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Brian A Jonas
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Journal Articles

A weekly low-dose regimen of decitabine and venetoclax is efficacious and less myelotoxic in a racially diverse cohort

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Clinical Trials & Observations
Mendel Goldfinger, Ioannis Mantzaris, Aditi Shastri, Yogen Saunthararajah, Kira Gritsman, R. Alejandro Sica, Noah Kornblum, Nishi Shah, David Levitz, Bradley Rockwell, Lauren C. Shapiro, Ridhi Gupta, Kith Pradhan, Xiaonan Xue, Anne Munoz, Aradhika Dhawan, Karen Fehn, Monica Comas, Jhannine Alyssa Verceles, Brian A. Jonas, Suman Kambhampati, Yang Shi, Ira Braunschweig, Dennis L. Cooper, Marina Konopleva, Eric J. Feldman, Amit Verma
Journal: Blood
Blood (2024) 144 (22): 2360–2363.
https://doi.org/10.1182/blood.2024025834
Published: 2024
Includes: Supplemental data
Journal Articles

Genetic risk stratification and outcomes among treatment-naive patients with AML treated with venetoclax and azacitidine

Free
CME Clinical Trials & Observations
Hartmut Döhner, Keith W. Pratz, Courtney D. DiNardo, Andrew H. Wei, Brian A. Jonas, Vinod A. Pullarkat, Michael J. Thirman, Christian Récher, Andre C. Schuh, Sunil Babu, Xiaotong Li, Grace Ku, Zihuan Liu, Yan Sun, Jalaja Potluri, Monique Dail, Brenda Chyla, Daniel A. Pollyea
Journal: Blood
Blood (2024) 144 (21): 2211–2222.
https://doi.org/10.1182/blood.2024024944
Published: 2024
Includes: Supplemental data
Journal Articles

Efficacy and Safety of Uproleselan Combined with Chemotherapy Vs. Chemotherapy Alone in Relapsed/Refractory Acute Myeloid Leukemia: Findings from an International Phase 3 Trial

Free
Daniel J. DeAngelo, Andre C. Schuh, Brian A. Jonas, Pamela S. Becker, Anjali S. Advani, Geoffrey L. Uy, Janusz Krawczyk, Harry P. Erba, Gabriel N Mannis, Chun Yew Fong, Florian Kuchenbauer, Mary-Elizabeth M. Percival, Jane L. Liesveld, William Blum, Brenda W Cooper, Alice Mims, Francesco Lanza, Jeroen J.W.M. Janssen, Juan Miguel Bergua Burgues, Tibor Kovacsovics, Norbert Vey, Martina V. Hemmer, Gaetano Bonifacio, Edwin Rock, Pau Montesinos
Journal: Blood
Blood (2024) 144 (Supplement 1): 733.
https://doi.org/10.1182/blood-2024-209097
Published: 2024
Journal Articles

IO-202, a Novel Anti-LILRB4 Antibody, with Azacitidine for Hypomethylating Agent-Naive Chronic Myelomonocytic Leukemia: Phase 1b Expansion Cohort Results

Free
Gabriel N Mannis, Ahmed Aribi, Neil Dunavin, Hetty E. Carraway, Jennifer N. Saultz, Gail J. Roboz, Brian A. Jonas, Yazan F Madanat, Guillermo Garcia-Manero, Deepa Jeyakumar, Daniel A Pollyea, Olatoyosi Odenike, William Blum, Gary J. Schiller, Yasuhiro Tabata, Donna Valencia, Tao Huang, Wen Hong Lin, Hong Xiang, Charlene Liao, Courtney D. DiNardo
Journal: Blood
Blood (2024) 144 (Supplement 1): 1008.
https://doi.org/10.1182/blood-2024-206538
Published: 2024
Journal Articles

Time to Response and Overall Survival in Patients with m IDH1 Relapsed/Refractory Acute Myeloid Leukemia Treated with Olutasidenib

