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Issue Archive

Volume 115, Issue 15
April 15 2010
Issue Cover

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS
Fibrinogen amyloidosis: the clot thickens!
Maria M. Picken
View Articletitled, Fibrinogen amyloidosis: the clot thickens!
CLINICAL TRIALS
HIV-associated lymphoma
Alexandra M. Levine
View Articletitled, HIV-associated lymphoma
IMMUNOBIOLOGY
CD137 in NK cells
Jacqueline Marvel,Thierry Walzer
View Articletitled, CD137 in NK cells

REVIEW ARTICLES

NFAT pulls the strings during CD4+ T helper cell effector functions
Natascha Hermann-Kleiter,Gottfried Baier
View Articletitled, NFAT pulls the strings during CD4<sup>+</sup> T helper cell effector functions

CLINICAL TRIALS AND OBSERVATIONS

Hereditary fibrinogen A α-chain amyloidosis: phenotypic characterization of a systemic disease and the role of liver transplantation
Clinical Trials & Observations
Arie J. Stangou,Nicholas R. Banner,Bruce M. Hendry,Mohamed Rela,Bernard Portmann,Julia Wendon,Mark Monaghan,Philip MacCarthy,Muriel Buxton-Thomas,Christopher J. Mathias,Juris J. Liepnieks,John O'Grady,Nigel D. Heaton,Merrill D. Benson
View Articletitled, Hereditary fibrinogen A α-chain amyloidosis: phenotypic characterization of a systemic disease and the role of liver transplantation
Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma
Clinical Trials & Observations
Joseph A. Sparano,Jeannette Y. Lee,Lawrence D. Kaplan,Alexandra M. Levine,Juan Carlos Ramos,Richard F. Ambinder,William Wachsman,David Aboulafia,Ariela Noy,David H. Henry,Jamie Von Roenn,Bruce J. Dezube,Scot C. Remick,Manisha H. Shah,Lawrence Leichman,Lee Ratner,Ethel Cesarman,Amy Chadburn,Ronald Mitsuyasu,for the AIDS Malignancy Consortium
View Articletitled, Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma
The role of tumor histogenesis, FDG-PET, and short-course EPOCH with dose-dense rituximab (SC-EPOCH-RR) in HIV-associated diffuse large B-cell lymphoma
Clinical Trials & Observations
Kieron Dunleavy,Richard F. Little,Stefania Pittaluga,Nicole Grant,Alan S. Wayne,Jorge A. Carrasquillo,Seth M. Steinberg,Robert Yarchoan,Elaine S. Jaffe,Wyndham H. Wilson
View Articletitled, The role of tumor histogenesis, FDG-PET, and short-course EPOCH with dose-dense rituximab (SC-EPOCH-RR) in HIV-associated diffuse large B-cell lymphoma

GENE THERAPY

Targeting human telomerase reverse transcriptase with recombinant lentivector is highly effective to stimulate antitumor CD8 T-cell immunity in vivo
Olivier Adotévi,Karine Mollier,Christine Neuveut,Magalie Dosset,Patrice Ravel,Wolf-Hervé Fridman,Eric Tartour,Pierre Charneau,Simon Wain-Hobson,Pierre Langlade-Demoyen
View Articletitled, Targeting human telomerase reverse transcriptase with recombinant lentivector is highly effective to stimulate antitumor CD8 T-cell immunity in vivo
A zinc-finger transcriptional activator designed to interact with the γ-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts
Andrew Wilber,Ulrich Tschulena,Phillip W. Hargrove,Yoon-Sang Kim,Derek A. Persons,Carlos F. Barbas, III,Arthur W. Nienhuis
View Articletitled, A zinc-finger transcriptional activator designed to interact with the γ-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis
Thomas Bee,Gemma Swiers,Sawako Muroi,Amir Pozner,Wade Nottingham,Ana Cristina Santos,Pik-Shan Li,Ichiro Taniuchi,Marella F. T. R. de Bruijn
View Articletitled, Nonredundant roles for <em>Runx1</em> alternative promoters reflect their activity at discrete stages of developmental hematopoiesis
Supplemental data

IMMUNOBIOLOGY

Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70
Joanne Shaw,Yui-Hsi Wang,Tomoki Ito,Kazuhiko Arima,Yong-Jun Liu
View Articletitled, Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70
CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells
Tina Baessler,Jean Enno Charton,Benjamin Joachim Schmiedel,Frank Grünebach,Matthias Krusch,Alexander Wacker,Hans-Georg Rammensee,Helmut Rainer Salih
View Articletitled, CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells
Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease
Roland C. Zahn,Melisa D. Rett,Ming Li,Haili Tang,Birgit Korioth-Schmitz,Harikrishnan Balachandran,Robert White,Sarah Pryputniewicz,Norman L. Letvin,Amitinder Kaur,David C. Montefiori,Angela Carville,Vanessa M. Hirsch,Jonathan S. Allan,Jörn E. Schmitz
View Articletitled, Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease
Supplemental data
Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers
e-blood
P'ng Loke,David Favre,Peter W. Hunt,Jacqueline M. Leung,Bittoo Kanwar,Jeffrey N. Martin,Steven G. Deeks,Joseph M. McCune
View Articletitled, Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers
Supplemental data

