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Issue Archive

Volume 122, Issue 25
December 12 2013
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
The mouse that lost its appetite for human
William G. Kerr
View Articletitled, The mouse that lost its appetite for human
PLATELETS & THROMBOPOIESIS
Spotlight on FLI1, RUNX1, and platelet dysfunction
A. Koneti Rao
View Articletitled, Spotlight on <em>FLI1, RUNX1</em>, and platelet dysfunction
THROMBOSIS & HEMOSTASIS
Platelet von Willebrand factor: sweet resistance
Peter J. Lenting,Cécile V. Denis
View Articletitled, Platelet von Willebrand factor: sweet resistance
TRANSPLANTATION
Donating used CARs
Aaron P. Rapoport
View Articletitled, Donating used CARs
VASCULAR BIOLOGY
Shockingly: the loss of Lyn leads to leakiness
Seth J. Corey,Regina M. Day
View Articletitled, Shockingly: the loss of Lyn leads to leakiness

BLOOD WORK

Invasive neighbors
Ambra Paolini,Goretta Bonacorsi
View Articletitled, Invasive neighbors
Peripheral smear clues for Bordetella pertussis
Soumya Pandey,Neslihan Cetin
View Articletitled, Peripheral smear clues for <em>Bordetella pertussis</em>

PLENARY PAPER

BLT-humanized C57BL/6 Rag2−/−γc−/−CD47−/− mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection
Kerry J. Lavender,Wendy W. Pang,Ronald J. Messer,Amanda K. Duley,Brent Race,Katie Phillips,Dana Scott,Karin E. Peterson,Charles K. Chan,Ulf Dittmer,Timothy Dudek,Todd M. Allen,Irving L. Weissman,Kim J. Hasenkrug
View Articletitled, BLT-humanized C57BL/6 <em>Rag2</em><sup><em>−/−</em></sup><em>γ</em><sub><em>c</em></sub><sup><em>−/−</em></sup><em>CD47</em><sup><em>−/−</em></sup> mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection
Supplemental data

PERSPECTIVES

The genetic basis of myelodysplasia and its clinical relevance
Mario Cazzola,Matteo G. Della Porta,Luca Malcovati
View Articletitled, The genetic basis of myelodysplasia and its clinical relevance

REVIEW ARTICLE

Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells
Igor I. Slukvin
View Articletitled, Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis
Clinical Trials & Observations
Francisco Cervantes,Alessandro M. Vannucchi,Jean-Jacques Kiladjian,Haifa Kathrin Al-Ali,Andres Sirulnik,Viktoriya Stalbovskaya,Mari McQuitty,Deborah S. Hunter,Richard S. Levy,Francesco Passamonti,Tiziano Barbui,Giovanni Barosi,Claire N. Harrison,Laurent Knoops,Heinz Gisslinger,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators,on behalf of the COMFORT-II investigators
View Articletitled, Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis
Supplemental data

IMMUNOBIOLOGY

Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9
Ewa Zajac,Bernhard Schweighofer,Tatyana A. Kupriyanova,Anna Juncker-Jensen,Petra Minder,James P. Quigley,Elena I. Deryugina
View Articletitled, Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9
Supplemental data

LYMPHOID NEOPLASIA

Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjögren’s syndrome
Gaetane Nocturne,Saida Boudaoud,Corinne Miceli-Richard,Say Viengchareun,Thierry Lazure,Joanne Nititham,Kimberly E. Taylor,Averil Ma,Florence Busato,Judith Melki,Christopher J. Lessard,Kathy L. Sivils,Jean-Jacques Dubost,Eric Hachulla,Jacques Eric Gottenberg,Marc Lombès,Jorg Tost,Lindsey A. Criswell,Xavier Mariette
View Articletitled, Germline and somatic genetic variations of <em>TNFAIP3</em> in lymphoma complicating primary Sjögren’s syndrome
Supplemental data
Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes
Michael J. Clemente,Bartlomiej Przychodzen,Andres Jerez,Brittney E. Dienes,Manuel G. Afable,Holleh Husseinzadeh,Hanna L. M. Rajala,Marcin W. Wlodarski,Satu Mustjoki,Jaroslaw P. Maciejewski
View Articletitled, Deep sequencing of the T-cell receptor repertoire in CD8<sup>+</sup> T-large granular lymphocyte leukemia identifies signature landscapes
Supplemental data