Free
Eunice S. Wang, Jorge E. Cortes, Justin M. Watts, Brian A. Jonas, Andrew H Wei, Jay Yang, Joseph G Jurcic, Gail J. Roboz, Karen Seiter, Alice Mims, Karen Yee, Brent Ferrell, Shira N. Dinner, William B. Donnellan, William Blum, Francois Di Trapani, Hua Tian, Stephane De Botton
Journal: Blood
Blood (2024) 144 (Supplement 1): 1514.
https://doi.org/10.1182/blood-2024-198504
Published: 2024
Journal Articles

Updated Results of a Phase I Study of Uproleselan Combined with Azacitidine and Venetoclax for the Treatment of Older or Unfit Patients with Treatment Naïve Acute Myeloid Leukemia

Free
Brian A. Jonas, Zarir E. Karanjawala, Laura Molnar, Ashley Linh Dang-Chu, Mehrdad Abedi, Naseem S. Esteghamat, Aaron S. Rosenberg, Francisco Andres Socola, Lihong Qi, Joseph M. Tuscano
Journal: Blood
Blood (2024) 144 (Supplement 1): 1503.
https://doi.org/10.1182/blood-2024-212328
Published: 2024
Journal Articles

The Incidence of CNS Relapse in Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) and Its Impact on Clinical Outcome: Results from Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND)

Free
Kashish J. Shah, Mobachir El Kettani, Ravi Narra, Alice Mims, Alexander Coltoff, Georgio Medawar, Brooke Hisrich, Rory M. Shallis, Cameron J. Hunter, Vamsi K. Kota, Tamer Othman, Brian A. Jonas, Shreya Desai, Guilherme Sacchi de Camargo Correia, Anand Ashwin Patel, Adam S. Duvall, Neil D. Palmisiano, Emily K Curran, Zulfa Omer, Anjali S. Advani, Ehab L. Atallah, Mark R. Litzow, Talha Badar
Journal: Blood
Blood (2024) 144 (Supplement 1): 4184.
https://doi.org/10.1182/blood-2024-205812
Published: 2024
Journal Articles

Phase 1 Safety and Efficacy of Tuspetinib Plus Venetoclax Combination Therapy in Study Participants with Relapsed or Refractory Acute Myeloid Leukemia (AML) Support Exploration of Triplet Combination Therapy of Tuspetinib Plus Venetoclax and Azacitidine for Newly Diagnosed AML

Free
Naval Daver, Kyoo Hyung Lee, Yunsuk Choi, Pau Montesinos, Brian A. Jonas, Martha L. Arellano, Uma Borate, Justin M. Watts, Paul B. Koller, Chul Won Jung, Sang Kyun Sohn, Amir T. Fathi, Pankit Vachhani, Nikolai A. Podoltsev, Olga Salamero, Sung-Soo Yoon, Jeong-Ok Lee, Gabriel N Mannis, Shuhying Tan, Sudipto Mukherjee, Harry Erba, Ho-Jin Shin, Uwe Platzbecker, Mar Tormo, Eric Tam, Leanne Berkahn, Teresa Bernal, Donna Nguyen Haney, Jia Hu, Ranjeet Kumar Sinha, Nawazish Khan, Vivian Costa Victory, William G. Rice, Rafael Bejar
Journal: Blood
Blood (2024) 144 (Supplement 1): 4255.
https://doi.org/10.1182/blood-2024-200397
Published: 2024
Journal Articles

A Phase I Study of CD19 CAR T-Cells with Escalating Doses of Lymphodepletion with or without Rituximab in Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Free
Naseem S. Esteghamat, Joseph M Tuscano, Brian A. Jonas, Aaron S. Rosenberg, Rasmus T. Hoeg, Francisco Andres Socola, Brian Fury, Jordan Pavlic, Geralyn Annett, Jan A. Nolta, Mehrdad Abedi
Journal: Blood
Blood (2024) 144 (Supplement 1): 2085.
https://doi.org/10.1182/blood-2024-206680
Published: 2024
Journal Articles

Combination of Olutasidenib and Azacitidine Induces Durable Complete Remissions in m IDH1 Acute Myeloid Leukemia: A Multicohort Open-Label Phase 1/2 Trial

