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Issue Archive

Volume 113, Issue 16
April 16 2009
Issue Cover

Table of Contents

INSIDE BLOOD

GENE THERAPY
FVIIa gene delivery: potential treatment for hemophilia?
John H. McVey
View Articletitled, FVIIa gene delivery: potential treatment for hemophilia?
RED CELLS & IRON
Truth or dare: role of Liar in EPO-dependent signaling
Dwayne L. Barber
View Articletitled, Truth or dare: role of Liar in EPO-dependent signaling
INSIDE BLOOD
MiR-sensing chemotherapy resistance in CLL
George A. Calin
View Articletitled, MiR-sensing chemotherapy resistance in CLL

REVIEW ARTICLES

Differentiation therapy of leukemia: 3 decades of development
Daniel Nowak,Daphne Stewart,H. Phillip Koeffler
View Articletitled, Differentiation therapy of leukemia: 3 decades of development

CLINICAL TRIALS AND OBSERVATIONS

Improved patient survival for acute myeloid leukemia: a population-based study of 9729 patients diagnosed in Sweden between 1973 and 2005
Clinical Trials & Observations
Åsa Rangert Derolf,Sigurdur Yngvi Kristinsson,Therese M.-L. Andersson,Ola Landgren,Paul W. Dickman,Magnus Björkholm
View Articletitled, Improved patient survival for acute myeloid leukemia: a population-based study of 9729 patients diagnosed in Sweden between 1973 and 2005
Long-term outcomes to fludarabine and rituximab in Waldenström macroglobulinemia
Clinical Trials & Observations
Steven P. Treon,Andrew R. Branagan,Leukothea Ioakimidis,Jacob D. Soumerai,Christopher J. Patterson,Barry Turnbull,Parveen Wasi,Christos Emmanouilides,Stanley R. Frankel,Andrew Lister,Pierre Morel,Jeffrey Matous,Stephanie A. Gregory,Eva Kimby
View Articletitled, Long-term outcomes to fludarabine and rituximab in Waldenström macroglobulinemia
Malignant mesothelioma after radiation treatment for Hodgkin lymphoma
Brief Report
Marie L. De Bruin,Jacobus A. Burgers,Paul Baas,Mars B. van 't Veer,Evert M. Noordijk,Marieke W. J. Louwman,Josée M. Zijlstra,Hendrik van den Berg,Berthe M. P. Aleman,Flora E. van Leeuwen
View Articletitled, Malignant mesothelioma after radiation treatment for Hodgkin lymphoma

GENE THERAPY

Successful treatment of canine hemophilia by continuous expression of canine FVIIa
Paris Margaritis,Elise Roy,Majed N. Aljamali,Harre D. Downey,Urs Giger,Shangzhen Zhou,Elizabeth Merricks,Aaron Dillow,Mirella Ezban,Timothy C. Nichols,Katherine A. High
View Articletitled, Successful treatment of canine hemophilia by continuous expression of canine FVIIa

HEMATOPOIESIS AND STEM CELLS

Forward RNAi screens in primary human hematopoietic stem/progenitor cells
Nicole Ali,Christine Karlsson,Marie Aspling,Guang Hu,Nir Hacohen,David T. Scadden,Jonas Larsson
View Articletitled, Forward RNAi screens in primary human hematopoietic stem/progenitor cells
Supplemental data

