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Journal Articles

Diagnosis and Management of AML in Pediatric Patients: Consensus Recommendations from an International Expert Panel

Free
C. Michel Zwaan, Sarah K Tasian, Richard Aplenc, Lisa Eidenschink Brodersen, Barbara Buldini, Barbara De Moerloose, Michael N Dworzak, Linda Fogelstrand, Brenda ES Gibson, Bianca F Goemans, Henrik Hasle, Betsy A Hirsch, Gertjan JL Kaspers, Jan-Henning Klusmann, Matthew A Kutny, Thomas Lehrnbecher, Franco Locatelli, Shoeil Meshinchi, Arnaud Petit, Martina Pigazzi, Anne Tierens, E Anders Kolb, Dirk Reinhardt, Daisuke Tomizawa, Todd M Cooper
Journal: Blood
Blood blood.2024027904.
https://doi.org/10.1182/blood.2024027904
Published: 2025
Includes: Supplemental data
Journal Articles

A Phase 3 Randomized Trial for Patients with De Novo AML Comparing Standard Therapy Including Gemtuzumab Ozogamicin (GO) to CPX-351 with GO - a Report from the Children's Oncology Group

Free
Jessica A. Pollard, Todd A. Alonzo, Robert Gerbing, Matthew A. Kutny, Betsy Hirsch, Gordana Raca, Kasey Leger, Jennifer J. Wilkes, Aman Wadhwa, Zachary Graff, Reena Pabari, Samir Kahwash, Karen M Chisholm, Joseph Chewning, John T. Horan, Richard Aplenc, Katherine Tarlock, Sarah Menig, Olga Militano, Bonnie Ky, Chad A. Hudson, Lisa Eidenschink Brodersen, Michael R. Loken, Soheil Meshinchi, Anders Kolb, Todd M Cooper
Journal: Blood
Blood (2024) 144 (Supplement 1): 967.
https://doi.org/10.1182/blood-2024-205666
Published: 2024
Journal Articles

Molecular Features, Treatments and Outcomes for Pediatric AML Patients from APAL2020SC Pediatric Acute Leukemia (PedAL) Screening Trial

Free
Michele S. Redell, Robert Gerbing, Todd A. Alonzo, Jim Wang, Maureen O'Brien, Sarah K. Tasian, Matthew A. Kutny, Todd M Cooper
Journal: Blood
Blood (2024) 144 (Supplement 1): 4233.
https://doi.org/10.1182/blood-2024-200978
Published: 2024
Journal Articles

APAL2020K/ITCC-101: A Phase I Trial of the Menin Inhibitor Ziftomenib in Combination with Chemotherapy in Children with Relapsed/Refractory KMT2A- rearranged , NUP98- rearranged , or NPM1- mutant Acute Leukemias

Free
Elisabeth Salzer, Janine Stutterheim, Branko Cuglievan, Blake E. Tomkinson, Mollie Leoni, Harm Van Tinteren, Alwin D.R. Huitema, Marieke Willemse, Gwen L Nichols, Francisco Bautista, Sarah K. Tasian, Todd M Cooper, Christian Zwaan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4265.3.
https://doi.org/10.1182/blood-2024-204583
Published: 2024
Journal Articles

Treatment Intensification Does Not Improve Outcome for Children with Myeloid Leukemia of Down Syndrome (ML-DS) Who Are MRD-Positive after Induction Therapy: A Report from the Children's Oncology Group

Free
Johann K. Hitzler, Todd A. Alonzo, Robert Gerbing, Jim Wang, Amy Beckman, Betsy Hirsch, Susana C. Raimondi, Karen M Chisholm, Shelton A. Viola, Anupam Verma, Lisa Eidenschink Brodersen, Michael R. Loken, Jeffrey W. Taub, Alan S Gamis, E. Anders Kolb, Todd M Cooper, Jason N. Berman
Journal: Blood
Blood (2024) 144 (Supplement 1): 2949.
https://doi.org/10.1182/blood-2024-202621
Published: 2024
Journal Articles

Retrospective Cohort Analysis of Response and Survival of Children, Adolescents, and Young Adults (CAYA) with Relapsed and/or Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL) and Lymphoma (T-LL) Treated with Curative Intent: A TACL Consortium Study

