseppe Basso,Karin R. Rabin,Martin Schrappe,Gunnar Cario,Georg Mann,Maria Morak,Renate Panzer-Grümayer,Veerle Mondelaers,Tim Lammens,Hélène Cavé,Batia Stark,Ithamar Ganmore,Anthony V. Moorman,Ajay Vora,Stephen P. Hunger,Ching-Hon Pui,Charles G. Mullighan,Atsushi Manabe,Gabriele Escherich,Jerzy R. Kowalczyk,James A. Whitlock,C. Michel Zwaan
Clinical, genomic, and imaging predictors of myeloma progression from asymptomatic monoclonal gammopathies (SWOG S0120)
Madhav V. Dhodapkar,Rachael Sexton,Sarah Waheed,Saad Usmani,Xenofon Papanikolaou,Bijay Nair,Nathan Petty,John D. Shaughnessy, Jr,Antje Hoering,John Crowley,Robert Z. Orlowski,Bart Barlogie
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
THROMBOSIS AND HEMOSTASIS
The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status
Brief Report
Julie Rayes,Lubka T. Roumenina,Jordan D. Dimitrov,Yohann Repessé,Mathieu Ing,Olivier Christophe,T. Sakari Jokiranta,Lise Halbwachs-Mecarelli,Annie Borel-Derlon,Srinivas V. Kaveri,Véronique Frémeaux-Bacchi,Sébastien Lacroix-Desmazes
TRANSPLANTATION
Impact of thymoglobulin prior to pediatric unrelated umbilical cord blood transplantation on immune reconstitution and clinical outcome
Caroline A. Lindemans,Robert Chiesa,Persis J. Amrolia,Kanchan Rao,Olga Nikolajeva,Arianne de Wildt,Corinne E. Gerhardt,Kimberly C. Gilmour,Marc B. Bierings,Paul Veys,Jaap J. Boelens
Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy
Mary Eapen,John P. Klein,Annalisa Ruggeri,Stephen Spellman,Stephanie J. Lee,Claudio Anasetti,William Arcese,Juliet N. Barker,Lee Ann Baxter-Lowe,Maria Brown,Marcelo A. Fernandez-Vina,John Freeman,Wensheng He,Anna Paola Iori,Mary M. Horowitz,Franco Locatelli,Susana Marino,Martin Maiers,Gerard Michel,Guillermo F. Sanz,Eliane Gluckman,Vanderson Rocha,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation,for the Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation
VASCULAR BIOLOGY
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Cover Image
Cover Image
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Colocalization of VWF and FH in the Weibel-Palade bodies of ECs. HUVEC were grown on coverslips, fixed with PFA (4%), permeabilized with Triton X-100 (0.5%), and stained for intracellular VWF and FH. FH was stained with a pool of 3 biotinylated anti-FH antibodies: FH1 and FH2 (Quidel), and OX24 (AbDSerotec) followed by streptavidin-FITC. VWF was stained with a rabbit polyclonal anti-human VWF IgG (Dako) or a rabbit IgG control, followed by an Alexa Fluor 555-labeled goat anti-rabbit IgG. Nuclei were stained with Hoechst 33342 dye. Cells were washed and mounted in fluorescent mounting medium Fluoprep (bioMérieux). Images were acquired using an Axiovert 200M microscope (Zeiss) equipped with Apotome (63×). The image depicts the overlay of the green, red, and blue fluorescence. See the article by Rayes et al on page 121.
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