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Volume 96, Issue 10

November 15 2000

In this Issue

FOCUS ON HEMATOLOGY
PLENARY PAPERS
FEATURED MICROGRAPH
REVIEW ARTICLES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

FOCUS ON HEMATOLOGY

Introduction: fibrinogen as a determinant of the metastatic potential of tumor cells

Michael W. Mosesson

View Articletitled, Introduction: fibrinogen as a determinant of the metastatic potential of tumor cells

Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells

Joseph S. Palumbo,Keith W. Kombrinck,Angela F. Drew,Timothy S. Grimes,John H. Kiser,Jay L. Degen,Thomas H. Bugge

View Articletitled, Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells

PLENARY PAPERS

Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia

Arthur A. Axelrad,Denise Eskinazi,Paulo N. Correa,Dominick Amato

View Articletitled, Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia

Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins

Patrick André,Cécile V. Denis,Jerry Ware,Simin Saffaripour,Richard O. Hynes,Zaverio M. Ruggeri,Denisa D. Wagner

View Articletitled, Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins

Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis
Clinical Trials & Observations

Paolo Simioni,Paolo Prandoni,Anthonie W. A. Lensing,Davide Manfrin,Daniela Tormene,Sabrina Gavasso,Bruno Girolami,Corrado Sardella,Martin Prins,Antonio Girolami

View Articletitled, Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis

FEATURED MICROGRAPH

Congenital relapsing fever (Borrelia hermsii)
Clinical Trials & Observations

View Articletitled, Congenital relapsing fever (Borrelia hermsii)

REVIEW ARTICLES

Molecular mechanisms of platelet exocytosis: insights into the “secrete” life of thrombocytes

Guy L. Reed,Michael L. Fitzgerald,János Polgár

View Articletitled, Molecular mechanisms of platelet exocytosis: insights into the “secrete” life of thrombocytes

The molecular biology of chronic myeloid leukemia

Michael W. N. Deininger,John M. Goldman,Junia V. Melo

View Articletitled, The molecular biology of chronic myeloid leukemia

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Oral isobutyramide reduces transfusion requirements in some patients with homozygous β-thalassemia
Clinical Trials & Observations

Susanne Reich,Christoph Bührer,Günter Henze,Dieter Ohlendorf,Michael Mesche,Pranav Sinha,Andreas Kage,Christian Müller,Barbara Vetter,Andreas E. Kulozik

View Articletitled, Oral isobutyramide reduces transfusion requirements in some patients with homozygous β-thalassemia

Increased lipoprotein (a) levels as an independent risk factor for venous thromboembolism
Clinical Trials & Observations

Mario von Depka,Ulrike Nowak-Göttl,Roswith Eisert,Christian Dieterich,Monika Barthels,Inge Scharrer,Arnold Ganser,Silke Ehrenforth

View Articletitled, Increased lipoprotein (a) levels as an independent risk factor for venous thromboembolism

Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly Asian descent
Clinical Trials & Observations

Sylvia T. Singer,Vivian Wu,Robert Mignacca,Frans A. Kuypers,Phyllis Morel,Elliott P. Vichinsky

View Articletitled, Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly Asian descent

Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia
Clinical Trials & Observations

Ruben A. Mesa,Curtis A. Hanson,S. Vincent Rajkumar,Georgene Schroeder,Ayalew Tefferi

View Articletitled, Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia

Traumatic lumbar puncture at diagnosis adversely affects outcome in childhood acute lymphoblastic leukemia
Clinical Trials & Observations

Amar Gajjar,Patricia L. Harrison,John T. Sandlund,Gaston K. Rivera,Raul C. Ribeiro,Jeffrey E. Rubnitz,Bassem Razzouk,Mary V. Relling,William E. Evans,James M. Boyett,Ching-Hon Pui

View Articletitled, Traumatic lumbar puncture at diagnosis adversely affects outcome in childhood acute lymphoblastic leukemia

GENE THERAPY

Lentivirus-based vectors transduce mouse hematopoietic stem cells with similar efficiency to Moloney murine leukemia virus–based vectors

Stephane Barrette,Janet L. Douglas,Nancy E. Seidel,David M. Bodine

View Articletitled, Lentivirus-based vectors transduce mouse hematopoietic stem cells with similar efficiency to Moloney murine leukemia virus–based vectors

High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors

Patrick Salmon,Vincent Kindler,Odile Ducrey,Bernard Chapuis,Rudolf H. Zubler,Didier Trono