IMMUNOBIOLOGY

T-cell receptor– and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue
Rachel David,Liang Ma,Aleksandar Ivetic,Aya Takesono,Anne J. Ridley,Jian-Guo Chai,Victor L. Tybulewicz,Federica M. Marelli-Berg
View Articletitled, T-cell receptor– and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue
Supplemental data
Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting
Nancy S. Longo,Patricia L. Lugar,Sule Yavuz,Wen Zhang,Peter H. L. Krijger,Daniel E. Russ,Dereje D. Jima,Sandeep S. Dave,Amrie C. Grammer,Peter E. Lipsky
View Articletitled, Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting
Supplemental data
Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses
Pierre Bruhns,Bruno Iannascoli,Patrick England,David A. Mancardi,Nadine Fernandez,Sylvie Jorieux,Marc Daëron
View Articletitled, Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses
Supplemental data
In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein
Risaku Fukumoto,Vibeke Andresen,Izabela Bialuk,Valentina Cecchinato,Jean-Claude Walser,Valerio W. Valeri,Julie M. Nauroth,Antoine Gessain,Christophe Nicot,Genoveffa Franchini
View Articletitled, In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12<sup>I</sup> protein

LYMPHOID NEOPLASIA

The impact of Fc engineering on an anti-CD19 antibody: increased Fcγ receptor affinity enhances B-cell clearing in nonhuman primates
Jonathan Zalevsky,Irene W. L. Leung,Sher Karki,Seung Y. Chu,Eugene A. Zhukovsky,John R. Desjarlais,David F. Carmichael,Chris E. Lawrence
View Articletitled, The impact of Fc engineering on an anti-CD19 antibody: increased Fcγ receptor affinity enhances B-cell clearing in nonhuman primates
Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation
Deepa Sampath,George A. Calin,Vinay K. Puduvalli,Gopal Gopisetty,Cristian Taccioli,Chang-Gong Liu,Brett Ewald,Chaomei Liu,Michael J. Keating,William Plunkett
View Articletitled, Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation
Supplemental data
Differentiation stage–specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas
Raquel Malumbres,Kristopher A. Sarosiek,Elena Cubedo,Jose W. Ruiz,Xiaoyu Jiang,Randy D. Gascoyne,Robert Tibshirani,Izidore S. Lossos
View Articletitled, Differentiation stage–specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas
Supplemental data
Tumor burden influences exposure and response to rituximab: pharmacokinetic-pharmacodynamic modeling using a syngeneic bioluminescent murine model expressing human CD20
David Daydé,David Ternant,Marc Ohresser,Stéphanie Lerondel,Sabrina Pesnel,Hervé Watier,Alain Le Pape,Pierre Bardos,Gilles Paintaud,Guillaume Cartron
View Articletitled, Tumor burden influences exposure and response to rituximab: pharmacokinetic-pharmacodynamic modeling using a syngeneic bioluminescent murine model expressing human CD20
Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival
Nathalie A. Johnson,Merrill Boyle,Ali Bashashati,Stephen Leach,Angela Brooks-Wilson,Laurie H. Sehn,Mukesh Chhanabhai,Ryan R. Brinkman,Joseph M. Connors,Andrew P. Weng,Randy D. Gascoyne
View Articletitled, Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival
Supplemental data
Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks
Enrique M. Ocio,Patricia Maiso,Xi Chen,Mercedes Garayoa,Stela Álvarez-Fernández,Laura San-Segundo,David Vilanova,Lucía López-Corral,Juan C. Montero,Teresa Hernández-Iglesias,Enrique de Álava,Carlos Galmarini,Pablo Avilés,Carmen Cuevas,Jesús F. San-Miguel,Atanasio Pandiella
View Articletitled, Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks
Supplemental data
A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity
John E. Weldon,Laiman Xiang,Oleg Chertov,Inger Margulies,Robert J. Kreitman,David J. FitzGerald,Ira Pastan
View Articletitled, A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity
miR-34a as part of the resistance network in chronic lymphocytic leukemia
Thorsten Zenz,Julia Mohr,Eric Eldering,Arnon P. Kater,Andreas Bühler,Dirk Kienle,Dirk Winkler,Jan Dürig,Marinus H. J. van Oers,Daniel Mertens,Hartmut Döhner,Stephan Stilgenbauer
View Articletitled, miR-34a as part of the resistance network in chronic lymphocytic leukemia
Supplemental data
Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a “vaccinal effect” of rituximab
Brief Report
Shannon P. Hilchey,Ollivier Hyrien,Tim R. Mosmann,Alexandra M. Livingstone,Jonathan W. Friedberg,Faith Young,Richard I. Fisher,Raymond J. Kelleher, Jr,Richard B. Bankert,Steven H. Bernstein
View Articletitled, Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a “vaccinal effect” of rituximab

