Helmut Gadner,for the Histiocyte Society,Milen Minkov,for the Histiocyte Society,Nicole Grois,for the Histiocyte Society,Ulrike Pötschger,for the Histiocyte Society,Elfriede Thiem,for the Histiocyte Society,Maurizio Aricò,for the Histiocyte Society,Itziar Astigarraga,for the Histiocyte Society,Jorge Braier,for the Histiocyte Society,Jean Donadieu,for the Histiocyte Society,Jan-Inge Henter,for the Histiocyte Society,Gritta Janka-Schaub,for the Histiocyte Society,Kenneth L. McClain,for the Histiocyte Society,Sheila Weitzman,for the Histiocyte Society,Kevin Windebank,for the Histiocyte Society,Stephan Ladisch,for the Histiocyte Society

View Articletitled, Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis

HEMATOPOIESIS AND STEM CELLS

Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function

Sarah J. Stein,Albert S. Baldwin

View Articletitled, Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function

Supplemental data

IMMUNOBIOLOGY

Characterization of a novel NKG2D and NKp46 double-mutant mouse reveals subtle variations in the NK cell repertoire

Sam Sheppard,Chiara Triulzi,Michele Ardolino,Daniel Serna,Lily Zhang,David H. Raulet,Nadia Guerra

View Articletitled, Characterization of a novel NKG2D and NKp46 double-mutant mouse reveals subtle variations in the NK cell repertoire

Supplemental data

CD141⁺ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice

Sonja Meixlsperger,Carol S. Leung,Patrick C. Rämer,Maggi Pack,Liliana D. Vanoaica,Gaëlle Breton,Steve Pascolo,Andres M. Salazar,Andrzej Dzionek,Jürgen Schmitz,Ralph M. Steinman,Christian Münz

View Articletitled, CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice

Supplemental data

LYMPHOID NEOPLASIA

Adult T-cell leukemia cells overexpress Wnt5a and promote osteoclast differentiation

Marcia Bellon,Nga Ling Ko,Min-Jung Lee,Yuan Yao,Thomas A. Waldmann,Jane B. Trepel,Christophe Nicot

View Articletitled, Adult T-cell leukemia cells overexpress Wnt5a and promote osteoclast differentiation

Supplemental data

Autologous/reduced-intensity allogeneic stem cell transplantation vs autologous transplantation in multiple myeloma: long-term results of the EBMT-NMAM2000 study

Gösta Gahrton,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Simona Iacobelli,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Bo Björkstrand,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Ute Hegenbart,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Astrid Gruber,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Hildegard Greinix,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Liisa Volin,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Franco Narni,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Angelo Michele Carella,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Meral Beksac,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Alberto Bosi,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Giuseppe Milone,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Paolo Corradini,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Stefan Schönland,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Kristina Friberg,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Anja van Biezen,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Hartmut Goldschmidt,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Theo de Witte,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Curly Morris,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Dietger Niederwieser,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Laurent Garderet,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee,Nicolaus Kröger,for the EBMT Chronic Malignancies Working Party Plasma Cell Disorders Subcommittee

View Articletitled, Autologous/reduced-intensity allogeneic stem cell transplantation vs autologous transplantation in multiple myeloma: long-term results of the EBMT-NMAM2000 study

New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia
Brief Report

Lucia Brandimarte,Valentina Pierini,Danika Di Giacomo,Chiara Borga,Filomena Nozza,Paolo Gorello,Marco Giordan,Giovanni Cazzaniga,Geertruy te Kronnie,Roberta La Starza,Cristina Mecucci

View Articletitled, New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia

Supplemental data

Leukemia surfaceome analysis reveals new disease-associated features
e-blood

Paulina Mirkowska,Andreas Hofmann,Lukasz Sedek,Lucie Slamova,Ester Mejstrikova,Tomasz Szczepanski,Maike Schmitz,Gunnar Cario,Martin Stanulla,Martin Schrappe,Vincent H. J. van der Velden,Beat C. Bornhauser,Bernd Wollscheid,Jean-Pierre Bourquin

View Articletitled, Leukemia surfaceome analysis reveals new disease-associated features

Supplemental data

MYELOID NEOPLASIA

GM-CSF–dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia

Eric Padron,Jeffrey S. Painter,Sateesh Kunigal,Adam W. Mailloux,Kathy McGraw,Jessica M. McDaniel,Eunhee Kim,Christopher Bebbington,Mark Baer,Geoffrey Yarranton,Jeffrey Lancet,Rami S. Komrokji,Omar Abdel-Wahab,Alan F. List,Pearlie K. Epling-Burnette

View Articletitled, GM-CSF–dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia

Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

The Thr224Asn mutation in the VPS45 gene is associated with the congenital neutropenia and primary myelofibrosis of infancy