LYMPHOID NEOPLASIA

CD160 signaling mediates PI3K-dependent survival and growth signals in chronic lymphocytic leukemia
Feng-Ting Liu,Jerome Giustiniani,Timothy Farren,Li Jia,Armand Bensussan,John G. Gribben,Samir G. Agrawal
View Articletitled, CD160 signaling mediates PI3K-dependent survival and growth signals in chronic lymphocytic leukemia
Supplemental data
Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogénétique Hématologique study
Etienne Coyaud,Stephanie Struski,Nais Prade,Julien Familiades,Ruth Eichner,Cathy Quelen,Marina Bousquet,Francine Mugneret,Pascaline Talmant,Marie-Pierre Pages,Christine Lefebvre,Dominique Penther,Eric Lippert,Nathalie Nadal,Sylvie Taviaux,Bruce Poppe,Isabelle Luquet,Laurence Baranger,Virginie Eclache,Isabelle Radford,Carole Barin,Marie-Joëlle Mozziconacci,Marina Lafage-Pochitaloff,Hélène Antoine-Poirel,Christiane Charrin,Christine Perot,Christine Terre,Pierre Brousset,Nicole Dastugue,Cyril Broccardo
View Articletitled, Wide diversity of <em>PAX5</em> alterations in B-ALL: a Groupe Francophone de Cytogénétique Hématologique study
Supplemental data

MYELOID NEOPLASIA

Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML
Thomas A. Paul,Juraj Bies,Donald Small,Linda Wolff
View Articletitled, Signatures of polycomb repression and reduced H3K4 trimethylation are associated with <em>p15INK4b</em> DNA methylation in AML
Supplemental data
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
Alfonso Quintás-Cardama,Kris Vaddi,Phillip Liu,Taghi Manshouri,Jun Li,Peggy A. Scherle,Eian Caulder,Xiaoming Wen,Yanlong Li,Paul Waeltz,Mark Rupar,Timothy Burn,Yvonne Lo,Jennifer Kelley,Maryanne Covington,Stacey Shepard,James D. Rodgers,Patrick Haley,Hagop Kantarjian,Jordan S. Fridman,Srdan Verstovsek
View Articletitled, Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Tyrosine kinase Btk regulates E-selectin–mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) γ2 and PI3Kγ pathways
Helena Mueller,Anika Stadtmann,Hugo Van Aken,Emilio Hirsch,Demin Wang,Klaus Ley,Alexander Zarbock
View Articletitled, Tyrosine kinase Btk regulates E-selectin–mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) γ2 and PI3Kγ pathways
Supplemental data

PLATELETS AND THROMBOPOIESIS

RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency
Gurpreet Kaur,Gauthami Jalagadugula,Guangfen Mao,A. Koneti Rao
View Articletitled, RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (<em>ALOX12</em>): studies in human RUNX1 haplodeficiency

RED CELLS, IRON, AND ERYTHROPOIESIS

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis
Dae-Hoon Lee,Li-Juan Zhou,Zheng Zhou,Jian-Xin Xie,Ji-Ung Jung,Yu Liu,Cai-Xia Xi,Lin Mei,Wen-Cheng Xiong
View Articletitled, Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis
Supplemental data

TRANSPLANTATION

Allo-HLA reactivity of virus-specific memory T cells is common
Avital L. Amir,Lloyd J. A. D'Orsogna,Dave L. Roelen,Marleen M. van Loenen,Renate S. Hagedoorn,Renate de Boer,Menno A. W. G. van der Hoorn,Michel G. D. Kester,Ilias I. N. Doxiadis,J. H. Frederik Falkenburg,Frans H. J. Claas,Mirjam H. M. Heemskerk
View Articletitled, Allo-HLA reactivity of virus-specific memory T cells is common
Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation
Brief Report
Itzel Bustos Villalobos,Yoshiyuki Takahashi,Yoshiki Akatsuka,Hideki Muramatsu,Nobuhiro Nishio,Asahito Hama,Hiroshi Yagasaki,Hiroh Saji,Motohiro Kato,Seishi Ogawa,Seiji Kojima
View Articletitled, Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation
Supplemental data
Donor activating KIR3DS1 is associated with decreased acute GVHD in unrelated allogeneic hematopoietic stem cell transplantation
Brief Report
Jeffrey M. Venstrom,Ted A. Gooley,Stephen Spellman,James Pring,Mari Malkki,Bo Dupont,Effie Petersdorf,Katharine C. Hsu
View Articletitled, Donor activating <em>KIR3DS1</em> is associated with decreased acute GVHD in unrelated allogeneic hematopoietic stem cell transplantation
Supplemental data

VASCULAR BIOLOGY

Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia
Hiroyasu Kidoya,Hisamichi Naito,Nobuyuki Takakura
View Articletitled, Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia
Supplemental data

CORRESPONDENCE

Failure of the Ipsogen MutaScreen kit to detect the JAK2 617V>F mutation in samples with additional rare exon 14 mutations: implications for clinical testing and report of a novel 618C>F mutation in addition to 617V>F
Ilka Warshawsky,Frank Mularo,Carol Hren,Maureen Jakubowski
View Articletitled, Failure of the Ipsogen MutaScreen kit to detect the <em>JAK2</em> 617V&gt;F mutation in samples with additional rare exon 14 mutations: implications for clinical testing and report of a novel 618C&gt;F mutation in addition to 617V&gt;F
The role of CBFβ in AML1-ETO's activity
Colin Kwok,Bernd B. Zeisig,Shuo Dong,Chi Wai Eric So
View Articletitled, The role of CBFβ in AML1-ETO's activity
Supplemental data
All Issues

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