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Journal Articles

Progressive Gut Microbiome Dysbiosis Is Associated with Chronic Lymphocytic Leukemia Pathogenesis and Development in the Eµ-TCL1 Mouse Model

Sydney A Skupa, Audrey L Smith, Alexandria P Eiken, Elizabeth A Schmitz, Kathryn M Cooper, Christopher R D'Angelo, Dalia El-Gamal
Journal: Blood
Blood (2023) 142 (Supplement 1): 4630.
https://doi.org/10.1182/blood-2023-189606
Published: 2023
Journal Articles

Single-Cell Multiomics for Residual Disease Detection in Acute Myelogenous Leukemia after Allogeneic Hematopoietic Cell Transplantation

Melinda Ann Biernacki, Olivia Waltner, Sami B Kanaan, Rula Green Gladden, Shruti Bhise, Todd M. Cooper, Monica Thakar, Soheil Meshinchi, Marie Bleakley, Xueyan Chen, Scott N Furlan
Journal: Blood
Blood (2022) 140 (Supplement 1): 10215–10216.
https://doi.org/10.1182/blood-2022-171164
Published: 2022
Journal Articles

Expanding the High-Risk Definition for Children with Newly Diagnosed Acute Myeloid Leukemia

Adam J. Lamble, Rhonda E. Ries, Todd A. Alonzo, Yi-Cheng Wang, Jason E Farrar, Benjamin J. Huang, Matthew A. Kutny, Jessica A. Pollard, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Todd M. Cooper, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3393–3394.
https://doi.org/10.1182/blood-2022-167680
Published: 2022
Journal Articles

CXCR4 (CD184) Expression in Pediatric AML Is Associated with Bone Marrow Retention, Specific Disease Characteristics, and Worse Outcomes: A Report of 1004 Patients from the Children's Oncology Group AAML1031 Protocol

Andrew J. Menssen, Chad A. Hudson, Todd A. Alonzo, Robert B. Gerbing, Laura Pardo, Fan-Chi Hsu, Loren L. Lott, Fangyan Dai, Keely Ghiradelli, Yi-Cheng Wang, E. Anders Kolb, Todd M. Cooper, Jessica A. Pollard, Michael R. Loken, Richard Aplenc, Lisa Eidenschink Brodersen, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3452–3453.
https://doi.org/10.1182/blood-2022-163682
Published: 2022
Journal Articles

Safety and Activity of Flotetuzumab in Pediatric and Young Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia: Results from the COG PEPN1812 Phase 1 Trial

Adam J. Lamble, Xiaowei Liu, Charles Minard, Olga Militano, Melanie Brooke Bernhardt, Todd M. Cooper, Edward A. Kolb, Erin H. Breese, Elizabeth Fox, Sarah K Tasian, Brenda J. Weigel
Journal: Blood
Blood (2022) 140 (Supplement 1): 6209–6210.
https://doi.org/10.1182/blood-2022-158029
Published: 2022
Journal Articles

Phase I Study of Tagraxofusp with or without Chemotherapy in Pediatric Patients with Relapsed or Refractory CD123-Expressing Hematologic Malignancies: A Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium Trial

Adam J. Lamble, Yueh-Yun Chi, Bill H. Chang, Anupam Verma, Kelly E Faulk, Alexandra McLean Stevens, Lauren Pommert, Sarah Tucker, Benjamin Brookhart, Nirali N. Shah, Christopher L. Brooks, Tariq I. Mughal, Alan S. Wayne, Soheil Meshinchi, Todd M. Cooper
Journal: Blood
Blood (2022) 140 (Supplement 1): 6102–6103.
https://doi.org/10.1182/blood-2022-163503
Published: 2022
Journal Articles

Pathogenic TP53 mutations Are Associated with a Poor Prognosis in De Novo AML

Adam J. Lamble, Rhonda E. Ries, Alice Dang, Todd A. Alonzo, Karen Chisholm, Pandurang Kolekar, Yanling Liu, Quang Tran, Todd M. Cooper, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Xiaotu Ma, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6297–6298.
https://doi.org/10.1182/blood-2022-162832
Published: 2022
Journal Articles