Free
Jorge E. Cortes, Gail J. Roboz, Justin M. Watts, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, Brent Ferrell, Jay Yang, Eunice S. Wang, William Blum, Alice Mims
Journal: Blood
Blood (2024) 144 (Supplement 1): 2886.
https://doi.org/10.1182/blood-2024-201710
Published: 2024
Journal Articles

Factors Impacting Response to Olutasidenib in Patients with mIDH1 Acute Myeloid Leukemia

Free
Eunice S. Wang, Brian A. Jonas, Justin M. Watts, Joseph Jurcic, P. Brent Ferrell, Jr., Shira N. Dinner, Jay Yang, Karen Seiter, Alice Mims, William B. Donnellan, William Blum, Jorge Cortes
Journal: Blood
Blood (2023) 142 (Supplement 1): 6047.
https://doi.org/10.1182/blood-2023-187584
Published: 2023
Journal Articles

Olutasidenib for the Treatment of mIDH1 Acute Myeloid Leukemia in Patients Relapsed or Refractory to Hematopoietic Stem Cell Transplant, Prior mIDH1 Inhibitor, or Venetoclax

Free
Jorge Cortes, Joseph Jurcic, Maria R. Baer, William Blum, P. Brent Ferrell, Jr., Brian A. Jonas, Sangmin Lee, Alice Mims, Shyam Ajay Patel, Gary J. Schiller, Jay Yang, Justin M. Watts
Journal: Blood
Blood (2023) 142 (Supplement 1): 2888.
https://doi.org/10.1182/blood-2023-187861
Published: 2023
Journal Articles

Tuspetinib Myeloid Kinase Inhibitor Safety and Efficacy As Monotherapy and Combined with Venetoclax in Phase 1/2 Trial of Patients with Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML)

Free
Naval Daver, Kyoo Hyung Lee, Yunsuk Choi, Brian A. Jonas, Martha Arellano, Paul B. Koller, Chul W. Jung, Sang Kyun Sohn, Amir T. Fathi, Jeong-Ok Lee, Sung-Soo Yoon, Justin M. Watts, Pankit Vachhani, Ho-Jin Shin, Jia Hu, Ranjeet Sinha, Nawazish Khan, William G. Rice, Rafael Bejar
Journal: Blood
Blood (2023) 142 (Supplement 1): 162.
https://doi.org/10.1182/blood-2023-182296
Published: 2023
Journal Articles

Outcomes in Chemotherapy-Ineligible Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia Treated with Venetoclax Plus Azacitidine: A Pooled Analysis

Free
Adriano Venditti, Jing-Zhou Hou, Pierre Fenaux, Brian A. Jonas, Radovan Vrhovac, Pau Montesinos, Jacqueline S. Garcia, David Rizzieri, Michael J Thirman, Stanley Kotey, Jalaja Potluri, Mazaher Dhalla, Vinod Pullarkat
Journal: Blood
Blood (2023) 142 (Supplement 1): 2886.
https://doi.org/10.1182/blood-2023-182045
Published: 2023
Journal Articles

A Phase 1b/2 Trial of Liposomal Cytarabine and Daunorubicin (CPX-351) in Intermediate to High-Risk Acute Myeloid Leukemia for Patients Who Have Failed an Initial Cycle of Induction Chemotherapy

Free
Corbin Pontious, Ramiro Garzon, James S. Blachly, Bradley Wayne Blaser, Hannah Choe, Nicole R. Grieselhuber, Meixiao Long, Sumithira Vasu, Sarah A Wall, Karilyn T. Larkin, Ann-Kathrin Eisfeld, Kristin L Koenig, Kieran D Sahasrabudhe, Gabriela Sanchez-Petitto, Ayman Saad, Bhavana Bhatnagar, Justin Lyberger, Uma M. Borate, Alice Mims, Brian A. Jonas, Gregory K Behbehani
Journal: Blood
Blood (2023) 142 (Supplement 1): 5946.
https://doi.org/10.1182/blood-2023-184344
Published: 2023
Journal Articles

Preliminary Results from a Phase 1b/2 Open-Label, Multicenter, Dose Optimization Clinical Study of the Safety, Tolerability, and Pharmacokinetic (PK) and Pharmacodynamic (PD) Profiles of Cfi-400945 As a Single Agent or in Combination with Azacitidine in Patients (Pts) with Acute Myeloid Leukemia, Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia (TWT-202)