MYELOID NEOPLASIA

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
Brief Report
Soo Jin Kim,Hongbo Zhao,Swanand Hardikar,Anup Kumar Singh,Margaret A. Goodell,Taiping Chen
View Articletitled, A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type–specific hypomethylated regions
e-blood
Matthias Zilbauer,Tim F. Rayner,Christine Clark,Alison J. Coffey,Chris J. Joyce,Priit Palta,Aarno Palotie,Paul A. Lyons,Kenneth G. C. Smith
View Articletitled, Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type–specific hypomethylated regions
Supplemental data

PLATELETS AND THROMBOPOIESIS

Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects
Brief Report
Jacqueline Stockley,Neil V. Morgan,Danai Bem,Gillian C. Lowe,Marie Lordkipanidzé,Ban Dawood,Michael A. Simpson,Kirsty Macfarlane,Kevin Horner,Vincenzo C. Leo,Katherine Talks,Jayashree Motwani,Jonathan T. Wilde,Peter W. Collins,Michael Makris,Steve P. Watson,Martina E. Daly,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group
View Articletitled, Enrichment of <em>FLI1</em> and <em>RUNX1</em> mutations in families with excessive bleeding and platelet dense granule secretion defects
Supplemental data

THROMBOSIS AND HEMOSTASIS

Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo
Dongying Ma,Daniella M. Mizurini,Teresa C. F. Assumpção,Yuan Li,Yanwei Qi,Michail Kotsyfakis,José M. C. Ribeiro,Robson Q. Monteiro,Ivo M. B. Francischetti
View Articletitled, Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (<em>Desmodus rotundus</em>) inhibits inflammation and thrombosis in vivo
Supplemental data
Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis
Brief Report
Rachel T. McGrath,Maartje van den Biggelaar,Barry Byrne,Jamie M. O’Sullivan,Orla Rawley,Richard O’Kennedy,Jan Voorberg,Roger J. S. Preston,James S. O’Donnell
View Articletitled, Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis

TRANSPLANTATION

Long-term outcome and prospective validation of NIH response criteria in 39 patients receiving imatinib for steroid-refractory chronic GVHD
Clinical Trials & Observations
Attilio Olivieri,Michele Cimminiello,Paolo Corradini,Nicola Mordini,Roberta Fedele,Carmine Selleri,Francesco Onida,Francesca Patriarca,Enzo Pavone,Silvia Svegliati,Armando Gabrielli,Paola Bresciani,Roberta Nuccorini,Sara Pascale,Sabrina Coluzzi,Fabrizio Pane,Antonella Poloni,Jacopo Olivieri,Pietro Leoni,Andrea Bacigalupo
View Articletitled, Long-term outcome and prospective validation of NIH response criteria in 39 patients receiving imatinib for steroid-refractory chronic GVHD
Supplemental data
The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease
Shan He,Fang Xie,Yongnian Liu,Qing Tong,Kazuhiro Mochizuki,Philip E. Lapinski,Ram-Shankar Mani,Pavan Reddy,Izumi Mochizuki,Arul M. Chinnaiyan,Shin Mineishi,Philip D. King,Yi Zhang
View Articletitled, The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease
Supplemental data
Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
James N. Kochenderfer,Mark E. Dudley,Robert O. Carpenter,Sadik H. Kassim,Jeremy J. Rose,William G. Telford,Frances T. Hakim,David C. Halverson,Daniel H. Fowler,Nancy M. Hardy,Anthony R. Mato,Dennis D. Hickstein,Juan C. Gea-Banacloche,Steven Z. Pavletic,Claude Sportes,Irina Maric,Steven A. Feldman,Brenna G. Hansen,Jennifer S. Wilder,Bazetta Blacklock-Schuver,Bipulendu Jena,Michael R. Bishop,Ronald E. Gress,Steven A. Rosenberg
View Articletitled, Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
Supplemental data

VASCULAR BIOLOGY

A critical role for Lyn kinase in strengthening endothelial integrity and barrier function
Jingyan Han,Guoying Zhang,Emily J. Welch,Ying Liang,Jian Fu,Stephen M. Vogel,Clifford A. Lowell,Xiaoping Du,David A. Cheresh,Asrar B. Malik,Zhenyu Li
View Articletitled, A critical role for Lyn kinase in strengthening endothelial integrity and barrier function
Supplemental data
All Issues

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