View Articletitled, High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors

HEMATOPOIESIS

In vivo kinetics of murine hemopoietic stem cells

Janis L. Abkowitz,Daniela Golinelli,David E. Harrison,Peter Guttorp

View Articletitled, In vivo kinetics of murine hemopoietic stem cells

Stem cell factor induces phosphatidylinositol 3′-kinase–dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells

Thamar B. van Dijk,Emile van den Akker,Martine Parren-van Amelsvoort,Hiroyuki Mano,Bob Löwenberg,Marieke von Lindern

View Articletitled, Stem cell factor induces phosphatidylinositol 3′-kinase–dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells

An in vivo competitive repopulation assay for various sources of human hematopoietic stem cells

Elen S. Rosler,John E. Brandt,John Chute,Ronald Hoffman

View Articletitled, An in vivo competitive repopulation assay for various sources of human hematopoietic stem cells

SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways

Rafael F. Duarte,David A. Frank

View Articletitled, SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells

Yutaka Yatomi,Tsukasa Ohmori,Ge Rile,Fuminori Kazama,Hirotaka Okamoto,Takamitsu Sano,Kaneo Satoh,Shoji Kume,Gabor Tigyi,Yasuyuki Igarashi,Yukio Ozaki

View Articletitled, Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells

FcγRIIA requires a Gi-dependent pathway for an efficient stimulation of phosphoinositide 3-kinase, calcium mobilization, and platelet aggregation

Marie-Pierre Gratacap,Jean-Pascal Hérault,Cécile Viala,Ashraf Ragab,Pierre Savi,Jean-Marc Herbert,Hugues Chap,Monique Plantavid,Bernard Payrastre

View Articletitled, FcγRIIA requires a Gi-dependent pathway for an efficient stimulation of phosphoinositide 3-kinase, calcium mobilization, and platelet aggregation

Autosomal-dominant giant platelet syndromes: a hint of the same genetic defect as in Fechtner syndrome owing to a similar genetic linkage to chromosome 22q11-13

Amos Toren,Galit Rozenfeld-Granot,Bianca Rocca,Charles J. Epstein,Ninette Amariglio,Ferdinando Laghi,Raffaele Landolfi,Frida Brok-Simoni,Lena E. Carlsson,Gideon Rechavi,Andreas Greinacher

View Articletitled, Autosomal-dominant giant platelet syndromes: a hint of the same genetic defect as in Fechtner syndrome owing to a similar genetic linkage to chromosome 22q11-13

Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB–stimulated chemotaxis

Agneta Siegbahn,Matilda Johnell,Charlotte Rorsman,Mirella Ezban,Carl-Henrik Heldin,Lars Rönnstrand

View Articletitled, Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB–stimulated chemotaxis

Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor–related protein

Jaap G. Neels,Birgit M. M. van den Berg,Koen Mertens,Hans ter Maat,Hans Pannekoek,Anton-Jan van Zonneveld,Peter J. Lenting

View Articletitled, Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor–related protein

Interleukin 1β inhibits interleukin 6–mediated rat γ fibrinogen gene expression

Zhixin Zhang,Gerald M. Fuller

View Articletitled, Interleukin 1β inhibits interleukin 6–mediated rat γ fibrinogen gene expression

Fibrinogen Alès: a homozygous case of dysfibrinogenemia (γ-Asp³³⁰ →Val) characterized by a defective fibrin polymerization site “a”

Karim Chabane Lounes,Claudine Soria,Shah Sultan Mirshahi,Pierre Desvignes,Massoud Mirshahi,Olivier Bertrand,Pierre Bonnet,Jaap Koopman,Jeannette Soria

View Articletitled, Fibrinogen Alès: a homozygous case of dysfibrinogenemia (γ-Asp330 →Val) characterized by a defective fibrin polymerization site “a”

Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX–von Willebrand factor interaction

Nayna Mistry,Susan L. Cranmer,Yuping Yuan,Pierre Mangin,Sacha M. Dopheide,Ian Harper,Simon Giuliano,Dave E. Dunstan,Francois Lanza,Hatem H. Salem,Shaun P. Jackson

View Articletitled, Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX–von Willebrand factor interaction

IMMUNOBIOLOGY

Efficient priming of protein antigen–specific human CD4⁺ T cells by monocyte-derived dendritic cells

Katia Schlienger,Nancy Craighead,Kelvin P. Lee,Bruce L. Levine,Carl H. June

View Articletitled, Efficient priming of protein antigen–specific human CD4+ T cells by monocyte-derived dendritic cells

A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-γ treatment

Paul J. Mosca,Amy C. Hobeika,Timothy M. Clay,Smita K. Nair,Elaine K. Thomas,Michael A. Morse,H. Kim Lyerly

View Articletitled, A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-γ treatment

