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Issue Archive

Volume 114, Issue 26
December 17 2009
Issue Cover

Table of Contents

INSIDE BLOOD

INSIDE BLOOD
Complement in antibody therapy: friend or foe?
Martino Introna,Josée Golay
View Articletitled, Complement in antibody therapy: friend or foe?
PLATELETS & THROMBOPOIESIS
ITP has elevated BAFF expression
John W. Semple
View Articletitled, ITP has elevated BAFF expression
THROMBOSIS & HEMOSTASIS
A mischief of mice
Thomas J. Kunicki
View Articletitled, A mischief of mice

PERSPECTIVES

Objectives of iron chelation therapy in myelodysplastic syndromes: more than meets the eye?
Vinod Pullarkat
View Articletitled, Objectives of iron chelation therapy in myelodysplastic syndromes: more than meets the eye?

HOW I TREAT

How I treat age-related morbidities in elderly persons with hemophilia
Pier M. Mannucci,Roger E. G. Schutgens,Elena Santagostino,Evelien P. Mauser-Bunschoten
View Articletitled, How I treat age-related morbidities in elderly persons with hemophilia

CLINICAL TRIALS AND OBSERVATIONS

Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
Clinical Trials & Observations
Nicolaus Kröger,Ernst Holler,Guido Kobbe,Martin Bornhäuser,Rainer Schwerdtfeger,Herrad Baurmann,Arnon Nagler,Wolfgang Bethge,Matthias Stelljes,Lutz Uharek,Hannes Wandt,Andreas Burchert,Paolo Corradini,Jörg Schubert,Martin Kaufmann,Peter Dreger,Gerald G. Wulf,Hermann Einsele,Tatjana Zabelina,Hans Michael Kvasnicka,Jürgen Thiele,Ronald Brand,Axel R. Zander,Dietger Niederwieser,Theo M. de Witte
View Articletitled, Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
Epidemiologic study on survival of chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia patients with BCR-ABL T315I mutation
Clinical Trials & Observations
Franck E. Nicolini,Michael J. Mauro,Giovanni Martinelli,Dong-Wook Kim,Simona Soverini,Martin C. Müller,Andreas Hochhaus,Jorge Cortes,Charles Chuah,Inge H. Dufva,Jane F. Apperley,Fumiharu Yagasaki,Jay D. Pearson,Senaka Peter,Cesar Sanz Rodriguez,Claude Preudhomme,Francis Giles,John M. Goldman,Wei Zhou
View Articletitled, Epidemiologic study on survival of chronic myeloid leukemia and Ph<sup>+</sup> acute lymphoblastic leukemia patients with BCR-ABL T315I mutation

HEMATOPOIESIS AND STEM CELLS

The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis
Patrycja Sroczynska,Christophe Lancrin,Valerie Kouskoff,Georges Lacaud
View Articletitled, The differential activities of <em>Runx1</em> promoters define milestones during embryonic hematopoiesis
Supplemental data
TLR8-dependent TNF-α overexpression in Fanconi anemia group C cells
Scott M. Vanderwerf,Johanna Svahn,Susan Olson,R. Keaney Rathbun,Christina Harrington,Jane Yates,Winifred Keeble,David C. Anderson,Praveen Anur,Noemi F. Pereira,Daniela V. Pilonetto,Ricardo Pasquini,Grover C. Bagby
View Articletitled, TLR8-dependent TNF-α overexpression in Fanconi anemia group C cells
Supplemental data

IMMUNOBIOLOGY

Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling
Cindy Banh,Céline Fugère,Laurent Brossay
View Articletitled, Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling
Supplemental data

LYMPHOID NEOPLASIA

Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage
Jitka Malcikova,Jana Smardova,Ludmila Rocnova,Boris Tichy,Petr Kuglik,Vladimira Vranova,Sona Cejkova,Miluse Svitakova,Hana Skuhrova Francova,Yvona Brychtova,Michael Doubek,Martin Brejcha,Martin Klabusay,Jiri Mayer,Sarka Pospisilova,Martin Trbusek
View Articletitled, Monoallelic and biallelic inactivation of <em>TP53</em> gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage
Supplemental data
BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt
Przemyslaw Juszczynski,Linfeng Chen,Evan O'Donnell,Jose M. Polo,Stella M. Ranuncolo,Riccardo Dalla-Favera,Ari Melnick,Margaret A. Shipp
View Articletitled, BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt
Supplemental data
Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model
Siao-Yi Wang,Suresh Veeramani,Emilian Racila,Jeffrey Cagley,David C. Fritzinger,Carl-Wilhelm Vogel,William St John,George J. Weiner
View Articletitled, Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model