MYELOID NEOPLASIA

ICSBP-mediated immune protection against BCR-ABL–induced leukemia requires the CCL6 and CCL9 chemokines
Valentina Nardi,Olaia Naveiras,Mohammad Azam,George Q. Daley
View Articletitled, ICSBP-mediated immune protection against BCR-ABL–induced leukemia requires the CCL6 and CCL9 chemokines
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
Masafumi Nakayama,Hisaya Akiba,Kazuyoshi Takeda,Yuko Kojima,Masaaki Hashiguchi,Miyuki Azuma,Hideo Yagita,Ko Okumura
View Articletitled, Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
Supplemental data

PLATELETS AND THROMBOPOIESIS

A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function
Nicole Soranzo,Augusto Rendon,Christian Gieger,Chris I. Jones,Nicholas A. Watkins,Stephan Menzel,Angela Döring,Jonathan Stephens,Holger Prokisch,Wendy Erber,Simon C. Potter,Sarah L. Bray,Philippa Burns,Jennifer Jolley,Mario Falchi,Brigitte Kühnel,Jeanette Erdmann,Heribert Schunkert,Nilesh J. Samani,Thomas Illig,Stephen F. Garner,Angela Rankin,Christa Meisinger,John R. Bradley,Swee Lay Thein,Alison H. Goodall,Tim D. Spector,Panos Deloukas,Willem H. Ouwehand
View Articletitled, A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function
Supplemental data
T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a–specific, HLA-DRB3*0101–restricted CD4+ T cells
Maria Therese Ahlen,Anne Husebekk,Mette Kjær Killie,Bjørn Skogen,Tor B. Stuge
View Articletitled, T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a–specific, HLA-DRB3*0101–restricted CD4<sup>+</sup> T cells

RED CELLS, IRON, AND ERYTHROPOIESIS

Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation
Amy L. Samuels,S. Peter Klinken,Evan Ingley
View Articletitled, Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K–dependent and warfarin-sensitive secretion
Masayoshi Souri,Hiroki Iwata,Wei Guang Zhang,Akitada Ichinose
View Articletitled, Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K–dependent and warfarin-sensitive secretion
Supplemental data

TRANSPLANTATION

Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease
Stefanie Sarantopoulos,Kristen E. Stevenson,Haesook T. Kim,Corey S. Cutler,Nazmim S. Bhuiya,Michael Schowalter,Vincent T. Ho,Edwin P. Alyea,John Koreth,Bruce R. Blazar,Robert J. Soiffer,Joseph H. Antin,Jerome Ritz
View Articletitled, Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease
Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell–depleted allogeneic hematopoietic cell transplantation
Junli Yu,Jeffrey M. Venstrom,Xiao-Rong Liu,James Pring,Reenat S. Hasan,Richard J. O'Reilly,Katharine C. Hsu
View Articletitled, Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell–depleted allogeneic hematopoietic cell transplantation
Supplemental data

CORRESPONDENCE

Long-term efficacy of the complement inhibitor eculizumab in cold agglutinin disease
Alexander Röth,Andreas Hüttmann,Russell P. Rother,Ulrich Dührsen,Thomas Philipp
View Articletitled, Long-term efficacy of the complement inhibitor eculizumab in cold agglutinin disease
Homozygous deletion of HFE: the Sardinian hemochromatosis?
Sara Pelucchi,Raffaella Mariani,Francesca Bertola,Cristina Arosio,Alberto Piperno
View Articletitled, Homozygous deletion of <em>HFE</em>: the Sardinian hemochromatosis?
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