Free
Brian A. Jonas, Karen Yee, Alice Mims, Paul B. Koller, Joseph Brandwein, Gail J. Roboz, Glenn Michelson, Linh Nguyen, Mark R Bray, Emily Roberts-Thomson, Roger Sidhu, Gautam Borthakur
Journal: Blood
Blood (2023) 142 (Supplement 1): 4294.
https://doi.org/10.1182/blood-2023-182027
Published: 2023
Journal Articles

Ipilimumab plus decitabine for patients with MDS or AML in posttransplant or transplant-naïve settings

Free
Clinical Trials & Observations
Jacqueline S. Garcia, Yael Flamand, Livius Penter, Michael Keng, Benjamin K. Tomlinson, Lourdes M. Mendez, Paul Koller, Nicole Cullen, Yohei Arihara, Kathleen Pfaff, Jacquelyn O. Wolff, Andrew M. Brunner, Ilene Galinsky, Asad Bashey, Joseph H. Antin, Corey Cutler, Vincent Ho, Brian A. Jonas, Marlise R. Luskin, Martha Wadleigh, Eric S. Winer, Alexandra Savell, Rebecca Leonard, Taylor Robertson, Matthew S. Davids, Howard Streicher, Scott J. Rodig, Jerome Ritz, Catherine J. Wu, Daniel J. DeAngelo, Donna Neuberg, Richard M. Stone, Robert J. Soiffer
Journal: Blood
Blood (2023) 141 (15): 1884–1888.
https://doi.org/10.1182/blood.2022017686
Published: 2023
Includes: Supplemental data
Journal Articles

Venetoclax and idasanutlin in relapsed/refractory AML: a nonrandomized, open-label phase 1b trial

Free
Clinical Trials & Observations
Naval G. Daver, Monique Dail, Jacqueline S. Garcia, Brian A. Jonas, Karen W. L. Yee, Kevin R. Kelly, Norbert Vey, Sarit Assouline, Gail J. Roboz, Stefania Paolini, Daniel A. Pollyea, Agostino Tafuri, Joseph M. Brandwein, Arnaud Pigneux, Bayard L. Powell, Pierre Fenaux, Rebecca L. Olin, Giuseppe Visani, Giovanni Martinelli, Maika Onishi, Jue Wang, Weize Huang, Cherie Green, Marion G. Ott, Wan-Jen Hong, Marina Y. Konopleva, Michael Andreeff
Journal: Blood
Blood (2023) 141 (11): 1265–1276.
https://doi.org/10.1182/blood.2022016362
Published: 2023
Includes: Supplemental data
Journal Articles

ELN Risk Stratification Is Not Predictive of Outcomes for Treatment-Naïve Patients with Acute Myeloid Leukemia Treated with Venetoclax and Azacitidine

Free
Hartmut Döhner, Keith W. Pratz, Courtney D. DiNardo, Brian A. Jonas, Vinod A. Pullarkat, Michael J. Thirman, Christian Recher, Andre C. Schuh, Sunil Babu, Monique Dail, Grace Ku, Yan Sun, Jalaja Potluri, Brenda Chyla, Daniel A. Pollyea
Journal: Blood
Blood (2022) 140 (Supplement 1): 1441–1444.
https://doi.org/10.1182/blood-2022-169509
Published: 2022
Journal Articles

Measurable Residual Disease Conversion Rate with Consolidation Chemotherapy in Acute Myeloid Leukemia

Free
Daria Gaut, Caspian Oliai, Jonathan Boiarsky, Shiliang Zhang, Tali Azenkot, Vanessa E. Kennedy, Vishesh Khanna, Karla Olmedo Gutierrez, Navika D. Shukla, Benjamin Moskoff, Anand Ashwin Patel, Deepa Jeyakumar, Gabriel N. Mannis, Aaron C. Logan, Brian A. Jonas, Gary J. Schiller
Journal: Blood
Blood (2022) 140 (Supplement 1): 3374–3376.
https://doi.org/10.1182/blood-2022-156842
Published: 2022