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Issue Archive

Volume 115, Issue 17
April 29 2010
Blood Cover Image for Volume 115, Issue 17

Table of Contents

INSIDE BLOOD

IMMUNOBIOLOGY
When T cells cannot help
Eva Severinson
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CLINICAL TRIALS
Haploidentical transplantation in children
Kirk R. Schultz
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HEMATOPOIESIS & STEM CELLS
Fanconi anemia strikes early in utero
Johnson M. Liu
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INSIDE BLOOD
Positioning NK-κB in multiple myeloma
Bernard Klein
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INSIDE BLOOD
Genetic relicts from the origin of ALL
Markus Müschen
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RED CELLS & IRON
2 out of 3 isn't bad
James P. Kushner
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REVIEW ARTICLES

Deadly allies: the fatal interplay between platelets and metastasizing cancer cells
Luise Erpenbeck,Michael P. Schön
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CLINICAL TRIALS AND OBSERVATIONS

Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplantation in children with very high-risk acute lymphoblastic leukemia: impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant group
Clinical Trials & Observations
Thomas Klingebiel,Jacqueline Cornish,Myriam Labopin,Franco Locatelli,Philippe Darbyshire,Rupert Handgretinger,Adriana Balduzzi,Joanna Owoc-Lempach,Franca Fagioli,Reuven Or,Christina Peters,Franco Aversa,Emmanuelle Polge,Giorgio Dini,Vanderson Rocha,on behalf of the Pediatric Diseases and Acute Leukemia Working Parties of the European Group for Blood and Marrow Transplantation (EBMT)
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Improved survival of children and adolescents with sickle cell disease
Clinical Trials & Observations
Charles T. Quinn,Zora R. Rogers,Timothy L. McCavit,George R. Buchanan
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HEMATOPOIESIS AND STEM CELLS

Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage
Asmin Tulpule,M. William Lensch,Justine D. Miller,Karyn Austin,Alan D'Andrea,Thorsten M. Schlaeger,Akiko Shimamura,George Q. Daley
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Supplemental data
Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression
Roy Drissen,Boris Guyot,Lin Zhang,Ann Atzberger,Jackie Sloane-Stanley,Bill Wood,Catherine Porcher,Paresh Vyas
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Supplemental data
Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose γ-irradiation
Hui Yu,Hongmei Shen,Youzhong Yuan,Richard XuFeng,Xiaoxia Hu,Sean P. Garrison,Lin Zhang,Jian Yu,Gerard P. Zambetti,Tao Cheng
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Supplemental data
Haploinsufficiency of Apc leads to ineffective hematopoiesis
Jianghong Wang,Anthony A. Fernald,John Anastasi,Michelle M. Le Beau,Zhijian Qian
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Supplemental data
The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS
Steven W. Lane,Stephen M. Sykes,Fatima Al-Shahrour,Sebastian Shterental,Mahnaz Paktinat,Cristina Lo Celso,Jonathan L. Jesneck,Benjamin L. Ebert,David A. Williams,D. Gary Gilliland
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Supplemental data

IMMUNOBIOLOGY

Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function
Vanessa Morales-Tirado,Dorothy K. Sojka,Shoshana D. Katzman,Christopher A. Lazarski,Fred D. Finkelman,Joseph F. Urban,Deborah J. Fowell
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Supplemental data
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell–mediated rejection of systemic lymphoma in immunodeficient mice
John C. Markley,Michel Sadelain
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Supplemental data
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
Xiangdong Liu,Niu Shin,Holly K. Koblish,Gengjie Yang,Qian Wang,Kathy Wang,Lynn Leffet,Michael J. Hansbury,Beth Thomas,Mark Rupar,Paul Waeltz,Kevin J. Bowman,Padmaja Polam,Richard B. Sparks,Eddy W. Yue,Yanlong Li,Richard Wynn,Jordan S. Fridman,Timothy C. Burn,Andrew P. Combs,Robert C. Newton,Peggy A. Scherle
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Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells
Andreas Weigert,Sarah Cremer,Martina Victoria Schmidt,Andreas von Knethen,Carlo Angioni,Gerd Geisslinger,Bernhard Brüne
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Supplemental data