Presentation of proteins encapsulated in sterically stabilized liposomes by dendritic cells initiates CD8⁺ T-cell responses in vivo

Ralf Ignatius,Karsten Mahnke,Miguel Rivera,Keelung Hong,Frank Isdell,Ralph M. Steinman,Melissa Pope,Leonidas Stamatatos

View Articletitled, Presentation of proteins encapsulated in sterically stabilized liposomes by dendritic cells initiates CD8+ T-cell responses in vivo

Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6–independent phenotype by murine plasmacytomas and hybridomas

Rashmi Rawat,G. Jonah Rainey,Cynthia D. Thompson,Michelle R. Frazier-Jessen,Robert T. Brown,Richard P. Nordan

View Articletitled, Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6–independent phenotype by murine plasmacytomas and hybridomas

Immunophenotypic analysis of B cells in PNH: insights into the generation of circulating naive and memory B cells

Stephen J. Richards,Gareth J. Morgan,Peter Hillmen

View Articletitled, Immunophenotypic analysis of B cells in PNH: insights into the generation of circulating naive and memory B cells

NEOPLASIA

Differentiation-independent retinoid induction of folate receptor type β, a potential tumor target in myeloid leukemia

Hui Wang,Xuan Zheng,Frederick G. Behm,Manohar Ratnam

View Articletitled, Differentiation-independent retinoid induction of folate receptor type β, a potential tumor target in myeloid leukemia

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

Davide Genini,Souichi Adachi,Qi Chao,David W. Rose,Carlos J. Carrera,Howard B. Cottam,Dennis A. Carson,Lorenzo M. Leoni

View Articletitled, Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

Therapeutic efficacy of FcγRI/CD64-directed bispecific antibodies in B-cell lymphoma

Jamie Honeychurch,Alison L. Tutt,Thomas Valerius,Ingmar A. F. M. Heijnen,Jan G. J. Van de Winkel,Martin J. Glennie

View Articletitled, Therapeutic efficacy of FcγRI/CD64-directed bispecific antibodies in B-cell lymphoma

HIV-1 protease inhibitors decrease proliferation and induce differentiation of human myelocytic leukemia cells

Takayuki Ikezoe,Eric S. Daar,Jun-ichi Hisatake,Hirokuni Taguchi,H. Phillip Koeffler

View Articletitled, HIV-1 protease inhibitors decrease proliferation and induce differentiation of human myelocytic leukemia cells

Loss of PTEN expression leading to high Akt activation in human multiple myelomas

Teresa Hyun,Alan Yam,Salvatore Pece,Xiaozhen Xie,Jie Zhang,Toru Miki,J. Silvio Gutkind,Weiqun Li

View Articletitled, Loss of PTEN expression leading to high Akt activation in human multiple myelomas

Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immune-privileged sites

Sietske A. Riemersma,Ekaterina S. Jordanova,Roelandt F. J. Schop,Katja Philippo,Leendert H. J. Looijenga,Ed Schuuring,Philip M. Kluin

View Articletitled, Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immune-privileged sites

Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus–associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor–producing cells that occur mainly in type II cryoglobulinemia

Valli De Re,Salvatore De Vita,Alessandra Marzotto,Maurizio Rupolo,Annunziata Gloghini,Barbara Pivetta,Daniela Gasparotto,Antonino Carbone,Mauro Boiocchi

View Articletitled, Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus–associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor–producing cells that occur mainly in type II cryoglobulinemia

PHAGOCYTES

P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo

Keith E. Norman,Andreas G. Katopodis,Gebhard Thoma,Frank Kolbinger,Anne E. Hicks,Matthew J. Cotter,A. Graham Pockley,Paul G. Hellewell

View Articletitled, P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo

Supplemental data

Down-regulation of L-selectin expression in neutrophils by nonsteroidal anti-inflammatory drugs: role of intracellular ATP concentration

Maria Victoria Gómez-Gaviro,Carmen Domı́nguez-Jiménez,Jorge Moreno Carretero,Pedro Sabando,Isidoro González-Alvaro,Francisco Sánchez-Madrid,Federico Dı́az-González

View Articletitled, Down-regulation of L-selectin expression in neutrophils by nonsteroidal anti-inflammatory drugs: role of intracellular ATP concentration

VCAM-1 has a tissue-specific role in mediating interleukin-4–induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration

Karen Y. Larbi,Andrew R. Allen,Frederick W. K. Tam,Dorian O. Haskard,Roy R. Lobb,Patricia M. R. Silva,Sussan Nourshargh

View Articletitled, VCAM-1 has a tissue-specific role in mediating interleukin-4–induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration

RED CELLS

The survival characteristics of dense sickle cells

Robert S. Franco,Zahida Yasin,Joni M. Lohmann,Mary B. Palascak,Therese A. Nemeth,Murray Weiner,Clinton H. Joiner,Donald L. Rucknagel

View Articletitled, The survival characteristics of dense sickle cells

Molecular analysis of δ-aminolevulinate dehydratase deficiency in a patient with an unusual late-onset porphyria

Reiko Akagi,Chiaki Nishitani,Hideo Harigae,Yutaka Horie,Luba Garbaczewski,A. Hassoun,R. Mercelis,L. Verstraeten,Shigeru Sassa

View Articletitled, Molecular analysis of δ-aminolevulinate dehydratase deficiency in a patient with an unusual late-onset porphyria

The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with β-thalassemia major

Filippo Centis,Laura Tabellini,Guido Lucarelli,Ornella Buffi,Paola Tonucci,Barbara Persini,Mauro Annibali,Roberto Emiliani,Anca Iliescu,Simona Rapa,Raffaella Rossi,Lisa Ma,Emanuele Angelucci,Stanley L. Schrier

View Articletitled, The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with β-thalassemia major

TRANSFUSION MEDICINE

o-Raffinose cross-linked hemoglobin improves the hemostatic defect associated with anemia and thrombocytopenia in rabbits

David H. Lee,Leslie Bardossy,Nichole Peterson,Morris A. Blajchman

View Articletitled, o-Raffinose cross-linked hemoglobin improves the hemostatic defect associated with anemia and thrombocytopenia in rabbits

TRANSPLANTATION

Limited engraftment capacity of bone marrow–derived mesenchymal cells following T-cell–depleted hematopoietic stem cell transplantation

Daniela Cilloni,Carmelo Carlo-Stella,Franca Falzetti,Gabriella Sammarelli,Ester Regazzi,Simona Colla,Vittorio Rizzoli,Franco Aversa,Massimo F. Martelli,Antonio Tabilio

View Articletitled, Limited engraftment capacity of bone marrow–derived mesenchymal cells following T-cell–depleted hematopoietic stem cell transplantation

BRIEF REPORTS

Lymphoproliferative disease of granular T lymphocytes presenting as aplastic anemia
Clinical Trials & Observations Brief Report

Ronald S. Go,Ayalew Tefferi,Chin-Yang Li,John A. Lust,Robert L. Phyliky

View Articletitled, Lymphoproliferative disease of granular T lymphocytes presenting as aplastic anemia

Spontaneous remission of granulocyte colony-stimulating factor–associated leukemia in a child with severe congenital neutropenia
Brief Report

Sima Jeha,Ka Wah Chan,Andrew G. Aprikyan,W. Keith Hoots,Steven Culbert,Hallie Zietz,David C. Dale,Maher Albitar

View Articletitled, Spontaneous remission of granulocyte colony-stimulating factor–associated leukemia in a child with severe congenital neutropenia

Novel mutation in the γ-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K–dependent blood coagulation factors
Brief Report

Henri M. H. Spronk,Roula A. Farah,George R. Buchanan,Cees Vermeer,Berry A. M. Soute

View Articletitled, Novel mutation in the γ-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K–dependent blood coagulation factors

Hereditary hemochromatosis in a patient with congenital dyserythropoietic anemia
Brief Report

Silvia Fargion,Luca Valenti,Anna Ludovica Fracanzani,Maurizio Sampietro,Maria Domenica Cappellini,Anna Scaccabarozzi,Davide Soligo,Chiara Mariani,Gemino Fiorelli

View Articletitled, Hereditary hemochromatosis in a patient with congenital dyserythropoietic anemia

CORRESPONDENCE

Angiogenesis in acute myeloid leukemia

Francesco Di Raimondo,Giuseppe A. Palumbo,Maria Pia Azzaro,Rosario Giustolisi

View Articletitled, Angiogenesis in acute myeloid leukemia

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Issue Archive

Table of Contents

FOCUS ON HEMATOLOGY

PLENARY PAPERS

Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis Clinical Trials & Observations

FEATURED MICROGRAPH

Congenital relapsing fever (Borrelia hermsii) Clinical Trials & Observations

REVIEW ARTICLES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Oral isobutyramide reduces transfusion requirements in some patients with homozygous β-thalassemia Clinical Trials & Observations

Increased lipoprotein (a) levels as an independent risk factor for venous thromboembolism Clinical Trials & Observations

Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly Asian descent Clinical Trials & Observations

Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia Clinical Trials & Observations

Traumatic lumbar puncture at diagnosis adversely affects outcome in childhood acute lymphoblastic leukemia Clinical Trials & Observations