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Issue Archive

Volume 124, Issue 15
October 9 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Renal risk and response in amyloidosis
Clinical Trials & Observations
Angela Dispenzieri
View Articletitled, Renal risk and response in amyloidosis
INSIDE BLOOD COMMENTARY
It takes a village
Clinical Trials & Observations
Naomi Winick
View Articletitled, It takes a village
INSIDE BLOOD COMMENTARY
Concealed dagger in FLT3/ITD+ AML
Yishai Ofran
View Articletitled, Concealed dagger in FLT3/ITD<sup>+</sup> AML
INSIDE BLOOD COMMENTARY
Inflammatory Langerhans cell differentiation
Herbert Strobl
View Articletitled, Inflammatory Langerhans cell differentiation
INSIDE BLOOD COMMENTARY
Macrophages shine bright
Oliver Soehnlein
View Articletitled, Macrophages shine bright
INSIDE BLOOD COMMENTARY
Self-control of platelets: a new ITIM story
Xiaoping Du
View Articletitled, Self-control of platelets: a new ITIM story
INSIDE BLOOD COMMENTARY
CEA a thrombus CAM: CEACAM2, a twin of CEACAM1?
Andrea Kristina Horst
View Articletitled, CEA a thrombus CAM: CEACAM2, a twin of CEACAM1?

PLENARY PAPER

A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis
Clinical Trials & Observations
Giovanni Palladini,Ute Hegenbart,Paolo Milani,Christoph Kimmich,Andrea Foli,Anthony D. Ho,Marta Vidus Rosin,Riccardo Albertini,Remigio Moratti,Giampaolo Merlini,Stefan Schönland
View Articletitled, A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis
Supplemental data

BLOOD SPOTLIGHT

Molecular and clinical predictors of inhibitor risk and its prevention and treatment in mild hemophilia A
Giancarlo Castaman,Karin Fijnvandraat
View Articletitled, Molecular and clinical predictors of inhibitor risk and its prevention and treatment in mild hemophilia A

REVIEW ARTICLE

Autoimmune and other cytopenias in primary immunodeficiencies: pathomechanisms, novel differential diagnoses, and treatment
Clinical Trials & Observations
Markus G. Seidel
View Articletitled, Autoimmune and other cytopenias in primary immunodeficiencies: pathomechanisms, novel differential diagnoses, and treatment

CLINICAL TRIALS AND OBSERVATIONS

6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children's Oncology Group study
Clinical Trials & Observations
Smita Bhatia,Wendy Landier,Lindsey Hageman,Heeyoung Kim,Yanjun Chen,Kristine R. Crews,William E. Evans,Bruce Bostrom,Jacqueline Casillas,David S. Dickens,Kelly W. Maloney,Joseph P. Neglia,Yaddanapudi Ravindranath,A. Kim Ritchey,F. Lennie Wong,Mary V. Relling
View Articletitled, 6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children's Oncology Group study
Supplemental data
Impact of induction regimen and stem cell transplantation on outcomes in double-hit lymphoma: a multicenter retrospective analysis
Clinical Trials & Observations
Adam M. Petrich,Mitul Gandhi,Borko Jovanovic,Jorge J. Castillo,Saurabh Rajguru,David T. Yang,Khushboo A. Shah,Jeremy D. Whyman,Frederick Lansigan,Francisco J. Hernandez-Ilizaliturri,Lisa X. Lee,Stefan K. Barta,Shruthi Melinamani,Reem Karmali,Camille Adeimy,Scott Smith,Neil Dalal,Chadi Nabhan,David Peace,Julie Vose,Andrew M. Evens,Namrata Shah,Timothy S. Fenske,Andrew D. Zelenetz,Daniel J. Landsburg,Christina Howlett,Anthony Mato,Michael Jaglal,Julio C. Chavez,Judy P. Tsai,Nishitha Reddy,Shaoying Li,Caitlin Handler,Christopher R. Flowers,Jonathon B. Cohen,Kristie A. Blum,Kevin Song,Haowei (Linda) Sun,Oliver Press,Ryan Cassaday,Jesse Jaso,L. Jeffrey Medeiros,Aliyah R. Sohani,Jeremy S. Abramson
View Articletitled, Impact of induction regimen and stem cell transplantation on outcomes in double-hit lymphoma: a multicenter retrospective analysis
Supplemental data

