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Volume 124, Issue 11
September 11 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Thrombus formation reimagined
Robert Flaumenhaft
View Articletitled, Thrombus formation reimagined
INSIDE BLOOD COMMENTARY
COMPLEMENTing the diagnosis of aHUS
Clinical Trials & Observations
Vahid Afshar-Kharghan
View Articletitled, COMPLEMENTing the diagnosis of aHUS
INSIDE BLOOD COMMENTARY
Rotem in postpartum hemorrhage
Clinical Trials & Observations
Johanna G. van der Bom
View Articletitled, Rotem in postpartum hemorrhage
INSIDE BLOOD COMMENTARY
Cellular dynamics of resolving inflammation
Juhi Bagaitkar
View Articletitled, Cellular dynamics of resolving inflammation
INSIDE BLOOD COMMENTARY
Cellular therapy of the host to prevent GVHD
James Ferrara
View Articletitled, Cellular therapy of the host to prevent GVHD

PLENARY PAPER

New insights into the spatiotemporal localization of prothrombinase in vivo
Lacramioara Ivanciu,Sriram Krishnaswamy,Rodney M. Camire
View Articletitled, New insights into the spatiotemporal localization of prothrombinase in vivo
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Dynamics of complement activation in aHUS and how to monitor eculizumab therapy
Clinical Trials & Observations
Marina Noris,Miriam Galbusera,Sara Gastoldi,Paolo Macor,Federica Banterla,Elena Bresin,Claudio Tripodo,Serena Bettoni,Roberta Donadelli,Elisabetta Valoti,Francesco Tedesco,Alessandro Amore,Rosanna Coppo,Piero Ruggenenti,Eliana Gotti,Giuseppe Remuzzi
View Articletitled, Dynamics of complement activation in aHUS and how to monitor eculizumab therapy
Supplemental data
Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study
Clinical Trials & Observations
Peter W. Collins,Graeme Lilley,Daniel Bruynseels,David Burkett-St. Laurent,Rebecca Cannings-John,Elizabeth Precious,Vincent Hamlyn,Julia Sanders,Raza Alikhan,Rachel Rayment,Alexandra Rees,Abigail Kaye,Judith E. Hall,Shantini Paranjothy,Andrew Weeks,Rachel E. Collis
View Articletitled, Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo
Hui Yu,Geoffrey Neale,Hui Zhang,Han M. Lee,Zhijun Ma,Sheng Zhou,Bernard G. Forget,Brian P. Sorrentino
View Articletitled, Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo
Supplemental data
RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence
e-blood
Michael Lie-A-Ling,Elli Marinopoulou,Yaoyong Li,Rahima Patel,Monika Stefanska,Constanze Bonifer,Crispin Miller,Valerie Kouskoff,Georges Lacaud
View Articletitled, RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence
Supplemental data

IMMUNOBIOLOGY

Resolution of acute inflammation bridges the gap between innate and adaptive immunity
Justine Newson,Melanie Stables,Efthimia Karra,Frederick Arce-Vargas,Sergio Quezada,Madhur Motwani,Matthias Mack,Simon Yona,Tatsiana Audzevich,Derek W. Gilroy
View Articletitled, Resolution of acute inflammation bridges the gap between innate and adaptive immunity
Supplemental data

LYMPHOID NEOPLASIA

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma
Siobhan V. Glavey,Salomon Manier,Alessandro Natoni,Antonio Sacco,Michele Moschetta,Michaela R. Reagan,Laura S. Murillo,Ilyas Sahin,Ping Wu,Yuji Mishima,Yu Zhang,Wenjing Zhang,Yong Zhang,Gareth Morgan,Lokesh Joshi,Aldo M. Roccaro,Irene M. Ghobrial,Michael E. O’Dwyer
View Articletitled, The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma
Supplemental data

MYELOID NEOPLASIA

PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene
Zhuyan Guo,Anlai Wang,Weidong Zhang,Mikhail Levit,Qiang Gao,Claude Barberis,Michel Tabart,Jingxin Zhang,Dietmar Hoffmann,Dmitri Wiederschain,Jennifer Rocnik,Fangxian Sun,Josh Murtie,Christoph Lengauer,Stefan Gross,Bailin Zhang,Hong Cheng,Vinod Patel,Laurent Schio,Francisco Adrian,Marion Dorsch,Carlos Garcia-Echeverria,Shih-Min A. Huang
View Articletitled, PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene
Supplemental data
Genetic alterations of the cohesin complex genes in myeloid malignancies
Swapna Thota,Aaron D. Viny,Hideki Makishima,Barbara Spitzer,Tomas Radivoyevitch,Bartlomiej Przychodzen,Mikkael A. Sekeres,Ross L. Levine,Jaroslaw P. Maciejewski
View Articletitled, Genetic alterations of the cohesin complex genes in myeloid malignancies
Supplemental data

