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Volume 114, Issue 23

November 26 2009

Blood Cover Image for Volume 114, Issue 23

In this Issue

INSIDE BLOOD
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
PLATELETS AND THROMBOPOIESIS
THROMBOSIS AND HEMOSTASIS
VASCULAR BIOLOGY
CORRESPONDENCE

Table of Contents

INSIDE BLOOD

PLATELETS & THROMBOPOIESIS

The proof is in the crystal

José A. López,Adam Munday

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CLINICAL TRIALS

Childhood ITP: knowing when to worry?

Michele P. Lambert

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GENE THERAPY

Arming CTLs against immunosuppressors

Patrizia Comoli

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REVIEW ARTICLES

Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genes

George A. Calin,Carlo M. Croce

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CLINICAL TRIALS AND OBSERVATIONS

Primary radiotherapy showed favorable outcome in treating extranodal nasal-type NK/T-cell lymphoma in children and adolescents
Clinical Trials & Observations

Zhao-Yang Wang,Ye-Xiong Li,Wei-Hu Wang,Jing Jin,Hua Wang,Yong-Wen Song,Qing-Feng Liu,Shu-Lian Wang,Yue-Ping Liu,Shu-Nan Qi,Hui Fang,Xin-Fan Liu,Zi-Hao Yu

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Intracranial hemorrhage (ICH) in children with immune thrombocytopenia (ITP): study of 40 cases
Clinical Trials & Observations

Bethan Psaila,Aleksandra Petrovic,Lemke K. Page,Jill Menell,Matthew Schonholz,James B. Bussel

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GENE THERAPY

Generation of Epstein-Barr virus–specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506)

Biagio De Angelis,Gianpietro Dotti,Concetta Quintarelli,Leslie E. Huye,Lan Zhang,Ming Zhang,Fabrizio Pane,Helen E. Heslop,Malcolm K. Brenner,Cliona M. Rooney,Barbara Savoldo

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Supplemental data

Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease

Jennifer Brewin,Christoph Mancao,Karin Straathof,Helen Karlsson,Sujith Samarasinghe,Persis J. Amrolia,Martin Pule

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Supplemental data

HEMATOPOIESIS AND STEM CELLS

Systematic in vivo structure-function analysis of p300 in hematopoiesis

Erin A. Kimbrel,Madeleine E. Lemieux,Xiaobo Xia,Tina N. Davis,Vivienne I. Rebel,Andrew L. Kung

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Supplemental data

Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification

Arnaud Gandillet,Alicia G. Serrano,Stella Pearson,Michael Lie-A-Ling,Georges Lacaud,Valerie Kouskoff

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Supplemental data

IMMUNOBIOLOGY

Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4

Jeffrey M. Milush,Brian R. Long,Jennifer E. Snyder-Cappione,Amedeo J. Cappione, III,Vanessa A. York,Lishomwa C. Ndhlovu,Lewis L. Lanier,Jakob Michaëlsson,Douglas F. Nixon

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LYMPHOID NEOPLASIA

In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia

Carlo Calissano,Rajendra N. Damle,Gregory Hayes,Elizabeth J. Murphy,Marc K. Hellerstein,Carol Moreno,Cristina Sison,Matthew S. Kaufman,Jonathan E. Kolitz,Steven L. Allen,Kanti R. Rai,Nicholas Chiorazzi

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Supplemental data

Genetic variation in CXCR4 and risk of chronic lymphocytic leukemia
Brief Report

Dalemari Crowther-Swanepoel,Mobshra Qureshi,Martin J. S. Dyer,Estella Matutes,Claire Dearden,Daniel Catovsky,Richard S. Houlston

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Supplemental data

MYELOID NEOPLASIA

Relationship of differential gene expression profiles in CD34⁺ myelodysplastic syndrome marrow cells to disease subtype and progression

Kunju Sridhar,Douglas T. Ross,Robert Tibshirani,Atul J. Butte,Peter L. Greenberg

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Supplemental data

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

Jason A. Powell,Daniel Thomas,Emma F. Barry,Chung H. Kok,Barbara J. McClure,Anna Tsykin,L. Bik To,Anna Brown,Ian D. Lewis,Kirsten Herbert,Gregory J. Goodall,Terence P. Speed,Norio Asou,Bindya Jacob,Motomi Osato,David N. Haylock,Susan K. Nilsson,Richard J. D'Andrea,Angel F. Lopez,Mark A. Guthridge

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Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

Jessica A. Van Ziffle,Clifford A. Lowell

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Supplemental data

PLATELETS AND THROMBOPOIESIS

Glycoprotein Ibα inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism
Brief Report

Paul A. McEwan,Robert K. Andrews,Jonas Emsley

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Supplemental data

THROMBOSIS AND HEMOSTASIS

Contributions of extravascular and intravascular cells to fibrin network formation, structure, and stability

Robert A. Campbell,Katherine A. Overmyer,Craig H. Selzman,Brett C. Sheridan,Alisa S. Wolberg

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Supplemental data

VASCULAR BIOLOGY

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity

Alexander Nyström,Zabeena P. Shaik,Donald Gullberg,Thomas Krieg,Beate Eckes,Roy Zent,Ambra Pozzi,Renato V. Iozzo

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Supplemental data

CORRESPONDENCE

Insufficient evidence to suggest less stringent therapy in hemophilia B?

Ingrid E. M. den Uijl,Goris Roosendaal,Kathelijn Fischer

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Response: Comparing joint arthroplasties in severe hemophilia A with severe hemophilia B

Giuseppe Tagariello,Alfonso Iorio,Pier M. Mannucci

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Delayed but functional neutrophil extracellular trap formation in neonates

Veronica Marcos,Claudia Nussbaum,Ljubomir Vitkov,Andreas Hector,Eva-Maria Wiedenbauer,Dirk Roos,Taco Kuijpers,Wolf Dietrich Krautgartner,Orsolya Genzel-Boroviczény,Markus Sperandio,Dominik Hartl

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Response: Gestational age as a factor in neutrophil extracellular trap formation

Christian Con Yost,Guy A. Zimmerman

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Cover Image

Cover Image

The glycoprotein Ibα-OS1 peptide complex crystal structure illustrated as a cartoon depiction demonstrates how a small peptide (cyan) can inhibit the large protein-protein interaction formed with von Willebrand factor through an allosteric mechanism stabilizing a key loop (brown). See the article by McEwan et al on page 4883.
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