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Issue Archive

Volume 119, Issue 14
April 5 2012
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
A new chelator in the house
Ali T. Taher,Khaled M. Musallam
View Articletitled, A new chelator in the house
CLINICAL TRIALS
Evidence over hope for pregnancy complications
Ian A. Greer
View Articletitled, Evidence over hope for pregnancy complications
INSIDE BLOOD
BRAF mutation: supporting diversity in HCL
Jan A. Burger
View Articletitled, BRAF mutation: supporting diversity in HCL
PLATELETS & THROMBOPOIESIS
Does “more” necessarily mean “better”?
Luciana Teofili,Luigi Maria Larocca
View Articletitled, Does “more” necessarily mean “better”?
THROMBOSIS & HEMOSTASIS
Aβ and C(lot), but not D(egradation)
Alisa S. Wolberg
View Articletitled, Aβ and C(lot), but not D(egradation)
THROMBOSIS & HEMOSTASIS
JAMming the signals
Jonathan M. Gibbins
View Articletitled, JAMming the signals
TRANSPLANTATION
Azacitidine after allo-SCT: the good without the bad?
Mohamad Mohty,Patrice Chevallier
View Articletitled, Azacitidine after allo-SCT: the good without the bad?

Blood Work

Circulating mitotic figures in CMV-associated hydrops fetalis
Ronald Jackups,Mitra Mehrad
View Articletitled, Circulating mitotic figures in CMV-associated hydrops fetalis

Plenary Papers

MYELOID NEOPLASIA
Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis
Hideki Makishima,Valeria Visconte,Hirotoshi Sakaguchi,Anna M. Jankowska,Sarah Abu Kar,Andres Jerez,Bartlomiej Przychodzen,Manoj Bupathi,Kathryn Guinta,Manuel G. Afable,Mikkael A. Sekeres,Richard A. Padgett,Ramon V. Tiu,Jaroslaw P. Maciejewski
View Articletitled, Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis
Supplemental data
MYELOID NEOPLASIA
Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes
Frederik Damm,Olivier Kosmider,Véronique Gelsi-Boyer,Aline Renneville,Nadine Carbuccia,Claire Hidalgo-Curtis,Véronique Della Valle,Lucile Couronné,Laurianne Scourzic,Virginie Chesnais,Agnes Guerci-Bresler,Bohrane Slama,Odile Beyne-Rauzy,Aline Schmidt-Tanguy,Aspasia Stamatoullas-Bastard,François Dreyfus,Thomas Prébet,Stéphane de Botton,Norbert Vey,Michael A. Morgan,Nicholas C. P. Cross,Claude Preudhomme,Daniel Birnbaum,Olivier A. Bernard,Michaela Fontenay,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies,on behalf of the Groupe Francophone des Myélodysplasies
View Articletitled, Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes
Supplemental data

Perspectives

Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?
Hans Carl Hasselbalch
View Articletitled, Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?

Review Articles

Hematopoietic stem cells: to be or Notch to be
Anna Bigas,Lluis Espinosa
View Articletitled, Hematopoietic stem cells: to be or Notch to be
Asthma and coagulation
J. Daan de Boer,Christof J. Majoor,Cornelis van 't Veer,Elisabeth H. D. Bel,Tom van der Poll
View Articletitled, Asthma and coagulation

How I Treat

How I treat HIV-associated lymphoma
Kieron Dunleavy,Wyndham H. Wilson
View Articletitled, How I treat HIV-associated lymphoma

Clinical Trials and Observations

Risk stratification–directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations
Chen-Hua Yan,Dai-Hong Liu,Kai-Yan Liu,Lan-Ping Xu,Yan-Rong Liu,Huan Chen,Wei Han,Yu Wang,Ya-Zhen Qin,Xiao-Jun Huang
View Articletitled, Risk stratification–directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation

Hematopoiesis and Stem Cells

FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway
Abdullah Mahmood Ali,Arun Pradhan,Thiyam Ramsingh Singh,Changhu Du,Jie Li,Kebola Wahengbam,Elke Grassman,Arleen D. Auerbach,Qishen Pang,Amom Ruhikanta Meetei
View Articletitled, FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway
Supplemental data

Immunobiology

Regulation of mast cell survival and function by tuberous sclerosis complex 1
Jinwook Shin,Hongjie Pan,Xiao-Ping Zhong
View Articletitled, Regulation of mast cell survival and function by tuberous sclerosis complex 1
Supplemental data
Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis
Polidy Pean,Eric Nerrienet,Yoann Madec,Laurence Borand,Didier Laureillard,Marcelo Fernandez,Olivier Marcy,Chan Sarin,Kerya Phon,Sylvia Taylor,Gianfranco Pancino,Françoise Barré-Sinoussi,Daniel Scott-Algara,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team,for the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team
View Articletitled, Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis
Supplemental data