Free
Melinda G Pauly, Yueh-Yun Chi, Jemily Malvar, Roy Leong, Susan Colace, Nathan Gossai, Nobuko Hijiya, Chintan Parekh, Susan R Rheingold, Anupam Verma, Bill H Chang, Todd M Cooper, Andrew Doan, Yamilet Huerta, Kelly Elizabeth Faulk, Diane Hanna, Kenneth Matthew Heym, Mallorie M. Heneghan, Joel Kaplan, Luciano Dalla-Pozza, Seth E. Karol, Andrew E. Place, Jenna Rossoff, Eric S. Schafer, Tamra Slone, Michelle L. Hermiston, Maria Luisa Sulis
Journal: Blood
Blood (2024) 144 (Supplement 1): 4187.
https://doi.org/10.1182/blood-2024-209138
Published: 2024
Journal Articles

PEPN2312: A Pediatric Early Phase Clinical Trials Network (PEP-CTN) Phase 1 Trial of Imetelstat with Fludarabine/Cytarabine in Pediatric Patients with Relapsed/Refractory AML, MDS, or JMML

Free
Alexandra McLean Stevens, Maureen M. O'Brien, Xiaowei Liu, Charles G Minard, Olga Militano, Joel M Reid, Shyamala Navada, Todd M Cooper, Sarah K. Tasian, Elizabeth Fox, Brenda J. Weigel
Journal: Blood
Blood (2024) 144 (Supplement 1): 4265.4.
https://doi.org/10.1182/blood-2024-207907
Published: 2024
Journal Articles

Progressive Gut Microbiome Dysbiosis Is Associated with Chronic Lymphocytic Leukemia Pathogenesis and Development in the Eµ-TCL1 Mouse Model

Free
Sydney A Skupa, Audrey L Smith, Alexandria P Eiken, Elizabeth A Schmitz, Kathryn M Cooper, Christopher R D'Angelo, Dalia El-Gamal
Journal: Blood
Blood (2023) 142 (Supplement 1): 4630.
https://doi.org/10.1182/blood-2023-189606
Published: 2023
Journal Articles

Phase I Study of Tagraxofusp with or without Chemotherapy in Pediatric Patients with Relapsed or Refractory CD123-Expressing Hematologic Malignancies: A Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium Trial

Free
Adam J. Lamble, Yueh-Yun Chi, Bill H. Chang, Anupam Verma, Kelly E Faulk, Alexandra McLean Stevens, Lauren Pommert, Sarah Tucker, Benjamin Brookhart, Nirali N. Shah, Christopher L. Brooks, Tariq I. Mughal, Alan S. Wayne, Soheil Meshinchi, Todd M. Cooper
Journal: Blood
Blood (2022) 140 (Supplement 1): 6102–6103.
https://doi.org/10.1182/blood-2022-163503
Published: 2022
Journal Articles

Single-Cell Multiomics for Residual Disease Detection in Acute Myelogenous Leukemia after Allogeneic Hematopoietic Cell Transplantation

Free
Melinda Ann Biernacki, Olivia Waltner, Sami B Kanaan, Rula Green Gladden, Shruti Bhise, Todd M. Cooper, Monica Thakar, Soheil Meshinchi, Marie Bleakley, Xueyan Chen, Scott N Furlan
Journal: Blood
Blood (2022) 140 (Supplement 1): 10215–10216.
https://doi.org/10.1182/blood-2022-171164
Published: 2022
Journal Articles

Pathogenic TP53 mutations Are Associated with a Poor Prognosis in De Novo AML

Free
Adam J. Lamble, Rhonda E. Ries, Alice Dang, Todd A. Alonzo, Karen Chisholm, Pandurang Kolekar, Yanling Liu, Quang Tran, Todd M. Cooper, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Xiaotu Ma, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6297–6298.
https://doi.org/10.1182/blood-2022-162832
Published: 2022
Journal Articles

Distinct Latent Trajectory Phenotypes of Left Ventricular Function Associated with Differential Survival Among Children Treated for Acute Myeloid Leukemia: A Report from the Children's Oncology Group

Free
Kelly D. Getz, Robert B. Gerbing, Todd A. Alonzo, Yimei Li, Kasey J Leger, Jessica A. Pollard, Dava Szalda, Lillian Sung, Todd M. Cooper, Edward A. Kolb, Alan S. Gamis, Bonnie Ky, Richard Aplenc
Journal: Blood
Blood (2022) 140 (Supplement 1): 1014–1015.
https://doi.org/10.1182/blood-2022-170218
Published: 2022
Journal Articles

Expanding the High-Risk Definition for Children with Newly Diagnosed Acute Myeloid Leukemia

Free
Adam J. Lamble, Rhonda E. Ries, Todd A. Alonzo, Yi-Cheng Wang, Jason E Farrar, Benjamin J. Huang, Matthew A. Kutny, Jessica A. Pollard, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Todd M. Cooper, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3393–3394.
https://doi.org/10.1182/blood-2022-167680
Published: 2022
Journal Articles