Distinct Latent Trajectory Phenotypes of Left Ventricular Function Associated with Differential Survival Among Children Treated for Acute Myeloid Leukemia: A Report from the Children's Oncology Group

Kelly D. Getz, Robert B. Gerbing, Todd A. Alonzo, Yimei Li, Kasey J Leger, Jessica A. Pollard, Dava Szalda, Lillian Sung, Todd M. Cooper, Edward A. Kolb, Alan S. Gamis, Bonnie Ky, Richard Aplenc
Journal: Blood
Blood (2022) 140 (Supplement 1): 1014–1015.
https://doi.org/10.1182/blood-2022-170218
Published: 2022
Journal Articles

Significant Improvements in Survival for Patients with t(6;9)(p23;q34)/ DEK-NUP214 in Contemporary Trials with Intensification of Therapy: A Report from the Children's Oncology Group

Katherine Tarlock, Todd A. Alonzo, Robert B. Gerbing, Yi-Cheng Wang, Rhonda E. Ries, Betsy A Hirsch, Beverly Lange, William G. Woods, Todd M. Cooper, Alan S. Gamis, Jessica A. Pollard, Richard Aplenc, Anders E. Kolb, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 519.
https://doi.org/10.1182/blood-2021-147576
Published: 2021
Journal Articles

Single-Cell Transcriptomics for Residual Disease Detection in Acute Myelogenous Leukemia Post Allogeneic Hematopoietic Cell Transplantation

Sami B Kanaan, Shruti Bhise, Todd M. Cooper, Soheil Meshinchi, Scott N Furlan
Journal: Blood
Blood (2021) 138 (Supplement 1): 518.
https://doi.org/10.1182/blood-2021-151504
Published: 2021
Journal Articles

Combining Atovaquone with Intensive Conventional Chemotherapy for Pediatric Acute Myeloid Leukemia (AML) Is Feasible and Well Tolerated

Alexandra McLean Stevens, Eric Schafer, Minhua Li, Maci Terrell, Raushan Rashid, Hana Paek, Allison Weisnicht, Noah J Keogh, Michelle C Alozie, Hailey H Oviedo, Alan K Gonzalez, Alicia Mangubat-Medina, Haopei Wang, Eunji Jo, Cara A Rabik, Claire Bocchini, Susan Hilsenbeck, Zachary T Ball, Todd M. Cooper, Michele Redell
Journal: Blood
Blood (2021) 138 (Supplement 1): 2312.
https://doi.org/10.1182/blood-2021-146057
Published: 2021
Journal Articles

CEBPA -bZip mutations are associated with favorable prognosis in de novo AML: a report from the Children’s Oncology Group

Clinical Trials & Observations
Katherine Tarlock, Adam J. Lamble, Yi-Cheng Wang, Robert B. Gerbing, Rhonda E. Ries, Michael R. Loken, Lisa Eidenschink Brodersen, Laura Pardo, Amanda Leonti, Jenny L. Smith, Tiffany A. Hylkema, William G. Woods, Todd M. Cooper, E. Anders Kolb, Alan S. Gamis, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (13): 1137–1147.
https://doi.org/10.1182/blood.2020009652
Published: 2021
Includes: Supplemental data
Journal Articles

Venetoclax Crosses the Blood Brain Barrier: A Pharmacokinetic Analysis of the Cerebrospinal Fluid in Pediatric Leukemia Patients

Ahmed Hamed Salem, PhD FCP, Mohamed A Badawi, PhD, Andrew E. Place, MDPhD, Tammy L. Palenski, PhD, Richard Arrendale, PhD, Su Young Kim, Sara Federico, MD, Todd M. Cooper, DO, Rajeev Menon, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-137197
Published: 2020
Journal Articles

Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia Harboring Heterogeneous Genomic Profiles Respond to Venetoclax in Combination with Chemotherapy