Lymphoid Neoplasia

The role of sex and weight on rituximab clearance and serum elimination half-life in elderly patients with DLBCL
Clinical Trials & Observations
Carsten Müller,Niels Murawski,Martin H. J. Wiesen,Gerhard Held,Viola Poeschel,Samira Zeynalova,Michael Wenger,Christina Nickenig,Norma Peter,Eva Lengfelder,Bernd Metzner,Tanja Rixecker,Carsten Zwick,Michael Pfreundschuh,Marcel Reiser
View Articletitled, The role of sex and weight on rituximab clearance and serum elimination half-life in elderly patients with DLBCL
The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives
Steven H. Bernstein,Sundararajan Venkatesh,Min Li,Jae Lee,Bin Lu,Shannon P. Hilchey,Kimberly M. Morse,Hollie M. Metcalfe,Jolanta Skalska,Michael Andreeff,Paul S. Brookes,Carolyn K. Suzuki
View Articletitled, The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives
Supplemental data
Both variant and IGHV4-34–expressing hairy cell leukemia lack the BRAF V600E mutation
Brief Report
Liqiang Xi,Evgeny Arons,Winnifred Navarro,Katherine R. Calvo,Maryalice Stetler-Stevenson,Mark Raffeld,Robert J. Kreitman
View Articletitled, Both variant and IGHV4-34–expressing hairy cell leukemia lack the <em>BRAF</em> V600E mutation
Supplemental data

Platelets and Thrombopoiesis

Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD
Catherine Léon,Katja Evert,Frank Dombrowski,Fabien Pertuy,Anita Eckly,Patricia Laeuffer,Christian Gachet,Andreas Greinacher
View Articletitled, Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD
JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets
Meghna U. Naik,Timothy J. Stalker,Lawrence F. Brass,Ulhas P. Naik
View Articletitled, JAM-A protects from thrombosis by suppressing integrin α<sub>IIb</sub>β<sub>3</sub>-dependent outside-in signaling in platelets
Supplemental data

Red Cells, Iron, and Erythropoiesis

A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload
Clinical Trials & Observations
Ellis J. Neufeld,Renzo Galanello,Vip Viprakasit,Yesim Aydinok,Antonio Piga,Paul Harmatz,Gian Luca Forni,Farrukh T. Shah,Rachael F. Grace,John B. Porter,John C. Wood,Jennifer Peppe,Amber Jones,Hugh Young Rienhoff, Jr
View Articletitled, A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload
Supplemental data

Thrombosis and Hemostasis

Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial
Clinical Trials & Observations
Ida Martinelli,Piero Ruggenenti,Irene Cetin,Giorgio Pardi,Annalisa Perna,Patrizia Vergani,Barbara Acaia,Fabio Facchinetti,Giovanni Battista La Sala,Maddalena Bozzo,Stefania Rampello,Luca Marozio,Olimpia Diadei,Giulia Gherardi,Sergio Carminati,Giuseppe Remuzzi,Pier Mannuccio Mannucci,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group,for the HAPPY Study Group
View Articletitled, Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial
Supplemental data
Aβ delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin
Daria Zamolodchikov,Sidney Strickland
View Articletitled, Aβ delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin
Supplemental data

Transplantation

Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)
Oliver C. Goodyear,Mike Dennis,Nadira Y. Jilani,Justin Loke,Shamyla Siddique,Gordon Ryan,Jane Nunnick,Rahela Khanum,Manoj Raghavan,Mark Cook,John A. Snowden,Mike Griffiths,Nigel Russell,John Yin,Charles Crawley,Gordon Cook,Paresh Vyas,Paul Moss,Ram Malladi,Charles F. Craddock
View Articletitled, Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)
Supplemental data

Vascular Biology

ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling
Fang Liu,Inyoung Kang,Changwon Park,Li-Wei Chang,Wei Wang,Dongjun Lee,Dae-Sik Lim,Daniel Vittet,Jeanne M. Nerbonne,Kyunghee Choi
View Articletitled, ER71 specifies Flk-1<sup>+</sup> hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling
Supplemental data

Retraction

Huang X, Kushekhar K, Nolte I, Kooistra W, Visser L, Bouwman I, Kouprie N, Veenstra R, van Imhoff G, Olver B, Houlston RS, Poppema S, Diepstra A, Hepkema B, van den Berg A. Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups. Blood. 2011;118(19):5211–5217.
View Articletitled, Huang X, Kushekhar K, Nolte I, Kooistra W, Visser L, Bouwman I, Kouprie N, Veenstra R, van Imhoff G, Olver B, Houlston RS, Poppema S, Diepstra A, Hepkema B, van den Berg A. Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups. <em>Blood</em>. 2011;118(19):<span class="related-article">5211–5217</span>.
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