MYELOID NEOPLASIA

MicroRNA 29b functions in acute myeloid leukemia
Ramiro Garzon,Catherine E. A. Heaphy,Violaine Havelange,Muller Fabbri,Stefano Volinia,Twee Tsao,Nicola Zanesi,Steven M. Kornblau,Guido Marcucci,George A. Calin,Michael Andreeff,Carlo M. Croce
View Articletitled, MicroRNA 29b functions in acute myeloid leukemia
Supplemental data
Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs
Karl J. Aichberger,Karoline V. Gleixner,Irina Mirkina,Sabine Cerny-Reiterer,Barbara Peter,Veronika Ferenc,Michael Kneidinger,Christian Baumgartner,Matthias Mayerhofer,Alexander Gruze,Winfried F. Pickl,Christian Sillaber,Peter Valent
View Articletitled, Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs
AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations
Jih-Luh Tang,Hsin-An Hou,Chien-Yuan Chen,Chieh-Yu Liu,Wen-Chien Chou,Mei-Hsuan Tseng,Chi-Fei Huang,Fen-Yu Lee,Ming-Chih Liu,Ming Yao,Shang-Yi Huang,Bor-Sheng Ko,Szu-Chun Hsu,Shang-Ju Wu,Woei Tsay,Yao-Chang Chen,Liang-In Lin,Hwei-Fang Tien
View Articletitled, <em>AML1/RUNX1</em> mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations
Supplemental data

PLATELETS AND THROMBOPOIESIS

The effects of BAFF and BAFF-R-Fc fusion protein in immune thrombocytopenia
Xiao-juan Zhu,Yan Shi,Jun Peng,Cheng-shan Guo,Ning-ning Shan,Ping Qin,Xue-bin Ji,Ming Hou
View Articletitled, The effects of BAFF and BAFF-R-Fc fusion protein in immune thrombocytopenia
Supplemental data

THROMBOSIS AND HEMOSTASIS

Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice
Jordan A. Shavit,Ani Manichaikul,Heidi L. Lemmerhirt,Karl W. Broman,David Ginsburg
View Articletitled, Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice

TRANSPLANTATION

IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation
Christoph Bucher,Lisa Koch,Christine Vogtenhuber,Emily Goren,Meghan Munger,Angela Panoskaltsis-Mortari,Pallavur Sivakumar,Bruce R. Blazar
View Articletitled, IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation
Supplemental data

VASCULAR BIOLOGY

Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate
Elina Kivi,Kati Elima,Kristiina Aalto,Yvonne Nymalm,Kaisa Auvinen,Erkki Koivunen,Diana M. Otto,Paul R. Crocker,Tiina A. Salminen,Marko Salmi,Sirpa Jalkanen
View Articletitled, Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate
Supplemental data
Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites
Ronen Ben-Ami,Russell E. Lewis,Konstantinos Leventakos,Dimitrios P. Kontoyiannis
View Articletitled, <em>Aspergillus fumigatus</em> inhibits angiogenesis through the production of gliotoxin and other secondary metabolites
Supplemental data

CORRESPONDENCE

Multidrug resistance–associated protein 4 (MRP4) gene polymorphisms and treatment response in adult acute lymphoblastic leukemia
Monika Brüggemann,Heiko Trautmann,Dieter Hoelzer,Michael Kneba,Nicola Gökbuget,Thorsten Raff
View Articletitled, Multidrug resistance–associated protein 4 (<em>MRP4</em>) gene polymorphisms and treatment response in adult acute lymphoblastic leukemia
Response: MRP4 gene polymorphisms and treatment response in adult ALL
Maja Krajinovic,Marc Ansari,Daniel Sinnett
View Articletitled, Response: <em>MRP4</em> gene polymorphisms and treatment response in adult ALL
Central nervous system prophylaxis in mantle cell lymphoma
Moshe E. Gatt,Sigal Grisaro
View Articletitled, Central nervous system prophylaxis in mantle cell lymphoma
Response: CNS prophylaxis in MCL
Michele Ghielmini,Emanuele Zucca
View Articletitled, Response: CNS prophylaxis in MCL
Vascular complications after splenectomy for hematologic disorders
Gregory J. Kato
View Articletitled, Vascular complications after splenectomy for hematologic disorders
Restoration of the human stem cell niche after stem cell transplantation
Sonja Zweegman,Floortje L. Kessler,Johanna W. A. M. Celie,Jeroen J. W. M. Janssen,Jacob van den Born,Gerrit J. Schuurhuis,Angelika M. Dräger
View Articletitled, Restoration of the human stem cell niche after stem cell transplantation
Response: Optimizing the niche conditions for maximal stem cell engraftment: human and animal model data
Massimo Dominici,Edwin M. Horwitz
View Articletitled, Response: Optimizing the niche conditions for maximal stem cell engraftment: human and animal model data
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