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Issue Archive

Volume 123, Issue 8
February 20 2014
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
Notch and human hematopoietic stem cells
Ivan Maillard
View Articletitled, Notch and human hematopoietic stem cells
IMMUNOBIOLOGY
Targeting cytokines in ALPS: it’s FAShionable
David T. Teachey
View Articletitled, Targeting cytokines in ALPS: it’s FAShionable
INSIDE BLOOD
Clonal B-cell lymphocytosis: a new member?
Maurilio Ponzoni,Paolo Ghia
View Articletitled, Clonal B-cell lymphocytosis: a new member?
MYELOID NEOPLASIA
Boldly Targeting Kinases without mutations
Matthew S. Davids
View Articletitled, Boldly Targeting Kinases without mutations
PHAGOCYTES, GRANULOCYTES, & MYELOPOIESIS
SLPI is essential for granulopoiesis
Martijn A. Nolte
View Articletitled, SLPI is essential for granulopoiesis
PLATELETS & THROMBOPOIESIS
Inhibit the calpain to climb the mountain
Rafal Pawlinski
View Articletitled, Inhibit the calpain to climb the mountain
RED CELLS, IRON, & ERYTHROPOIESIS
Critical models for the anemia of inflammation
Paula G. Fraenkel
View Articletitled, Critical models for the anemia of inflammation

BLOOD WORK

A leukemic presentation of a “triple-hit” lymphoma
Dong Chen,Rhett P. Ketterling
View Articletitled, A leukemic presentation of a “triple-hit” lymphoma
Darier’s sign in mastocytosis
Benjamin T. Galen,Michal G. Rose
View Articletitled, Darier’s sign in mastocytosis

PLENARY PAPER

A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin
Airie Kim,Eileen Fung,Sona G. Parikh,Erika V. Valore,Victoria Gabayan,Elizabeta Nemeth,Tomas Ganz
View Articletitled, A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin
Supplemental data

PLENARY PAPER

Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus
Sara Gardenghi,Tom M. Renaud,Alessandra Meloni,Carla Casu,Bart J. Crielaard,Laura M. Bystrom,Noa Greenberg-Kushnir,Barbra J. Sasu,Keegan S. Cooke,Stefano Rivella
View Articletitled, Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed <em>Brucella abortus</em>
Supplemental data

EVIDENCE-BASED FOCUSED REVIEW

Platelet transfusions for critically ill patients with thrombocytopenia
CME
Lani Lieberman,Rachel S. Bercovitz,Naushin S. Sholapur,Nancy M. Heddle,Simon J. Stanworth,Donald M. Arnold
View Articletitled, Platelet transfusions for critically ill patients with thrombocytopenia
Supplemental data

HOW I TREAT

How I treat target-specific oral anticoagulant–associated bleeding
Clinical Trials & Observations
Deborah M. Siegal,David A. Garcia,Mark A. Crowther
View Articletitled, How I treat target-specific oral anticoagulant–associated bleeding

CLINICAL TRIALS AND OBSERVATIONS

Results of an open-label multicenter phase 2 trial of lenalidomide monotherapy in refractory mycosis fungoides and Sézary syndrome
Clinical Trials & Observations
Christiane Querfeld,Steven T. Rosen,Joan Guitart,Madeleine Duvic,Youn H. Kim,Stephen W. Dusza,Timothy M. Kuzel
View Articletitled, Results of an open-label multicenter phase 2 trial of lenalidomide monotherapy in refractory mycosis fungoides and Sézary syndrome

HEMATOPOIESIS AND STEM CELLS

Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors
Patricia Benveniste,Pablo Serra,Dzana Dervovic,Elaine Herer,Gisele Knowles,Mahmood Mohtashami,Juan Carlos Zúñiga-Pflücker
View Articletitled, Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors
Supplemental data

IMMUNOBIOLOGY

IL-17 protects T cells from apoptosis and contributes to development of ALPS-like phenotypes
Elena Boggio,Nausicaa Clemente,Anna Mondino,Giuseppe Cappellano,Elisabetta Orilieri,Casimiro L. Gigliotti,Erika Toth,Ugo Ramenghi,Umberto Dianzani,Annalisa Chiocchetti
View Articletitled, IL-17 protects T cells from apoptosis and contributes to development of ALPS-like phenotypes
Supplemental data