LYMPHOID NEOPLASIA

Classical and/or alternative NF-κB pathway activation in multiple myeloma
Yulia N. Demchenko,Oleg K. Glebov,Adriana Zingone,Jonathan J. Keats,P. Leif Bergsagel,W. Michael Kuehl
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Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
Caroline M. Bateman,Susan M. Colman,Tracy Chaplin,Bryan D. Young,Tim O. Eden,Manoo Bhakta,Eric J. Gratias,Elisabeth R. van Wering,Giovanni Cazzaniga,Christine J. Harrison,Richard Hain,Philip Ancliff,Anthony M. Ford,Lyndal Kearney,Mel Greaves
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Supplemental data
Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma
Gaofeng Fan,Matthew J. Simmons,Sheng Ge,Jui Dutta-Simmons,Jérôme Kucharczak,Yacov Ron,David Weissmann,Chiann-Chyi Chen,Chandreyee Mukherjee,Eileen White,Céline Gélinas
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Supplemental data
The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4
Adelheid Bursen,Karen Schwabe,Brigitte Rüster,Reinhard Henschler,Martin Ruthardt,Theo Dingermann,Rolf Marschalek
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Supplemental data
Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenström macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy
Jia Li,Daniel M.-Y. Sze,Ross D. Brown,Mark J. Cowley,Warren Kaplan,Sui-Lin Mo,Shihong Yang,Esther Aklilu,Karieshma Kabani,Yen S. Loh,Tetsuo Yamagishi,Yuling Chen,P. Joy Ho,Douglas E. Joshua
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Supplemental data

MYELOID NEOPLASIA

Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera–like disease
Hajime Akada,Dongqing Yan,Haiying Zou,Steven Fiering,Robert E. Hutchison,M. Golam Mohi
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Supplemental data
Palmitoylation of oncogenic NRAS is essential for leukemogenesis
Benjamin Cuiffo,Ruibao Ren
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PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

MyD88-dependent TLR4 signaling is selectively impaired in alveolar macrophages from asymptomatic HIV+ persons
Souvenir D. Tachado,Xin Li,Medhavi Bole,Katharine Swan,Asha Anandaiah,Naimish R. Patel,Henry Koziel
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RED CELLS, IRON, AND ERYTHROPOIESIS

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia
Barbra J. Sasu,Keegan S. Cooke,Tara L. Arvedson,Cherylene Plewa,Aaron R. Ellison,Jackie Sheng,Aaron Winters,Todd Juan,Hongyan Li,C. Glenn Begley,Graham Molineux
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TRANSPLANTATION

Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease–associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation
Yume Nguyen,Abed Al-Lehibi,Elizabeth Gorbe,Ellen Li,Michael Haagenson,Tao Wang,Stephen Spellman,Stephanie J. Lee,Nicholas O. Davidson
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VASCULAR BIOLOGY

Platelet interleukin-1α drives cerebrovascular inflammation
Peter Thornton,Barry W. McColl,Andrew Greenhalgh,Adam Denes,Stuart M. Allan,Nancy J. Rothwell
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Supplemental data

CORRESPONDENCE

The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not
Albert G. Tsai,Zhengfei Lu,Michael R. Lieber
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Response: The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not
Eva Maria Murga Penas,Judith Dierlamm
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Meis1 maintains stemness signature in MLL-AF9 leukemia
Ashish R. Kumar,Aaron L. Sarver,Baolin Wu,John H. Kersey
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Bone marrow as a site for pancreatic islet transplantation
Anastasio Salazar-Bañuelos,Luis Benitez-Bribiesca,David L. Sigalet,Greg Korbutt,James R. Wright, Jr
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No influence of gene polymorphism of LCT (C13910T) on transplantation outcomes in acute myeloid leukemia patients who received transplantations from HLA-identical sibling donors
Ahmet H. Elmaagacli,Nina Steckel,Markus Ditschkowski,Yael Hegerfeldt,Hellmut Ottinger,Rudolf Trenschel,Dietrich W. Beelen
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Response: Significant influence of LCT-13910C>T on transplantation outcomes in acute myeloid leukemia patients receiving transplantations from HLA-identical sibling donors
Hanns Hauser,Otto Zach,Otto Krieger,Hedwig Kasparu,Josef Koenig,Michael Girschikofsky,Dieter Lutz
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All Issues

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