HEMATOPOIESIS AND STEM CELLS

UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity
Marie-Eve Bordeleau,Romain Aucagne,Jalila Chagraoui,Simon Girard,Nadine Mayotte,Éric Bonneil,Pierre Thibault,Caroline Pabst,Anne Bergeron,Frédéric Barabé,Josée Hébert,Martin Sauvageau,Christel Boutonnet,Sylvain Meloche,Guy Sauvageau
View Articletitled, UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity
Supplemental data

IMMUNOBIOLOGY

Loss of STAT3 in murine NK cells enhances NK cell–dependent tumor surveillance
Dagmar Gotthardt,Eva M. Putz,Elisabeth Straka,Petra Kudweis,Mario Biaggio,Valeria Poli,Birgit Strobl,Mathias Müller,Veronika Sexl
View Articletitled, Loss of STAT3 in murine NK cells enhances NK cell–dependent tumor surveillance
Supplemental data

LYMPHOID NEOPLASIA

Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis
Esther Rodríguez-Díez,Victor Quereda,Florian Bellutti,Michaela Prchal-Murphy,David Partida,Manuel Eguren,Karoline Kollmann,Marta Gómez de Cedrón,Pierre Dubus,Marta Cañamero,Dolores Martínez,Veronika Sexl,Marcos Malumbres
View Articletitled, Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis
Supplemental data

MYELOID NEOPLASIA

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells
Philipp B. Staber,Pu Zhang,Min Ye,Robert S. Welner,Elena Levantini,Annalisa Di Ruscio,Alexander K. Ebralidze,Christian Bach,Hong Zhang,Junyan Zhang,Katrina Vanura,Ruud Delwel,Henry Yang,Gang Huang,Daniel G. Tenen
View Articletitled, The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells
Supplemental data
NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report
Fabiana Ostronoff,Megan Othus,Robert B. Gerbing,Michael R. Loken,Susana C. Raimondi,Betsy A. Hirsch,Beverly J. Lange,Stephen Petersdorf,Jerald Radich,Frederick R. Appelbaum,Alan S. Gamis,Todd A. Alonzo,Soheil Meshinchi
View Articletitled, <em>NUP98/NSD1</em> and <em>FLT3/ITD</em> coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report
Supplemental data
Impact of early molecular response in children with chronic myeloid leukemia treated in the French Glivec phase 4 study
Brief Report
Frédéric Millot,Joelle Guilhot,André Baruchel,Arnaud Petit,Yves Bertrand,Françoise Mazingue,Patrick Lutz,Cecile Vérité,Christian Berthou,Claire Galambrun,Nicolas Sirvent,Karima Yakouben,Claudine Schmitt,Virginie Gandemer,Yves Reguerre,Gérard Couillault,Françoise Mechinaud,Jean-Michel Cayuela
View Articletitled, Impact of early molecular response in children with chronic myeloid leukemia treated in the French Glivec phase 4 study
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Human blood BDCA-1 dendritic cells differentiate into Langerhans-like cells with thymic stromal lymphopoietin and TGF-β
Carolina Martínez-Cingolani,Maximilien Grandclaudon,Marine Jeanmougin,Mabel Jouve,Raphaël Zollinger,Vassili Soumelis
View Articletitled, Human blood BDCA-1 dendritic cells differentiate into Langerhans-like cells with thymic stromal lymphopoietin and TGF-β
Supplemental data
Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo
e-blood
Asif J. Iqbal,Eileen McNeill,Theodore S. Kapellos,Daniel Regan-Komito,Sophie Norman,Sarah Burd,Nicola Smart,Daniel E. W. Machemer,Elena Stylianou,Helen McShane,Keith M. Channon,Ajay Chawla,David R. Greaves
View Articletitled, Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo
Supplemental data