THROMBOSIS AND HEMOSTASIS

Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation
Yasuaki Shida,Natalia Rydz,David Stegner,Christine Brown,Jeffrey Mewburn,Kate Sponagle,Ozge Danisment,Bredon Crawford,Barbara Vidal,Carol A. Hegadorn,Cynthia M. Pruss,Bernhard Nieswandt,David Lillicrap
View Articletitled, Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation
A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets
John D. Welsh,Timothy J. Stalker,Roman Voronov,Ryan W. Muthard,Maurizio Tomaiuolo,Scott L. Diamond,Lawrence F. Brass
View Articletitled, A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets
Supplemental data
A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment
Maurizio Tomaiuolo,Timothy J. Stalker,John D. Welsh,Scott L. Diamond,Talid Sinno,Lawrence F. Brass
View Articletitled, A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment
Supplemental data
A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity
Timothy J. Stalker,John D. Welsh,Maurizio Tomaiuolo,Jie Wu,Thomas V. Colace,Scott L. Diamond,Lawrence F. Brass
View Articletitled, A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity
Supplemental data

TRANSPLANTATION

Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models
Mareike Florek,Emanuela I. Sega,Dennis B. Leveson-Gower,Jeanette Baker,Antonia M. S. Müller,Dominik Schneidawind,Everett Meyer,Robert S. Negrin
View Articletitled, Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models
Supplemental data

BLOOD WORK

Building bridges to diagnosis and malignancy
Rosanne St. Bernard,Cyrus C. Hsia
View Articletitled, Building bridges to diagnosis and malignancy
Severe vitamin B12 deficiency mimicking thrombotic thrombocytopenic purpura
Joshua K. Routh,Sara C. Koenig
View Articletitled, Severe vitamin B12 deficiency mimicking thrombotic thrombocytopenic purpura

ERRATA

Birmann BM, Neuhouser ML, Rosner B, et al. Prediagnosis biomarkers of insulin-like growth factor-1, insulin, and interleukin-6 dysregulation and multiple myeloma risk in the Multiple Myeloma Cohort Consortium. Blood. 2012;120(25):4929-4937.
View Articletitled, Birmann BM, Neuhouser ML, Rosner B, et al. Prediagnosis biomarkers of insulin-like growth factor-1, insulin, and interleukin-6 dysregulation and multiple myeloma risk in the Multiple Myeloma Cohort Consortium. <em>Blood</em>. 2012;120(25):4929-4937.
Lavender KJ, Pang WW, Messer RJ, et al. BLT-humanized C57BL/6 Rag2−/−γc−/−CD47–/– mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection. Blood. 2013;122(25):4013-4020.
View Articletitled, Lavender KJ, Pang WW, Messer RJ, et al. BLT-humanized C57BL/6 <em>Rag2</em><sup><em>−/−</em></sup><em>γ<sub>c</sub></em><sup><em>−/−</em></sup><em>CD47</em><sup><em>–</em>/–</sup> mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection. <em>Blood</em>. 2013;122(25):4013-4020.
Claus R, Lucas DM, Ruppert AS, et al. Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia. Blood. 2014;124(1):42-48.
View Articletitled, Claus R, Lucas DM, Ruppert AS, et al. Validation of <em>ZAP-70</em> methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia. <em>Blood</em>. 2014;124(1):42-48.
  • Cover Image

    Cover Image

    issue cover

    Fluorescently labeled factor Xai (cyan) and platelets (red) are seen at the site of laser injury using the cremaster injury model. The endothelium is illuminated due to green fluorescent protein (GFP) expression in Tie2-GFP-hemophilia B (HB) mice. The endothelium defined by GFP fluorescence (green), and platelets (red) distribution following laser injury in HB mice was visualized after infusion of Alexa647-FXai, the Alexa555-labeled platelet antibody, and unlabeled FV-810SYA. Confocal image and 3D reconstruction was obtained 3 min after the injury was made. See the article by Ivanciu et al on page 1705.

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