Andrew E. Place, MDPhD, Seth E. Karol, MD, Christopher J. Forlenza, MD, Marion Gambart, MD, Todd M. Cooper, DO, Christopher Fraser, MBBS, Gunnar Cario, MD PhD, Maureen M O'Brien, MD, Nicolas U. Gerber, MD, Phillip Barnette, MD, Dirk Reinhardt, MDPhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Mignon L. Loh, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-137376
Published: 2020
Journal Articles

CPX-351 Population Pharmacokinetics in Pediatric and Adult Patients with Acute Myeloid Leukemia (AML)

Qi Wang, Todd M. Cooper, DO, Michael J. Absalon, E. Anders Kolb, MD, Grygoriy Vasilinin, Nathalie H. Gosselin, Todd A. Alonzo, PhD, J.F. Marier
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-137163
Published: 2020
Journal Articles

Newly Diagnosed Childhood AML Patients Treated with Bortezomib Show Superior Survival If CD74 Is Expressed: A Report of 991 Patients from the Children's Oncology Group AAML1031 Protocol

Lisa Eidenschink Brodersen, PhD, Chad A. Hudson, MDPhD, Todd A. Alonzo, PhD, Robert B. Gerbing, MA, Laura Pardo, Amanda R. Leonti, MS, Timothy P. Singleton, MD, Fan-Chi Hsu, PhD, Loren L. Lott, Fangyan Dai, Keely Ghiradelli, E. Anders Kolb, MD, Todd M. Cooper, DO, Jessica A. Pollard, MD, Michael R. Loken, PhD, Richard Aplenc, MD PhD, Soheil Meshinchi, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39.
https://doi.org/10.1182/blood-2020-142659
Published: 2020
Journal Articles

CPX-351 Exposure-Response Analyses for Efficacy and Safety in Pediatric Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)

Qi Wang, Nathalie H. Gosselin, Michael J. Absalon, E. Anders Kolb, MD, J.F. Marier, Todd A. Alonzo, PhD, Stefan Faderl, Todd M. Cooper, DO
Journal: Blood
Blood (2020) 136 (Supplement 1): 3.
https://doi.org/10.1182/blood-2020-137205
Published: 2020
Journal Articles

Integrated Stem Cell Signature and Cytomolecular Risk Determination in Pediatric Acute Myeloid Leukemia

Benjamin J. Huang, MD, Jenny L. Smith, MSc, MD, Rhonda E. Ries, MA, Amanda R. Leonti, MS, Erin Lynn Crowgey, PhD, Scott N. Furlan, MD, Timothy Shaw, PhD, Lisa Wei, BS, Yi-Cheng Wang, MS, Robert B. Gerbing, MA, Todd A. Alonzo, PhD, Todd M. Cooper, DO, Edward A. Kolb, MD, Xiaotu Ma, PhD, Jason E. Farrar, MD, Timothy Junius Triche, Jr., PhD, Soheil Meshinchi, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-142638
Published: 2020
Journal Articles

Venetoclax Alone or in Combination with Chemotherapy: Responses in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia with Heterogeneous Genomic Profiles

Seth E. Karol, MD, Henrique Bittencourt, MD PhD, Daniel A. Morgenstern, MD, Margaret E. Macy, MD, Seong Lin Khaw, MD, Todd M. Cooper, DO, Arnaud Petit, MD PhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Andrew E. Place, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136999
Published: 2020
Journal Articles

The Molecular Characteristics and Clinical Relevance of NUP98 -Other Translocations in Pediatric Acute Myeloid Leukemia

Eline J.M. Bertrums, Jenny L. Smith, MSc, MD, Rhonda E. Ries, MA, Todd A. Alonzo, PhD, Fabiana Ostronoff, MD, Gertjan J.L. Kaspers, Prof. MD PhD, Henrik Hasle, PhD, Christian M. Zwaan, Betsy A Hirsch, PhD, Susana C. Raimondi, PhD, Todd M. Cooper, DO, Richard Aplenc, MD PhD, Alan S. Gamis, MD MPH, Edward A. Kolb, MD, Bianca F. Goemans, MD PhD, Soheil Meshinchi, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 36–37.
https://doi.org/10.1182/blood-2020-137537
Published: 2020