PLATELETS AND THROMBOPOIESIS

Paired immunoglobulin-like receptor B regulates platelet activation
Xuemei Fan,Panlai Shi,Jing Dai,Yeling Lu,Xue Chen,Xiaoye Liu,Kandi Zhang,Xiaolin Wu,Yueping Sun,Kemin Wang,Li Zhu,Cheng Cheng Zhang,Junfeng Zhang,Guo-qiang Chen,Junke Zheng,Junling Liu
View Articletitled, Paired immunoglobulin-like receptor B regulates platelet activation
Supplemental data
CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo
Musaed M. Alshahrani,Eunice Yang,Jana Yip,Simona S. Ghanem,Simon L. Abdallah,Anthony M. deAngelis,Cindy J. O’Malley,Fatemeh Moheimani,Sonia M. Najjar,Denise E. Jackson
View Articletitled, CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo
Supplemental data

THROMBOSIS AND HEMOSTASIS

Binding of anti–platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4
Martin Kreimann,Sven Brandt,Krystin Krauel,Stephan Block,Christiane A. Helm,Werner Weitschies,Andreas Greinacher,Mihaela Delcea
View Articletitled, Binding of anti–platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4
Supplemental data
The impact of bleeding complications in patients receiving target-specific oral anticoagulants: a systematic review and meta-analysis
Chatree Chai-Adisaksopha,Mark Crowther,Tetsuya Isayama,Wendy Lim
View Articletitled, The impact of bleeding complications in patients receiving target-specific oral anticoagulants: a systematic review and meta-analysis
Supplemental data

TRANSPLANTATION

Impact of acute and chronic graft-versus-host disease on human B-cell generation and replication
Brief Report
Salomé Glauzy,Juliette Soret,Isabelle Fournier,Corinne Douay,Hélène Moins-Teisserenc,Régis Peffault de Latour,Guitta Maki,Marie Robin,Gérard Socié,Antoine Toubert,Emmanuel Clave
View Articletitled, Impact of acute and chronic graft-versus-host disease on human B-cell generation and replication
Supplemental data

BLOOD WORK

Coexistent BCR-ABL1 and JAK2 V617F: converting CML dwarves to ET staghorns with imatinib therapy
Craig Soderquist,Adam Bagg
View Articletitled, Coexistent <em>BCR-ABL1</em> and <em>JAK2</em> V617F: converting CML dwarves to ET staghorns with imatinib therapy
Basophilic blast phase of chronic myelogenous leukemia
Hani M. Babiker,Maria Proytcheva
View Articletitled, Basophilic blast phase of chronic myelogenous leukemia

CORRESPONDENCE

The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like CALR variants
Clinical Trials & Observations
Ayalew Tefferi,Terra L. Lasho,Alexander Tischer,Emnet A. Wassie,Christy M. Finke,Alem A. Belachew,Rhett P. Ketterling,Curtis A. Hanson,Animesh D. Pardanani
View Articletitled, The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like <em>CALR</em> variants
Supplemental data
Lenalidomide-induced diarrhea in patients with myeloma is caused by bile acid malabsorption that responds to treatment
Charlotte Pawlyn,Mohid S. Khan,Ann Muls,Priya Sriskandarajah,Martin F. Kaiser,Faith E. Davies,Gareth J. Morgan,H. Jervoise N. Andreyev
View Articletitled, Lenalidomide-induced diarrhea in patients with myeloma is caused by bile acid malabsorption that responds to treatment

ERRATA

Lo SM, Choi M, Liu J, et al. Phenotype diversity in type 1 Gaucher disease: discovering the genetic basis of Gaucher disease/hematologic malignancy phenotype by individual genome analysis. Blood. 2012;119(20):4731-4740.
View Articletitled, Lo SM, Choi M, Liu J, et al. Phenotype diversity in type 1 Gaucher disease: discovering the genetic basis of Gaucher disease/hematologic malignancy phenotype by individual genome analysis. <em>Blood.</em> 2012;119(20):<span class="related-article">4731-4740</span>.
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