Polina Stepensky,Ann Saada,Marianne Cowan,Adi Tabib,Ute Fischer,Yackov Berkun,Hani Saleh,Natalia Simanovsky,Aviram Kogot-Levin,Michael Weintraub,Hamam Ganaiem,Avraham Shaag,Shamir Zenvirt,Arndt Borkhardt,Orly Elpeleg,Nia J. Bryant,Dror Mevorach

View Articletitled, The Thr224Asn mutation in the VPS45 gene is associated with the congenital neutropenia and primary myelofibrosis of infancy

Supplemental data

THROMBOSIS AND HEMOSTASIS

Reperfusion of cerebral artery thrombosis by the GPIb–VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs

Stefania Momi,Michela Tantucci,Maarten Van Roy,Hans Ulrichts,Giovanni Ricci,Paolo Gresele

View Articletitled, Reperfusion of cerebral artery thrombosis by the GPIb–VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs

Supplemental data

TRANSPLANTATION

Incidence, risk factors, and outcomes of sclerosis in patients with chronic graft-versus-host disease

Yoshihiro Inamoto,Barry E. Storer,Effie W. Petersdorf,J. Lee Nelson,Stephanie J. Lee,Paul A. Carpenter,Brenda M. Sandmaier,John A. Hansen,Paul J. Martin,Mary E. D. Flowers

View Articletitled, Incidence, risk factors, and outcomes of sclerosis in patients with chronic graft-versus-host disease

ERRATA

Romano M, Dri P, Dadalt L, Patriarca P, Baralle FE. Biochemical and molecular characterization of hereditary myeloperoxidase deficiency. Blood. 1997;90(10):4126-4134.

View Articletitled, Romano M, Dri P, Dadalt L, Patriarca P, Baralle FE. Biochemical and molecular characterization of hereditary myeloperoxidase deficiency. Blood. 1997;90(10):4126-4134.

Treppendahl MB, Qiu X, Søgaard A, et al. Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML. Blood. 2012;119(1):206-216.

View Articletitled, Treppendahl MB, Qiu X, Søgaard A, et al. Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML. Blood. 2012;119(1):206-216.

Marsh JC, Bacigalupo A, Schrezenmeier H, et al. Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT Severe Aplastic Anaemia Working Party. Blood. 2012;119(23):5391-5396.

View Articletitled, Marsh JC, Bacigalupo A, Schrezenmeier H, et al. Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT Severe Aplastic Anaemia Working Party. Blood. 2012;119(23):5391-5396.

Parguiña AF, Alonso J, Rosa I, et al. A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation. Blood. 2012;120(26):e117-e126.

View Articletitled, Parguiña AF, Alonso J, Rosa I, et al. A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation. Blood. 2012;120(26):e117-e126.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Continuing Medical Education (CME) questions: Thrombosis in PNH
CME

View Articletitled, Continuing Medical Education (CME) questions: Thrombosis in PNH

Cover Image

Cover Image

The cover shows a splenic white pulp area of a mouse with reconstituted human immune system components. Human B cells are stained for CD20 in green, human T cells for CD3 in blue, and human dendritic cells (DCs) for DEC-205 in red. The authors describe that all human conventional and plasmacytoid DCs develop in these mice and can be activated by synthetic single- and double-stranded RNA mimics. The smallest conventional DC subset with the highest DEC-205 expression produces high levels of IFN-a in addition to IL-12 after double-stranded RNA recognition, and the combination of antigen targeting to DEC-205 with synthetic double-stranded RNA as adjuvant is able to elicit viral antigen specific CD4⁺ T cell responses in these mice. See the article by Meixlsperger et al on page 5034.
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INSIDE BLOOD

When “rare” is no excuse for progress Clinical Trials & Observations

BLOOD WORK

REVIEW ARTICLE

Thrombosis in paroxysmal nocturnal hemoglobinuria CME

HOW I TREAT

CLINICAL TRIALS AND OBSERVATIONS

Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

IMMUNOBIOLOGY

LYMPHOID NEOPLASIA

New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia Brief Report

Leukemia surfaceome analysis reveals new disease-associated features e-blood

MYELOID NEOPLASIA

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

THROMBOSIS AND HEMOSTASIS

TRANSPLANTATION

ERRATA

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Continuing Medical Education (CME) questions: Thrombosis in PNH CME

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When “rare” is no excuse for progress
Clinical Trials & Observations

Thrombosis in paroxysmal nocturnal hemoglobinuria
CME

Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis
Clinical Trials & Observations

New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia
Brief Report

Leukemia surfaceome analysis reveals new disease-associated features
e-blood

Continuing Medical Education (CME) questions: Thrombosis in PNH
CME