LYMPHOID NEOPLASIA

A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma
Itziar Salaverria,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Idoia Martin-Guerrero,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Rabea Wagener,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Markus Kreuz,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Christian W. Kohler,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Julia Richter,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Barbara Pienkowska-Grela,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Patrick Adam,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Birgit Burkhardt,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Alexander Claviez,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Christine Damm-Welk,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Hans G. Drexler,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Michael Hummel,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Elaine S. Jaffe,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Ralf Küppers,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Christine Lefebvre,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Jasmin Lisfeld,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Markus Löffler,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Roderick A. F. Macleod,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Inga Nagel,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Ilske Oschlies,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Maciej Rosolowski,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Robert B. Russell,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Grzegorz Rymkiewicz,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Detlev Schindler,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Matthias Schlesner,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,René Scholtysik,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Carsten Schwaenen,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Rainer Spang,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Monika Szczepanowski,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Lorenz Trümper,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Inga Vater,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Swen Wessendorf,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Wolfram Klapper,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group,Reiner Siebert,for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group
View Articletitled, A recurrent 11q aberration pattern characterizes a subset of <em>MYC</em>-negative high-grade B-cell lymphomas resembling Burkitt lymphoma
Supplemental data
Clonal B-cell lymphocytosis exhibiting immunophenotypic features consistent with a marginal-zone origin: is this a distinct entity?
Aliki Xochelli,Christina Kalpadakis,Anne Gardiner,Panagiotis Baliakas,Theodoros P. Vassilakopoulos,Sarah Mould,Zadie Davis,Evangelia Stalika,George Kanellis,Maria K. Angelopoulou,Neil McIver-Brown,Rachel Ibbotson,Sotirios Sachanas,Penelope Korkolopoulou,Anastasia Athanasiadou,Achilles Anagnostopoulos,Helen A. Papadaki,Theodora Papadaki,Kostas Stamatopoulos,Gerassimos A. Pangalis,David Oscier
View Articletitled, Clonal B-cell lymphocytosis exhibiting immunophenotypic features consistent with a marginal-zone origin: is this a distinct entity?
Bruton’s tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)
Jennifer A. Woyach,Engin Bojnik,Amy S. Ruppert,Matthew R. Stefanovski,Virginia M. Goettl,Kelly A. Smucker,Lisa L. Smith,Jason A. Dubovsky,William H. Towns,Jessica MacMurray,Bonnie K. Harrington,Melanie E. Davis,Stefania Gobessi,Luca Laurenti,Betty Y. Chang,Joseph J. Buggy,Dimitar G. Efremov,John C. Byrd,Amy J. Johnson
View Articletitled, Bruton’s tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)
Supplemental data
Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue
Brief Report
David W. Scott,George W. Wright,P. Mickey Williams,Chih-Jian Lih,William Walsh,Elaine S. Jaffe,Andreas Rosenwald,Elias Campo,Wing C. Chan,Joseph M. Connors,Erlend B. Smeland,Anja Mottok,Rita M. Braziel,German Ott,Jan Delabie,Raymond R. Tubbs,James R. Cook,Dennis D. Weisenburger,Timothy C. Greiner,Betty J. Glinsmann-Gibson,Kai Fu,Louis M. Staudt,Randy D. Gascoyne,Lisa M. Rimsza
View Articletitled, Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue
Supplemental data

MYELOID NEOPLASIA

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells
Eva Nievergall,Hayley S. Ramshaw,Agnes S. M. Yong,Mark Biondo,Samantha J. Busfield,Gino Vairo,Angel F. Lopez,Timothy P. Hughes,Deborah L. White,Devendra K. Hiwase
View Articletitled, Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells
Supplemental data
Identification of Bruton’s tyrosine kinase as a therapeutic target in acute myeloid leukemia
Stuart A. Rushworth,Megan Y. Murray,Lyubov Zaitseva,Kristian M. Bowles,David J. MacEwan
View Articletitled, Identification of Bruton’s tyrosine kinase as a therapeutic target in acute myeloid leukemia
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation
Olga Klimenkova,Wienke Ellerbeck,Maksim Klimiankou,Murat Ünalan,Siarhei Kandabarau,Anna Gigina,Kais Hussein,Cornelia Zeidler,Karl Welte,Julia Skokowa
View Articletitled, A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation
Supplemental data

PLATELETS AND THROMBOPOIESIS

Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype
Tarun Tyagi,Shadab Ahmad,Neha Gupta,Anita Sahu,Yasmin Ahmad,Velu Nair,Tathagat Chatterjee,Nitin Bajaj,Shantanu Sengupta,Lilly Ganju,Shashi Bala Singh,Mohammad Z. Ashraf
View Articletitled, Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype
Supplemental data
Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets
Fabien Pertuy,Anita Eckly,Josiane Weber,Fabienne Proamer,Jean-Yves Rinckel,François Lanza,Christian Gachet,Catherine Léon
View Articletitled, Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets
Supplemental data
Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay
e-blood
Marie Lordkipanidzé,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Gillian C. Lowe,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Nicholas S. Kirkby,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Melissa V. Chan,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Martina H. Lundberg,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Neil V. Morgan,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Danai Bem,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Shaista P. Nisar,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Vincenzo C. Leo,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Matthew L. Jones,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Stuart J. Mundell,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Martina E. Daly,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Andrew D. Mumford,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Timothy D. Warner,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Steve P. Watson,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group
View Articletitled, Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well <em>Optimul</em> assay
Supplemental data

TRANSPLANTATION

Identification of a permissible HLA mismatch in hematopoietic stem cell transplantation
Marcelo A. Fernandez-Viña,Tao Wang,Stephanie J. Lee,Michael Haagenson,Mahmoud Aljurf,Medhat Askar,Minoo Battiwalla,Lee-Ann Baxter-Lowe,James Gajewski,Ann A. Jakubowski,Susana Marino,Machteld Oudshoorn,Steven G. E. Marsh,Effie W. Petersdorf,Kirk Schultz,E. Victoria Turner,Edmund K. Waller,Ann Woolfrey,John Umejiego,Stephen R. Spellman,Michelle Setterholm
View Articletitled, Identification of a permissible HLA mismatch in hematopoietic stem cell transplantation
Supplemental data

ERRATA

Zardo G, Ciolfi A, Vian L, et al. Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression. Blood. 2012;119(17):4034-4046.
View Articletitled, Zardo G, Ciolfi A, Vian L, et al. Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression. <em>Blood</em>. 2012;119(17):<span class="related-article">4034-4046</span>.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Platelet transfusions in the ICU
CME
View Articletitled, Platelet transfusions in the ICU
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