Safety and Activity of Flotetuzumab in Pediatric and Young Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia: Results from the COG PEPN1812 Phase 1 Trial

Free
Adam J. Lamble, Xiaowei Liu, Charles Minard, Olga Militano, Melanie Brooke Bernhardt, Todd M. Cooper, Edward A. Kolb, Erin H. Breese, Elizabeth Fox, Sarah K Tasian, Brenda J. Weigel
Journal: Blood
Blood (2022) 140 (Supplement 1): 6209–6210.
https://doi.org/10.1182/blood-2022-158029
Published: 2022
Journal Articles

CXCR4 (CD184) Expression in Pediatric AML Is Associated with Bone Marrow Retention, Specific Disease Characteristics, and Worse Outcomes: A Report of 1004 Patients from the Children's Oncology Group AAML1031 Protocol

Free
Andrew J. Menssen, Chad A. Hudson, Todd A. Alonzo, Robert B. Gerbing, Laura Pardo, Fan-Chi Hsu, Loren L. Lott, Fangyan Dai, Keely Ghiradelli, Yi-Cheng Wang, E. Anders Kolb, Todd M. Cooper, Jessica A. Pollard, Michael R. Loken, Richard Aplenc, Lisa Eidenschink Brodersen, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3452–3453.
https://doi.org/10.1182/blood-2022-163682
Published: 2022
Journal Articles

Combining Atovaquone with Intensive Conventional Chemotherapy for Pediatric Acute Myeloid Leukemia (AML) Is Feasible and Well Tolerated

Free
Alexandra McLean Stevens, Eric Schafer, Minhua Li, Maci Terrell, Raushan Rashid, Hana Paek, Allison Weisnicht, Noah J Keogh, Michelle C Alozie, Hailey H Oviedo, Alan K Gonzalez, Alicia Mangubat-Medina, Haopei Wang, Eunji Jo, Cara A Rabik, Claire Bocchini, Susan Hilsenbeck, Zachary T Ball, Todd M. Cooper, Michele Redell
Journal: Blood
Blood (2021) 138 (Supplement 1): 2312.
https://doi.org/10.1182/blood-2021-146057
Published: 2021
Journal Articles

Significant Improvements in Survival for Patients with t(6;9)(p23;q34)/ DEK-NUP214 in Contemporary Trials with Intensification of Therapy: A Report from the Children's Oncology Group

Free
Katherine Tarlock, Todd A. Alonzo, Robert B. Gerbing, Yi-Cheng Wang, Rhonda E. Ries, Betsy A Hirsch, Beverly Lange, William G. Woods, Todd M. Cooper, Alan S. Gamis, Jessica A. Pollard, Richard Aplenc, Anders E. Kolb, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 519.
https://doi.org/10.1182/blood-2021-147576
Published: 2021
Journal Articles

Single-Cell Transcriptomics for Residual Disease Detection in Acute Myelogenous Leukemia Post Allogeneic Hematopoietic Cell Transplantation

Free
Sami B Kanaan, Shruti Bhise, Todd M. Cooper, Soheil Meshinchi, Scott N Furlan
Journal: Blood
Blood (2021) 138 (Supplement 1): 518.
https://doi.org/10.1182/blood-2021-151504
Published: 2021
Journal Articles

CEBPA -bZip mutations are associated with favorable prognosis in de novo AML: a report from the Children’s Oncology Group

Free
Clinical Trials & Observations
Katherine Tarlock, Adam J. Lamble, Yi-Cheng Wang, Robert B. Gerbing, Rhonda E. Ries, Michael R. Loken, Lisa Eidenschink Brodersen, Laura Pardo, Amanda Leonti, Jenny L. Smith, Tiffany A. Hylkema, William G. Woods, Todd M. Cooper, E. Anders Kolb, Alan S. Gamis, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (13): 1137–1147.
https://doi.org/10.1182/blood.2020009652
Published: 2021
Includes: Supplemental data
Journal Articles

CPX-351 Exposure-Response Analyses for Efficacy and Safety in Pediatric Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)

Free
Qi Wang, Nathalie H. Gosselin, Michael J. Absalon, E. Anders Kolb, MD, J.F. Marier, Todd A. Alonzo, PhD, Stefan Faderl, Todd M. Cooper, DO
Journal: Blood
Blood (2020) 136 (Supplement 1): 3.
https://doi.org/10.1182/blood-2020-137205
Published: 2020